naproxen has been researched along with dinoprostone in 131 studies
| Studies (naproxen) | Trials (naproxen) | Recent Studies (post-2010) (naproxen) | Studies (dinoprostone) | Trials (dinoprostone) | Recent Studies (post-2010) (dinoprostone) |
|---|---|---|---|---|---|
| 4,551 | 1,057 | 1,429 | 29,105 | 1,346 | 6,357 |
| Protein | Taxonomy | naproxen (IC50) | dinoprostone (IC50) |
|---|---|---|---|
| Prostaglandin E2 receptor EP1 subtype | Homo sapiens (human) | 0.0155 | |
| Prostaglandin E2 receptor EP4 subtype | Homo sapiens (human) | 0.0031 | |
| Prostaglandin E2 receptor EP4 subtype | Rattus norvegicus (Norway rat) | 0.0021 | |
| Prostaglandin E2 receptor EP3 subtype | Homo sapiens (human) | 0.002 | |
| Prostaglandin E2 receptor EP2 subtype | Homo sapiens (human) | 0.0087 | |
| Prostacyclin receptor | Homo sapiens (human) | 0.26 | |
| Prostaglandin E2 receptor EP2 subtype | Rattus norvegicus (Norway rat) | 0.0052 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (16.79) | 18.7374 |
| 1990's | 51 (38.93) | 18.2507 |
| 2000's | 33 (25.19) | 29.6817 |
| 2010's | 22 (16.79) | 24.3611 |
| 2020's | 3 (2.29) | 2.80 |
| Authors | Studies |
|---|---|
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Duffy, EM; Jorgensen, WL | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Gale, D; Keenan, CM; Shoupe, TS; Wallace, JL | 1 |
| Bendele, AM; Benslay, DN; Hom, JT; Lee, SJ; Lindstrom, TD; Naismith, RW; Ruterbories, KJ; Spaethe, SM | 1 |
| Gerges, F; Khalil, H; Kholeif, A; Marzouk, S; Toppozada, M | 1 |
| Cheung, D; Filonzi, EL; Gallichio, M; Hamilton, JA; Last, K; McGrath, K; Piccoli, DS; Wojta, J | 1 |
| Croxtall, JD; Flower, RJ | 1 |
| Basch, CM; Robinson, DR; Simon, LS; Young, DY | 1 |
| Bassleer, C; Franchimont, P; Henrotin, Y | 1 |
| Hsu, HP; Lane, N; Shortkroff, S; Sledge, CB; Spector, M; Taylor-Zapatka, S; Thornhill, TS | 1 |
| Goldhaber, P; Hall, CM; Howell, TH; Jeffcoat, MK; Johnson, HG; Odle, BM; Offenbacher, S; Smith, MA; Williams, RC | 1 |
| Bachetti, T; Bucolo, C; Canossa, M; Mangiafico, S; Marino, A; Spampinato, S | 1 |
| Baracos, VE; Olomu, JM | 1 |
| Aperia, A; Körner, A; Linné, T; Persson, B; Rudberg, S | 1 |
| Berg, KJ; Djøseland, O; Nilsen, L; Rootwelt, K | 1 |
| Chin, RC; Chiou, SS; Goodman, SB; Lee, JS | 2 |
| Baracos, VE; Fisher, BD; Reid, DC | 1 |
| Barradas, MA; Dandona, P; Jeremy, JY; Kirk, RM; Mikhailidis, DP | 2 |
| Fritz, ME; Green, MD; Mayambala, CS; Odle, BM; Offenbacher, S; Sena, FJ; Smith, MA; van Dyke, TE; Yeh, KC | 1 |
| Andersson, KE; Eriksson, LO; Kullendorff, CM; Larsson, B | 1 |
| Holland, PJ; Kelly, RW; McLaughlin, S; Russell, RI; Sturrock, RD; Taha, AS | 1 |
| Russell, RI | 1 |
| McKnight, GW; Wallace, JL | 1 |
| Cox, PG; Moons, MM; Russel, FG; van Ginneken, CA | 1 |
| Cox, PG; Moons, WM; Russel, FG; van Ginneken, CA | 1 |
| Hsu, HP; Lane, N; Shortkroff, S; Sledge, CB; Spector, M; Thornhill, TS | 1 |
| Bremme, K; Bygdeman, M; Eneroth, P; Gottlieb, C; Kindahl, H; Nilsson, B; Olsson, M; Svanborg, K | 1 |
| Pujol, JP | 1 |
| Baracos, VE; Tian, S | 1 |
| Baracos, VE; Fields, AL; Strelkov, AB | 1 |
| Chan, WY | 2 |
| Jackson, BA | 1 |
| Kothari, HV; Ku, EC; Lee, W; Scholer, DW | 1 |
| Foidart, JB; Mahieu, P | 1 |
| Dvornik, D; Lee, D | 1 |
| Carvounis, CP; Cushley, P; Hueber, P; Patchin, D; Schroeder, ET | 1 |
| Bremme, K; Bygdeman, M; Eneroth, P; Gottlieb, C; Svanborg, K | 1 |
| Blazaki, D; Löscher, W | 1 |
| Abramovich, S; Fuller, A; Lavelle, R; MacKinnon, M; O'Grady, J | 1 |
| Christensen, P; Kamper, AL; Strandgaard, S; Svendsen, UG | 1 |
| Isomäki, H; Laitinen, O; Nissilä, M; Nuotio, P; Nykänen, E; Seppälä, E; Vapaatalo, H | 1 |
| Aziz, MZ; Green, K; Jay, WM; Pritchett, PM | 1 |
| Kimble, EF; Kothari, HV; Ku, EC; Lee, W; Liauw, L; Tjan, J | 1 |
| Colombo, G; Glässer, A; Luzzani, F; Schiatti, P; Selva, D | 1 |
| Chan, WY; Fuchs, F; Powell, AM | 1 |
| Akerlund, M; Kostrzewska, A; Laudański, T | 1 |
| Chiou, S; Vesely, DL | 1 |
| Kajiyama, G; Lane, NE; Smith, RL | 1 |
| Dainaka, J; Hashii, H; Inoue, K; Kimura, K; Motonaga, A; Nishimura, T; Ueda, F; Yamate, K | 1 |
| Barbacane, RC; Bartle, L; Conti, P; Reale, M; Sipe, JD | 1 |
| Bell, CJ; McKnight, GW; Wallace, JL | 1 |
| Bilodeau, JF; Castonguay, A; Chung, FL; Wang, M | 1 |
| Bailleul, F; Bertin, P; Jaeger, S; Lapicque, F; Netter, P; Payan, E; Rigaud, M; Treves, R | 1 |
| Colling, E; Göthert, M; Jakschik, J; Likungu, J; Molderings, GJ | 1 |
| Hill, RE; Hunt, RH; James, C; Johnson, DM; Rainsford, KD; Salena, BJ; Stetsko, PI | 1 |
| Cominelli, F; Ferretti, M; Laine, L; Sloane, R | 1 |
| Bucolo, C; Spadaro, A | 1 |
| Marcinkiewicz, M; Parolisi, S; Peura, DA; Sarosiek, J | 1 |
| Mue, S; Ohuchi, K; Watanabe, M; Yamada, M | 1 |
| Lipscomb, GR; Rees, WD | 1 |
| Day, RO; Francis, H; Geisslinger, G; Vial, J; Williams, KM | 1 |
| Lebbe, C; Meijer, DK; Poelstra, K; Reichen, J; Sägesser, H; Wartna, E | 1 |
| Castonguay, A; Rioux, N | 1 |
| Albrecht, C; Lebbe, C; Meijer, DK; Melgert, BN; Poelstra, K; Reichen, J; Sägesser, H | 1 |
| de Jong, PE; de Zeeuw, D; Haas, M; Kluppel, AC; Meijer, DK; Moolenaar, F; Wartna, ES | 1 |
| Kajiyama, G; Schurman, DJ; Smith, RL | 1 |
| de Jong, PE; de Zeeuw, D; Haas, M; Meijer, DK; Moolenaar, F | 1 |
| Duval, N; Fernandes, JC; Martel-Pelletier, J; Mineau, F; Pelletier, JP | 1 |
| Grundy, D; Maubach, KA | 1 |
| Gierse, JK; Isakson, PC; Koboldt, CM; Seibert, K; Walker, MC | 1 |
| Brunsden, AM; Grundy, D | 1 |
| Asfaha, S; McKnight, W; Muscará, MN; Wallace, JL | 1 |
| Arnout, J; Buntinx, A; Dallob, A; De Lepeleire, I; De Schepper, PJ; Depré, M; Ebel, DL; Gertz, BJ; Schwartz, JI; Tanaka, W; Van Hecken, A; Wong, PH; Wynants, K | 1 |
| Brzozowski, T; Drozdowicz, D; Hahn, E; Konturek, PC; Konturek, SJ; Kwiecień, S; Pajdo, R; Pawlik, M; Ptak, A; Sliwowski, Z | 1 |
| Jurenka, RA; Stanley, DW; Tunaz, H | 1 |
| Di Battista, JA; Fahmi, H; He, Y; Martel-Pelletier, J; Pelletier, JP; Zhang, M | 1 |
| Fernandes, JC; Hilal, G; Lajeunesse, D; Martel-Pelletier, J; Massicotte, F; Pelletier, JP | 1 |
| Büyükgüzel, K; Putnam, SM; Stanley, D; Tunaz, H | 1 |
| Kato, S; Kunikata, T; Miyazawa, T; Takeuchi, K; Tanaka, A | 1 |
| Baylas, H; Huseyinov, A; Vardar, S | 1 |
| Agrawal, N; Dallob, A; De Schepper, P; DeTora, L; Gertz, B; Gottesdiener, K; Greenberg, H; Hawkey, CJ; Wagner, J; Waldman, S; Wight, N; Wong, P | 1 |
| Capone, ML; Di Gregorio, P; Grana, M; Merciaro, G; Minuz, P; Patrignani, P; Patrono, C; Ricciotti, E; Sciulli, MG; Tacconelli, S | 1 |
| Gross, GJ; Moore, J | 1 |
| Branch, CD; Gopalan, B; Ito, I; Ramesh, R; Roth, JA; Stephens, C | 1 |
| Breese, E; Del Soldato, P; Mitchell, J; Warner, T; Wood, E; Zacharowski, P | 1 |
| Arroyo, V; Clària, J; Escolar, G; Ginès, P; Jiménez, W; Kent, JD; López-Parra, M; Ruiz-Del-Arbol, L; Vucelic, B | 1 |
| Enck, P; Glatzle, J; Grundy, D; Kreis, M; Mueller, MH; Wang, B | 1 |
| Guévremont, M; Laufer, S; Marcouiller, P; Martel-Pelletier, J; Pelletier, JP; Ranger, P; Reboul, P | 1 |
| Fernandes, JC; Lajeunesse, D; Martel-Pelletier, J; Massicotte, F; Pelletier, JP | 1 |
| Augustyniak, ME; Cochran, ED; Earl, RA; Ellis, JL; Garvey, DS; Gordon, LJ; Janero, DR; Khanapure, SP; Letts, LG; Melim, TL; Murty, MG; Schwalb, DJ; Selig, WM; Shumway, MJ; Trocha, AM; Young, DV; Zemtseva, IS | 1 |
| Antonioli, L; Blandizzi, C; Cei, S; Colucci, R; Del Tacca, M; Fornai, M; Gabriele, M; Graziani, F; Tonelli, M; Vassalle, C | 1 |
| Bishop-Bailey, D; Mitchell, JA; Vojnovic, I; Warner, TD | 1 |
| Danhof, M; Della Pasqua, OE; Huntjens, DR; Spalding, DJ | 2 |
| Takahira, Y; Takeuchi, K; Tanaka, A; Yokota, A | 1 |
| Anzellotti, P; Capone, ML; Di Francesco, L; Di Gregorio, P; Merciaro, G; Patrignani, P; Sciulli, MG; Tacconelli, S | 1 |
| Acuto, G; Allais, G; Benedetto, C; Borgogno, P; Bussone, G; Castagnoli Gabellari, I; De Lorenzo, C; Mana, O; Zonca, M | 1 |
| Barrientos, RM; Bland, ST; Hein, AM; Maier, SF; Rudy, JW; Stutzman, DL; Watkins, LR | 1 |
| Bland, JS; Carroll, B; Darland, G; Hall, A; Katke, J; Lamb, J; Lerman, RH; Minich, DM; Tripp, M | 1 |
| Anwyl, R; Ashe, KH; Cleary, J; Cole, G; Falinska, A; Frautschy, S; Kotilinek, LA; Lesne, S; Lim, GP; Panizzon, K; Rowan, M; Simonyi, A; Sun, GY; Wallis, RA; Wang, Q; Westerman, MA; Younkin, LH; Younkin, SG | 1 |
| Besz, D; Brune, K; Cheremina, O; Hinz, B; Zlotnick, S | 1 |
| Buyse, M; Farinotti, R; Zrieki, A | 1 |
| Ferrari, A; Leoni, J; Maglio, DH; Paz, ML; Weill, FS | 1 |
| Dial, EJ; Lichtenberger, LM; Moore, JE; Romero, JJ | 1 |
| Finn, A; Oerther, SC | 1 |
| Caliendo, G; Cirino, G; Santagada, V; Wallace, JL | 1 |
| Boring, D; Chattopadhyay, M; Crowell, JA; Goswami, S; Kashfi, K; Kodela, R; Rodes, DB; Velazquez, CA | 1 |
| Angesjö, M; Berge, OG; Krekels, EH; Möller, KA; Sjögren, I; Visser, SA | 1 |
| Bani, D; Bolla, M; Masini, E; Pini, A; Viappiani, S | 1 |
| Cairns, BE; Dong, XD; Svensson, P; Wong, H | 1 |
| Elmes, SJ; McIntosh, F; Perkins, MN; Rashid, MH; Theberge, Y | 1 |
| Fischer, SM; Lubet, RA; Mikulec, CD; Rundhaug, JE; Simper, MS | 1 |
| Ara, N; Ichikawa, T; Iijima, K; Ishihara, K; Iwabuchi, T; Kamata, Y; Koike, T; Shimosegawa, T; Shinkai, H | 1 |
| Baldelli, F; Cipriani, S; D'Amore, C; Distrutti, E; Fiorucci, S; Francisci, D; Mencarelli, A; Renga, B; Santucci, L | 1 |
| Danhof, M; Della Pasqua, O; Sahota, T; Sanderson, I | 2 |
| Blackler, RW; Elsheikh, W; Flannigan, KL; Wallace, JL | 1 |
| Atli, O; Burukoglu, D; Ilgin, S; Perk, BO; Uzun, B | 1 |
| Amoruso, A; Bardelli, C; Brunelleschi, S; Dalli, J; Federici Canova, D; Fresu, LG; Miglietta, D; Perretti, M | 1 |
| Anzini, M; Belmonte, G; Biava, M; Cheleschi, S; Di Capua, A; Fioravanti, A; Giordani, A; Pascarelli, NA; Sticozzi, C; Valacchi, G | 1 |
| Arcuri, F; Bruni, S; Carrarelli, P; Funghi, L; Luisi, S; Petraglia, F | 1 |
| Carvalhaes, A; De Nucci, G; Gagliano-Jucá, T; Magalhães, AF; Moreno, RA; Napolitano, M; Trevisan, MS; Wallace, JL; Zaminelli, T | 1 |
| Bolognesi, MP; Hsueh, MF; Kraus, VB; Wellman, SS | 1 |
| Bommi, PV; Brown, PH; Chang, K; Francisco-Cruz, A; Gelincik, O; Kanth, P; Kopelovich, L; Lee, JJ; Lim, R; Lipkin, SM; Liu, DD; Lynch, PM; Marnett, LJ; Milne, GL; Mork, ME; Perloff, M; Revuelta, M; Reyes-Uribe, L; Richmond, E; Samadder, NJ; Sei, S; Shoemaker, RH; Solis, LM; Stoffel, EM; Szabo, E; Taggart, MW; Umar, A; Vilar, E; Vornik, L; Wistuba, II; Wu, W; You, YN | 1 |
| Flint, JD; Gilroy, DW; Glanville, JRW; Hosin, AA; Jalali, P; Maini, AA; Patel, AA; Wallace, JL | 1 |
1 review(s) available for naproxen and dinoprostone
| Article | Year |
|---|---|
[Interleukin 1, prostaglandin E2 and articular inflammation].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Dinoprostone; Humans; Interleukin-1; Naproxen | 1989 |
23 trial(s) available for naproxen and dinoprostone
| Article | Year |
|---|---|
Effect of prostaglandin E2 or prostaglandin synthesis inhibitors on human gonadotrophins and prolactin.
Topics: Adult; Dinoprostone; Female; Follicle Stimulating Hormone; Humans; Indomethacin; Luteinizing Hormone; Male; Naproxen; Prolactin; Prostaglandins | 1992 |
Effects of naproxen on renal function in older patients with mild to moderate renal dysfunction.
Topics: Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Creatine; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Hemodynamics; Humans; Kidney; Kidney Diseases; Middle Aged; Naproxen; Prostaglandins F; Thromboxane B2 | 1992 |
Effects of short-term treatment with naproxen on kidney function in insulin-dependent diabetic patients with microalbuminuria.
Topics: Adult; Albuminuria; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Dinoprostone; Double-Blind Method; Female; Humans; Kidney; Kidney Glomerulus; Kidney Tubules; Male; Naproxen; Time Factors | 1991 |
Effect on gastric and duodenal mucosal prostaglandins of repeated intake of therapeutic doses of naproxen and etodolac in rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Dinoprostone; Double-Blind Method; Duodenum; Epoprostenol; Etodolac; Female; Gastric Mucosa; Humans; Indoleacetic Acids; Intestinal Mucosa; Male; Middle Aged; Naproxen; Prospective Studies; Prostaglandins; Thromboxane B2 | 1990 |
Endoscopic evaluation of etodolac and naproxen, and their relative effects on gastric and duodenal prostaglandins.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dinoprostone; Dose-Response Relationship, Drug; Duodenum; Endoscopy; Epoprostenol; Etodolac; Female; Gastric Mucosa; Humans; Indoleacetic Acids; Male; Middle Aged; Mucous Membrane; Naproxen; Osteoarthritis; Patient Compliance; Prostaglandins; Stomach; Thromboxane B2; Time Factors | 1990 |
Naproxen in otitis media with effusion.
Topics: Body Fluids; Child; Child, Preschool; Clinical Trials as Topic; Dinoprostone; Double-Blind Method; Ear, Middle; Humans; Naproxen; Otitis Media with Effusion; Prostaglandins E; Suction | 1986 |
Effects of sulindac and naproxen in patients with chronic glomerular disease.
Topics: Adult; Chronic Disease; Clinical Trials as Topic; Creatinine; Dinoprost; Dinoprostone; Female; Glomerulonephritis; Humans; Indenes; Kidney; Male; Middle Aged; Naproxen; Prostaglandins E; Prostaglandins F; Random Allocation; Sulindac | 1986 |
Effects of naproxen sodium on menstrual prostaglandins and primary dysmenorrhea.
Topics: Adult; Dinoprost; Dinoprostone; Dysmenorrhea; Female; Humans; Menstruation; Naproxen; Prostaglandins E; Prostaglandins F | 1983 |
Effects of chronic NSAIDs on gastric mucosal injury related to mucosal prostanoids, and plasma drug concentrations in human volunteers.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Anti-Inflammatory Agents, Non-Steroidal; Apazone; Dinoprostone; Gastric Fundus; Gastric Mucosa; Humans; Indomethacin; Male; Naproxen; Piroxicam; Pyloric Antrum; Thromboxane B2 | 1993 |
A randomized double-blind comparison of placebo, etodolac, and naproxen on gastrointestinal injury and prostaglandin production.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Dinoprostone; Double-Blind Method; Drug Administration Schedule; Endoscopy, Gastrointestinal; Etodolac; Female; Gastric Mucosa; Humans; Male; Naproxen; Prospective Studies; Stomach Ulcer; Time Factors | 1995 |
Prostaglandin E2 content in residual gastric juice reflects endoscopic damage to the gastric mucosa after naproxen sodium administration.
Topics: Adult; Cross-Over Studies; Dinoprostone; Double-Blind Method; Female; Gastric Juice; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Male; Middle Aged; Naproxen | 1996 |
Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers.
Topics: Adolescent; Adult; Bleeding Time; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Female; Humans; Ibuprofen; Isoenzymes; Lactones; Lipopolysaccharides; Meloxicam; Membrane Proteins; Middle Aged; Naproxen; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Sulfones; Thiazines; Thiazoles; Thromboxane B2 | 2000 |
Effects of selective cyclooxygenase-2 inhibition on gingival tissue levels of prostaglandin E2 and prostaglandin F2alpha and clinical parameters of chronic periodontitis.
Topics: Adult; Chronic Disease; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dental Plaque Index; Dental Scaling; Dinoprost; Dinoprostone; Double-Blind Method; Female; Follow-Up Studies; Gingiva; Humans; Isoenzymes; Male; Matched-Pair Analysis; Membrane Proteins; Middle Aged; Naproxen; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Placebos; Prostaglandin-Endoperoxide Synthases; Root Planing; Statistics as Topic; Statistics, Nonparametric; Sulfonamides | 2003 |
Characterization of etoricoxib, a novel, selective COX-2 inhibitor.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Cyclooxygenase 2; Dinoprostone; Double-Blind Method; Drug Tolerance; Etoricoxib; Female; Gastric Mucosa; Humans; Isoenzymes; Lipopolysaccharides; Male; Membrane Proteins; Middle Aged; Naproxen; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Pyridines; Sulfones | 2003 |
Clinical pharmacology of platelet, monocyte, and vascular cyclooxygenase inhibition by naproxen and low-dose aspirin in healthy subjects.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aspirin; Blood Platelets; Cardiotonic Agents; Cross-Over Studies; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Endothelial Cells; Endothelium, Vascular; Female; Humans; Isoenzymes; Male; Membrane Proteins; Middle Aged; Monocytes; Naproxen; Prostaglandin-Endoperoxide Synthases; Prostaglandins I; Thromboxane B2 | 2004 |
Effects of celecoxib and naproxen on renal function in nonazotemic patients with cirrhosis and ascites.
Topics: Ascites; Celecoxib; Dinoprostone; Double-Blind Method; Female; Furosemide; Glomerular Filtration Rate; Humans; Kidney; Liver Cirrhosis; Male; Middle Aged; Naproxen; Platelet Aggregation; Pyrazoles; Renin; Sulfonamides | 2005 |
Cyclooxygenase-2 induction after oral surgery does not entirely account for analgesia after selective blockade of cyclooxygenase 2 in the preoperative period.
Topics: Actins; Adult; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Double-Blind Method; Female; Humans; Lactones; Male; Microdialysis; Naproxen; Oral Surgical Procedures; Pain, Postoperative; Prostaglandins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfones | 2006 |
Human pharmacology of naproxen sodium.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; Humans; Lipopolysaccharides; Monocytes; Naproxen; Platelet Aggregation; Thromboxane B2 | 2007 |
Clinical safety and efficacy of NG440: a novel combination of rho iso-alpha acids from hops, rosemary, and oleanolic acid for inflammatory conditions.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Cell Count; Blood Coagulation; Blood Pressure; Cells, Cultured; Cross-Over Studies; Cyclopentanes; Dinoprostone; Double-Blind Method; Drug Combinations; Feces; Female; Humans; Humulus; Kidney Function Tests; Leukocyte L1 Antigen Complex; Liver Function Tests; Male; Mice; Naproxen; Oleanolic Acid; Pain; Plant Extracts; Rheumatic Diseases; Rosmarinus | 2007 |
Increased gastric mucus secretion alleviates non-steroidal anti-inflammatory drug-induced abdominal pain.
Topics: Abdominal Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Etodolac; Gastric Mucosa; Humans; Male; Mucus; Naproxen; Stomach; Young Adult | 2013 |
Rebamipide does not protect against naproxen-induced gastric damage: a randomized double-blind controlled trial.
Topics: Adolescent; Adult; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Double-Blind Method; Female; Gastric Mucosa; Gastrointestinal Agents; Humans; Male; Middle Aged; Naproxen; Quinolones; Stomach Diseases; Young Adult | 2016 |
Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa.
Topics: Adult; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemoprevention; Colorectal Neoplasms, Hereditary Nonpolyposis; Dinoprostone; Disease Models, Animal; Female; Humans; Intestinal Mucosa; Male; Mice; Middle Aged; Naproxen | 2021 |
Potent anti-inflammatory effects of an H
Topics: Adolescent; Adult; Dinoprostone; Escherichia coli; Humans; Hydrogen Sulfide; Inflammation; Male; Middle Aged; Monocytes; Naproxen; Neutrophils; Pain; Phenotype; Solubility; Ultraviolet Rays; Vasoconstriction; Young Adult | 2021 |
107 other study(ies) available for naproxen and dinoprostone
| Article | Year |
|---|---|
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Prediction of drug solubility from Monte Carlo simulations.
Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility | 2000 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Exacerbation of experimental colitis by nonsteroidal anti-inflammatory drugs is not related to elevated leukotriene B4 synthesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Dinoprostone; Drug Combinations; Indomethacin; Leukotriene B4; Male; Misoprostol; Naproxen; Peroxidase; Quinolines; Rats; Rats, Inbred Strains | 1992 |
Anti-inflammatory activity of BF389, a Di-T-butylphenol, in animal models of arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis, Experimental; Collagen; Diamines; Diclofenac; Dinoprostone; Disease Models, Animal; Female; Interleukin-1; Leukotriene B4; Male; Naproxen; Oxazines; Phenols; Piroxicam; Rats; Rats, Inbred Lew; Thromboxane B2 | 1992 |
Independent regulation of plasminogen activator inhibitor 2 and plasminogen activator inhibitor 1 in human synovial fibroblasts.
Topics: Blotting, Northern; Blotting, Western; Cells, Cultured; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Glucocorticoids; Humans; Indomethacin; Interleukin-1; Naproxen; Plasminogen Activator Inhibitor 1; Plasminogen Activator Inhibitor 2; RNA, Messenger; Synovial Membrane | 1992 |
Lipocortin 1 mediates dexamethasone-induced growth arrest of the A549 lung adenocarcinoma cell line.
Topics: Adenocarcinoma; Aldosterone; Annexins; Antibodies, Monoclonal; Calcium-Binding Proteins; Cell Division; Cell Membrane; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Humans; Hydrocortisone; Indomethacin; Kinetics; Lung Neoplasms; Mifepristone; Naproxen; Phospholipases; Progesterone; Recombinant Proteins | 1992 |
Effects of sodium naproxen on differentiated human chondrocytes cultivated in clusters.
Topics: Aspirin; Cartilage; Cell Differentiation; Cell Division; Cells, Cultured; Collagen; Dinoprostone; DNA; Humans; Naproxen; Prostaglandins; Radioimmunoassay; Thymidine; Tritium | 1992 |
Synovium-like tissue from loose joint replacement prosthesis: comparison of human material with a canine model.
Topics: Adult; Aged; Animals; Cells, Cultured; Collagen; Dinoprostone; Dogs; Enzyme-Linked Immunosorbent Assay; Female; Humans; Interleukin-1; Joint Prosthesis; Male; Middle Aged; Models, Biological; Naproxen; Radioimmunoassay; Synovial Membrane | 1992 |
Effects of NSAIDs on beagle crevicular cyclooxygenase metabolites and periodontal bone loss.
Topics: Administration, Oral; Administration, Topical; Alveolar Bone Loss; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Flurbiprofen; Gingival Crevicular Fluid; Ibuprofen; Naproxen; Prostaglandins F; Thromboxane B2 | 1992 |
Effects of sodium naproxen eye drops on rabbit ocular inflammation induced by sodium arachidonate.
Topics: Animals; Arachidonic Acid; Conjunctivitis; Dinoprostone; Eye; Eye Proteins; Intraocular Pressure; Iritis; Leukotriene B4; Male; Naproxen; Neutrophils; Ophthalmic Solutions; Rabbits | 1991 |
Prostaglandin synthesis and fatty acid composition of phospholipids and triglycerides in skeletal muscle of chicks fed combinations of flaxseed oil and animal tallow.
Topics: Animals; Chickens; Diet; Dietary Fats; Dinoprostone; Fats; Fatty Acids, Omega-3; Food, Formulated; Lipids; Muscles; Naproxen; Phospholipids; Plant Oils; Triglycerides | 1991 |
Renal functional effects of prostaglandin synthesis inhibition in patients with insulin-dependent diabetes mellitus of long duration without nephropathy.
Topics: Adult; Albuminuria; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Dinoprostone; Diuresis; Female; Glomerular Filtration Rate; Humans; Insulin; Kidney; Kidney Function Tests; Naproxen; Prostaglandin Antagonists; Reference Values; Renal Circulation | 1991 |
Modulation of the membrane surrounding particulate cement and polyethylene in the rabbit tibia.
Topics: Animals; Biocompatible Materials; Bone Cements; Dinoprostone; Female; Knee Joint; Methylmethacrylates; Molecular Weight; Naproxen; Polyethylenes; Prostheses and Implants; Prosthesis Failure; Rabbits; Surface Properties; Synovial Membrane; Tibia | 1991 |
Effect of systemic inhibition of prostaglandin synthesis on muscle protein balance after trauma in the rat.
Topics: Anesthesia; Animals; Dinoprostone; Hindlimb; Muscle Proteins; Naproxen; Prostaglandin Antagonists; Prostaglandins; Rats; Rats, Inbred Strains; Wounds and Injuries | 1991 |
Suppression of prostaglandin E2 synthesis in the membrane surrounding particulate polymethylmethacrylate in the rabbit tibia.
Topics: Animals; Bone Cements; Bone Resorption; Dinoprostone; Female; Foreign-Body Reaction; Joint Prosthesis; Membranes; Methylmethacrylate; Methylmethacrylates; Naproxen; Prosthesis Failure; Rabbits; Tibia | 1991 |
Effects of the prodrug nabumetone, and its active metabolite, 6-MNA, on human and rat gastric mucosal prostanoids and platelet function.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Butanones; Dinoprostone; Epoprostenol; Gastric Mucosa; Humans; Indomethacin; Male; Nabumetone; Naphthaleneacetic Acids; Naproxen; Platelet Aggregation; Platelet Aggregation Inhibitors; Prodrugs; Rats; Rats, Inbred Strains | 1990 |
The effect of nabumetone and its principal active metabolite on in vitro human gastric mucosal prostanoid synthesis and platelet function.
Topics: 6-Ketoprostaglandin F1 alpha; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Butanones; Culture Techniques; Dinoprostone; Epoprostenol; Gastric Mucosa; Humans; Indomethacin; Nabumetone; Naphthaleneacetic Acids; Naproxen; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1990 |
Inhibition of human periodontal prostaglandin E2 synthesis with selected agents.
Topics: Arachidonic Acid; Arachidonic Acids; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dinoprostone; Eicosapentaenoic Acid; Flurbiprofen; Humans; Ibuprofen; Ketoprofen; Meclofenamic Acid; Naproxen; Periodontitis; Periodontium; Vitamin E | 1990 |
Influence of renal sympathectomy, sodium depletion and prostaglandin synthetase inhibition on prostaglandin production and [3H]PGE2 binding characteristics in rat kidney.
Topics: Animals; Cyclooxygenase Inhibitors; Denervation; Dinoprostone; Kidney; Male; Naproxen; Prostaglandins; Rats; Rats, Inbred Strains; Sodium; Sulindac; Sympathectomy; Tritium | 1990 |
The mucoid cap over superficial gastric damage in the rat. A high-pH microenvironment dissipated by nonsteroidal antiinflammatory drugs and endothelin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Endothelins; Endothelium, Vascular; Fibrin; Gastric Mucosa; Hydrochloric Acid; Hydrogen-Ion Concentration; Indomethacin; Male; Mucus; Naproxen; Peptides; Rats; Rats, Inbred Strains; Regional Blood Flow; Time Factors | 1990 |
Naproxen and indomethacin: disposition and effects in the isolated perfused rat kidney.
Topics: Animals; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Kidney; Male; Naproxen; Perfusion; Rats; Rats, Inbred Strains | 1990 |
Renal disposition and effects of naproxen and its l-enantiomer in the isolated perfused rat kidney.
Topics: Animals; Dinoprostone; Dose-Response Relationship, Drug; Glomerular Filtration Rate; In Vitro Techniques; Kidney; Male; Naproxen; Perfusion; Rats; Rats, Inbred Strains; Stereoisomerism | 1990 |
Tissue changes around loose prostheses. A canine model to investigate the effects of an antiinflammatory agent.
Topics: Animals; Anti-Inflammatory Agents; Bone Resorption; Cells, Cultured; Dinoprostone; Disease Models, Animal; Dogs; Hip Joint; Hip Prosthesis; Interleukin-1; Knee Joint; Knee Prosthesis; Naproxen; Prosthesis Failure; Radiography; Reoperation | 1990 |
15-Keto-13,14-dihydroprostaglandin E2- and F2 alpha-metabolite levels in blood from men and women given prostaglandin E2 orally.
Topics: Administration, Oral; Adult; Dinoprost; Dinoprostone; Female; Humans; Male; Menstrual Cycle; Naproxen; Prostaglandins | 1989 |
Prostaglandin-dependent muscle wasting during infection in the broiler chick (Gallus domesticus) and the laboratory rat (Rattus norvegicus).
Topics: Animals; Chickens; Dinoprostone; Eating; Escherichia coli Infections; Female; Male; Muscle Proteins; Muscles; Naproxen; Organ Size; Prostaglandin Antagonists; Prostaglandins; Rats; Rats, Inbred Strains; Weight Loss | 1989 |
Effects of systemic inhibition of prostaglandin production on protein metabolism in tumor-bearing rats.
Topics: Amino Acids; Animals; Cell Line; Dinoprostone; Liver Neoplasms, Experimental; Male; Muscles; Naproxen; Neoplasm Proteins; Prostaglandin Antagonists; Proteins; Rats; Rats, Inbred Strains; Reference Values | 1989 |
Enhanced prostaglandin synthesis in the parturient rat uterus and its effects on myometrial oxytocin receptor concentrations.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dinoprost; Dinoprostone; Female; Labor, Obstetric; Microsomes; Myometrium; Naproxen; Pregnancy; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Prostaglandins E; Prostaglandins F; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Receptors, Oxytocin; Thromboxane B2; Uterine Contraction; Uterus | 1987 |
Prostaglandin E2 synthesis in the inner medullary collecting duct of the rat: implications for vasopressin-dependent cyclic AMP formation.
Topics: Animals; Arginine Vasopressin; Cyclic AMP; Dinoprostone; In Vitro Techniques; Kidney Medulla; Kidney Tubules; Kidney Tubules, Collecting; Male; Naproxen; Osmolar Concentration; Prostaglandins E; Rats; Rats, Inbred Strains | 1986 |
Effect of diclofenac sodium on the arachidonic acid cascade.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Hydroxyeicosatetraenoic Acids; Ibuprofen; Leukocytes; Lipoxygenase Inhibitors; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Naproxen; Phospholipids; Piroxicam; Prostaglandins E; Rats; SRS-A; Thiazines; Triglycerides | 1986 |
Glomerular mesangial cell contractility in vitro is controlled by an angiotensin-prostaglandin balance.
Topics: Angiotensin II; Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Dinoprostone; Fluorescent Antibody Technique; Glomerular Mesangium; Indomethacin; Lipoxygenase Inhibitors; Microscopy, Phase-Contrast; Naproxen; Prostaglandins; Prostaglandins E; Pyrazoles; Rats; Receptors, Angiotensin | 1986 |
Etodolac: effect on prostaglandin concentrations in gastric mucosa of rats.
Topics: 6-Ketoprostaglandin F1 alpha; Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Etodolac; Gastric Mucosa; Male; Naproxen; Piroxicam; Prostaglandins; Prostaglandins E; Rats; Rats, Inbred Strains; Thiazines; Time Factors | 1985 |
Renal prostaglandins and natriuretic action of oxytocin and vasopressin in rats.
Topics: Animals; Dinoprost; Dinoprostone; Electrolytes; Kidney; Male; Naproxen; Natriuresis; Oxytocin; Prostaglandins E; Prostaglandins F; Radioimmunoassay; Rats; Rats, Inbred Strains; Vasopressins | 1988 |
Effects of histidine on vasopressin action: role of decreased prostaglandin production.
Topics: Amphotericin B; Animals; Bufonidae; Dinoprostone; Female; Histidine; In Vitro Techniques; Naproxen; Osmolar Concentration; Reference Values; Urinary Bladder; Vasopressins | 1988 |
The effects of oral administration of prostaglandin E2 on the human ejaculate.
Topics: Administration, Oral; Dinoprostone; Ejaculation; Humans; Male; Naproxen; Prostaglandins; Prostaglandins B; Prostaglandins F; Semen; Sperm Count | 1988 |
Effect of non-steroidal anti-inflammatory drugs on fertility of male rats.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Dinoprostone; Fertility; Indomethacin; Kinetics; Male; Naproxen; Phenylbutazone; Prostaglandins E; Rats; Rats, Inbred Strains; Semen | 1986 |
Comparison of the effects of different anti-inflammatory drugs on synovial fluid prostanoid concentrations in patients with rheumatoid arthritis.
Topics: 6-Ketoprostaglandin F1 alpha; Acetaminophen; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Carbazoles; Diclofenac; Dinoprostone; Guanidines; Humans; Indomethacin; Naproxen; ortho-Aminobenzoates; Prednisolone; Prostaglandins; Prostaglandins E; Quinazolines; Synovial Fluid; Thromboxane B2 | 1985 |
The effect of naproxen on the ocular inflammatory response following extracapsular lens extraction in rabbits.
Topics: Animals; Aqueous Humor; Cataract Extraction; Cornea; Dinoprostone; Eye Proteins; Female; Intraocular Pressure; Leukocyte Count; Male; Naproxen; Neutrophils; Postoperative Complications; Prostaglandins E; Rabbits; Uveitis, Anterior | 1985 |
The effects of diclofenac sodium on arachidonic acid metabolism.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Chemotaxis, Leukocyte; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Hydroxyeicosatetraenoic Acids; Ibuprofen; Indomethacin; Leukocytes; Lipoxygenase; Naproxen; Phospholipases A; Phospholipases A2; Phospholipids; Piroxicam; Prostaglandins E; SRS-A; Thiazines; Triglycerides | 1985 |
Inhibition of PG production by MDL 035, a new non-steroidal non-acidic anti-inflammatory compound, in rat gastric mucosa and inflammatory exudate.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dinoprostone; Dose-Response Relationship, Drug; Exudates and Transudates; Gastric Mucosa; Imidazoles; In Vitro Techniques; Indomethacin; Inflammation; Male; Naproxen; Prostaglandins; Prostaglandins E; Rats; Stomach Ulcer | 1984 |
Interaction of vasopressin and prostaglandins in the nonpregnant human uterus.
Topics: Arginine Vasopressin; Arteries; Dinoprost; Dinoprostone; Female; Humans; In Vitro Techniques; Indomethacin; Lypressin; Myometrium; Naproxen; Prostaglandins E; Prostaglandins F; Regional Blood Flow; Uterus | 1984 |
Dimethyl sulfoxide inhibits renal Na(+)-K(+)-ATPase at a site different from ouabain and atrial peptides.
Topics: Animals; Atrial Natriuretic Factor; Binding Sites; Cattle; Dimethyl Sulfoxide; Dinoprostone; Kidney; Kidney Cortex; Kidney Medulla; Naproxen; Ouabain; Peptide Fragments; Protein Precursors; Sodium-Potassium-Exchanging ATPase | 1995 |
Nonsteroidal antiinflammatory drugs: effects on normal and interleukin 1 treated human articular chondrocyte metabolism in vitro.
Topics: Cartilage, Articular; Cell Division; Cells, Cultured; Collagenases; Diclofenac; Dinoprostone; Extracellular Matrix; Humans; Ibuprofen; Interleukin-1; Interleukin-6; Naproxen; Reference Values; Salicylates | 1995 |
Effect of etodolac on prostaglandin E2 biosynthesis, active oxygen generation and bradykinin formation.
Topics: Animals; Aspirin; Bradykinin; Bromelains; Cartilage, Articular; Cell Line; Concanavalin A; Depression, Chemical; Diclofenac; Dinoprostone; Dogs; Etodolac; Gastric Mucosa; Guinea Pigs; Indomethacin; Interleukin-1; Ketoprofen; Kidney; Naproxen; Oxygen; Pain; Piroxicam; Rabbits; Rats | 1994 |
The down-regulation of IL-6-stimulated fibrinogen steady state mRNA and protein levels by human recombinant IL-1 is not PGE2-dependent: effects of IL-1 receptor antagonist (IL-1RA).
Topics: Arachidonic Acid; Carcinoma, Hepatocellular; Dinoprostone; Down-Regulation; Fibrinogen; Gene Expression; Humans; Indomethacin; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Interleukin-6; Naproxen; Phospholipases A; Recombinant Proteins; RNA, Messenger; Sialoglycoproteins; Tumor Cells, Cultured | 1995 |
Adaptation of rat gastric mucosa to aspirin requires mucosal contact.
Topics: Adaptation, Physiological; Animals; Aspirin; Dinoprostone; Gastric Mucosa; Gastritis; Gastrointestinal Hemorrhage; Indomethacin; Male; Naproxen; Ornithine Decarboxylase; Peroxidase; Rats; Rats, Wistar | 1995 |
Effects of nonsteroidal antiinflammatory drugs on oxidative pathways in A/J mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Deoxyguanosine; Dinoprostone; DNA; DNA Damage; Female; Ibuprofen; Lipid Peroxidation; Liver; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Naproxen; Nitrosamines; Oxidation-Reduction; Oxidative Stress; Piroxicam; Sulindac | 1995 |
Sodium naproxen: concentration and effect on inflammatory response mediators in human rheumatoid synovial fluid.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Arthritis, Rheumatoid; Biomarkers; Chromatography, High Pressure Liquid; Dinoprostone; Female; Humans; Hyaluronic Acid; Immunoenzyme Techniques; Knee Joint; Leukotriene B4; Male; Middle Aged; Naproxen; Protein Binding; Synovial Fluid; Thromboxane B2 | 1994 |
Modulation of noradrenaline release from the sympathetic nerves of the human saphenous vein and pulmonary artery by presynaptic EP3- and DP-receptors.
Topics: Adrenergic Fibers; Adult; Aged; Dinoprostone; Electric Stimulation; Female; Humans; In Vitro Techniques; Male; Middle Aged; Naproxen; Norepinephrine; Pulmonary Artery; Pulmonary Veins; Receptors, Presynaptic; Receptors, Prostaglandin; Receptors, Prostaglandin E; Saphenous Vein; Tritium | 1994 |
Effect of sodium naproxen on inflammatory response induced by anterior chamber paracentesis in the rabbit.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Atropine; Ciliary Body; Cyclooxygenase Inhibitors; Dinoprostone; Drug Interactions; Female; Leukotriene B4; Mydriatics; Naproxen; Neutrophils; Ophthalmic Solutions; Peroxidase; Phenylephrine; Rabbits | 1995 |
Enhancement by cyclo-oxygenase inhibitors of platelet-activating factor production in thapsigargin-stimulated macrophages.
Topics: Animals; Arachidonic Acid; Bucladesine; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Ibuprofen; Indomethacin; Macrophages, Peritoneal; Male; Naproxen; Platelet Activating Factor; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Terpenes; Thapsigargin | 1995 |
Gastric mucosal injury and adaptation to oral and rectal administration of naproxen.
Topics: Administration, Oral; Administration, Rectal; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Female; Gastric Mucosa; Humans; Male; Middle Aged; Naproxen; Oxytocics; Prospective Studies | 1996 |
Naproxen concentrations in plasma and synovial fluid and effects on prostanoid concentrations.
Topics: Adult; Aged; Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis; Auranofin; Blood Proteins; Dinoprostone; Drug Administration Schedule; Female; Half-Life; Humans; Male; Middle Aged; Naproxen; Nonlinear Dynamics; Platelet Aggregation Inhibitors; Prostaglandins E; Serum Albumin; Synovial Fluid | 1995 |
Targeting naproxen to non-parenchymal liver cells protects against endotoxin induced liver damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Lipopolysaccharides; Liver; Male; Naproxen; Rats; Rats, Sprague-Dawley; Serum Albumin | 1997 |
Recovery from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced immunosuppression in A/J mice by treatment with nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Antibody-Producing Cells; Aspirin; Carcinogens; Dinoprostone; Female; Immunity, Cellular; Killer Cells, Natural; Mice; Mice, Inbred A; Naproxen; Nitrosamines; Spleen; Sulindac | 1997 |
Targeting naproxen coupled to human serum albumin to nonparenchymal cells reduces endotoxin-induced mortality in rats with biliary cirrhosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Dose-Response Relationship, Drug; Drug Combinations; Escherichia coli; Kidney; Lipopolysaccharides; Liver; Liver Cirrhosis, Biliary; Male; Naproxen; Rats; Rats, Sprague-Dawley; Serum Albumin; Survival Rate; Tumor Necrosis Factor-alpha | 1997 |
Drug-targeting to the kidney: renal delivery and degradation of a naproxen-lysozyme conjugate in vivo.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Female; Iodine Radioisotopes; Kidney Diseases; Kidney Tubules, Proximal; Kinetics; Male; Muramidase; Naproxen; Rats; Rats, Wistar; Tissue Distribution | 1997 |
Staphylococcal septic arthritis: antibiotic and nonsteroidal anti-inflammatory drug treatment in a rabbit model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Infectious; Cartilage, Articular; Ceftriaxone; Cephalosporins; Dinoprostone; Disease Models, Animal; Drug Therapy, Combination; Female; Glycosaminoglycans; Hydroxyproline; Knee Joint; Naproxen; Rabbits; Staphylococcal Infections; Staphylococcus aureus; Synovial Fluid; Synovitis | 1997 |
Renal targeting of a non-steroidal anti-inflammatory drug: effects on renal prostaglandin synthesis in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Diuretics; Drug Carriers; Furosemide; Kidney; Male; Muramidase; Naproxen; Natriuresis; Rats; Rats, Wistar; Urination | 1998 |
Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes.
Topics: Aged; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Isoenzymes; Male; Membrane Proteins; Middle Aged; Naproxen; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Osteoarthritis; Prostaglandin-Endoperoxide Synthases | 1998 |
The role of prostaglandins in the bradykinin-induced activation of serosal afferents of the rat jejunum in vitro.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Capsaicin; Cyclooxygenase Inhibitors; Dinoprostone; Electrophysiology; Extracellular Space; In Vitro Techniques; Jejunum; Male; Membrane Potentials; Naproxen; Neurons, Afferent; Patch-Clamp Techniques; Physical Stimulation; Prostaglandins; Rats; Stimulation, Chemical | 1999 |
Kinetic basis for selective inhibition of cyclo-oxygenases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Ibuprofen; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Kinetics; Male; Membrane Proteins; Mice; Naproxen; Oxygen; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sheep; Structure-Activity Relationship; Sulfonamides; Tetramethylphenylenediamine; Thermodynamics | 1999 |
Sensitization of visceral afferents to bradykinin in rat jejunum in vitro.
Topics: Adenosine; Animals; Bradykinin; Bucladesine; Cyclooxygenase Inhibitors; Dinoprostone; Histamine; Histamine Antagonists; Histamine H2 Antagonists; In Vitro Techniques; Jejunum; Male; Membrane Potentials; Naproxen; Neurons, Afferent; Piperidines; Ranitidine; Rats; Rats, Inbred Strains; Serotonin; Stimulation, Chemical; Triazines; Triazoles; Xanthines | 1999 |
Wound collagen deposition in rats: effects of an NO-NSAID and a selective COX-2 inhibitor.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Collagen; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Exudates and Transudates; Gastric Mucosa; Inflammation; Isoenzymes; Male; Membrane Proteins; Naproxen; Nitrates; Nitric Oxide Donors; Nitrites; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Thromboxanes; Wound Healing | 2000 |
Gastroprotective and ulcer healing effects of nitric oxide-releasing non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Ethanol; Gastric Mucosa; Isoenzymes; Male; Membrane Proteins; Microcirculation; Models, Animal; Naproxen; Nitric Oxide; Nitrobenzenes; Nitroso Compounds; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Stomach; Stomach Ulcer; Sulfonamides | 2000 |
Prostaglandin biosynthesis by fat body from true armyworms, Pseudaletia unipuncta.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Fat Body; Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Indomethacin; Microsomes; Moths; Naproxen; Prostaglandin D2; Prostaglandins; Prostaglandins A; Temperature | 2001 |
Differential regulation of interleukin-1 beta-induced cyclooxygenase-2 gene expression by nimesulide in human synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Interleukin-1; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Naproxen; Nitrobenzenes; Osteoarthritis; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides; Synovial Membrane | 2001 |
Endogenous prostaglandin E2 and insulin-like growth factor 1 can modulate the levels of parathyroid hormone receptor in human osteoarthritic osteoblasts.
Topics: Aged; Aged, 80 and over; Bone Remodeling; Cells, Cultured; Cholera Toxin; Cyclic AMP; Cyclooxygenase Inhibitors; Dinoprostone; Female; Gene Expression Regulation; Humans; Insulin-Like Growth Factor I; Male; Middle Aged; Naproxen; Osteoarthritis; Osteoblasts; Parathyroid Hormone; Pertussis Toxin; Receptor, IGF Type 1; Receptors, Parathyroid Hormone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Second Messenger Systems; Virulence Factors, Bordetella | 2001 |
Prostaglandin biosynthesis by midgut tissue isolated from the tobacco hornworm, Manduca sexta.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Culture Techniques; Cyclooxygenase Inhibitors; Digestive System; Dinoprost; Dinoprostone; Hydrogen-Ion Concentration; Indomethacin; Insect Proteins; Manduca; Molecular Structure; Moths; Naproxen; Prostaglandin D2; Prostaglandins; Prostaglandins A; Prostaglandins B; Subcellular Fractions; Temperature; Time Factors | 2002 |
Pathogenic importance of intestinal hypermotility in NSAID-induced small intestinal damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Flurbiprofen; Gastrointestinal Motility; Indomethacin; Intestinal Mucosa; Intestine, Small; Male; Naproxen; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Sprague-Dawley | 2002 |
Effect of COX-1/COX-2 inhibition versus selective COX-2 inhibition on coronary vasodilator responses to arachidonic acid and acetylcholine.
Topics: Acetylcholine; Animals; Arachidonic Acid; Blood Pressure; Coronary Circulation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Isoenzymes; Lipopolysaccharides; Male; Naproxen; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thromboxane B2; Vasodilation; Vasodilator Agents | 2004 |
Nanoparticle based systemic gene therapy for lung cancer: molecular mechanisms and strategies to suppress nanoparticle-mediated inflammatory response.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Dinoprostone; Female; Gene Expression; Genetic Therapy; Humans; Inflammation; Lung Neoplasms; Mice; Nanostructures; Naproxen; RNA-Binding Protein FUS; Signal Transduction; Transcription Factor AP-1; Transgenes | 2004 |
NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Cells, Cultured; Cyclic AMP; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Flurbiprofen; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indomethacin; Membrane Proteins; Naproxen; Nitric Oxide Donors; Nitroprusside; Phosphodiesterase Inhibitors; Prostaglandin-Endoperoxide Synthases; Purinones; Synovial Membrane; Time Factors | 2005 |
Lipopolysaccharide-induced changes in mesenteric afferent sensitivity of rat jejunum in vitro: role of prostaglandins.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; In Vitro Techniques; Jejunum; Lipopolysaccharides; Lymph Nodes; Male; Naproxen; Neurons, Afferent; Prostaglandin Antagonists; Prostaglandins; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Xanthones | 2005 |
Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis.
Topics: Acetates; Aged; Arachidonic Acid; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipopolysaccharides; Male; Masoprocol; Naproxen; Osteoarthritis, Knee; Pyrroles; Signal Transduction; Synovial Membrane | 2005 |
Modulation of insulin-like growth factor 1 levels in human osteoarthritic subchondral bone osteoblasts.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Culture Media; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Female; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Protein 4; Insulin-Like Growth Factor Binding Protein 5; Insulin-Like Growth Factor I; Isoquinolines; Male; Middle Aged; Naproxen; Osteoarthritis; Osteoblasts; Parathyroid Hormone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides | 2006 |
NMI-1182, a gastro-protective cyclo-oxygenase-inhibiting nitric oxide donor.
Topics: Animals; Anti-Inflammatory Agents; Aorta, Abdominal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Edema; Gastric Mucosa; Humans; In Vitro Techniques; Inflammation; Male; Molecular Structure; Naphthalenes; Naproxen; Neutrophil Infiltration; Nitric Oxide Donors; Protective Agents; Rats; Rats, Sprague-Dawley; Vasodilation | 2005 |
Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2.
Topics: Aspirin; Blood Platelets; Blood Proteins; Calcimycin; Calcium; Celecoxib; Cell Line; Cerebrospinal Fluid Proteins; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Indomethacin; Ionophores; Lactones; Meloxicam; Naproxen; Organ Specificity; Organic Chemicals; Protein Binding; Pyrazoles; Sodium Salicylate; Sulfonamides; Sulfones; Synovial Fluid; Thiazines; Thiazoles; Thromboxane A2 | 2006 |
Correlation between in vitro and in vivo concentration-effect relationships of naproxen in rats and healthy volunteers.
Topics: Adult; Animals; Blood Proteins; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Humans; Male; Naproxen; Protein Binding; Rats; Rats, Sprague-Dawley; Thromboxane B2 | 2006 |
Factors involved in upregulation of inducible nitric oxide synthase in rat small intestine following administration of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Disease Models, Animal; Enterobacteriaceae; Flurbiprofen; Gastrointestinal Motility; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Lactones; Male; Naproxen; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrazoles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfones; Time Factors; Up-Regulation | 2006 |
Naproxen sodium in short-term prophylaxis of pure menstrual migraine: pathophysiological and clinical considerations.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Adult; Cyclooxygenase Inhibitors; Dinoprostone; Down-Regulation; Drug Administration Schedule; Female; Humans; Menstruation Disturbances; Middle Aged; Migraine Disorders; Naproxen; Predictive Value of Tests; Thromboxane B2; Time Factors; Treatment Outcome | 2007 |
Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fear; Gene Expression Regulation; Hippocampus; Interleukin-1beta; Learning Disabilities; Male; Naproxen; Prostaglandins; Rats; Rats, Sprague-Dawley | 2007 |
Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity.
Topics: Amyloid beta-Peptides; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Furans; Hippocampus; Ibuprofen; Inflammation Mediators; Interleukin-1beta; Male; Memory; Memory Disorders; Mice; Mice, Inbred C57BL; Naproxen; Neuronal Plasticity; Peptide Fragments; Rats; Synapses; Tumor Necrosis Factor-alpha | 2008 |
Impact of naproxen sodium at over-the-counter doses on cyclooxygenase isoforms in human volunteers.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Escherichia coli; Female; Humans; In Vitro Techniques; Isoenzymes; Lipopolysaccharides; Male; Middle Aged; Naproxen; Platelet Aggregation; Thromboxane B2 | 2008 |
Cyclooxygenase inhibitors down regulate P-glycoprotein in human colorectal Caco-2 cell line.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Caco-2 Cells; Celecoxib; Colorectal Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Naproxen; Neoplasm Proteins; Pyrazoles; Reproducibility of Results; RNA, Messenger; Sulfonamides; Time Factors | 2008 |
Time-course evaluation and treatment of skin inflammatory immune response after ultraviolet B irradiation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Dermatitis; Dinoprostone; Epidermis; Female; Humans; Immunity; Interleukin-6; Keratinocytes; Male; Mice; Naproxen; Nitric Oxide Synthase Type II; Skin; Time Factors; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 2008 |
Naproxen-PC: a GI safe and highly effective anti-inflammatory.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Edema; Gastrointestinal Hemorrhage; Glycine max; Inflammation; Lecithins; Naproxen; Rats; Synovial Fluid | 2009 |
Impact of chronic inflammation on the pharmacokinetic-pharmacodynamic relationship of naproxen.
Topics: Animals; Dinoprostone; Dose-Response Relationship, Drug; Freund's Adjuvant; Inflammation; Naproxen; Rats; Rats, Sprague-Dawley; Thromboxane B2 | 2010 |
Can L(+)-lactate be used as a marker of experimentally induced inflammation in rats?
Topics: Animals; Arthritis, Experimental; Biomarkers; Carrageenan; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Freund's Adjuvant; Joints; Lactic Acid; Lactones; Male; Naproxen; Rats; Rats, Sprague-Dawley; Sulfones | 2010 |
Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Blood Pressure; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Gastric Mucosa; Hydrogen Sulfide; Hypertension; Intestinal Mucosa; Intestine, Small; Male; Mice; Molecular Structure; Naproxen; Rats; Rats, Wistar; Stomach Ulcer | 2010 |
NO-releasing NSAIDs suppress NF-κB signaling in vitro and in vivo through S-nitrosylation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blotting, Western; Caspase 3; Cell Proliferation; Colonic Neoplasms; Dinoprostone; Dose-Response Relationship, Drug; Gastric Mucosa; HT29 Cells; Humans; Male; Naproxen; NF-kappa B; Nitrates; Nitric Oxide; Nitric Oxide Donors; Rats; Rats, Wistar; S-Nitrosothiols; Signal Transduction; Stomach; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2010 |
Pharmacokinetic-pharmacodynamic modeling of the inhibitory effects of naproxen on the time-courses of inflammatory pain, fever, and the ex vivo synthesis of TXB2 and PGE2 in rats.
Topics: Animals; Antipyretics; Arthritis; Dinoprostone; Disease Models, Animal; Fever; Gene Expression Regulation; Inhibitory Concentration 50; Male; Models, Chemical; Naproxen; Oxytocics; Pain; Rats; Rats, Sprague-Dawley; T-Box Domain Proteins; Time Factors | 2011 |
Prevention of bleomycin-induced lung fibrosis in mice by a novel approach of parallel inhibition of cyclooxygenase and nitric-oxide donation using NCX 466, a prototype cyclooxygenase inhibitor and nitric-oxide donor.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Bleomycin; Collagen; Cyclooxygenase Inhibitors; Deoxyguanosine; Dinoprostone; Inflammation; Lung; Male; Mice; Mice, Inbred C57BL; Naproxen; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; Peroxidase; Propionates; Prostaglandin-Endoperoxide Synthases; Pulmonary Fibrosis; Thiobarbiturates; Transforming Growth Factor beta | 2012 |
Intramuscular ketorolac inhibits activation of rat peripheral NMDA receptors.
Topics: Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Excitatory Amino Acid Agonists; Female; Injections, Intramuscular; Ketorolac; Male; Naproxen; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serotonin; Trigeminal Nerve | 2012 |
Pharmacological validation of early and late phase of rat mono-iodoacetate model using the Tekscan system.
Topics: Alkylating Agents; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Chronic Disease; Dexamethasone; Dinoprostone; Disease Models, Animal; Duloxetine Hydrochloride; Hindlimb; Iodoacetates; Male; Morphine; Muscle Fibers, Skeletal; Naproxen; Neurons, Afferent; Pain Measurement; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Restraint, Physical; Synovial Fluid; Thiophenes; Weight-Bearing | 2013 |
The chemopreventive efficacies of nonsteroidal anti-inflammatory drugs: the relationship of short-term biomarkers to long-term skin tumor outcome.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Biomarkers, Tumor; Blotting, Western; Cell Proliferation; Cells, Cultured; Dinoprostone; Female; Humans; Keratinocytes; Mice; Mice, Hairless; Naproxen; Skin Neoplasms; Sulindac; Ultraviolet Rays | 2013 |
In vivo administration of ritonavir worsens intestinal damage caused by cyclooxygease inhibitors.
Topics: Alprostadil; Animals; Apoptosis; Aspirin; Chemokine CCL2; Cyclooxygenase Inhibitors; Dinoprostone; Drug Synergism; HIV Protease Inhibitors; HT29 Cells; Humans; Integrin alpha1beta1; Intestinal Mucosa; Intestine, Small; Ketoprofen; Mice; Mice, Inbred C57BL; Misoprostol; Naproxen; Nitric Oxide Synthase Type II; Ritonavir; RNA, Messenger; Tumor Necrosis Factor-alpha | 2014 |
Model-based analysis of thromboxane B₂ and prostaglandin E₂ as biomarkers in the safety evaluation of naproxen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Biomarkers; Computer Simulation; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Feasibility Studies; Humans; Intestinal Absorption; Male; Metabolic Clearance Rate; Models, Biological; Naproxen; Rats; Rats, Sprague-Dawley; Risk Assessment; Species Specificity; Thromboxane B2 | 2014 |
Enhanced chemopreventive effects of a hydrogen sulfide-releasing anti-inflammatory drug (ATB-346) in experimental colorectal cancer.
Topics: Aberrant Crypt Foci; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Colon; Colorectal Neoplasms; Dinoprostone; Male; Mice; Naproxen; Protective Agents; Rats; Thromboxane B2 | 2014 |
Evaluation of the reproductive toxicity of naproxen sodium and meloxicam in male rats.
Topics: Alprostadil; Animals; Catalase; Cyclooxygenase Inhibitors; Dinoprostone; Follicle Stimulating Hormone; Glutathione; Glutathione Peroxidase; Luteinizing Hormone; Male; Meloxicam; Naproxen; Rats, Wistar; Sperm Count; Sperm Motility; Superoxide Dismutase; Testis; Testosterone; Thiazines; Thiazoles | 2015 |
Characterization of the anti-inflammatory properties of NCX 429, a dual-acting compound releasing nitric oxide and naproxen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Interleukin-1beta; Matrix Metalloproteinase 9; Mice; Naproxen; NF-kappa B; Nitrates; Nitric Oxide; Nitric Oxide Donors; Peritonitis; Phagocytosis | 2015 |
Model-based prediction of the acute and long-term safety profile of naproxen in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Dinoprostone; Dose-Response Relationship, Drug; Male; Models, Biological; Naproxen; Peptic Ulcer; Rats; Thromboxane B2 | 2015 |
Chondroprotective effect of three different classes of anti-inflammatory agents on human osteoarthritic chondrocytes exposed to IL-1β.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cell Culture Techniques; Cell Survival; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Gene Expression; Humans; Interleukin-1beta; Matrix Metalloproteinases; Middle Aged; Molecular Structure; Naproxen; NF-kappa B; Nitrates; Osteoarthritis, Hip; Pyrroles | 2015 |
Naproxen sodium decreases prostaglandins secretion from cultured human endometrial stromal cells modulating metabolizing enzymes mRNA expression.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Endometrium; Female; Humans; Naproxen; Stromal Cells; Tumor Necrosis Factor-alpha; Young Adult | 2016 |
Anti-inflammatory effects of naproxen sodium on human osteoarthritis synovial fluid immune cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Dinoprostone; Flow Cytometry; Humans; Hyaluronic Acid; Inflammation; Interleukin-1beta; Interleukin-6; Interleukin-8; Lipopolysaccharides; Macrophages; Monocytes; Naproxen; Neutrophils; NF-kappa B; Osteoarthritis, Knee; Synovial Fluid; T-Lymphocytes; THP-1 Cells; Tumor Necrosis Factor-alpha | 2020 |