| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
cephaloridine
Cephaloridine: A cephalosporin antibiotic.. cefaloridine : A cephalosporin compound having pyridinium-1-ylmethyl and 2-thienylacetamido side-groups. A first-generation semisynthetic derivative of cephalosporin C. | 1.97 | 1 | 0 | beta-lactam antibiotic allergen;
cephalosporin;
semisynthetic derivative | antibacterial drug |
serine
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group. | 1.98 | 1 | 0 | L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group. | 2.37 | 2 | 0 | beta-lactam antibiotic;
penicillin allergen;
penicillin | antibacterial drug |
penicillanic acid
Penicillanic Acid: A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed). penicillanic acid : A penam that consists of 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane bearing a carboxy group at position 2 and having (2S,5R)-configuration. | 4.16 | 5 | 0 | penicillanic acids | |
amoxicillin
Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.. amoxicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group. | 1.95 | 1 | 0 | penicillin allergen;
penicillin | antibacterial drug |
cephalosporin c
cephalosporin C: RN given refers to parent cpd; structure in Merck, 9th ed, #1937. cephalosporin C : A cephalosporin antibiotic carrying a 3-acetoxymethyl substituent and a 6-oxo-N(6)-L-lysino group at position 7. | 3.46 | 2 | 0 | cephalosporin | fungal metabolite |
brobactam
[no description available] | 3.46 | 2 | 0 | | |
6-iodopenicillanic acid
6-iodopenicillanic acid: RN given refers to parent cpd(2S-(2alpha,5alpha,6beta))-isomer | 1.97 | 1 | 0 | | |
oa 6129a
OA 6129A: from Streptomyces sp. OA-6129; structure given in first source | 1.96 | 1 | 0 | carbapenems | |
sulbactam
[no description available] | 2.66 | 3 | 0 | penicillanic acids | |
oa 6129c
OA 6129C: from Streptomyces sp. OA-6129; structure given in first source | 1.96 | 1 | 0 | | |
oa 6129b(1)
OA 6129B(1): from Streptomyces sp. OA-6129; structure given in first source | 1.96 | 1 | 0 | | |
beta-lactams
2-azetidinone: structure in first source. azetidin-2-one : An unsubstituted beta-lactam compound.. beta-lactam : A lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon. | 5.59 | 14 | 0 | beta-lactam antibiotic allergen;
beta-lactam | |
ps 5
PS 5: lactam antibiotic from Streptomyces sp. A271 ATCC 31358; RN given refers to (5R-cis)-isomer; structure in fifth source | 1.96 | 1 | 0 | carbapenems | |
thienamycin
thienamycin: beta-lactam antibiotic; RN given refers to cpd without isomeric designation | 3.06 | 1 | 0 | carbapenems | |
clavulanic acid
Clavulanic Acid: A beta-lactam antibiotic produced by the actinobacterium Streptomyces clavuligerus. It is a suicide inhibitor of bacterial beta-lactamase enzymes. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.. clavulanate : The conjugate base of clavulanic acid.. clavulanic acid : Antibiotic isolated from Streptomyces clavuligerus. It acts as a suicide inhibitor of bacterial beta-lactamase enzymes. | 4.83 | 6 | 0 | oxapenam | antibacterial drug;
anxiolytic drug;
bacterial metabolite;
EC 3.5.2.6 (beta-lactamase) inhibitor |
x 14547-a
X 14547-A: structure. indanomycin : An indene that is (3aS,7aR)-2,3,3a,4,5,7a-hexahydro-1H-indene which is substituted at the 2-pro-R position by a 1H-pyrrol-2-ylcarbonyl group, at the 9-pro-S position by an ethyl group, and at the 5-pro-R position by a hexa-1,3-dineyl group in which position 4 has been substituted by a (2R,3S,6R)-6-[(1R)-1-carboxyethyl]-3-methyltetrahydropyran-2-yl group. It exhibits activity against Gram-positive bacteria as well as antihypertensive and antitumour. It also functions as an effective growth promoter for ruminants. | 1.97 | 1 | 0 | | |