Bladder, Underactive

Symptom of underactive detrusor muscle of the URINARY BLADDER that contracts with abnormally reduced strength or duration resulting in an incomplete and/or prolonged bladder emptying.

Synonym
Hypotonic Bladder
Detrusor Underactivity
Underactive Detrusor
Underactive Bladder
Urinary Bladder, Underactive
Bladder, Underactive
Underactive Urinary Bladder
Underactive Detrusor Function

Excerpt	Reference
"Pharmacological treatment options for underactive bladder (UAB) syndrome are limited."	( Takeda, H; Tatemichi, S; Tezuka, M; Yonekubo-Awaka, S, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	17 (58.62)	28.8240
2020's	12 (41.38)	9.53

Drug	Relationship Strength	Studies	Trials
nickel	low	1	0
bethanechol	low	1	0
distigmine	low	1	0
midodrine	low	1	0
potassium chloride	low	1	0
urapidil	low	1	0
carbachol	low	5	0
leucine	low	2	0
methylprednisolone	low	1	0
thiazoles	low	3	0
titanium	low	1	0
holmium	low	1	0
amoxicillin	medium	1	1
fomesafen	low	4	0
tadalafil	low	2	0
tamsulosin	low	1	0
glycogen	low	1	0
rn 1734	low	1	0
clavulanic acid	medium	1	1
naloxone	low	1	0
silodosin	low	2	0
z 338	low	2	0
transforming growth factor beta	low	1	0
acyclovir	low	1	0
valacyclovir	low	1	0

Protein Targets (331)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
Thymidine kinase	0	1	0	1
thioredoxin reductase	2	0	0	2
phosphopantetheinyl transferase	1	0	0	1
GLS protein	2	0	0	2
TDP1 protein	3	0	0	3
Smad3	1	0	0	1
thyroid stimulating hormone receptor	2	0	0	2
EWS/FLI fusion protein	2	0	0	2
arylsulfatase A	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	5	0	0	5
activating transcription factor 6	1	0	0	1
Histone H2A.x	2	0	0	2
Bloom syndrome protein isoform 1	2	0	0	2
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
lamin isoform A-delta10	2	0	0	2
Solute carrier family 22 member 1	0	0	0	1
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	6	0	6
Solute carrier family 22 member 6	0	0	0	1
Bile salt export pump	0	3	0	3
Bile salt export pump	0	8	0	8
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	3	0	3
Cytochrome P450 2J2	0	3	0	3
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	2
Canalicular multispecific organic anion transporter 1	0	6	0	6
Thymidine kinase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, Beta-lactamase	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
AR protein	3	0	0	3
apical membrane antigen 1, AMA1	1	0	0	1
estrogen nuclear receptor alpha	6	0	0	6
Beta-lactamase	0	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
Beta-lactamase SHV-1	0	1	0	2
Beta-lactamase SHV-1	0	2	0	3
Beta-lactamase	0	1	0	2
Kappa-type opioid receptor	0	2	1	4
Solute carrier family 15 member 1	0	3	0	4
Solute carrier family 15 member 1	0	2	0	2
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	1
USP1 protein, partial	2	0	0	2
regulator of G-protein signaling 4	1	0	0	1
chromobox protein homolog 1	3	0	0	3
flap endonuclease 1	1	0	0	1
Muscarinic acetylcholine receptor M2	0	3	2	6
Muscarinic acetylcholine receptor M4	0	3	2	6
Muscarinic acetylcholine receptor M5	0	3	2	6
Muscarinic acetylcholine receptor M1	0	3	2	6
Muscarinic acetylcholine receptor M3	0	3	2	6
acetylcholinesterase	3	0	0	3
GALC protein	1	0	0	1
peroxisome proliferator activated receptor gamma	2	0	0	2
IDH1	2	0	0	2
thyroid stimulating hormone receptor	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	1	0	0	1
geminin	2	0	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Muscarinic acetylcholine receptor M1	0	3	1	6
Muscarinic acetylcholine receptor M3	0	3	1	5
Muscarinic acetylcholine receptor M4	0	3	0	4
Muscarinic acetylcholine receptor M5	0	3	0	4
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Muscarinic acetylcholine receptor M2	0	3	0	4
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Delta-type opioid receptor	0	2	1	5
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	1	2
Muscarinic acetylcholine receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	0	1	3
Muscarinic acetylcholine receptor M2	0	0	0	3
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Neutrophil elastase	0	1	0	1
Beta-lactamase OXA-1	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Beta-lactamase TEM	0	2	0	3
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Class D beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase	0	1	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	2	0	2
Beta-lactamase class B VIM-2	0	0	0	1
Luciferase	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
progesterone receptor	2	0	0	2
estrogen-related nuclear receptor alpha	2	0	0	2
pregnane X nuclear receptor	4	0	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	1	0	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	2
Phospholipase A-2-activating protein	0	1	0	1
PPM1D protein	1	0	0	1
GLI family zinc finger 3	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
nonstructural protein 1	1	0	0	1
glucocorticoid receptor [Homo sapiens]	1	0	0	1
retinoid X nuclear receptor alpha	1	0	0	1
G	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Glucocorticoid receptor	0	2	0	2
Glycine receptor subunit alpha-1	0	2	0	2
Androgen receptor	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Inositol hexakisphosphate kinase 1	2	0	0	2
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
cytochrome P450 2C9, partial	2	0	0	2
ATP-dependent phosphofructokinase	2	0	0	2
RAR-related orphan receptor gamma	1	0	0	1
cytochrome P450 2D6	2	0	0	2
Cytochrome P450 2D6	0	1	0	1
Histidine decarboxylase	0	0	1	1
D(3) dopamine receptor	0	1	0	1
Adenosine receptor A1	0	1	0	1
Delta-type opioid receptor	0	2	2	4
Kappa-type opioid receptor	0	1	0	2
Mu-type opioid receptor	0	2	2	4
Kappa-type opioid receptor	0	1	2	3
Mu-type opioid receptor	0	2	1	4
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	2	5
Mu-type opioid receptor	0	1	0	2
Mu-type opioid receptor	0	2	1	3
Beta-2 adrenergic receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Carbonic anhydrase 9	0	1	0	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Alpha-1A adrenergic receptor	0	2	1	3
Potassium voltage-gated channel subfamily E member 1	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	4	1	5
Alpha-1A adrenergic receptor	0	4	2	6
Alpha-1B adrenergic receptor	0	4	2	6
Alpha-1A adrenergic receptor	0	3	0	3
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
Spike glycoprotein	2	0	0	2
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
nuclear receptor subfamily 1, group I, member 3	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
retinoic acid nuclear receptor alpha variant 1	1	0	0	1
Phosphodiesterase	0	1	0	1
aryl hydrocarbon receptor	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
mitogen-activated protein kinase 1	2	0	0	2
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	1	2
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	1	3
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Acetylcholinesterase	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	1	1
peripheral myelin protein 22	1	0	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Alpha-2A adrenergic receptor	0	1	0	1
Tryptophan 5-hydroxylase 1	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	0	1	1
Alpha-1D adrenergic receptor	0	2	0	2
Sodium-dependent dopamine transporter	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Microtubule-associated protein tau	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Histamine H2 receptor	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
GABA theta subunit	1	0	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
thioredoxin glutathione reductase	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Valacyclovir hydrolase	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(8)

Research Excerpts

Treatment

Research

Studies (29)

Protein Targets (331)

Bladder, Underactive

Synonyms(8)

Research Excerpts

Treatment

Research

Studies (29)

Drugs Studied (31)

Protein Targets (331)