Page last updated: 2024-09-28

Linitis Plastica

A condition where the stomach wall becomes thickened, rubbery and loses its ability to distend. The stomach assumes a leather bottle shape. It is most often seen in adenocarcinoma of the stomach. The term is often used synonymously with diffuse adenocarcinoma of the stomach.

Synonyms(1)

Synonym
Linitis Plastica

Research

Studies (27)

TimeframeStudies, This Condition (%)All Conditions %
pre-19907 (25.93)23.3326
1990's3 (11.11)12.5806
2000's10 (37.04)18.1394
2010's7 (25.93)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
hydrochloric acid0low10
thiamine0low10
uracil0low10
fluorouracil0low50
guaifenesin0low10
iohexol0low10
oxonic acid0medium21
tegafur0medium31
mitomycin0low10
gadolinium0low10
barium sulfate0low30
amoxicillin0low10
amikacin0low10
16-fluoroestradiol0low10
fluorodeoxyglucose f180low30
fulvestrant0low10
methotrexate0low30
sulbactam0low10
docetaxel anhydrous0low10
bromochloroacetic acid0low30
picibanil0low10
tamoxifen0low10
s 1 (combination)0medium21
transforming growth factor beta0low10
vitamin b 120low10
folic acid0low10
trypsinogen0low10

Protein Targets (421)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
estrogen nuclear receptor alpha110011
peripheral myelin protein 223003
histone acetyltransferase KAT2A isoform 12002
lamin isoform A-delta104004
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 409011
Bile salt export pump011011
Canalicular multispecific organic anion transporter 10909
Aminoglycoside 3'-phosphotransferase 0001
ATP-dependent phosphofructokinase3003
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, Beta-lactamase3003
Chain A, 2-oxoglutarate Oxygenase3003
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0102
AR protein100010
apical membrane antigen 1, AMA12002
Beta-lactamase 0001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)3003
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
DNA polymerase kappa isoform 12002
Bile salt export pump0202
Beta-lactamase SHV-10001
Beta-lactamase SHV-10102
Cytochrome P450 2C9 0101
Beta-lactamase0102
Kappa-type opioid receptor0001
Solute carrier family 15 member 10101
Solute carrier family 15 member 10101
Cytochrome P450 2J20101
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
RAR-related orphan receptor gamma6006
aldehyde dehydrogenase 1 family, member A14004
nuclear receptor subfamily 1, group I, member 39009
retinoic acid nuclear receptor alpha variant 15005
thyroid stimulating hormone receptor3003
nuclear factor erythroid 2-related factor 2 isoform 16006
Cellular tumor antigen p539009
Nuclear receptor ROR-gamma1001
PPM1D protein2002
TDP1 protein6006
GLI family zinc finger 37007
caspase 7, apoptosis-related cysteine protease3003
cytochrome P450 family 3 subfamily A polypeptide 44004
glucocorticoid receptor [Homo sapiens]6006
estrogen-related nuclear receptor alpha7007
farnesoid X nuclear receptor8008
pregnane X nuclear receptor4004
67.9K protein5005
peroxisome proliferator activated receptor gamma6006
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
caspase-33003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
nuclear receptor subfamily 1, group I, member 23003
thyroid hormone receptor beta isoform 26006
Interferon beta3003
Serum paraoxonase/arylesterase 10101
Kinesin-like protein KIF110101
Spike glycoprotein5016
ATPase family AAA domain-containing protein 54004
Ataxin-24004
Nucleotide-binding oligomerization domain-containing protein 20101
Chain A, Uracil Phosphoribosyltransferase0101
Luciferase1001
interleukin 81001
endonuclease IV1001
acetylcholinesterase2002
glp-1 receptor, partial2002
Skn7p0001
thioredoxin reductase4004
pregnane X receptor1001
hypoxia-inducible factor 1 alpha subunit3003
ATAD5 protein, partial4004
Microtubule-associated protein tau4004
Thrombopoietin1001
thyroid stimulating hormone receptor2002
estrogen receptor 2 (ER beta)6006
progesterone receptor6006
EWS/FLI fusion protein3003
nonstructural protein 11001
retinoid X nuclear receptor alpha6006
peroxisome proliferator-activated receptor delta6006
arylsulfatase A3003
IDH13003
euchromatic histone-lysine N-methyltransferase 24004
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x4004
peripheral myelin protein 22 isoform 11001
hemoglobin subunit beta1001
chromobox protein homolog 14004
nuclear factor erythroid 2-related factor 2 isoform 24004
huntingtin isoform 21001
flap endonuclease 13003
serine/threonine-protein kinase mTOR isoform 12002
geminin7007
Vpr1001
survival motor neuron protein isoform d2002
muscleblind-like protein 1 isoform 12002
Voltage-dependent calcium channel gamma-2 subunit6006
Solute carrier family 22 member 80001
Epidermal growth factor receptor0202
Amyloid-beta precursor protein1001
Thymidylate synthase0404
Aromatase0101
Glutamate receptor 26006
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Dihydrofolate reductase0011
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, Ferritin light chain3003
acid sphingomyelinase2002
USP1 protein, partial3003
glucocerebrosidase2002
alpha-galactosidase2002
activating transcription factor 64004
lysosomal alpha-glucosidase preproprotein1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
DNA polymerase beta2002
Thymidylate synthase0404
Dihydrofolate reductase0235
Aldo-keto reductase family 1 member B10101
Alpha-synuclein2002
Folylpolyglutamate synthase, mitochondrial0104
Solute carrier organic anion transporter family member 1A30102
Folylpolyglutamate synthase, mitochondrial0104
Multidrug resistance associated protein0103
GALC protein1001
GLS protein1001
G1001
aryl hydrocarbon receptor2002
heat shock protein beta-12002
Nuclear receptor subfamily 1 group I member 20011
HLA class I histocompatibility antigen, B alpha chain 1001
Estrogen receptor04310
Estrogen receptor0113
Progesterone receptor0202
Polyunsaturated fatty acid 5-lipoxygenase0202
Steroid hormone receptor ERR10202
Bifunctional epoxide hydrolase 20202
Beta-lactamase TEM0303
Inositol hexakisphosphate kinase 11001
Estrogen receptor beta0415
Bile acid receptor0101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
cytochrome P450 2C9, partial1001
SMAD family member 22002
SMAD family member 32002
Rap guanine nucleotide exchange factor 31001
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase 10202
Carbonic anhydrase 20213
Carbonic anhydrase 40101
Carbonic anhydrase 60202
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase0101
Carbonic anhydrase 70101
Carbonic anhydrase 90101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase0101
Carbonic anhydrase 130101
Carbonic anhydrase 5B, mitochondrial0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
dopamine D1 receptor1001
ClpP1001
15-lipoxygenase, partial1001
phosphopantetheinyl transferase2002
Thymidylate synthase 0101
Thymidylate synthase 0101
Bloom syndrome protein isoform 11001
cellular tumor antigen p53 isoform a2002
polyunsaturated fatty acid lipoxygenase ALOX121001
vitamin D3 receptor isoform VDRA2002
transcriptional regulator ERG isoform 32002
importin subunit beta-1 isoform 11001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
snurportin-11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
M-phase phosphoprotein 82002
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Integrin beta-32002
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Integrin alpha-IIb2002
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Dihydrofolate reductase0101
Pteridine reductase 10101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
TAR DNA-binding protein 432002
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60001
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80001
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Broad substrate specificity ATP-binding cassette transporter ABCG20001
Fumarate hydratase2002
cytochrome P450 2D61001
polyprotein2002
Indoleamine 2,3-dioxygenase 10101
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase0101
Beta-lactamase0101
Beta-lactamase0101
Replicase polyprotein 1ab0112
Beta-lactamase OXA-10101
5-hydroxytryptamine receptor 1A0303
Metallo-beta-lactamase type 20101
Angiotensin-converting enzyme0101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0101
Class D beta-lactamase0101
Beta-lactamase 0101
Beta-lactamase 0101
Metallo-b-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0101
Beta-lactamase class B VIM-2 0001
Chain A, CES1 protein0101
DNA polymerase III, partial1001
regulator of G-protein signaling 41001
bromodomain adjacent to zinc finger domain 2B1001
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
Caspase-71001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
cytochrome P450 2D6 isoform 11001
NPC intracellular cholesterol transporter 1 precursor1001
interferon gamma precursor0001
D(1A) dopamine receptor1001
caspase-31001
ubiquitin-conjugating enzyme E2 N0101
ras-related protein Rab-9A1001
nuclear receptor ROR-gamma isoform 12002
cytochrome P450 3A4 isoform 11001
streptokinase A precursor0011
lethal factor (plasmid)1001
Gamma-aminobutyric acid receptor subunit pi1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transmembrane protease serine 20011
5-hydroxytryptamine receptor 40202
Serine/threonine-protein kinase D30101
Lysosomal acid glucosylceramidase0011
Receptor tyrosine-protein kinase erbB-20101
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Protein kinase C beta type0101
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Procathepsin L0011
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
ATP-dependent translocase ABCB10213
Beta-1 adrenergic receptor0202
Cytochrome P450 3A40101
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Adenosine receptor A30202
Muscarinic acetylcholine receptor M10202
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Beta-3 adrenergic receptor0202
D(2) dopamine receptor0202
Androgen receptor0202
Gamma-aminobutyric acid receptor subunit beta-11001
Alpha-1B adrenergic receptor0202
Protein kinase C alpha type0101
Alpha-2B adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Muscarinic acetylcholine receptor M30202
Cytochrome P450 2B60101
Substance-K receptor0202
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Prostaglandin G/H synthase 10101
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Sodium-dependent noradrenaline transporter 0202
Thromboxane-A synthase 0101
Protein kinase C eta type0101
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
5-hydroxytryptamine receptor 1B0202
Adenosine receptor A2a0202
Gamma-aminobutyric acid receptor subunit alpha-61001
B2 bradykinin receptor0202
Adenosine receptor A10202
Sodium-dependent serotonin transporter0202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Mu-type opioid receptor0202
D(3) dopamine receptor0202
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
5-hydroxytryptamine receptor 2B0202
Protein kinase C iota type0101
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0202
Histamine H2 receptor1001
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60202
Estrogen-related receptor gamma0101
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Sodium-dependent dopamine transporter 0202
Protein kinase C epsilon type0101
Protein kinase C theta type0101
Protein kinase C zeta type0101
Protein kinase C delta type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Potassium voltage-gated channel subfamily H member 20202
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10101
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
GABA theta subunit1001
Sigma non-opioid intracellular receptor 10202
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
Gamma-aminobutyric acid receptor subunit epsilon1001
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
potassium voltage-gated channel subfamily H member 2 isoform d1001
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Solute carrier family 22 member 1 0102
Transketolase0011
Thiamine-binding periplasmic protein0011
Solute carrier family 22 member 10101
Solute carrier family 22 member 20101
Chain A, Uracil-DNA Glycosylase0101
Protein cereblon0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]