Page last updated: 2024-12-07

6,6'-dicorynomycolyl trehalose

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID125053
MeSH IDM0127736

Synonyms (9)

Synonym
6,6'-dicorynomycolyl trehalose
93379-98-7
trehalose 6,6'-dicorynomycolate
6,6'-dicorynomycolyl alpha, alpha'-trehalose
beta-d-glucopyranoside, 6-o-(3-hydroxy-1-oxo-2-tetradecyloctadecyl)-beta-d-glucopyranosyl, (3as-(3aalpha,4beta,6aalpha))-
trehalose dicorynomycolate
dcymt
s-tdcm
[(2r,3s,4s,5r)-3,4,5-trihydroxy-6-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[(3-hydroxy-2-tetradecyloctadecanoyl)oxymethyl]oxan-2-yl]oxyoxan-2-yl]methyl 3-hydroxy-2-tetradecyloctadecanoate

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" In comparison of toxicity in vivo among TDM and four TDCMs such as TDCM(2R,3R), TDCM(2S,3R), TDCM(2R,3S) and TDCM(2S,3S), all of the TDCMs appeared to be less toxic than TDM itself."( Inhibitory effect of trehalose dimycolate (TDM) and its stereoisometric derivatives, trehalose dicorynomycolates (TDCMs), with low toxicity on lung metastasis of tumour cells in mice.
Azuma, I; Garcia, DM; Hata, K; Imagawa, H; Koike, Y; Mitobe, M; Nishizawa, M; Nobuchi, Y; Watanabe, R; Yamada, H; Yoo, YC, 1999
)
0.3
"Immunological, immunocytochemical and fertility analyses were performed to determine the potential toxic side effects of porcine zona pellucida (pZP) vaccinations on target animals, including horses and dogs."( Evaluation of somatic and reproductive immunotoxic effects of the porcine zona pellucida vaccination.
Barber, MR; Fayrer-Hosken, RA, 2000
)
0.31
"Vizantin, 6,6'-bis-O-(3-nonyldodecanoyl)-α,α'-trehalose, was developed as a safe immunostimulator on the basis of a structure-activity relationship (SAR) study with trehalose 6,6'-dicorynomycolate (TDCM)."( Development of vizantin, a safe immunostimulant, based on the structure-activity relationship of trehalose-6,6'-dicorynomycolate.
Himeno, S; Imagawa, H; Inoue, M; Nagahama, M; Nakano, M; Nishizawa, M; Oda, M; Sakurai, J; Setsu, K; Shibutani, M; Watanabe, N; Yabiku, K; Yamamoto, H, 2013
)
0.39
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (26)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's10 (38.46)18.2507
2000's7 (26.92)29.6817
2010's8 (30.77)24.3611
2020's1 (3.85)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.09

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.09 (24.57)
Research Supply Index3.37 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.09)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (3.70%)5.53%
Reviews1 (3.70%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other25 (92.59%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]