| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
aminolevulinic acid
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.. 5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp. | 2.01 | 1 | 0 | 4-oxo monocarboxylic acid;
amino acid zwitterion;
delta-amino acid | antineoplastic agent;
dermatologic drug;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite;
prodrug;
Saccharomyces cerevisiae metabolite |
5-aminovaleric acid
5-aminovaleric acid: from red fox anal secretion; RN given refers to parent cpd. 5-aminopentanoic acid : A delta-amino acid comprising pentanoic acid with an amino substituent at C-5; a methylene homologue of gamma-aminobutyric acid (GABA) that is a weak GABA agonist. | 2.01 | 1 | 0 | amino acid zwitterion;
delta-amino acid;
omega-amino fatty acid | human metabolite |
alanylalanine
alanylalanine: RN given refers to (DL)-isomer | 2.41 | 2 | 0 | dipeptide | |
bay-k-8644
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester: A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.. Bay-K-8644 : A racemate comprising equimolar amounts of (R)- and (S)-Bay-K-8644. methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate : A pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6. | 2.02 | 1 | 0 | (trifluoromethyl)benzenes;
C-nitro compound;
dihydropyridine;
methyl ester | |
potassium chloride
Potassium Chloride: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.. potassium chloride : A metal chloride salt with a K(+) counterion. | 2.04 | 1 | 0 | inorganic chloride;
inorganic potassium salt;
potassium salt | fertilizer |
cephaloridine
Cephaloridine: A cephalosporin antibiotic.. cefaloridine : A cephalosporin compound having pyridinium-1-ylmethyl and 2-thienylacetamido side-groups. A first-generation semisynthetic derivative of cephalosporin C. | 2.06 | 1 | 0 | beta-lactam antibiotic allergen;
cephalosporin;
semisynthetic derivative | antibacterial drug |
aldosterone
[no description available] | 3.8 | 2 | 1 | 11beta-hydroxy steroid;
18-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
mineralocorticoid;
primary alpha-hydroxy ketone;
steroid aldehyde | human metabolite;
mouse metabolite |
penicillin g
Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group. | 2.44 | 2 | 0 | penicillin allergen;
penicillin | antibacterial drug;
drug allergen;
epitope |
cephalothin
Cephalothin: A cephalosporin antibiotic.. cefalotin : A semisynthetic, first-generation cephalosporin antibiotic with acetoxymethyl and (2-thienylacetyl)nitrilo moieties at positions 3 and 7, respectively, of the core structure. Administered parenterally during surgery and to treat a wide spectrum of blood infections. | 2.44 | 2 | 0 | azabicycloalkene;
beta-lactam antibiotic allergen;
carboxylic acid;
cephalosporin;
semisynthetic derivative;
thiophenes | antibacterial drug;
antimicrobial agent |
tyrosine
Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring. | 7.03 | 1 | 0 | amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine | EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical |
cloxacillin
Cloxacillin: A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.. cloxacillin : A semisynthetic penicillin antibiotic carrying a 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido group at position 6. | 2.44 | 2 | 0 | penicillin allergen;
penicillin;
semisynthetic derivative | antibacterial agent;
antibacterial drug |
oxacillin
Oxacillin: An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.. oxacillin : A penicillin antibiotic carrying a 5-methyl-3-phenylisoxazole-4-carboxamide group at position 6beta. | 2.44 | 2 | 0 | penicillin | antibacterial agent;
antibacterial drug |
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group. | 2.44 | 2 | 0 | beta-lactam antibiotic;
penicillin allergen;
penicillin | antibacterial drug |
penicillin v
Penicillin V: A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.. phenoxymethylpenicillin : A penicillin compound having a 6beta-(phenoxyacetyl)amino side-chain. | 2.02 | 1 | 0 | penicillin allergen;
penicillin | |
glycylglycine
[no description available] | 2.93 | 4 | 0 | dipeptide zwitterion;
dipeptide | human metabolite |
levulinic acid
levulinic acid: inhibits 5-aminolevulinic acid dehydratase; RN given refers to parent cpd; structure in Merck Index, 9th ed, #5316. 4-oxopentanoic acid : An oxopentanoic acid with the oxo group in the 4-position. | 2.06 | 1 | 0 | oxopentanoic acid;
straight-chain saturated fatty acid | plant metabolite |
dicloxacillin
Dicloxacillin: One of the PENICILLINS which is resistant to PENICILLINASE.. dicloxacillin : A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]formyl group. | 2.44 | 2 | 0 | dichlorobenzene;
penicillin | antibacterial drug |
cyclacillin
Cyclacillin: A cyclohexylamido analog of PENICILLANIC ACID. | 2.44 | 2 | 0 | penicillin | antibacterial drug |
floxacillin
Floxacillin: Antibiotic analog of CLOXACILLIN.. flucloxacillin : A penicillin compound having a 6beta-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamido] side-chain. | 2.02 | 1 | 0 | penicillin allergen;
penicillin | antibacterial drug |
cephalexin
Cephalexin: A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.. cephalexin : A semisynthetic first-generation cephalosporin antibiotic having methyl and beta-(2R)-2-amino-2-phenylacetamido groups at the 3- and 7- of the cephem skeleton, respectively. It is effective against both Gram-negative and Gram-positive organisms, and is used for treatment of infections of the skin, respiratory tract and urinary tract. | 2.44 | 2 | 0 | beta-lactam antibiotic allergen;
cephalosporin;
semisynthetic derivative | antibacterial drug |
cephapirin
Cephapirin: Cephalosporin antibiotic, partly plasma-bound, that is effective against gram-negative and gram-positive organisms.. cephapirin : A cephalosporin with acetoxymethyl and 2(pyridin-4-ylsulfanyl)acetamido substituents at positions 3 and 7, respectively, of the cephem skeleton. It is used (as its sodium salt) as an antibiotic, being effective against gram-negative and gram-positive organisms. | 2.02 | 1 | 0 | cephalosporin | antibacterial drug |
cefazolin
Cefazolin: A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.. cefazolin : A first-generation cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups at positions 3 and 7 respectively. | 2.02 | 1 | 0 | beta-lactam antibiotic allergen;
cephalosporin;
tetrazoles;
thiadiazoles | antibacterial drug |
amoxicillin
Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.. amoxicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group. | 2.06 | 1 | 0 | penicillin allergen;
penicillin | antibacterial drug |
cephradine
Cephradine: A semi-synthetic cephalosporin antibiotic.. cephradine : A first-generation cephalosporin antibiotic with a methyl substituent at position 3, and a (2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetamido substituent at position 7, of the cephem skeleton. | 2.02 | 1 | 0 | beta-lactam antibiotic allergen;
cephalosporin | antibacterial drug |
cefmetazole
Cefmetazole: A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.. cefmetazole : A second-generation cephalosporin antibiotic having N(1)-methyltetrazol-5-ylthiomethyl, {[(cyanomethyl)sulfanyl]acetyl}amino and methoxy side-groups at positions 3, 7beta and 7alpha respectively of the parent cephem bicyclic structure. | 2.44 | 2 | 0 | cephalosporin | antibacterial drug |
piperacillin
Piperacillin: Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.. piperacillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carboxamido]-2-phenylacetamido group. | 2.02 | 1 | 0 | penicillin allergen;
penicillin | antibacterial drug |
captopril
Captopril: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.. captopril : A L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug. | 2.42 | 2 | 0 | alkanethiol;
L-proline derivative;
N-acylpyrrolidine;
pyrrolidinemonocarboxylic acid | antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor |
moxalactam
Moxalactam: Broad- spectrum beta-lactam antibiotic similar in structure to the CEPHALOSPORINS except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain CEPHALOSPORINS. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections.. moxalactam : A broad-spectrum oxacephem antibiotic in which the oxazine ring is substituted with a tetrazolylthiomethyl group and the azetidinone ring carries methoxy and 2-carboxy-2-(4-hydroxyphenyl)acetamido substituents. | 2.02 | 1 | 0 | cephalosporin;
oxacephem | antibacterial drug |
cefadroxil anhydrous
Cefadroxil: Long-acting, broad-spectrum, water-soluble, CEPHALEXIN derivative.. cefadroxil : A cephalosporin bearing methyl and (2R)-2-amino-2-(4-hydroxyphenyl)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. | 2.44 | 2 | 0 | cephalosporin | antibacterial drug |
cefaclor anhydrous
Cefaclor: Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN.. cefaclor : A cephalosporin bearing chloro and (R)-2-amino-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton. | 2.44 | 2 | 0 | cephalosporin | antibacterial drug;
drug allergen |
leucyltyrosine
leucyltyrosine: RN given refers to L-Tyr,L-Leu-isomer; RN for cpd without isomeric designation not avail 4/93 | 2.72 | 3 | 0 | dipeptide | metabolite |
leucyl-glycyl-glycine
leucyl-glycyl-glycine: RN given refers to (L-Leu)-isomer. Leu-Gly-Gly : A tripeptide composed of one L-leucine and two glycine residues joined in sequence. | 2.44 | 2 | 0 | tripeptide | metabolite |
glycyl-histidyl-lysine
glycyl-histidyl-lysine: found in human plasma; promotes proliferation of hepatoma cells, lymphocytes & mycoplsma; maintains viability of hepatocytes, eosinophils and macrophages; inhibits growth of glial cells; RN given refers to (L)-isomer. Gly-His-Lys : A tripeptide composed of glycine, L-histidine and L-lysine residues joined in sequence. | 2.06 | 1 | 0 | tripeptide | chelator;
hepatoprotective agent;
metabolite;
vulnerary |
leucylleucine
Leu-Leu : A dipeptide formed from two L-leucine residues. | 1.98 | 1 | 0 | dipeptide;
L-aminoacyl-L-amino acid zwitterion | human metabolite;
Mycoplasma genitalium metabolite |
phenylalanylleucine
phenylalanylleucine: RN given refers to (L)-isomer | 1.98 | 1 | 0 | dipeptide zwitterion;
dipeptide | plant metabolite |
leucyl-alanine
Leu-Ala : A dipeptide composed of L-leucine and L-alanine joined by a peptide linkage. | 2.4 | 2 | 0 | dipeptide | metabolite |
alanylproline
alanylproline: RN given refers to all (L)-isomer | 3.14 | 5 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
tyrosylleucine
[no description available] | 1.98 | 1 | 0 | dipeptide | metabolite |
Trp-Trp
tryptophyltryptophan: an antigelation agent. Trp-Trp : A dipeptide formed from two L-tryptophan residues. | 2.42 | 2 | 0 | dipeptide | Mycoplasma genitalium metabolite |
glycyltryptophan
glycyltryptophan: RN given refers to (L)-isomer. Gly-Trp : A dipeptide formed from glycine and L-tryptophan residues. | 2.71 | 3 | 0 | dipeptide | metabolite |
glycyltyrosine
Gly-Tyr : A dipeptide composed of glycine and L-tyrosine joined by a peptide linkage. | 2.42 | 2 | 0 | dipeptide | metabolite |
glycylleucine
Gly-Leu : A dipeptide composed of glycine and L-leucine joined by a peptide linkage. | 2.4 | 2 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
alanyltyrosine
alanyltyrosine: tyrosine source; RN given refers to (L)-isomer. Ala-Tyr : A dipeptide composed of L-alanine and L-tyrosine joined by a peptide linkage. | 2.71 | 3 | 0 | dipeptide | metabolite |
glycyl-l-phenylalanine
glycylphenylalanine: RN given refers to (DL)-isomer. Gly-Phe : A dipeptide formed from glycine and L-phenylalanine residues. | 2.71 | 3 | 0 | dipeptide zwitterion;
dipeptide | human metabolite;
metabolite |
aspartyl-phenylalanine
aspartyl-phenylalanine: metabolite of aspartame; may inhibit angiotensin converting enzyme; RN given refers to all (L)-isomer | 2.1 | 1 | 0 | dipeptide | human blood serum metabolite;
human xenobiotic metabolite |
glycylsarcosine
glycylsarcosine : A dipeptide obtained by formal condensation of the carboxy group of glycine with the amino group of sarcosine. | 2.01 | 1 | 0 | dipeptide zwitterion;
dipeptide | |
leucylleucine
leucylleucine: RN given refers to (DL-Leu-DL-Leu)-isomer | 1.93 | 1 | 0 | peptide | |
hippuryl-histidyl-leucine
hippuryl-histidyl-leucine: synthetic substrate for angiotensin converting enzyme; used in affinity chromatography | 2.04 | 1 | 0 | | |
diprotin a
[no description available] | 2 | 1 | 0 | peptide | |
alanylphenylalanine
alanylphenylalanine: RN given refers to (L-Ala-L-PheAla)-isomer | 2.71 | 3 | 0 | dipeptide | metabolite |
prolyl-glycyl-glycine
prolyl-glycyl-glycine: structure given in first source | 2.44 | 2 | 0 | oligopeptide | |
tryptophylglycine
Trp-Gly : A dipeptide formed from L-tryptophan and glycine residues. | 1.98 | 1 | 0 | dipeptide | metabolite |
glycylaspartic acid
glycylaspartic acid: RN given refers to (L)-isomer | 2.71 | 3 | 0 | dipeptide | metabolite |
n-glycylglutamic acid
N-glycylglutamic acid: RN given refers to (L)-isomer. Gly-Glu : A dipeptide formed from glycyl and L-glutamic acid residues. | 2.42 | 2 | 0 | dipeptide | metabolite |
histidylglycine
histidylglycine: RN given refers to all (L)-isomer. His-Gly : A dipeptide formed from L-histidine and glycine residues. | 1.98 | 1 | 0 | dipeptide | metabolite |
histidinoalanine
histidinoalanine: cross-linking amino acid in calcified tissue collagen; RN given refers to (L)-isomer | 2.01 | 1 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
paxilline
paxilline: structure given in first source; RN given refers to (2R-(2alpha,4bbeta,6aalpha,12bbeta,12calpha,14abeta))-isomer. paxilline : An indole diterpene alkaloid with formula C27H33NO4 isolated from Penicillium paxilli. It is a potent inhibitor of large conductance Ca2(+)- and voltage-activated K(+) (BK)-type channels. | 2.02 | 1 | 0 | diterpene alkaloid;
enone;
organic heterohexacyclic compound;
terpenoid indole alkaloid;
tertiary alcohol | anticonvulsant;
Aspergillus metabolite;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor;
genotoxin;
geroprotector;
mycotoxin;
Penicillium metabolite;
potassium channel blocker |
valylvaline
valylvaline: RN given refers to (L)-isomer. Val-Val : A dipeptide formed from two L-valine residues. | 2.4 | 2 | 0 | dipeptide | Mycoplasma genitalium metabolite |
tyrosyl-glycyl-glycine
tyrosyl-glycyl-glycine: RN given refers to L-isomer; this may not be the same as IMREG-1. Tyr-Gly-Gly : A tripeptide composed of one L-tyrosine and two glycine residues joined in sequence. | 2.02 | 1 | 0 | tripeptide zwitterion;
tripeptide | metabolite |
proctolin
proctolin: neurotransmitter in arthropods or invertebrates | 1.98 | 1 | 0 | | |
glycylglutamine
glycylglutamine: inhibitory neuropeptide derived from beta-endorphin; RN given refers to (L)-isomer | 1.98 | 1 | 0 | dipeptide zwitterion;
dipeptide | metabolite;
protective agent |
alanylglutamic acid
alanylglutamic acid: RN given refers to (L)-isomer. L-alanyl-L-glutamic acid : A dipeptide consisting of L-glutamic acid having an L-alanyl attached to its alpha-amino group | 2.01 | 1 | 0 | dipeptide | |
phenylalanylarginine
phenylalanylarginine: RN given refers to all (L)-isomer. Phe-Arg : A dipeptide composed of L-phenylalanine and L-arginine joined by a peptide linkage. | 1.98 | 1 | 0 | dipeptide | metabolite |
arginylproline
arginylproline: first & second amino acid in substance P sequence; RN given refers to (L)-isomer. Arg-Pro : A dipeptide obtained by formal condensation of the carboxy group of L-arginine with the amino group of L-proline. | 2.1 | 1 | 0 | dipeptide | |
prolylarginine
prolylarginine: fragment of tuftsin peptide with analgesic action; RN given refers to all L-isomer. Pro-Arg : A dipeptide formed from L-proline and L-arginine residues. | 2.02 | 1 | 0 | dipeptide | metabolite |
aspartylglycine
Asp-Gly : A dipeptide composed of L-aspartic acid and glycine joined by a peptide linkage. | 1.98 | 1 | 0 | dipeptide | metabolite |
prolyl-tyrosine
prolyl-tyrosine: structure given in first source. Pro-Tyr : A dipeptide formed from L-proline and L-tyrosine residues. | 2.4 | 2 | 0 | dipeptide | metabolite |
histidylproline
His-Pro : A dipeptide formed from L-histidine and L-proline residues. | 1.93 | 1 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
n-valyltryptophan
N-valyltryptophan: RN given refers to (L)-isomer | 2.42 | 2 | 0 | peptide | |
lysylproline
lysylproline: third & fourth amino acid in substance P sequence. Lys-Pro : A dipeptide formed from L-lysine and L-proline residues. | 2.1 | 1 | 0 | dipeptide | metabolite |
angiotensin ii
Giapreza: injectable form of angiotensin II used to increase blood pressure in adult patients with septic or other distributive shock. Ile(5)-angiotensin II : An angiotensin II that acts on the central nervous system (PDB entry: 1N9V). | 4.65 | 6 | 1 | amino acid zwitterion;
angiotensin II | human metabolite |
histidylleucine
His-Leu : A dipeptide formed from L-histidine and L-leucine residues. | 2.35 | 2 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
prolylglutamic acid
Pro-Glu : A dipeptide formed from L-proline and L-glutamic acid residues. | 2.72 | 3 | 0 | dipeptide | metabolite |
bradykinin
[no description available] | 2.01 | 1 | 0 | oligopeptide | human blood serum metabolite;
vasodilator agent |
cysteinylglycine
cysteinylglycine: RN given refers to (L)-isomer; RN for cpd without isomeric designation not in Chemlne 7/13/83. L-cysteinylglycine : A dipeptide consisting of glycine having an L-cysteinyl attached to its alpha-amino group. It is an intermediate metabolite in glutathione metabolism. | 2.72 | 3 | 0 | dipeptide zwitterion;
dipeptide | Escherichia coli metabolite;
human metabolite;
Saccharomyces cerevisiae metabolite |
ouabain
Ouabain: A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.. cardiac glycoside : Steroid lactones containing sugar residues that act on the contractile force of the cardiac muscles.. ouabain : A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus. | 2.1 | 1 | 0 | 11alpha-hydroxy steroid;
14beta-hydroxy steroid;
5beta-hydroxy steroid;
alpha-L-rhamnoside;
cardenolide glycoside;
steroid hormone | anti-arrhythmia drug;
cardiotonic drug;
EC 2.3.3.1 [citrate (Si)-synthase] inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
ion transport inhibitor;
plant metabolite |
cefoxitin
Cefoxitin: A semisynthetic cephamycin antibiotic resistant to beta-lactamase.. cefoxitin : A semisynthetic cephamycin antibiotic which, in addition to the methoxy group at the 7alpha position, has 2-thienylacetamido and carbamoyloxymethyl side-groups. It is resistant to beta-lactamase. | 2.02 | 1 | 0 | beta-lactam antibiotic allergen;
cephalosporin;
cephamycin;
semisynthetic derivative | antibacterial drug |
isoleucylvaline
isoleucylvaline: RN given refers to all (L)-isomer. Ile-Val : A dipeptide formed from L-isoleucine and L-valine residues. | 1.98 | 1 | 0 | dipeptide | metabolite |
cefamandole
Cefamandole: Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as the nafate.. cefamandole : A cephalosporin compound having (R)-mandelamido and N-methylthiotetrazole side-groups. | 2.44 | 2 | 0 | cephalosporin;
semisynthetic derivative | antibacterial drug |
aspartyl-aspartic acid
aspartyl-aspartic acid: do not confuse with cyclo(Asp-Asp). Asp-Asp : A dipeptide formed from two L-aspartic acid units. | 2.72 | 3 | 0 | dipeptide | Mycoplasma genitalium metabolite |
Phe-Tyr
Phe-Tyr : A dipeptide formed from L-phenylalanine and L-tyrosine residues. | 2.42 | 2 | 0 | dipeptide | metabolite |
n-glycylalanine
Gly-Ala : A dipeptide formed from glycine and L-alanine residues. | 2.42 | 2 | 0 | dipeptide | metabolite |
glycylvaline
glycylvaline: RN given refers to (DL)-isomer | 1.98 | 1 | 0 | dipeptide | human metabolite |
glycylproline
Gly-Pro : A dipeptide consisting of L-proline having a glycyl residue attached to its alpha-amino group. | 2.93 | 4 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
glycyllysine
glycyllysine: RN given refers to (L)-isomer. Gly-Lys : A dipeptide formed from glycine and L-lysine residues. | 2.42 | 2 | 0 | dipeptide | metabolite |
methionyltryptophan
Met-Trp : A dipeptide formed from L-methionine and L-tryptophan residues. | 2.1 | 1 | 0 | dipeptide | metabolite |
trimethionine
[no description available] | 2.44 | 2 | 0 | oligopeptide | |
sodium dodecyl sulfate
Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate. | 2.06 | 1 | 0 | organic sodium salt | detergent;
protein denaturant |
seryl-proline
Ser-Pro : A dipeptide formed from L-serine and L-proline residues. | 2.01 | 1 | 0 | dipeptide | metabolite |
7432 s
Ceftibuten: A cephalosporin antibacterial agent that is used in the treatment of infections, including urinary-tract and respiratory-tract infections.. ceftibuten : A third-generation cephalosporin antibiotic with a [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-4-carboxybut-2-enoyl]amino substituent at the 7 position of the cephem skeleton. An orally-administered agent, ceftibuten is used as the dihydrate to treat urinary-tract and respiratory-tract infections. | 2.02 | 1 | 0 | cephalosporin;
dicarboxylic acid | antibacterial drug |
pd 123319
PD123319 : An imidazopyridine consisting of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine having 4-(dimethylamino)-3-methylbenzyl, diphenylacetyl and carboxy and groups at positions 1, 5 and 6 respectively | 2.1 | 1 | 0 | imidazopyridine | angiotensin receptor antagonist;
endothelin receptor antagonist;
vasoconstrictor agent |
cefodizime
cefodizime: RN given refers to (6R-(6alpha,7beta(Z)))-isomer. cefodizime : A cephalosporin compound having 5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanyl}methyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups located at positions 3 and 7 respectively. | 2.44 | 2 | 0 | 1,3-thiazoles;
cephalosporin;
oxime O-ether | antibacterial drug;
EC 1.14.18.1 (tyrosinase) inhibitor |
cefixime
[no description available] | 2.44 | 2 | 0 | cephalosporin | antibacterial drug;
drug allergen |
lisinopril
Lisinopril: One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure. | 2.04 | 1 | 0 | dipeptide | EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor |
alanyl-alanyl-alanine
alanyl-alanyl-alanine: RN given refers to all (L)-isomer. Ala-Ala-Ala : A tripeptide composed of three L-alanine units joined by peptide linkages. | 2.72 | 3 | 0 | tripeptide | metabolite |
cefuroxime
[no description available] | 2.44 | 2 | 0 | 3-(carbamoyloxymethyl)cephalosporin;
furans;
oxime O-ether | drug allergen |
ceftriaxone
[no description available] | 2.02 | 1 | 0 | 1,2,4-triazines;
1,3-thiazoles;
cephalosporin;
oxime O-ether | antibacterial drug;
drug allergen;
EC 3.5.2.6 (beta-lactamase) inhibitor |
cefepime
Cefepime: A fourth-generation cephalosporin antibacterial agent that is used in the treatment of infections, including those of the abdomen, urinary tract, respiratory tract, and skin. It is effective against PSEUDOMONAS AERUGINOSA and may also be used in the empiric treatment of FEBRILE NEUTROPENIA.. cefepime : A cephalosporin bearing (1-methylpyrrolidinium-1-yl)methyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. | 2.44 | 2 | 0 | cephalosporin;
oxime O-ether | antibacterial drug |
hr 810
cefpirome: structure in first source. cefpirome : A fourth-generation cephalosporin antibiotic having 6,7-dihydro-5H-cyclopenta[b]pyridinium-1-ylmethyl and [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups located at positions 3 and 7 respectively. | 2.02 | 1 | 0 | cephalosporin;
cyclopentapyridine | |
alanylalanine
L-alanyl-L-alanine : A dipeptide consisting of two L-alanine units joined by a peptide linkage. | 2.71 | 3 | 0 | dipeptide zwitterion;
dipeptide | Mycoplasma genitalium metabolite |
tyrosyl-alanyl-glycine
tyrosyl-alanyl-glycine: RN given refers to unlabeled (L-Tyr-D-Ala)-isomer | 2.02 | 1 | 0 | | |
phenylalanylalanine
phenylalanylalanine: RN given refers to (L)-isomer. Phe-Ala : A dipeptide formed from L-phenylalanine and L-alanine residues. | 2.72 | 3 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
acetylalanylalanine
acetylalanylalanine: RN given refers to (D)-isomer | 2.01 | 1 | 0 | | |
alpha-aspartylalanine
alpha-aspartylalanine: found in pig brain. Asp-Ala : A dipeptide formed from L-alpha-aspartyl and L-valine residues. | 2.7 | 3 | 0 | dipeptide | metabolite |
alanyltyrosine
Tyr-Ala : A dipeptide formed from L-tyrosine and L-alanine residues. | 2.93 | 4 | 0 | dipeptide | metabolite |
cefotaxime
Cefotaxime: Semisynthetic broad-spectrum cephalosporin.. cefotaxime : A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups. | 2.44 | 2 | 0 | 1,3-thiazoles;
cephalosporin;
oxime O-ether | antibacterial drug;
drug allergen |
cefpodoxime
[no description available] | 2.44 | 2 | 0 | carboxylic acid;
cephalosporin | antibacterial drug |
prolylglycine
prolylglycine: RN given refers to (L)-isomer. L-prolylglycine : A dipeptide consisting of glycine having an L-prolyl group attached to its alpha-amino nitrogen. | 2.4 | 2 | 0 | dipeptide zwitterion;
dipeptide | |
aspartyllysine
aspartyllysine: from feces of axenic mice. Asp-Lys : A dipeptide formed from L-alpha-aspartyl and L-lysine residues. | 2.02 | 1 | 0 | dipeptide | metabolite |
methampicillin
methampicillin: RN given refers to parent cpd(2S-(2alpha,5alpha,6beta(S*)))-isomer. metampicillin : A penicillin compound having a 6beta-(2R)-2-(methylideneamino)-2-phenylacetamido side-group. | 2.44 | 2 | 0 | penicillin allergen;
penicillin | |
phenylalanylglycine
phenylalanylglycine: RN given refers to (DL)-isomer. Phe-Gly : A dipeptide formed from L-phenylalanine and glycine residues. | 2.42 | 2 | 0 | dipeptide | metabolite |
leucyl-phenylalanine
Leu-Phe : A dipeptide formed from L-leucine and L-phenylalanine residues. | 1.98 | 1 | 0 | dipeptide | metabolite |
glutamylalanine
Glu-Ala : A dipeptide formed from L-alpha-glutamyl and L-alanine residues. | 2.93 | 4 | 0 | dipeptide | metabolite |
glutaminyl-glycine
Gln-Gly : A dipeptide formed from L-glutamine and glycine residues. | 1.98 | 1 | 0 | dipeptide | metabolite |
methionylglycine
methionylglycine: RN given refers to (L)-isomer. Met-Gly : A dipeptide formed from L-methionine and glycine residues. | 1.98 | 1 | 0 | dipeptide | metabolite |
phenylalanylphenylalanine
Phe-Phe : A dipeptide formed from two L-phenylalanine residues. | 2.93 | 4 | 0 | dipeptide;
L-aminoacyl-L-amino acid zwitterion | human blood serum metabolite;
Mycoplasma genitalium metabolite |
valylleucine
valylleucine: RN given refers to all L-isomer. Val-Leu : A dipeptide formed from L-valine and L-leucine residues. | 1.98 | 1 | 0 | dipeptide | metabolite |
phenylalanyl-valine
Val-Phe : A dipeptide formed from L-valine and L-phenylalanine residues. | 3.27 | 6 | 0 | dipeptide | metabolite |
alanylglycine
[no description available] | 3.12 | 5 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
alpha-glutamyltryptophan
Trp-Glu : A dipeptide formed from L-tryptophan and L-glutamic acid residues. | 1.98 | 1 | 0 | dipeptide | metabolite |
lysylglutamic acid
lysylglutamic acid: a geroprotective agent. Lys-Glu : A dipeptide formed from L-lysine and L-glutamic acid residues. | 2.02 | 1 | 0 | dipeptide | metabolite |
Ala-Lys
Ala-Lys : A dipeptide obtained by formal condensation of the carboxy group of L-alanine with the alpha-amino group of L-lysine. | 2.44 | 2 | 0 | dipeptide | marine metabolite |
phenylalanylproline
Phe-Pro : A dipeptide formed from L-phenylalanine and L-proline residues. | 2.74 | 3 | 0 | dipeptide | metabolite |
lysylglycine
lysylglycine: structure in first source. Lys-Gly : A dipeptide formed from L-lysine and glycine residues. | 1.98 | 1 | 0 | dipeptide | metabolite |
glycylhistidine
glycylhistidine: RN given refers to (L)-isomer. Gly-His : A dipeptide composed of glycine and L-histidine joined by a peptide linkage. | 2.93 | 4 | 0 | dipeptide zwitterion;
dipeptide | metabolite |
isoleucyl-tyrosine
isoleucyl-tyrosine: a dipeptide with antihypertensive effect. Ile-Tyr : A dipeptide formed from L-isoleucine and L-tyrosine residues. | 3.42 | 7 | 0 | dipeptide | metabolite |
prolyl-serine
Pro-Ser : A dipeptide formed from L-proline and L-serine residues. | 2.01 | 1 | 0 | dipeptide | metabolite |
valyl-prolyl-proline
Val-Pro-Pro : A tripeptide composed of L-valine and two L-proline units joined by peptide linkages. | 2.74 | 3 | 0 | tripeptide | metabolite |
prolylvaline
Val-Pro : A dipeptide formed from L-valine and L-proline residues. | 3.13 | 5 | 0 | dipeptide | metabolite |
isoleucyl-prolyl-proline
[no description available] | 2.02 | 1 | 0 | oligopeptide | |
isoleucyl-valyl-tyrosine
[no description available] | 2.94 | 4 | 0 | oligopeptide | |
prolyl-proline
Pro-Pro : A dipeptide formed from two L-proline residues. | 2.02 | 1 | 0 | dipeptide | human urinary metabolite;
Mycoplasma genitalium metabolite |
angiotensinogen
Angiotensinogen: An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM. | 1.93 | 1 | 0 | | |
cephapirin sodium
cephapirin sodium : The sodium salt of cephapirin. A first-generation cephalosporin antibiotic, it is effective against gram-negative and gram-positive organisms. Being more resistant to beta-lactamases than penicillins, it is effective agains most staphylococci, though not methicillin-resistant staphylococci. | 2.06 | 1 | 0 | cephalosporin;
organic sodium salt | antibacterial drug |
angiotensin i
Angiotensin I: A decapeptide that is cleaved from precursor angiotensinogen by RENIN. Angiotensin I has limited biological activity. It is converted to angiotensin II, a potent vasoconstrictor, after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME.. angiotensin I : A ten amino acid peptide formed by renin cleavage of angiotensinogen. Angiotensin I has no direct biological function except that high levels can stimulate catecholamine production. It is metabolized to its biologically active byproduct angiotensin II, a potent vasoconstrictor, by angiotensin converting enzyme (ACE) through cleavage of the two terminal amino acids.. angiotensin I dizwitterion : A peptide zwitterion that is the dizwitterionic form of angiotensin I having both carboxy groups deprotonated and the aspartyl amino group and arginine side-chain protonated. It is the major species at pH 7.3. | 4.65 | 6 | 1 | angiotensin;
peptide zwitterion | human metabolite;
neurotransmitter agent |