Alarm Clock Headache

Conditions in which the primary symptom is HEADACHE and the headache cannot be attributed to any known causes.

Synonyms(16)

Synonym
Hypnic Headache
Hypnic Headache Syndrome
Headache Disorders, Primary
Benign Cough Headache
Primary Headache Disorders
Headache, Thunderclap
Ice-Pick Headache
Primary Cough Headache
Primary Exertional Headache
Alarm Clock Headache
Cough Headache
Stabbing Headache
Benign Exertional Headache
Thunderclap Headache
Primary Thunderclap Headache
Primary Stabbing Headache

Research Excerpts

Overview

Excerpt	Reference
"Primary thunderclap headache is a rare type of headache that warrants significant testing to rule out more ominous possibilities."	( Black, DF; Garza, I, 2006)
"The diagnosis of primary cough headache is supported by a positive reaction to trial treatment with indomethacin."	( de Jong, G; Nap, LG; van den Berg, JS, 2009)
"Hypnic headache is a rare primary headache disorder that is characterized by exclusively sleep-related headache attacks in patients usually beyond 50 years of age."	( Holle, D; Obermann, M, 2010)
"Stabbing headache is a relatively rare type of chronic "primary" headache with distinctive features with respect to more common forms of paroxysmal headache, such as cluster headache and trigeminal neuralgia."	( Battaglia, G; Malaguarnera, M; Nicoletti, G; Rampello, L, 2012)
"Hypnic headache is an infrequent type of primary headache characterised by appearing almost exclusively during sleep and by waking the patient up."	( Casado-Naranjo, I; Gámez-Leyva, G; Gómez, M; Jiménez-Caballero, PE, 2012)
"The pain in hypnic headaches is more intense in males, although this needs to be corroborated in longer series."	( Casado-Naranjo, I; Gámez-Leyva, G; Gómez, M; Jiménez-Caballero, PE, 2012)
"Hypnic headache is a rare disorder characterized by frequent nocturnal attacks of a generalized headache in the elderly."	( Giudice, M; He, B; Peng, H; Wang, L; Zhang, L; Zhao, ZX, 2013)
"Hypnic headache is a rare primary headache disorder affecting middle age and above with a dull pain exclusively at nighttime."	( Patel, S, 2013)
"Idiopathic stabbing headache is a primary headache defined as "transient stabs of pain in the head that occur spontaneously in the absence of underlying organic disease."	( Hino-Fukuyo, N; Kakisaka, Y; Kano, S; Kure, S; Uematsu, M, 2014)
"Primary headache disorders are among the commonest disorders, affecting people in all countries."	( Gururaj, G; Kulkarni, GB; Rao, GN; Steiner, TJ; Stovner, LJ, 2015)
"Thunderclap headache is the most common clinical manifestation; however, other symptoms can result from complications of the disease, such as stroke, brain edema, and seizures."	( Aldandan, HW; Alrayes, MM; Alshagawi, ZA; Alzahrani, SK; Hadhiah, KM, 2021)

Treatment

Excerpt	Reference
"The treatment of primary headache disorders in the emergency department is variable."	( James, D; Patel, D; Perry, JJ; Taljaard, M; Yadav, K, 2022)
"This case report shows that secondary cough headache can also respond to medical treatment and can respond to a COX-2 inhibitor, not previously reported."	( Bahra, A; Farag, M, 2023)

Research

Studies (173)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	45 (26.01)	18.1394
2010's	103 (59.54)	28.8240
2020's	25 (14.45)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	6	0
bupropion	low	1	0
melatonin	medium	11	1
phenytoin	low	1	0
hydroxyindoleacetic acid	medium	1	1
acetaminophen	medium	8	2
acetazolamide	low	1	0
amitriptyline	medium	7	1
aspirin	low	1	0
benserazide	low	1	0
bupivacaine	low	1	0
caffeine	medium	10	1
verapamil	low	6	0
cetirizine	low	1	0
citalopram	low	2	0
clomipramine	low	1	0
cyproheptadine	low	1	0
diclofenac	low	2	0
valproic acid	low	1	0
etodolac	low	1	0
gabapentin	low	7	0
ibuprofen	low	1	0
lidocaine	medium	4	2
indomethacin	low	30	0
ketoprofen	low	1	0
ketorolac	low	1	0
lamotrigine	low	2	0
lomerizine	low	1	0
memantine	low	1	0
methenamine	low	1	0
metoclopramide	low	2	0
metoprolol	low	1	0
milrinone	low	3	0
nicardipine	low	3	0
nimodipine	low	16	0
nitroglycerin	low	2	0
octopamine	low	1	0
prochlorperazine	low	1	0
propofol	low	1	0
propranolol	low	2	0
sumatriptan	low	3	0
tyramine	low	1	0
xylometazoline	low	1	0
prednisolone	low	1	0
prednisone	low	3	0
methylprednisolone acetate	low	1	0
phenylephrine	low	1	0
levodopa	low	1	0
tyrosine	low	2	0
tryptophan	medium	2	1
tromethamine	low	1	0
methylprednisolone	medium	4	1
synephrine	low	1	0
cyclohexanol	low	1	0
ergotamine	low	1	0
diphenhydramine hydrochloride	low	1	0
ephedrine	low	1	0
dihydroergotamine	medium	3	1
lithium carbonate	low	1	0
levonorgestrel	low	1	0
glycyrrhizic acid	low	1	0
iodinated glycerol	low	2	0
isometheptene	medium	1	1
magnesium sulfate	low	1	0
ozone	low	1	0
propiconazole	low	1	0
duloxetine hydrochloride	low	1	0
venlafaxine hydrochloride	low	1	0
xenon radioisotopes	low	1	0
fluorodeoxyglucose f18	low	1	0
amezinium	low	1	0
3-aminophenoxazone	low	1	0
frovatriptan	low	1	0
vitamin b 6	medium	1	1
(3h)2-carbomethoxy-3-(4-fluorophenyl)tropane	low	1	0
mk 0663	low	2	0
ro 8-0576	low	1	0
naproxen	low	1	0
dexketoprofen trometamol	low	1	0
tolvaptan	medium	1	1
ferulic acid	low	1	0
cocaine	low	2	0
dipyrone	medium	3	1
leuprolide	low	1	0
flunarizine	low	2	0
capsaicin	low	1	0
levocetirizine	low	1	0
D-fructopyranose	low	4	0
lithium	low	1	0
bilirubin	low	2	0
vitamin k semiquinone radical	low	1	0
humulene	low	1	0
coenzyme q10	low	1	0
topiramate	low	5	0
morphine	low	2	0
enalapril	low	1	0
pregabalin	low	2	0
losartan potassium	low	1	0
ubiquinone	low	1	0
cardiovascular agents	low	2	0
vasoactive intestinal peptide	low	1	0
warfarin	low	1	0
calca protein, human	low	1	0
acyclovir	low	1	0
sildenafil citrate	low	1	0
eye	low	1	0

Protein Targets (1,007)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Sodium-dependent serotonin transporter	0	24	3	28
Sodium-dependent dopamine transporter	0	18	1	19
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	15	0	0	15
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Luciferase	11	0	0	11
thioredoxin reductase	32	0	0	32
phosphopantetheinyl transferase	12	0	0	12
ATAD5 protein, partial	13	0	0	13
TDP1 protein	29	0	0	29
Microtubule-associated protein tau	12	0	0	12
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	6	0	0	6
Smad3	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	20	0	0	20
nonstructural protein 1	6	0	0	6
67.9K protein	7	0	0	7
bromodomain adjacent to zinc finger domain 2B	8	0	0	8
IDH1	9	0	0	9
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
vitamin D3 receptor isoform VDRA	10	0	0	10
intestinal alkaline phosphatase precursor	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
glyceraldehyde-3-phosphate dehydrogenase isoform 1	1	0	0	1
DNA polymerase beta	3	0	0	3
flap endonuclease 1	9	0	0	9
ras-related protein Rab-9A	7	0	0	7
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	13	0	0	13
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
geminin	33	0	0	33
DNA polymerase kappa isoform 1	9	0	0	9
Vpr	2	0	0	2
muscleblind-like protein 1 isoform 1	5	0	0	5
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Glycoprotein hormones alpha chain	1	0	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
RAR-related orphan receptor gamma	18	0	0	18
GLS protein	22	0	0	22
thyroid stimulating hormone receptor	15	0	0	15
nuclear receptor subfamily 1, group I, member 3	22	0	0	22
progesterone receptor	22	0	0	22
EWS/FLI fusion protein	23	0	0	23
retinoic acid nuclear receptor alpha variant 1	29	0	0	29
retinoid X nuclear receptor alpha	21	0	0	21
estrogen-related nuclear receptor alpha	33	0	0	33
estrogen nuclear receptor alpha	43	0	0	43
peroxisome proliferator activated receptor gamma	19	0	0	19
aryl hydrocarbon receptor	12	0	0	12
chromobox protein homolog 1	28	0	0	28
thyroid hormone receptor beta isoform 2	23	0	0	23
peripheral myelin protein 22	20	0	0	20
cytochrome P450 3A4 isoform 1	9	0	0	9
Gamma-aminobutyric acid receptor subunit pi	9	6	3	18
ATP-binding cassette sub-family C member 3	0	33	0	33
Multidrug resistance-associated protein 4	0	33	0	33
Solute carrier family 22 member 6	0	9	0	10
Carbonic anhydrase 12	0	6	1	14
UDP-glucuronosyltransferase 1A9	0	1	0	5
Bile salt export pump	0	7	0	7
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Bile salt export pump	0	49	0	49
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	14	1	24
Carbonic anhydrase 2	0	15	2	25
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	1	1	3
Cytochrome P450 1A2	0	5	0	6
Prostaglandin G/H synthase 1	0	11	0	12
Carbonic anhydrase 3	0	6	1	13
Cytochrome P450 3A4	0	12	1	13
Cytochrome P450 2D6	0	11	0	11
Cytochrome P450 2C9	0	19	0	20
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	9	6	3	18
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	9	6	3	18
Gamma-aminobutyric acid receptor subunit gamma-2	9	6	4	19
UDP-glucuronosyltransferase 1-6	0	3	0	5
Glutamate receptor 2	11	0	0	11
Gamma-aminobutyric acid receptor subunit alpha-5	9	6	3	18
Gamma-aminobutyric acid receptor subunit alpha-3	9	6	3	18
Arachidonate 5-lipoxygenase-activating protein	0	3	0	3
UDP-glucuronosyltransferase 1A1	0	3	0	4
Carbonic anhydrase 4	0	6	1	13
Prostaglandin G/H synthase 1	0	16	0	16
Carbonic anhydrase 6	0	6	1	13
Gamma-aminobutyric acid receptor subunit gamma-1	9	6	3	18
Gamma-aminobutyric acid receptor subunit alpha-2	9	6	3	18
Gamma-aminobutyric acid receptor subunit alpha-4	9	6	3	18
Gamma-aminobutyric acid receptor subunit gamma-3	9	6	3	18
Gamma-aminobutyric acid receptor subunit alpha-6	9	6	3	18
Carbonic anhydrase 5A, mitochondrial	0	7	2	16
Prostaglandin G/H synthase 2	0	14	1	16
Carbonic anhydrase 7	0	6	1	13
Nuclear receptor ROR-gamma	8	0	0	8
Cytochrome P450 2J2	0	15	0	15
Gamma-aminobutyric acid receptor subunit alpha-1	9	7	4	20
Gamma-aminobutyric acid receptor subunit beta-3	9	6	3	18
Gamma-aminobutyric acid receptor subunit beta-2	9	6	4	19
Carbonic anhydrase 9	0	8	1	16
GABA theta subunit	9	6	3	18
Canalicular multispecific organic anion transporter 1	0	32	0	32
Carbonic anhydrase 15	0	4	0	8
Carbonic anhydrase 13	0	6	0	11
Gamma-aminobutyric acid receptor subunit epsilon	9	6	3	18
Carbonic anhydrase 14	0	6	1	14
Carbonic anhydrase 5B, mitochondrial	0	6	1	14
toxin B	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	12	0	0	12
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
GALC protein	2	0	0	2
GLI family zinc finger 3	30	0	0	30
cytochrome P450 family 3 subfamily A polypeptide 4	19	0	0	19
glucocorticoid receptor [Homo sapiens]	35	0	0	35
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
arylsulfatase A	15	0	0	15
Carbonic anhydrase	0	2	0	2
euchromatic histone-lysine N-methyltransferase 2	40	0	0	40
Bloom syndrome protein isoform 1	15	0	0	15
thyroid hormone receptor beta isoform a	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 1	18	0	0	18
survival motor neuron protein isoform d	10	0	0	10
Carbonic anhydrase	0	2	0	2
Prolyl endopeptidase	0	2	0	2
Carbonic anhydrase-related protein 11	0	1	0	3
Glycogen phosphorylase, muscle form	0	3	0	3
Renin	0	3	0	3
Carbonic anhydrase 2	0	2	0	2
Cathepsin B	0	1	0	1
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	11	1	12
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	3
Cytochrome P450 2C8	0	5	0	5
Cytochrome P450 2A6	0	2	0	2
5-hydroxytryptamine receptor 2A	0	12	1	13
Androgen receptor	0	4	0	4
Translocator protein	0	1	1	2
Cannabinoid receptor 1	0	1	0	1
Cytochrome P450 2B6	0	1	0	3
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Adenosine receptor A1	0	8	0	11
Serum paraoxonase/arylesterase 1	0	3	0	3
Dipeptidyl peptidase 4	0	0	0	1
Endochitinase	0	1	0	1
Adenosine receptor A2a	0	10	0	14
5-hydroxytryptamine receptor 2B	0	10	1	11
Sodium-dependent serotonin transporter	0	7	0	8
Delta-type opioid receptor	0	6	0	7
Cytochrome P450 2C19	0	6	0	6
Delta-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	6	1	10
Carbonic anhydrase	0	2	0	5
Kappa-type opioid receptor	0	4	0	4
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	6	1	0	7
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	1	3
Carbonic anhydrase	0	2	0	5
D(2) dopamine receptor	0	12	1	13
Cholinesterase	0	3	0	3
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	5	0	5
Fatty-acid amide hydrolase 1	0	3	0	3
Beta-carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	5	0	8
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	5
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	2	0	6
Carbonic anhydrase	0	2	0	6
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	4	0	4
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	3	1	4
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	5
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	1	5
Carbonic anhydrase 4	0	5	0	5
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	12	0	0	12
Chain B, HADH2 protein	12	0	0	12
Chain A, Ferritin light chain	6	0	0	6
Thymidine kinase	0	1	0	1
activating transcription factor 6	6	0	0	6
Histone H2A.x	7	0	0	7
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	7	0	0	7
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
lamin isoform A-delta10	32	0	0	32
Solute carrier family 22 member 1	0	10	0	13
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	7	0	8
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	4	0	5
Thymidine kinase	0	1	0	1
Spike glycoprotein	18	0	1	19
USP1 protein, partial	20	0	0	20
NFKB1 protein, partial	6	0	0	6
cytochrome P450 2D6	19	0	0	19
cytochrome P450 2D6 isoform 1	9	0	0	9
D(1A) dopamine receptor	15	0	0	15
atrial natriuretic peptide receptor 2 precursor	7	0	0	7
serine/threonine-protein kinase mTOR isoform 1	9	0	0	9
muscarinic acetylcholine receptor M1	18	0	0	18
Polyunsaturated fatty acid lipoxygenase ALOX15B	6	0	0	6
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	1	5
5-hydroxytryptamine receptor 4	0	26	0	26
Albumin	0	0	5	5
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	17	0	17
Muscarinic acetylcholine receptor M2	0	9	1	10
Muscarinic acetylcholine receptor M4	0	10	0	10
Muscarinic acetylcholine receptor M1	0	4	0	4
Muscarinic acetylcholine receptor M3	0	3	0	3
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M5	0	3	0	3
Muscarinic acetylcholine receptor M5	0	12	0	12
Alpha-2A adrenergic receptor	0	22	4	27
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M1	0	13	1	14
Angiotensin-converting enzyme	0	13	0	13
D(2) dopamine receptor	0	19	1	20
Alpha-2B adrenergic receptor	0	18	1	20
Alpha-2C adrenergic receptor	0	17	3	21
5-hydroxytryptamine receptor 1A	0	26	4	31
Muscarinic acetylcholine receptor M3	0	13	1	14
D(1A) dopamine receptor	0	16	1	18
D(1B) dopamine receptor	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	2	0	4
Sodium-dependent noradrenaline transporter	0	24	1	25
Histamine H2 receptor	0	8	0	8
Alpha-1D adrenergic receptor	0	17	2	20
5-hydroxytryptamine receptor 2A	0	24	1	25
5-hydroxytryptamine receptor 2C	0	27	1	28
5-hydroxytryptamine receptor 1B	0	22	1	23
5-hydroxytryptamine receptor 1D	0	6	2	8
5-hydroxytryptamine receptor 1F	0	5	1	6
5-hydroxytryptamine receptor 6	0	3	1	4
Histamine H1 receptor	0	2	0	2
5-hydroxytryptamine receptor 7	0	4	1	5
5-hydroxytryptamine receptor 5A	0	3	1	4
5-hydroxytryptamine receptor 5B	0	3	1	4
Histamine H1 receptor	0	13	1	14
D(3) dopamine receptor	0	18	0	18
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	4	0	6
UDP-glucuronosyltransferase 1A3	0	0	0	6
5-hydroxytryptamine receptor 3A	0	6	1	7
5-hydroxytryptamine receptor 2B	0	24	1	25
Alpha-1A adrenergic receptor	0	12	2	14
Histamine H2 receptor	9	2	0	12
5-hydroxytryptamine receptor 6	0	16	1	17
5-hydroxytryptamine receptor 7	0	9	0	9
Voltage-dependent N-type calcium channel subunit alpha-1B	0	5	0	5
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	1	5
Potassium voltage-gated channel subfamily H member 2	0	21	0	21
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	1	5
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	1	8
Sodium channel protein type 5 subunit alpha	0	6	0	6
Sodium channel protein type 9 subunit alpha	0	4	0	4
5-hydroxytryptamine receptor 4	0	4	1	6
Nuclear receptor subfamily 3 group C member 3	0	12	0	12
Sodium channel protein type 2 subunit alpha	0	3	0	3
Ataxin-2	20	0	0	20
Sigma non-opioid intracellular receptor 1	0	17	2	19
5-hydroxytryptamine receptor 3B	0	6	1	7
Sodium channel protein type 3 subunit alpha	0	4	0	4
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	3	0	3
Sodium channel protein type 10 subunit alpha	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	16	0	0	16
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	2	2
ras protein, partial	0	0	2	2
interleukin 8	4	0	0	4
AR protein	34	0	0	34
hypothetical protein, conserved	2	0	0	2
glucocerebrosidase	6	0	0	6
peroxisome proliferator-activated receptor delta	17	0	0	17
Rac1 protein	0	0	2	2
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	2	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
lethal factor (plasmid)	5	0	0	5
Prostaglandin-H2 D-isomerase	0	2	0	2
Prostaglandin G/H synthase 1	0	5	0	6
Prostaglandin G/H synthase 2	0	3	0	4
Epidermal growth factor receptor	0	5	0	5
Fatty acid-binding protein, liver	0	5	0	5
Integrin beta-3	1	1	0	2
Myeloperoxidase	0	4	0	4
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Integrin alpha-IIb	1	1	0	2
Glutathione hydrolase 1 proenzyme	0	1	0	1
Substance-P receptor	0	4	0	4
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Ras-related protein Rab-2A	0	0	2	2
Prostaglandin G/H synthase 2	0	9	0	9
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	3	0	3
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	3	2	5
regulator of G-protein signaling 4	16	0	0	16
M-phase phosphoprotein 8	10	0	0	10
Zinc finger protein mex-5	0	0	1	1
POsterior Segregation	0	0	1	1
Genome polyprotein	0	1	0	1
Replicase polyprotein 1ab	0	3	1	4
Hexokinase-2	0	1	0	1
ATP-dependent phosphofructokinase	18	0	0	18
Chain A, Cruzipain	3	0	0	3
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	7	0	0	7
Solute carrier organic anion transporter family member 1B3	0	5	0	6
Solute carrier organic anion transporter family member 1B1	0	7	0	8
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	2	3	5
Potassium channel subfamily K member 9	0	1	0	1
histone acetyltransferase KAT2A isoform 1	8	0	0	8
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	3	0	7
Neuronal acetylcholine receptor subunit beta-2	0	1	0	2
Sodium-dependent dopamine transporter	0	8	0	8
Neuronal acetylcholine receptor subunit beta-4	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	2
Acetylcholine receptor subunit delta	0	1	0	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
farnesoid X nuclear receptor	16	0	0	16
pregnane X nuclear receptor	28	0	0	28
thyroid stimulating hormone receptor	9	0	0	9
v-jun sarcoma virus 17 oncogene homolog (avian)	12	0	0	12
nuclear receptor ROR-gamma isoform 1	9	0	0	9
Cholinesterase	0	4	0	4
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	2	1	3
Adenosine receptor A3	0	6	1	7
Amine oxidase [flavin-containing] A	0	1	0	2
Acetylcholinesterase	0	10	0	10
Amine oxidase [flavin-containing] B	0	2	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	4	0	4
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	3	2	6
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	1	1	4
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	2	2	4
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	1	5
Guanine deaminase	0	1	0	1
15-lipoxygenase, partial	4	0	0	4
estrogen receptor 2 (ER beta)	13	0	0	13
vitamin D (1,25- dihydroxyvitamin D3) receptor	19	0	0	19
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	17	0	0	17
mitogen-activated protein kinase 1	8	0	0	8
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Transient receptor potential cation channel subfamily V member 1	0	2	1	3
Lysine-specific histone demethylase 1A	0	1	0	1
NADH-ubiquinone oxidoreductase chain 1	0	1	0	1
Cannabinoid receptor 1	0	5	0	5
Cannabinoid receptor 2	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
Corticotropin-releasing factor receptor 2	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	2	1	4
Transient receptor potential cation channel subfamily V member 4	0	0	1	1
Transient receptor potential cation channel subfamily V member 2	0	0	1	1
Angiopoietin-1 receptor	0	0	1	1
Multidrug and toxin extrusion protein 1	0	7	0	7
Histamine H4 receptor	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	4	0	0	4
Sodium-dependent noradrenaline transporter	0	3	0	3
Tryptophan 5-hydroxylase 1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	3	0	3
Aromatase	0	1	0	1
Sodium-dependent serotonin transporter	0	3	0	3
Sodium-dependent dopamine transporter	0	4	0	4
Transporter	0	6	0	6
Fumarate hydratase	5	0	0	5
PPM1D protein	4	0	0	4
Thrombopoietin	3	0	0	3
caspase 7, apoptosis-related cysteine protease	6	0	0	6
polyprotein	5	0	0	5
caspase-3	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	9	0	0	9
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
cellular tumor antigen p53 isoform a	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	15	0	0	15
Transmembrane protease serine 2	0	0	1	1
Interferon beta	20	0	0	20
Cellular tumor antigen p53	21	0	0	21
Procathepsin L	0	1	1	2
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Alpha-1B adrenergic receptor	0	9	2	11
Alpha-2B adrenergic receptor	0	5	2	7
Alpha-2C adrenergic receptor	0	5	2	7
Alpha-2A adrenergic receptor	0	5	2	7
Alpha-1D adrenergic receptor	0	7	2	9
Trypanothione reductase	0	2	0	2
Trypanothione reductase	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	1
Envelope glycoprotein	0	0	1	1
Angiotensin-converting enzyme 2	0	1	1	2
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	0	4	0	4
Amyloid-beta precursor protein	0	2	0	2
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	5	2	7
Gamma-aminobutyric acid receptor subunit beta-1	0	4	2	6
Gamma-aminobutyric acid receptor subunit gamma-2	0	5	2	7
D	0	3	0	3
Liver carboxylesterase 1	0	1	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	5	2	7
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	2	6
Glutamate receptor ionotropic, NMDA 1	0	3	0	6
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	2	6
Gamma-aminobutyric acid receptor subunit beta-2	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	2	6
Gamma-aminobutyric acid receptor subunit epsilon	0	4	0	4
Glutamate receptor ionotropic, NMDA 2A	0	3	0	6
Glutamate receptor ionotropic, NMDA 2C	0	3	0	6
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	4	0	4
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	2	6
Glutamate receptor ionotropic, NMDA 2D	0	3	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	0	4	0	4
Glutamate receptor ionotropic, NMDA 3B	0	3	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	0	4	0	4
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	0	6
Gamma-aminobutyric acid receptor subunit theta	0	4	0	4
cytochrome P450 2C19 precursor	4	0	0	4
huntingtin isoform 2	5	0	0	5
chaperonin GroEL	1	0	0	1
Glycogen phosphorylase, brain form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
D(3) dopamine receptor	0	3	0	3
Endothelin receptor type B	0	1	0	1
Endothelin receptor type B	0	1	0	1
D(1B) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	3	1	4
D(2) dopamine receptor	0	1	0	1
Histone-lysine N-methyltransferase SETD7	0	2	0	2
Aldo-keto reductase family 1 member B10	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	6	0	6
Cytochrome c oxidase subunit 2	0	2	0	2
Transthyretin	0	0	1	3
Albumin	0	6	6	12
Interleukin-8	0	2	0	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	4	1	5
Aldo-keto reductase family 1 member B1	0	4	0	4
Sodium- and chloride-dependent GABA transporter 1	0	4	0	4
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	4	0	4
Sodium- and chloride-dependent GABA transporter 3	0	4	0	4
Prostaglandin G/H synthase 2	0	4	0	6
Sodium- and chloride-dependent betaine transporter	0	4	0	4
Prostaglandin G/H synthase 2	0	3	0	4
Prostaglandin G/H synthase 1	0	4	0	6
P2Y purinoceptor 12	0	2	0	2
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
acetylcholinesterase	8	0	0	8
dopamine D1 receptor	5	0	0	5
SMAD family member 2	8	0	0	8
SMAD family member 3	8	0	0	8
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
Solute carrier family 22 member 2	0	1	0	2
ATP-dependent translocase ABCB1	0	5	0	5
ATP-dependent translocase ABCB1	0	12	1	22
ATP-dependent translocase ABCB1	0	5	0	6
Alpha-1A adrenergic receptor	0	4	4	9
Alpha-1B adrenergic receptor	0	2	3	6
Multidrug and toxin extrusion protein 2	0	1	0	1
ATPase family AAA domain-containing protein 5	10	0	0	10
endonuclease IV	5	0	0	5
peripheral myelin protein 22 isoform 1	10	0	0	10
eyes absent homolog 2 isoform a	1	0	0	1
Alpha-synuclein	2	1	0	3
TAR DNA-binding protein 43	5	0	0	5
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
glp-1 receptor, partial	8	0	0	8
heat shock protein beta-1	5	0	0	5
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Angiotensin-converting enzyme	0	1	0	1
Type-2 angiotensin II receptor	0	2	0	2
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Solute carrier family 15 member 1	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Angiotensin-converting enzyme	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Adenylate cyclase	0	1	0	1
Tyrosine-protein kinase Lck	0	2	0	2
Tyrosine-protein kinase Fyn	0	3	0	3
Beta-2 adrenergic receptor	0	6	3	9
Beta-1 adrenergic receptor	0	6	3	9
Thromboxane-A synthase	0	2	0	2
5-hydroxytryptamine receptor 1D	0	5	1	7
5-hydroxytryptamine receptor 1B	0	7	2	9
5-hydroxytryptamine receptor 5A	0	2	0	2
G	15	0	0	15
HLA class I histocompatibility antigen, B alpha chain	15	0	0	15
Inositol hexakisphosphate kinase 1	15	0	0	15
cytochrome P450 2C9, partial	15	0	0	15
ClpP	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
Acetylcholinesterase	0	3	0	3
Polyphenol oxidase 2	0	2	0	6
Pyruvate kinase PKM	0	1	0	1
Alpha-glucosidase MAL12	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Hyaluronidase-1	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Integrase	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
Voltage-dependent T-type calcium channel subunit alpha-1G	0	1	1	2
Voltage-dependent T-type calcium channel subunit alpha-1H	0	1	1	2
Sodium channel protein type 1 subunit alpha	0	4	0	4
Sodium channel protein type 2 subunit alpha	0	6	0	6
Sodium channel protein type 3 subunit alpha	0	3	0	3
Mu-type opioid receptor	0	5	2	8
Voltage-dependent L-type calcium channel subunit beta-1	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	2	0	2
Voltage-dependent N-type calcium channel subunit alpha-1B	0	2	0	2
Potassium channel subfamily K member 2	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	1	1	2
Prostaglandin D2 receptor 2	0	3	1	4
Dipeptidyl peptidase 4	0	1	0	1
Acetylcholinesterase	0	1	0	1
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Cytochrome P450 1B1	0	2	0	2
Transporter	0	1	0	1
Beta-2 adrenergic receptor	0	3	2	6
5-hydroxytryptamine receptor 1A	0	4	1	5
POU domain, class 2, transcription factor 1	0	0	0	4
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
transcriptional regulator ERG isoform 3	5	0	0	5
neuropeptide S receptor isoform A	5	0	0	5
Histone deacetylase 3	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Histone deacetylase 4	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	3	0	3
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Histone deacetylase 6	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Pancreatic alpha-amylase	0	1	0	1
Beta-glucuronidase	0	1	0	1
Beta-glucuronidase	0	1	0	1
High mobility group protein B1	0	0	2	2
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	4
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	1	2
High mobility group protein B1	0	0	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 2	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	1	0	1
Solute carrier organic anion transporter family member 1B2	0	1	0	1
alpha-galactosidase	1	0	0	1
cytochrome P450 2C9 precursor	3	0	0	3
Uracil nucleotide/cysteinyl leukotriene receptor	0	3	0	3
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Albumin	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	7
Prostaglandin G/H synthase 1	0	2	0	2
Caspase-1	0	4	0	5
Aldo-keto reductase family 1 member C3	0	4	0	4
Caspase-3	0	4	0	4
Caspase-4	0	4	0	4
Caspase-5	0	4	0	4
Caspase-9	0	4	0	4
Acid-sensing ion channel 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	8	0	0	8
Parkin	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Phospholipase A2, major isoenzyme	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Androgen receptor	0	2	1	3
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Aldo-keto reductase family 1 member C4	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	3	1	5
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	2	0	2
Guanine nucleotide-binding protein G	3	0	0	3
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	2	0	2
Lactoylglutathione lyase	0	2	0	2
Aldo-keto reductase family 1 member C1	0	2	0	2
Solute carrier family 22 member 7	0	1	0	3
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Cell division control protein 42 homolog	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Gonadotropin-releasing hormone receptor	0	1	0	1
Gonadotropin-releasing hormone receptor	0	2	0	2
beta-2 adrenergic receptor	1	0	0	1
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
apical membrane antigen 1, AMA1	2	0	0	2
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Plasma kallikrein	0	0	0	3
Tyrosinase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	3
SLC16A10 protein	0	0	0	3
Carbonic anhydrase-like protein, putative	0	0	0	3
Monocarboxylate transporter 10	0	0	0	3
phosphoglycerate kinase	1	0	0	1
Progesterone receptor	0	2	1	4
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	3	0	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
5-hydroxytryptamine receptor 1A	0	2	0	2
Type-1 angiotensin II receptor	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	3	1	4
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	3	1	4
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Carboxylic ester hydrolase	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
5-hydroxytryptamine receptor 3E	0	1	1	2
5-hydroxytryptamine receptor 3B	0	1	1	2
D(2) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	3	4
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	1	2
5-hydroxytryptamine receptor 3C	0	1	1	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Beta-1 adrenergic receptor	0	1	2	4
Beta-3 adrenergic receptor	0	2	3	5
Beta-1 adrenergic receptor	0	4	2	7
Beta-1 adrenergic receptor	0	2	0	2
Phosphodiesterase	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Aurora kinase A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Dual specificity protein kinase TTK	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Aurora kinase B	0	1	0	1
Inner centromere protein	0	1	0	1
Phosphodiesterase	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	1	4
Delta-type opioid receptor	0	3	2	6
Kappa-type opioid receptor	0	3	2	6
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Hormone-sensitive lipase	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Equilibrative nucleoside transporter 1	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Quinolone resistance protein NorA	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Voltage-dependent L-type calcium channel subunit beta-4	0	1	0	1
Voltage-dependent P/Q-type calcium channel subunit alpha-1A	0	1	0	1
Voltage-dependent calcium channel gamma-3 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-3	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	2	0	3
Voltage-dependent calcium channel gamma-7 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel gamma-1 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-2	0	1	0	1
Voltage-dependent R-type calcium channel subunit alpha-1E	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-4	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-3	0	1	0	1
Voltage-dependent calcium channel gamma-8 subunit	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Bile acid receptor	0	1	0	1
Voltage-dependent calcium channel gamma-6 subunit	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	2	0	2
Voltage-dependent calcium channel gamma-4 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-5 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	0	1	0	1
Trace amine-associated receptor 1	0	0	2	2
Alpha-1B adrenergic receptor	0	0	1	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Dihydrofolate reductase	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
pregnane X receptor	3	0	0	3
Mcl-1	0	1	0	1
Snq2p	0	0	0	1
neutrophil cytosol factor 1	0	1	0	1
D(4) dopamine receptor	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Beta-2 adrenergic receptor	0	2	0	3
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Vasopressin V1a receptor	0	3	1	4
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	1	1	2
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Carboxypeptidase M	0	1	0	1
5-hydroxytryptamine receptor 1E	0	1	0	1
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
Neuromedin-U receptor 2	0	0	1	1
Vasopressin V2 receptor	0	2	0	2
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Phospholipase A-2-activating protein	0	1	0	1
guanine nucleotide-binding protein subunit alpha-15	0	1	1	2
D(3) dopamine receptor isoform e	1	0	0	1
trace amine-associated receptor 1	0	1	1	2
Phenylethanolamine N-methyltransferase	0	1	0	1
Dopamine beta-hydroxylase	0	0	0	1
Beta-secretase 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Histamine H3 receptor	0	0	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Cocaine esterase	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
Glycoprotein	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Alarm Clock Headache

Synonyms(16)

Research Excerpts

Overview

Treatment

Research

Studies (173)

Drugs Studied (122)

Protein Targets (1,007)