Page last updated: 2024-09-27

Hydronephrosis, Infected

Distention of KIDNEY with the presence of PUS and suppurative destruction of the renal parenchyma. It is often associated with renal obstruction and can lead to total or nearly total loss of renal function.

Synonyms(2)

Synonym
Hydronephrosis, Infected
Pyonephrosis

Research Excerpts

Research

Studies (9)

TimeframeStudies, This Condition (%)All Conditions %
pre-19902 (22.22)23.3326
1990's0 (0.00)12.5806
2000's1 (11.11)18.1394
2010's6 (66.67)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
chlorpromazine0low10
sulfanilamide0low10
penicillanic acid0low10
vancomycin0low10
amoxicillin0low10
piperacillin0low10
cephalosporin c0low10
technetium tc 99m pentetate0low10
meropenem0low10
nitrofurazone0low10
piperacillin, tazobactam drug combination0low10
allopurinol0low10

Protein Targets (479)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
interleukin 81001
TDP1 protein3003
AR protein5005
thyroid stimulating hormone receptor2002
estrogen receptor 2 (ER beta)3003
progesterone receptor3003
glucocorticoid receptor [Homo sapiens]4004
estrogen-related nuclear receptor alpha5005
estrogen nuclear receptor alpha5005
IDH12002
euchromatic histone-lysine N-methyltransferase 22002
Bloom syndrome protein isoform 11001
transcriptional regulator ERG isoform 32002
thyroid hormone receptor beta isoform 24004
ras-related protein Rab-9A2002
nuclear factor erythroid 2-related factor 2 isoform 15005
geminin3003
survival motor neuron protein isoform d3003
lamin isoform A-delta103003
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40505
Polyphenol oxidase 20101
Voltage-dependent calcium channel gamma-2 subunit3003
Bile salt export pump0606
Hypoxanthine-guanine phosphoribosyltransferase0001
Cellular tumor antigen p534004
Glutamate receptor 23003
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase 0101
Adenosine receptor A2a0011
Xanthine dehydrogenase/oxidase0202
Nuclear receptor ROR-gamma0101
Xanthine dehydrogenase/oxidase0214
Purine nucleoside phosphorylase0011
TAR DNA-binding protein 431001
Canalicular multispecific organic anion transporter 10505
Shiga toxin subunit A0101
Histamine H3 receptor0103
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Beta-lactamase1001
Chain A, 2-oxoglutarate Oxygenase2002
Beta-lactamase 0002
Beta-lactamase 0002
Beta-lactamase 0003
Beta-lactamase 0002
apical membrane antigen 1, AMA11001
Beta-lactamase 0002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)1001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
DNA polymerase kappa isoform 12002
Bile salt export pump0202
Beta-lactamase SHV-10002
Beta-lactamase SHV-10003
Cytochrome P450 2C9 0202
Beta-lactamase0003
Kappa-type opioid receptor0002
Solute carrier family 15 member 10202
Solute carrier family 15 member 10101
Cytochrome P450 2J20202
B2 metallo-beta-lactamase 0002
Solute carrier family 15 member 20101
Beta-lactamase 0002
Beta-lactamase 0002
Solute carrier family 15 member 20101
Beta-lactamase 0002
Beta-lactamase 0002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Proteasome subunit beta type-110001
acetylcholinesterase2002
thioredoxin reductase2002
phosphopantetheinyl transferase1001
RAR-related orphan receptor gamma2002
ATAD5 protein, partial1001
Fumarate hydratase1001
USP1 protein, partial1001
NFKB1 protein, partial1001
GLI family zinc finger 32002
Microtubule-associated protein tau1001
Thrombopoietin1001
Smad32002
caspase 7, apoptosis-related cysteine protease1001
nuclear receptor subfamily 1, group I, member 34004
NADPH oxidase 10101
cytochrome P450 family 3 subfamily A polypeptide 42002
retinoic acid nuclear receptor alpha variant 13003
retinoid X nuclear receptor alpha3003
farnesoid X nuclear receptor2002
pregnane X nuclear receptor3003
G3003
cytochrome P450 2D62002
polyprotein1001
67.9K protein1001
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma3003
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
Snq2p0001
caspase-31001
Adenylate cyclase type 1 0202
thyroid stimulating hormone receptor2002
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Histone H2A.x3003
Caspase-71001
Spike glycoprotein0112
Replicase polyprotein 1ab0112
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a2002
D(1A) dopamine receptor1001
vitamin D3 receptor isoform VDRA1001
chromobox protein homolog 13003
potassium voltage-gated channel subfamily H member 2 isoform d1001
caspase-31001
histone deacetylase 9 isoform 31001
heat shock protein beta-12002
mitogen-activated protein kinase 11001
atrial natriuretic peptide receptor 2 precursor1001
serine/threonine-protein kinase mTOR isoform 11001
peripheral myelin protein 222002
cytochrome P450 3A4 isoform 12002
M-phase phosphoprotein 81001
histone acetyltransferase KAT2A isoform 12002
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)2002
Gamma-aminobutyric acid receptor subunit pi2002
Proteasome subunit alpha type-70001
Solute carrier family 22 member 1 0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transmembrane protease serine 20112
Glutamate receptor ionotropic, NMDA 2D0101
Transient receptor potential cation channel subfamily V member 10101
Glutamate receptor ionotropic, NMDA 3B0101
Voltage-dependent L-type calcium channel subunit alpha-1F0202
5-hydroxytryptamine receptor 40202
Potassium channel subfamily K member 20101
Epidermal growth factor receptor0101
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Albumin0022
Albumin0011
Major prion protein0011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Receptor tyrosine-protein kinase erbB-20101
Major prion protein0011
Integrin beta-32002
Cytochrome P450 1A20011
Tyrosine-protein kinase Fyn0101
Procathepsin L0112
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20303
Muscarinic acetylcholine receptor M40202
ATP-dependent translocase ABCB10102
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Integrin alpha-IIb2002
5-hydroxytryptamine receptor 1A0101
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0303
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
Cys-loop ligand-gated ion channel0101
Calmodulin-10213
Replicase polyprotein 1ab0112
Cytochrome P450 2D60112
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10202
Polyunsaturated fatty acid lipoxygenase ALOX150101
Angiotensin-converting enzyme0202
D(2) dopamine receptor0203
5-hydroxytryptamine receptor 2A0202
Gamma-aminobutyric acid receptor subunit beta-12002
Alpha-1B adrenergic receptor0404
Sphingomyelin phosphodiesterase0101
Alpha-2B adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Alpha-2C adrenergic receptor0202
D0202
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 1A0202
Alpha-2B adrenergic receptor0303
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
D(2) dopamine receptor0101
Muscarinic acetylcholine receptor M30202
Proteasome subunit beta type-10001
Substance-K receptor0202
D(1A) dopamine receptor0203
D(4) dopamine receptor0203
D(1B) dopamine receptor0102
Adenylate cyclase type 30202
Alpha-2C adrenergic receptor0303
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0303
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Alpha-1D adrenergic receptor0404
Sodium-dependent noradrenaline transporter 0202
Sodium-dependent dopamine transporter0202
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
D(1B) dopamine receptor0202
Proteasome subunit alpha type-10001
Proteasome subunit alpha type-20001
Proteasome subunit alpha type-30001
Proteasome subunit alpha type-40001
Adenylate cyclase type 20202
Adenylate cyclase type 40202
Proteasome subunit beta type-80001
Proteasome subunit beta type-90001
Proteasome subunit alpha type-50001
Proteasome subunit beta type-40001
Proteasome subunit beta type-60001
Proteasome subunit beta type-50001
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
5-hydroxytryptamine receptor 1B0202
Trypanothione reductase0202
Gamma-aminobutyric acid receptor subunit alpha-62002
D(4) dopamine receptor0202
5-hydroxytryptamine receptor 2B0202
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0202
Melanocortin receptor 40202
5-hydroxytryptamine receptor 7 0101
Melanocortin receptor 50202
Pleiotropic ABC efflux transporter of multiple drugs0102
5-hydroxytryptamine receptor 70101
Histamine H1 receptor0202
Mu-type opioid receptor0202
Glutamate receptor ionotropic, NMDA 1 0101
D(3) dopamine receptor0203
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Adenylate cyclase type 80202
Proteasome subunit beta type-100001
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
5-hydroxytryptamine receptor 2B0202
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0404
Histamine H2 receptor1001
Proteasome subunit beta type-30001
Proteasome subunit beta type-20001
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60202
5-hydroxytryptamine receptor 70101
Gastrin/cholecystokinin type B receptor0101
Spike glycoprotein1113
Proteasome subunit alpha type-60012
D(2) dopamine receptor0203
Calmodulin 0112
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
Aldehyde oxidase 10101
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Sodium-dependent dopamine transporter 0202
Adenylate cyclase type 60202
Adenylate cyclase type 50202
Glutamate receptor ionotropic, NMDA 10101
Aldehyde oxidase0202
Potassium voltage-gated channel subfamily H member 20202
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, NMDA 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0101
Glutamate receptor ionotropic, NMDA 2C0101
Sodium channel protein type 9 subunit alpha0101
Glutamate receptor ionotropic, NMDA 2D0101
Nuclear receptor subfamily 3 group C member 3 0202
Adenylyl cyclase 7 0202
Proteasome subunit alpha-type 80001
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0101
GABA theta subunit2002
Inositol hexakisphosphate kinase 13003
D0101
Sodium channel protein type 2 subunit alpha0101
Proteasome subunit beta type-70001
Ataxin-21001
Sigma non-opioid intracellular receptor 10202
Angiotensin-converting enzyme 2 0112
Gamma-aminobutyric acid receptor subunit epsilon2002
Sodium channel protein type 3 subunit alpha0101
Glutamate receptor ionotropic, NMDA 3A0101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Histamine H3 receptor0101
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial3003
Beta-lactamase 0002
Metallo-beta-lactamase type 20013
Metallo-beta-lactamase VIM-11 0001
Metallo-beta-lactamase VIM-20001
Metallo-beta-lactamase VIM-19 0002
Beta-lactamase 0002
Metallo-beta-lactamase0001
aryl hydrocarbon receptor2002
streptokinase A precursor0011
Beta-lactamase0001
Beta-lactamase TEM0001
Metallo-beta-lactamase VIM-130002
Metallo-beta-lactamase VIM-20002
Beta-lactamase 0002
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0002
Beta-lactamase 0001
Beta-lactamase 0012
Metallo-b-lactamase 0002
Beta-lactamase IMP-1 0001
BlaVIM-1 0002
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0002
Beta-lactamase class B VIM-2 0013
Beta-lactamase 0001
Beta-lactamase VIM-1 0002
hypoxia-inducible factor 1 alpha subunit1001
thioredoxin glutathione reductase1001
aldehyde dehydrogenase 1 family, member A11001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
thyroid hormone receptor beta isoform a1001
importin subunit beta-1 isoform 11001
snurportin-11001
nuclear receptor ROR-gamma isoform 11001
Metabotropic glutamate receptor 50101
Nuclear receptor ROR-gamma1001
Snake venom metalloproteinase BaP10101
NAD(+) hydrolase SARM10202
Beta-lactamase 0101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase OXA-70001
Beta-lactamase 0001
Class D beta-lactamase0001
Beta-lactamase 0001
Carbonic anhydrase 0001
Carbonic anhydrase 0101
EWS/FLI fusion protein2002
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Carbonic anhydrase0101
Carbonic anhydrase 120101
Carbonic anhydrase 10203
Carbonic anhydrase 20214
Carbonic anhydrase 20112
Cholinesterase0101
Carbonic anhydrase 30101
Acetylcholinesterase0101
Carbonic anhydrase 40101
Carbonic anhydrase 60202
Carbonic anhydrase 5A, mitochondrial0101
Delta-type opioid receptor0101
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Carbonic anhydrase 5A, mitochondrial0203
Carbonic anhydrase0101
Carbonic anhydrase 70101
Carbonic anhydrase0101
Disintegrin and metalloproteinase domain-containing protein 171001
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 90202
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
Carbonic anhydrase 0101
Delta carbonic anhydrase0101
Carbonic anhydrase 0101
Carbonic anhydrase 130101
Carbonic anhydrase 40101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
Protein argonaute-20011
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0102
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
heat shock protein HSP 90-alpha isoform 20101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Tetracycline resistance protein, class B0001
72 kDa type IV collagenase0101
Stromelysin-10101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
Multidrug transporter MdfA0101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Neutrophil collagenase0101
Alpha-synuclein0101
Collagenase 30101
Cannabinoid receptor 10101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Integrase 0101
Solute carrier family 22 member 80001
P2Y purinoceptor 120101
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Solute carrier family 22 member 70001
60 kDa heat shock protein, mitochondrial0101
Sodium-dependent serotonin transporter0101
10 kDa heat shock protein, mitochondrial0101
D-alanyl-D-alanine dipeptidase0101
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Transporter0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]