Deepoxy-deoxynivalenol (DON) is a mycotoxin produced by the Fusarium fungi. It is a common contaminant of cereal grains, such as wheat, barley, and corn. DON is a potent inhibitor of protein synthesis in eukaryotic cells, which can lead to a variety of toxic effects, including reduced growth, immune suppression, and gastrointestinal problems. DON has been shown to have a range of effects on animals and humans, including reduced weight gain, feed intake, and immune function. It is important to study DON because it is a significant food safety concern. DON can accumulate in food and feed, and exposure to high levels can lead to health problems. Researchers are working to understand the mechanisms of DON toxicity, develop methods for reducing contamination of food and feed, and develop strategies for managing DON exposure. '
deepoxy-deoxynivalenol: metabolite of deoxynivalenol [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 119324 |
| MeSH ID | M0138900 |
| Synonym |
|---|
| trichtheca-9,12-dien-8-one, 3,7,15-trihydroxy-, (3alpha,7alpha)- |
| deepoxy-deoxynivalenol |
| de-epoxy-deoxynivalenol |
| 88054-24-4 |
| deepoxydeoxynivalenol |
| AKOS027313856 |
| (2s,3r,5s,5ar,6s,9ar)-3,6-dihydroxy-5a-(hydroxymethyl)-5,8-dimethyl-10-methylene-2,3,4,5,5a,9a-hexahydro-2,5-methanobenzo[b]oxepin-7(6h)-one |
| (1s,2r,3s,7r,9s,10r)-3,10-dihydroxy-2-(hydroxymethyl)-1,5-dimethyl-12-methylidene-8-oxatricyclo[7.2.1.02,7]dodec-5-en-4-one |
| DTXSID601007920 |
| 3,7,15-trihydroxytrichotheca-9,12-dien-8-one |
| deepoxy-deoxynivalenol 50 microg/ml in acetonitrile |
| (1s,2r,3s,7r,9s,10r)-3,10-dihydroxy-2-(hydroxymethyl)-1,5-dimethyl-12-methylidene-8-oxatricyclo[7.2.1.0,dodec-5-en-4-one |
| Excerpt | Reference | Relevance |
|---|---|---|
| " In this study, validated ultra-high performance liquid chromatography (U-HPLC) combined with a HR-Orbitrap-MS analysis method is described for the identification and quantitative determination of the mycotoxin compounds (DON and deepoxy-deoxynivalenol (DOM-1)) in pig colostrum (milk) and serum." | ( Identification and determination of deoxynivalenol (DON) and deepoxy-deoxynivalenol (DOM-1) in pig colostrum and serum using liquid chromatography in combination with high resolution mass spectrometry (LC-MS/MS (HR)). Faldyna, M; Hlavova, K; Stastny, K; Stepanova, H, 2019) | 0.94 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " This effect may result from an altered bioavailability of DON from maize silage which made up a higher proportion of the daily ration." | ( No carry over of unmetabolised deoxynivalenol in milk of dairy cows fed high concentrate proportions. Breves, G; Dänicke, S; Keese, C; Meyer, U; Rehage, J; Schollenberger, M; Starke, A; Valenta, H; Weber, IA, 2008) | 0.35 |
| " Mycotoxin-detoxifying agents can thus interact with the oral bioavailability of antibiotics depending on the antibiotic and detoxifying agent, with possible adverse effects on the health of animals and humans." | ( Efficacy and safety testing of mycotoxin-detoxifying agents in broilers following the European Food Safety Authority guidelines. Croubels, S; De Backer, P; De Baere, S; De Saeger, S; Devreese, M; Eeckhout, M; Goossens, J; Hautekiet, V; Osselaere, A; Vandenbroucke, V; Watteyn, A, 2012) | 0.38 |
| "The knowledge of factors influencing the kinetics, metabolism and bioavailability of the Fusarium toxin deoxynivalenol (DON) is a basic prerequisite for evaluation of the transfer (carry over) of the toxin and its metabolites into edible tissues, and for a physiological specimen-based diagnosis of intoxication." | ( Kinetics and metabolism of the Fusarium toxin deoxynivalenol in farm animals: consequences for diagnosis of exposure and intoxication and carry over. Brezina, U; Dänicke, S, 2013) | 0.39 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " Three rats and one pig were dosed orally with 2 mg DON/kg and samples of their urine and faeces were extracted and incubated with beta-glucuronidase or with buffer only." | ( Lack of hepatic microsomal metabolism of deoxynivalenol and its metabolite, DOM-1. Buck, W; Côté, LM; Jeffery, E, 1987) | 0.27 |
| " A safety study with 2 commercially available detoxifying agents and veterinary drugs showed innovative results with regard to the pharmacokinetics of 2 antibiotics after oral dosing in the drinking water." | ( Efficacy and safety testing of mycotoxin-detoxifying agents in broilers following the European Food Safety Authority guidelines. Croubels, S; De Backer, P; De Baere, S; De Saeger, S; Devreese, M; Eeckhout, M; Goossens, J; Hautekiet, V; Osselaere, A; Vandenbroucke, V; Watteyn, A, 2012) | 0.38 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (6.25) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (8.33) | 29.6817 |
| 2010's | 36 (75.00) | 24.3611 |
| 2020's | 5 (10.42) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (18.79) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (4.08%) | 5.53% |
| Reviews | 1 (2.04%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 46 (93.88%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||