Acquired Encephalocele

Brain tissue herniation through a congenital or acquired defect in the skull. The majority of congenital encephaloceles occur in the occipital or frontal regions. Clinical features include a protuberant mass that may be pulsatile. The quantity and location of protruding neural tissue determines the type and degree of neurologic deficit. Visual defects, psychomotor developmental delay, and persistent motor deficits frequently occur.

Synonym
Tonsillar Herniation
Cranium Bifidum
Cerebellar Herniation
Bifid Cranium
Sincipital Encephalocele
Cranial Meningoencephalocele
Hernia, Cerebral
Cerebellar Hernia
Encephalocele, Sincipital
Craniocele
Encephalocele
Encephalocele, Acquired
Frontal Encephalocele
Occipital Encephalocele
Acquired Encephalocele
Encephalocele, Frontal
Tonsillar Hernia
Encephalocele, Occipital
Notoencephalocele
Cephalocele

Excerpt	Reference
"Transsphenoidal encephaloceles are rare congenital malformations that are classified among the medial dysraphias and that are therefore associated with an agenesis of the corpus callosum."	( Bonafé, A; David, J; Manelfe, C; Starling-Jardim, D; Touibi, S, 1978)
"Anterior encephalocele is more common in Southeast Asia than elsewhere."	( Alhady, F; Dunn, RC; Rapport, RL, 1981)
"Encephaloceles are rare congenital defects in the skull, through which the meninges and brain tissue have herilated."	( Harii, K; Hirabayashi, S; Sakurai, A; Sasaki, T; Sugawara, Y, 1996)
"Atretic cephaloceles are usually detected at birth."	( Martínez-Lage, JF; Piqueras, C; Poza, M, 1997)
"Frontoethmoidal encephaloceles are congenital malformations that cause complex deformities in the frontal, orbital, and nasal regions."	( Bilkay, U; Celik, N; Görken, C; Güner, U; Gürler, T; Mutluer, S; Songür, E, 1999)
"Atretic cephaloceles are thought to be involuted true meningoceles or encephaloceles."	( Aydin, MD, 2001)
"Intradiploic meningoencephalocele is rarely found in adulthood."	( A'teriitehau, C; Adem, C; Cordoliani, YS; Levêque, C, 2004)
"Anterior encephalocele is a rarely reported CNS malformation with a geographical predilection for South-East Asia."	( Agrawal, D; Mahapatra, AK, 2006)
"Atretic cephalocele is a clinicopathological entity, which is different from the common form of cephalocele."	( Carvalho, DR; Giuliani, LR; Pina-Neto, JM; Santos, AC; Simão, GN, 2006)
"Encephalocele is classified as a neural tube defect, but questions have been raised regarding whether its epidemiological characteristics are similar to those of other neural tube defects."	( Alverson, CJ; Correa, A; Cragan, JD; Rowland, CA, 2006)
"Frontoethmoidal encephaloceles are best operated on via a craniofacial approach which enables repair of the central nervous system and skeletal deformities in one stage."	( Honda, T; Kashiwa, K; Kobayashi, S; Nasu, W, 2008)
"These rare encephaloceles are classified into five anatomic types: spheno-ethmodial, transsphenoidal, spheno-orbital, transethmoidal, and spheno-maxillary."	( Arnold, H; Domarus, Hv; Giese, A; Kantelhardt, SR; Knopp, A; Knopp, U; Löning, M; Reusche, E; Stellmacher, F, 2009)
"Basal encephaloceles are rare, accounting for about 1."	( Aydin, AL; Ozer, AF; Sasani, M, 2009)
"An encephalocele is a protrusion of the cranial contents beyond the normal confines of the skull through a defect in the skull and the facial bones."	( Singh, AK; Upadhyaya, DN, 2009)
"Anterior encephaloceles are rare congenital malformations."	( Deori, P; Dutta, HK, 2010)
"Anterior encephaloceles are rare in Western countries and other states in India, but this defect is more commonly seen among the ethnic tea garden workers in Assam."	( Deori, P; Dutta, HK, 2010)
"If encephalocele is suspected, further imaging with high-resolution CT and MRI can be helpful."	( Abou-Hamden, A; Archer, JS; Berkovic, SF; Fabinyi, G; Fitt, G; Jackson, GD; Kalnins, R; Lau, M; Mitchell, LA, 2010)
"The encephalocele is removed at the neck, and the dural defect is repaired."	( Aojanepong, C, 2011)
"Encephaloceles are acquired or congenital defects in which intracranial contents protrude through a defect in the calvaria."	( Fulkerson, DH; Hamilton, KM; Wiens, AL, 2011)
"Cranium bifidum is a congenital anomaly caused by abnormal development of the cephalic neural tube."	( Iijima, Y; Okumoto, T; Yoshimura, Y, 2012)
"Naso-orbital encephaloceles are rarely seen."	( Alexander, AA; Fickenscher, KA; L'heureux, D; Saettele, MR; Shah, PA, 2011)
"Encephalocele is a rare congenital malformation of the central nervous system with protrusion of cranial content (meninges, brain, and ventricles in different combinations) beyond the normal confines of the skull."	( Cama, A; Consales, A; Merciadri, P; Pavanello, M; Piatelli, G; Ravegnani, GM; Secci, F, 2013)
"Sincipital encephalocele is a complex pathology without a unique standardized surgical treatment."	( Cama, A; Consales, A; Merciadri, P; Pavanello, M; Piatelli, G; Ravegnani, GM; Secci, F, 2013)
"Atretic cephalocele is a small skin-covered lesion, usually located at or near the mid-line of the scalp."	( Fukuyama, M; Hayashi, Y; Tanese, K; Tanikawa, A; Yasuda, F, 2016)
"Management of encephaloceles is challenging when massive brain herniation is present."	( Carneiro, JL; Pedrosa, HAS; Sampaio, FD; Vilela, MD, 2018)
"Intraorbital meningoencephalocele is a rare manifestation of neurofibromatosis type 1 (NF1) caused by secondary changes in sphenoid dysplasia, and it seriously affects patients' vision and facial appearance."	( He, X; Jia, W; Li, X; Li, Z; Niu, J; Su, F; Wang, D; Wang, J, 2019)
"Nasal meningoencephalocele is a rare condition that can be challenging to diagnose."	( Gehong, D; Hong, Z; Honggang, L; Jianhua, T; Xue, L; Ying, W, 2020)
"Primary encephalocele is a rare deformity that is challenging for the neurosurgeon."	( Boscherini, D; Bossou, R; de Buys Roessingh, A; Dolci, M; El Ezzi, O; Prod'homme, M, 2021)
"Encephaloceles are herniation of brain parenchyma through a bony skull defect that can cause drug-resistant epilepsy."	( Castiñeira-Mourenza, JA; Martínez-Pías, E; Prieto-González, AJ; Rodríguez-Osorio, X, 2021)
"Anterior temporal encephaloceles are an underdiagnosed cause of epilepsy, and a 3 T magnetic resonance imaging reviewed by an epilepsy expert radiologists is key to diagnosis."	( Castiñeira-Mourenza, JA; Martínez-Pías, E; Prieto-González, AJ; Rodríguez-Osorio, X, 2021)
"Encephalocele is a malformation due to a defect in the closure of the neural tube causing herniation of brain tissue and/or meninges through this congenital skull defect."	( Kahindo, AK; Kambale, JM; Kasereka, CM; Kavugho, FM; Mitamo, AA; Muhindo, AK; Sumai, MA; Yawi, JB, 2022)

Excerpt	Reference
"Encephaloceles have not been examined separately."	( Bower, C; D'Antoine, H; Stanley, FJ, 2009)
"Sincipital encephaloceles have been classified by Suwanwela and Suwanwela (1972) into frontoethmoidal, interfrontal, and those associated with craniofacial clefts."	( Singh, AK; Upadhyaya, DN, 2009)

Excerpt	Reference
"Eighteen cases of anterior encephalocele treated at the University of Malaya Hospital between 1970 and 1980 are discussed, and the literature concerning this defect is reviewed."	( Alhady, F; Dunn, RC; Rapport, RL, 1981)
"A case of a gigantic orbital meningoencephalocele in a neonate treated successfully by staged correction is presented."	( Cielecka-Kuszyk, J; Daszkiewicz, P; Grajkowska, W; Trzebicka, A, 1997)
"High incidences of encephalocele and tail defects were noted in the GD 16 fetuses of EHXA-treated dams fed either the low or adequate Zn diet, the highest incidences being in the low Zn group."	( Bui, LM; Commisso, JF; Faber, WD; Keen, CL; Taubeneck, MW; Uriu-Hare, JY, 1998)
"As the distinction between encephaloceles and cerebral heterotopias is based on the correlation of radiologic and clinical findings, the surgical treatment of tumorlike lesions of the nasal and pharyngeal region in children requires a careful preoperative evaluation of their possible connection to the cranial cavity."	( Klohs, G; Musil, A; Rath, FW; Taege, C, 2001)
"Epilepsy due to encephaloceles of the temporal pole may be an under recognized, treatable cause of refractory temporal lobe epilepsy (TLE)."	( Abou-Hamden, A; Archer, JS; Berkovic, SF; Fabinyi, G; Fitt, G; Jackson, GD; Kalnins, R; Lau, M; Mitchell, LA, 2010)
"Sincipital encephalocele is a complex pathology without a unique standardized surgical treatment."	( Cama, A; Consales, A; Merciadri, P; Pavanello, M; Piatelli, G; Ravegnani, GM; Secci, F, 2013)
"The standard treatment for cranium bifidum occultum is observation."	( Dossani, RH; Ghali, GE; Kalakoti, P; Nanda, A; Notarianni, C; Woerner, J; Yates, DM, 2017)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	178 (37.55)	23.3326
1990's	64 (13.50)	12.5806
2000's	98 (20.68)	18.1394
2010's	107 (22.57)	28.8240
2020's	27 (5.70)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	7	0
quinacrine	low	1	0
carbamates	low	1	0
formic acid	low	1	0
chloroacetic acid	low	1	0
chlorine	low	2	0
salicylic acid	low	39	0
lactic acid	low	3	0
formaldehyde	low	1	0
glycine	medium	1	1
glycerol	low	2	0
hydrogen cyanide	low	1	0
methanol	low	1	0
niacinamide	low	1	0
nitrous oxide	medium	4	1
putrescine	low	1	0
pyridoxine	low	1	0
thiosulfates	low	1	0
sulfites	low	1	0
spermidine	low	1	0
spermine	low	1	0
urea	low	3	0
n-methyl-3,4-methylenedioxyamphetamine	low	1	0
phenytoin	low	1	0
acetaminophen	low	2	0
acetazolamide	low	6	0
amantadine	low	1	0
amitriptyline	low	1	0
aspirin	low	1	0
bupivacaine	low	1	0
caffeine	medium	1	1
chlorambucil	low	1	0
chlordiazepoxide	low	1	0
clofibrate	low	2	0
dicyclomine	low	1	0
pentetic acid	low	3	0
valproic acid	low	2	0
doxylamine	low	1	0
endosulfan	low	1	0
erythrosine	low	1	0
fentanyl	medium	5	1
furosemide	low	1	0
gentamicin	low	1	0
haloperidol	low	1	0
halothane	medium	2	1
hydroxyurea	low	1	0
lidocaine	low	1	0
imipramine	low	1	0
iohexol	low	1	0
isoflurane	low	1	0
2-propanol	low	4	0
meclizine	low	1	0
meperidine	low	2	0
methoxyflurane	medium	1	1
midazolam	low	1	0
apnea	low	5	0
phenobarbital	low	1	0
potassium chloride	low	1	0
primidone	low	1	0
sevoflurane	low	1	0
thalidomide	low	1	0
prednisolone	low	1	0
floxuridine	low	1	0
thyroxine	low	1	0
prednisone	low	1	0
pilocarpine	low	1	0
aspartic acid	low	1	0
glutamine	low	2	0
bromodeoxyuridine	low	2	0
phenylephrine	low	1	0
levodopa	low	1	0
leucine	low	3	0
methionine	low	2	0
colchicine	low	1	0
ampicillin	low	1	0
mannitol	low	13	0
cytarabine	low	2	0
arginine	low	1	0
ethylene	low	1	0
triamcinolone acetonide	low	3	0
trichloroethylene	medium	2	1
2-ethylhexanol	low	1	0
propionitrile	low	2	0
acrylonitrile	low	2	0
1,2-dimethoxyethane	low	1	0
1-hexanol	low	1	0
2-ethylhexanoic acid	low	1	0
4-hydroxybutyric acid	low	1	0
methamphetamine	low	1	0
linamarin	low	1	0
phenoperidine	medium	2	1
deoxycytidine	low	1	0
durapatite	low	4	0
vancomycin	low	2	0
benperidol	medium	1	1
thiocholchicine	low	1	0
trimethaphan	low	2	0
mercury	low	1	0
tantalum	low	2	0
titanium	low	1	0
cadmium	low	1	0
cerium	low	1	0
gadolinium	low	3	0
xenon	low	2	0
galactosamine	low	1	0
ozone	low	1	0
cadmium chloride	low	1	0
bromocriptine	low	2	0
phenyl acetate	low	1	0
triamcinolone	low	1	0
4-methoxyamphetamine	low	2	0
transferrin	low	2	0
normeperidine	low	1	0
glutamic acid	low	1	0
cefazolin	low	1	0
amoxicillin	low	1	0
dobutamine	low	1	0
propiconazole	medium	101	1
fomesafen	low	3	0
cabergoline	low	1	0
gemcitabine	low	1	0
adenosine	low	1	0
efavirenz	low	1	0
n-acetylaspartic acid	low	1	0
cephalosporin c	low	1	0
delphinidin	low	1	0
fluorodeoxyglucose f18	low	3	0
coenzyme a	low	1	0
nsc-172755	low	1	0
fibrinogen	low	2	0
homocysteine	low	1	0
hydrogen sulfite	low	1	0
methotrexate	low	4	0
isospaglumic acid	low	1	0
alpha-pyrrolidinopropiophenone	low	1	0
carboplatin	low	1	0
elastin	low	1	0
inositol 3-phosphate	low	1	0
griseofulvin	low	1	0
metrizamide	low	2	0
retinol	low	6	0
cocaine	low	2	0
clindamycin	low	1	0
bromochloroacetic acid	low	3	0
enclomiphene	low	1	0
lincomycin	low	1	0
thiamylal	low	1	0
sodium dodecyl sulfate	low	1	0
vitamin k semiquinone radical	low	1	0
phenylephrine hydrochloride	medium	93	1
morphine	medium	1	1
nalbuphine	medium	1	1
aluminum	low	1	0
arsenic	low	2	0
indium	low	1	0
cysteine	low	1	0
cefotaxime	low	1	0
diadinoxanthin	low	1	0
gadolinium dtpa	low	4	0
ergoline	low	1	0
rivaroxaban	low	1	0
pituitrin	low	1	0
ro13-9904	low	3	0
chondroitin	low	1	0
heparitin sulfate	low	1	0
tetracycline	low	1	0
dicumarol	low	1	0
epidermal growth factor	low	1	0
exudates	low	1	0
acyclovir	low	2	0
folic acid	medium	26	1
trypan blue	low	2	0
eye	low	6	0
concanavalin a	low	1	0
metallothionein	low	1	0

Protein Targets (1,317)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
thyroid stimulating hormone receptor	27	0	0	27
estrogen nuclear receptor alpha	62	0	0	62
vitamin D (1,25- dihydroxyvitamin D3) receptor	20	0	0	20
thyroid hormone receptor beta isoform a	15	0	0	15
nuclear factor erythroid 2-related factor 2 isoform 1	40	0	0	40
RAR-related orphan receptor gamma	36	0	0	36
GLI family zinc finger 3	36	0	0	36
AR protein	58	0	0	58
caspase 7, apoptosis-related cysteine protease	8	0	0	8
nuclear receptor subfamily 1, group I, member 3	27	0	0	27
progesterone receptor	16	0	0	16
retinoic acid nuclear receptor alpha variant 1	39	0	0	39
estrogen-related nuclear receptor alpha	38	0	0	38
pregnane X nuclear receptor	28	0	0	28
caspase-3	8	0	0	8
Voltage-dependent calcium channel gamma-2 subunit	19	0	0	19
Glutamate receptor 2	19	2	1	22
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
mitogen-activated protein kinase 1	6	0	0	6
Carbonic anhydrase 1	0	19	1	29
Carbonic anhydrase 2	0	20	2	31
Solute carrier family 22 member 20	0	5	0	5
Solute carrier family 22 member 6	0	5	0	5
TDP1 protein	37	0	0	37
aldehyde dehydrogenase 1 family, member A1	29	0	0	29
estrogen receptor 2 (ER beta)	18	0	0	18
retinoid X nuclear receptor alpha	28	0	0	28
peroxisome proliferator activated receptor gamma	21	0	0	21
aryl hydrocarbon receptor	13	0	0	13
DNA polymerase iota isoform a (long)	16	0	0	16
geminin	38	0	0	38
Cellular tumor antigen p53	38	0	0	38
hypoxia-inducible factor 1 alpha subunit	9	0	0	9
peroxisome proliferator-activated receptor delta	20	0	0	20
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	23	0	0	23
activating transcription factor 6	18	0	0	18
v-jun sarcoma virus 17 oncogene homolog (avian)	18	0	0	18
Histone H2A.x	17	0	0	17
heat shock protein beta-1	9	0	0	9
lamin isoform A-delta10	33	0	0	33
Gamma-aminobutyric acid receptor subunit pi	14	5	0	19
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	14	5	0	19
Gamma-aminobutyric acid receptor subunit delta	14	5	0	19
Gamma-aminobutyric acid receptor subunit gamma-2	14	5	0	19
Gamma-aminobutyric acid receptor subunit alpha-5	14	5	0	19
Gamma-aminobutyric acid receptor subunit alpha-3	14	5	0	19
Gamma-aminobutyric acid receptor subunit gamma-1	14	5	0	19
Gamma-aminobutyric acid receptor subunit alpha-2	14	5	0	19
Gamma-aminobutyric acid receptor subunit alpha-4	14	5	0	19
Gamma-aminobutyric acid receptor subunit gamma-3	14	5	0	19
Gamma-aminobutyric acid receptor subunit alpha-6	14	5	0	19
Gamma-aminobutyric acid receptor subunit alpha-1	14	6	0	20
Gamma-aminobutyric acid receptor subunit beta-3	14	5	0	19
Gamma-aminobutyric acid receptor subunit beta-2	14	5	0	19
Tetraspanin	0	1	0	1
Proton-coupled amino acid transporter 1	0	3	0	4
GABA theta subunit	14	5	0	19
Gamma-aminobutyric acid receptor subunit epsilon	14	5	0	19
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 2C	0	10	1	12
5-hydroxytryptamine receptor 2A	0	10	1	11
5-hydroxytryptamine receptor 1A	0	13	1	15
5-hydroxytryptamine receptor 1B	0	8	1	9
5-hydroxytryptamine receptor 1D	0	5	1	6
5-hydroxytryptamine receptor 1F	0	5	1	6
5-hydroxytryptamine receptor 2B	0	9	1	10
5-hydroxytryptamine receptor 6	0	3	1	4
Sodium-dependent serotonin transporter	0	14	3	17
Sodium-dependent serotonin transporter	0	11	1	13
5-hydroxytryptamine receptor 7	0	4	1	5
5-hydroxytryptamine receptor 5A	0	3	1	4
5-hydroxytryptamine receptor 5B	0	3	1	4
5-hydroxytryptamine receptor 3A	0	3	1	4
5-hydroxytryptamine receptor 4	0	3	1	4
5-hydroxytryptamine receptor 3B	0	3	1	4
ATAD5 protein, partial	18	0	0	18
GLS protein	22	0	0	22
Microtubule-associated protein tau	10	0	0	10
Smad3	6	0	0	6
EWS/FLI fusion protein	22	0	0	22
chromobox protein homolog 1	27	0	0	27
thyroid hormone receptor beta isoform 2	32	0	0	32
peripheral myelin protein 22	22	0	0	22
cytochrome P450 3A4 isoform 1	14	0	0	14
ATP-binding cassette sub-family C member 3	0	30	0	30
Multidrug resistance-associated protein 4	0	30	0	33
Solute carrier family 22 member 6	0	7	0	8
Carbonic anhydrase 12	0	9	1	14
UDP-glucuronosyltransferase 1A9	0	1	0	4
Bile salt export pump	0	8	0	8
Bile salt export pump	0	45	0	45
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	1	0	3
Prostaglandin G/H synthase 1	0	5	0	5
Carbonic anhydrase 3	0	8	1	12
Cytochrome P450 3A4	0	11	1	15
Cytochrome P450 2D6	0	6	0	7
Cytochrome P450 2C9	0	13	0	13
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
Sulfotransferase 1A1	0	0	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	3
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	2	0	3
Carbonic anhydrase 4	0	13	1	17
Prostaglandin G/H synthase 1	0	6	0	6
Carbonic anhydrase 6	0	9	1	13
Carbonic anhydrase 5A, mitochondrial	0	11	1	16
Prostaglandin G/H synthase 2	0	4	0	5
Carbonic anhydrase 7	0	9	1	13
Nuclear receptor ROR-gamma	11	0	0	11
Cytochrome P450 2J2	0	8	0	8
Carbonic anhydrase 9	0	12	1	18
Canalicular multispecific organic anion transporter 1	0	30	0	30
Carbonic anhydrase 15	0	8	0	10
Carbonic anhydrase 13	0	8	0	11
Carbonic anhydrase 14	0	8	1	13
Carbonic anhydrase 5B, mitochondrial	0	9	1	14
toxin B	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	15	0	0	15
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	13	0	0	13
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
thioredoxin reductase	35	0	0	35
GALC protein	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	27	0	0	27
glucocorticoid receptor [Homo sapiens]	32	0	0	32
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	2	0	2
arylsulfatase A	18	0	0	18
Carbonic anhydrase	0	2	0	2
euchromatic histone-lysine N-methyltransferase 2	45	0	0	45
Bloom syndrome protein isoform 1	17	0	0	17
survival motor neuron protein isoform d	10	0	0	10
muscleblind-like protein 1 isoform 1	6	0	0	6
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	3	0	3
Carbonic anhydrase 2	0	2	0	2
Cathepsin B	0	1	0	1
Steryl-sulfatase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2A6	0	3	1	4
Androgen receptor	0	7	0	7
Translocator protein	0	3	1	4
Cannabinoid receptor 1	0	3	0	3
Cytochrome P450 2B6	0	1	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	6	2	10
Serum paraoxonase/arylesterase 1	0	3	0	3
Dipeptidyl peptidase 4	0	0	0	1
Endochitinase	0	1	0	1
Adenosine receptor A2a	0	5	2	10
Delta-type opioid receptor	0	5	0	6
Cytochrome P450 2C19	0	1	0	2
Delta-type opioid receptor	0	7	1	9
Mu-type opioid receptor	0	7	2	12
Carbonic anhydrase	0	4	0	5
Kappa-type opioid receptor	0	7	0	9
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	7	2	0	9
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	0	2
Carbonic anhydrase	0	1	0	2
D(2) dopamine receptor	0	6	1	7
Cholinesterase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	6	0	6
Fatty-acid amide hydrolase 1	0	3	0	3
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	11	3	15
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	3	0	3
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	5	1	6
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	2
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	1	5
Carbonic anhydrase 4	0	2	0	3
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	14	0	0	14
Chain B, HADH2 protein	14	0	0	14
Chain A, ATP-DEPENDENT DNA HELICASE Q1	7	0	0	7
Chain A, Ferritin light chain	11	0	0	11
Thymidine kinase	0	1	0	1
phosphopantetheinyl transferase	17	0	0	17
hemoglobin subunit beta	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	5	0	0	5
Solute carrier family 22 member 1	0	9	0	11
Purine nucleoside phosphorylase	0	2	0	2
Thymidine kinase, cytosolic	0	2	0	3
POU domain, class 2, transcription factor 2	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	1	0	3
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	3	0	5
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	3	0	6
Thymidine kinase	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	26	0	0	26
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	2	0	0	2
regulator of G-protein signaling 4	14	0	0	14
NPYLR7B	0	0	2	2
IDH1	14	0	0	14
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
flap endonuclease 1	12	0	0	12
nuclear receptor ROR-gamma isoform 1	13	0	0	13
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	3	0	3
Rap guanine nucleotide exchange factor 3	6	0	0	6
Epidermal growth factor receptor	0	6	0	6
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	5	2	8
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	3	3	8
Adenosine receptor A2b	0	1	1	4
Adenosine receptor A2b	0	3	1	5
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	3	3	9
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	2	1	3
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	3	0	3
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
acetylcholinesterase	9	0	0	9
NFKB1 protein, partial	10	0	0	10
putative alpha-glucosidase	2	0	0	2
histone acetyltransferase KAT2A isoform 1	12	0	0	12
Solute carrier family 22 member 2	0	2	0	3
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Matrix protein 2	0	1	1	2
Matrix protein 2	0	1	2	3
Glutamate receptor ionotropic, NMDA 1	0	10	3	14
Spike glycoprotein	23	0	1	24
Glutamate receptor ionotropic, NMDA 2A	0	10	2	13
Glutamate receptor ionotropic, NMDA 2C	0	10	2	13
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	10	2	13
Solute carrier family 22 member 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	10	2	13
Multidrug and toxin extrusion protein 1	0	4	0	4
Solute carrier family 22 member 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	10	2	13
ATP-dependent phosphofructokinase	21	0	0	21
USP1 protein, partial	16	0	0	16
cytochrome P450 2D6	18	0	0	18
cytochrome P450 2D6 isoform 1	6	0	0	6
D(1A) dopamine receptor	10	0	0	10
atrial natriuretic peptide receptor 2 precursor	4	0	0	4
serine/threonine-protein kinase mTOR isoform 1	10	0	0	10
muscarinic acetylcholine receptor M1	16	0	0	16
Polyunsaturated fatty acid lipoxygenase ALOX15B	9	0	0	9
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
5-hydroxytryptamine receptor 4	0	10	1	11
Albumin	0	0	2	2
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	11	0	11
Muscarinic acetylcholine receptor M2	0	11	1	12
Muscarinic acetylcholine receptor M4	0	9	0	9
Muscarinic acetylcholine receptor M1	0	8	1	10
Muscarinic acetylcholine receptor M3	0	7	1	9
Muscarinic acetylcholine receptor M4	0	7	1	9
Muscarinic acetylcholine receptor M5	0	8	1	10
Muscarinic acetylcholine receptor M5	0	11	0	11
Alpha-2A adrenergic receptor	0	12	2	14
Muscarinic acetylcholine receptor M2	0	7	1	9
Muscarinic acetylcholine receptor M1	0	11	2	13
Angiotensin-converting enzyme	0	5	0	5
D(2) dopamine receptor	0	10	2	14
Alpha-2B adrenergic receptor	0	15	0	15
Alpha-2C adrenergic receptor	0	11	1	12
Muscarinic acetylcholine receptor M3	0	9	0	9
D(1A) dopamine receptor	0	6	0	7
D(1B) dopamine receptor	0	3	0	4
UDP-glucuronosyltransferase 1A4	0	1	0	4
Sodium-dependent noradrenaline transporter	0	16	2	18
Histamine H2 receptor	0	8	0	8
Alpha-1D adrenergic receptor	0	10	0	10
5-hydroxytryptamine receptor 2A	0	15	1	16
5-hydroxytryptamine receptor 2C	0	11	1	12
Histamine H1 receptor	0	4	0	4
Histamine H1 receptor	0	9	0	9
D(3) dopamine receptor	0	16	1	19
Sodium channel protein type 1 subunit alpha	0	5	0	5
Sodium channel protein type 4 subunit alpha	0	5	0	6
UDP-glucuronosyltransferase 1A3	0	0	0	3
5-hydroxytryptamine receptor 2B	0	13	1	14
Alpha-1A adrenergic receptor	0	10	0	10
Histamine H2 receptor	13	2	0	17
5-hydroxytryptamine receptor 6	0	10	0	10
5-hydroxytryptamine receptor 7	0	4	0	4
Voltage-dependent N-type calcium channel subunit alpha-1B	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Sodium-dependent dopamine transporter	0	11	1	12
Potassium voltage-gated channel subfamily H member 2	0	14	0	14
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Sodium channel protein type 5 subunit alpha	0	5	0	5
Sodium channel protein type 9 subunit alpha	0	5	0	5
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Sodium channel protein type 2 subunit alpha	0	5	0	5
Ataxin-2	23	0	0	23
Sigma non-opioid intracellular receptor 1	0	18	1	19
Sodium channel protein type 3 subunit alpha	0	6	0	6
Sodium channel protein type 11 subunit alpha	0	3	0	3
Sodium channel protein type 8 subunit alpha	0	3	0	3
Histamine H3 receptor	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	3	0	3
Chain A, 2-oxoglutarate Oxygenase	12	0	0	12
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	3
apical membrane antigen 1, AMA1	6	0	0	6
Beta-lactamase	0	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	12	0	0	12
DNA polymerase eta isoform 1	5	0	0	5
urokinase-type plasminogen activator precursor	7	0	0	7
plasminogen precursor	7	0	0	7
urokinase plasminogen activator surface receptor precursor	7	0	0	7
DNA polymerase kappa isoform 1	12	0	0	12
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase SHV-1	0	1	0	3
Beta-lactamase	0	1	0	3
Solute carrier family 15 member 1	0	7	0	7
Solute carrier family 15 member 1	0	2	0	2
B2 metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	4	0	4
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Cruzipain	8	0	0	8
Beta-lactamase	0	0	0	2
acid sphingomyelinase	3	0	0	3
farnesoid X nuclear receptor	20	0	0	20
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	1	0	3
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
DNA polymerase beta	6	0	0	6
60 kDa heat shock protein, mitochondrial	0	3	0	3
Beta-lactamase OXA-7	0	0	0	1
10 kDa heat shock protein, mitochondrial	0	3	0	3
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
Thiosulfate sulfurtransferase	0	3	0	3
Metallo-beta-lactamase VIM-13	0	0	0	2
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	1	0	2
60 kDa chaperonin	0	3	0	3
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	3	0	3
Metallo-b-lactamase	0	0	0	3
Carbapenem-hydrolyzing beta-lactamase KPC	0	1	0	3
Histamine H3 receptor	0	0	0	2
Beta-lactamase class B VIM-2	0	0	0	3
Beta-lactamase VIM-1	0	0	0	2
neuropeptide S receptor isoform A	5	0	0	5
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
alpha-galactosidase	5	0	0	5
cytochrome P450 2C19 precursor	8	0	0	8
lethal factor (plasmid)	11	0	0	11
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	4
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	8	0	0	8
hypothetical protein, conserved	3	0	0	3
glucocerebrosidase	5	0	0	5
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Fatty acid-binding protein, liver	0	3	1	4
Integrin beta-3	4	1	1	6
Myeloperoxidase	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	4	1	1	6
Glutathione hydrolase 1 proenzyme	0	1	0	1
Substance-P receptor	0	2	0	2
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	4	1	5
glp-1 receptor, partial	13	0	0	13
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	9	0	0	9
thyroid stimulating hormone receptor	17	0	0	17
potassium voltage-gated channel subfamily H member 2 isoform d	16	0	0	16
D(4) dopamine receptor	0	4	1	7
Genome polyprotein	0	2	2	4
dopamine D1 receptor	9	0	0	9
Fumarate hydratase	11	0	0	11
G	11	0	0	11
polyprotein	11	0	0	11
vitamin D3 receptor isoform VDRA	14	0	0	14
Interferon beta	16	0	0	16
HLA class I histocompatibility antigen, B alpha chain	11	0	0	11
ATP-dependent translocase ABCB1	0	4	0	4
ATP-dependent translocase ABCB1	0	7	1	10
Beta-1 adrenergic receptor	0	4	1	5
5-hydroxytryptamine receptor 1A	0	4	0	4
D	0	5	0	5
D(3) dopamine receptor	0	4	0	4
Alpha-2B adrenergic receptor	0	7	0	7
ATP-dependent translocase ABCB1	0	4	1	5
Alpha-2C adrenergic receptor	0	7	0	7
Alpha-2A adrenergic receptor	0	7	0	7
D(1B) dopamine receptor	0	4	0	4
D(4) dopamine receptor	0	4	0	4
Alpha-synuclein	2	4	0	6
Inositol hexakisphosphate kinase 1	11	0	0	11
ATPase family AAA domain-containing protein 5	17	0	0	17
cytochrome P450 2C9, partial	11	0	0	11
pregnane X receptor	9	0	0	9
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
nuclear receptor subfamily 1, group I, member 2	7	0	0	7
cellular tumor antigen p53 isoform a	6	0	0	6
Nuclear hormone receptor family member daf-12	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	15	0	0	15
oxysterols receptor LXR-beta isoform 1	0	0	1	1
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	0	0	2
Thymidylate kinase	0	1	0	1
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	2	2	4
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
Cholinesterase	0	2	0	2
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	3	1	4
Amine oxidase [flavin-containing] A	0	2	0	2
Acetylcholinesterase	0	3	0	3
Amine oxidase [flavin-containing] B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	4
Guanine deaminase	0	1	0	1
DNA topoisomerase	0	1	0	1
15-lipoxygenase, partial	9	0	0	9
PPM1D protein	4	0	0	4
Thrombopoietin	7	0	0	7
67.9K protein	7	0	0	7
lysosomal alpha-glucosidase preproprotein	3	0	0	3
peripheral myelin protein 22 isoform 1	9	0	0	9
huntingtin isoform 2	3	0	0	3
ras-related protein Rab-9A	4	0	0	4
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
M-phase phosphoprotein 8	7	0	0	7
relaxin receptor 1 isoform 1	2	0	0	2
Telomerase reverse transcriptase	0	1	0	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Histone deacetylase 3	0	3	0	3
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Tyrosyl-DNA phosphodiesterase 2	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
Prothrombin	0	1	1	3
DNA ligase	0	1	0	1
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
DNA topoisomerase 1	0	1	1	6
DNA topoisomerase 2-alpha	0	3	0	3
Type-2 restriction enzyme BamHI	0	1	0	1
Somatostatin receptor type 1	0	1	0	1
Somatostatin receptor type 2	0	1	0	1
Somatostatin receptor type 4	0	1	0	1
Somatostatin receptor type 3	0	1	0	1
Somatostatin receptor type 5	0	1	0	1
Type-2 restriction enzyme HindIII	0	1	0	1
Histone deacetylase 4	0	3	0	3
Ribonuclease pancreatic	0	1	0	1
Inositol monophosphatase 1	4	0	0	4
DNA topoisomerase 2-beta	0	0	0	1
DNA topoisomerase 1	0	1	0	2
Histone deacetylase 1	0	3	0	3
DNA topoisomerase 1	0	1	0	1
Integrase	0	3	0	3
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
DNA topoisomerase type IB small subunit	0	0	1	1
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
Luciferase	10	0	0	10
Solute carrier family 22 member 11	0	2	0	4
Solute carrier family 22 member 8	0	2	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	1	0	2
Albumin	0	3	3	6
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase VIM-2	0	0	0	1
Solute carrier family 22 member 7	0	1	0	2
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 7	0	1	0	2
thioredoxin glutathione reductase	7	0	0	7
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	4	0	4
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	0	4
Protein-arginine deiminase type-4	0	3	0	3
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Peroxisome proliferator-activated receptor alpha	2	0	1	3
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Amyloid-beta precursor protein	0	2	0	2
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Tryptophan 5-hydroxylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	3
Liver carboxylesterase 1	0	1	0	4
Sodium-dependent dopamine transporter	0	5	1	6
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	0	3
Sodium-dependent dopamine transporter	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Leukotriene B4 receptor 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Transporter	0	5	0	5
Choline O-acetyltransferase	0	1	0	1
Histone acetyltransferase p300	0	2	0	2
Histone acetyltransferase KAT2B	0	1	0	1
Histone acetyltransferase KAT5	0	1	0	1
N-alpha-acetyltransferase 50	0	0	1	1
endonuclease IV	4	0	0	4
PAX8	0	0	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cytochrome P450 2C9 precursor	7	0	0	7
steroidogenic factor 1	0	1	0	1
caspase-1 isoform alpha precursor	3	0	0	3
Solute carrier family 22 member 3	0	2	0	2
Tubulin alpha-1A chain	0	3	1	4
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	2
Tubulin beta-4A chain	0	3	2	6
Tubulin beta chain	0	3	2	6
Tubulin alpha-3C chain	0	3	2	6
Serine/threonine-protein kinase pim-1	0	1	0	1
Tubulin alpha-1B chain	0	3	2	6
Tubulin alpha-4A chain	0	3	2	6
Tubulin beta-4B chain	0	3	2	6
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	3	2	6
Tubulin beta-2A chain	0	3	2	6
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	3	2	6
Tubulin beta-2B chain	0	3	0	3
Tubulin alpha-3E chain	0	3	2	6
Tubulin alpha-1A chain	0	3	2	6
Similar to alpha-tubulin isoform 1	0	2	0	2
Similar to alpha-tubulin isoform 1	0	2	0	2
CREB-binding protein	1	1	0	2
Tubulin alpha-1C chain	0	3	2	6
Tubulin beta-6 chain	0	3	2	6
Tubulin beta-2B chain	0	3	2	6
Tubulin beta-1 chain	0	3	2	6
LMP1 [Human herpesvirus 4]	0	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	4	0	5
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	3
Probable deoxycytidylate deaminase	0	0	0	2
Cytidine deaminase	0	1	0	4
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	2
Deoxynucleoside kinase	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Thymidine kinase 2	0	1	0	1
AAA family ATPase	0	0	0	2
Reverse transcriptase/RNaseH	0	2	2	9
NAD	0	1	0	1
Urease	0	1	0	1
NAD	0	1	0	2
Mitogen-activated protein kinase 1	0	1	0	1
ATP phosphoribosyltransferase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
G-protein coupled receptor 35	0	2	2	4
SMAD family member 2	11	0	0	11
SMAD family member 3	11	0	0	11
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
Caspase-7	3	0	0	3
caspase-3	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
mu-type opioid receptor isoform MOR-1	0	0	2	2
5-hydroxytryptamine receptor 2A	0	0	2	2
Tyrosine-protein kinase Lck	0	2	0	2
Tyrosine-protein kinase Fyn	0	4	0	4
Beta-2 adrenergic receptor	0	2	1	3
POU domain, class 2, transcription factor 1	0	0	0	2
Chain A, POL POLYPROTEIN	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain B, POL POLYPROTEIN	0	1	0	1
Chain A, POL POLYPROTEIN	0	1	0	1
Chain B, POL POLYPROTEIN	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
Prothrombin	0	1	0	1
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	1	0	1
Acetylcholinesterase	0	0	0	1
Cannabinoid receptor 1	0	2	0	2
Microsomal triglyceride transfer protein large subunit	0	1	0	1
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120	0	1	0	1
Protease	0	2	0	3
Fructose-1,6-bisphosphatase 1	0	0	0	1
Reverse transcriptase	0	1	1	2
Cholesterol 24-hydroxylase	0	0	1	1
chaperonin-containing TCP-1 beta subunit homolog	3	0	0	3
ubiquitin-conjugating enzyme E2 N	0	1	0	1
protein AF-9 isoform a	0	0	0	1
Estrogen receptor	1	6	1	8
Beta-3 adrenergic receptor	0	2	1	3
Alpha-1B adrenergic receptor	0	9	0	9
Substance-K receptor	0	2	0	2
C-8 sterol isomerase	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	0	2
thyrotropin-releasing hormone receptor	3	0	0	3
17-beta-hydroxysteroid dehydrogenase type 1	0	1	0	1
eyes absent homolog 2 isoform a	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Kappa-type opioid receptor	0	5	1	7
Mu-type opioid receptor	0	12	5	18
Delta-type opioid receptor	0	7	1	9
Kappa-type opioid receptor	0	9	2	12
Mu-type opioid receptor	0	5	1	8
interferon gamma precursor	0	0	0	1
streptokinase A precursor	0	0	1	1
Chain A, Dihydrofolate reductase	0	0	1	1
Thymidylate synthase	0	4	0	4
Dihydrofolate reductase	0	2	3	5
Aldo-keto reductase family 1 member B1	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	1	0	3
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Chain A, DEOXYNUCLEOSIDE KINASE	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Angiotensin-converting enzyme 2	0	0	1	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Glutathione reductase, mitochondrial	0	3	0	3
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	2
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	4	0	4
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Heme oxygenase 1	0	1	0	1
Heme oxygenase 2	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
nonstructural protein 1	4	0	0	4
Adenylate cyclase type 1	0	1	0	1
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Major prion protein	0	0	3	3
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	2
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	3	0	5
Beta-1 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Adenylate cyclase type 3	0	1	0	1
Alpha-1D adrenergic receptor	0	7	0	7
5-hydroxytryptamine receptor 3A	0	1	0	1
Beta-3 adrenergic receptor	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Alpha-1A adrenergic receptor	0	2	1	3
5-hydroxytryptamine receptor 2A	0	1	0	1
Alpha-1B adrenergic receptor	0	2	1	3
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
TAR DNA-binding protein 43	6	0	0	6
5-hydroxytryptamine receptor 4	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Adenylyl cyclase 7	0	1	0	1
D	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Stromelysin-1	0	1	2	3
Urease subunit alpha	0	2	0	2
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Urease subunit beta	0	2	0	2
Snq2p	0	0	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
Sphingomyelin phosphodiesterase	0	1	0	1
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
D(2) dopamine receptor	0	1	0	1
Envelope glycoprotein	0	0	1	1
Sodium-dependent serotonin transporter	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
Polyphenol oxidase 2	0	1	0	3
Tyrosinase	0	1	0	1
SLC16A10 protein	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
phosphoglycerate kinase	1	0	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Kappa-type opioid receptor	0	3	1	5
Solute carrier family 22 member 3	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	2	2
Trace amine-associated receptor 1	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Reduced folate transporter	0	2	0	2
Caspase-7	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Chain A, PROGESTERONE RECEPTOR	0	1	0	1
Glucocorticoid receptor	0	1	0	1
Glucocorticoid receptor	1	10	4	22
Progesterone receptor	0	4	1	8
Tegument protein VP16	0	0	1	1
Glucocorticoid receptor	0	2	2	5
Glucocorticoid receptor	0	1	1	2
Glycine receptor subunit alpha-1	0	10	0	10
Mineralocorticoid receptor	1	4	2	8
Coagulation factor VII	0	2	0	2
Androgen receptor	1	4	1	6
Thyroid hormone receptor alpha	0	1	1	2
Thyroid hormone receptor beta	0	1	1	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Tissue factor	0	3	0	3
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
Guanine nucleotide-binding protein G	2	0	0	2
Mitogen-activated protein kinase 14	0	1	0	1
Progesterone receptor	0	0	1	1
Estrogen receptor beta	1	4	1	6
Glucocorticoid receptor	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
60 kDa chaperonin	0	1	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
NAD-dependent protein deacetylase	0	1	0	1
Alpha-1B adrenergic receptor	0	0	1	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Vpr	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Gamma-aminobutyric acid	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
luciferase	0	0	0	1
Corticosteroid-binding globulin	0	1	0	1
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
heat shock protein 90, putative	0	0	0	1
Chain A, PUTRESCINE-BINDING PROTEIN	0	0	1	1
Chain A, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN	0	1	0	1
Chain B, S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN	0	1	0	1
Chain A, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN	0	1	0	1
Chain B, S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN	0	1	0	1
Ornithine decarboxylase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	3	0	3
S-adenosylmethionine decarboxylase proenzyme	0	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	3	0	3
Pyridoxal kinase	0	0	0	1
N	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
tumor susceptibility gene 101 protein	1	0	0	1
Riboflavin-binding protein	0	1	1	2
Major prion protein	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Trypanothione reductase	0	2	0	2
Aldehyde oxidase 1	0	1	0	1
Aldehyde oxidase	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Chain A, Activated Factor Xa Heavy Chain	0	1	0	1
Coagulation factor X	0	2	0	2
Coagulation factor XII	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Pyruvate kinase PKM	0	1	0	1
Sulfate anion transporter 1	0	0	0	1
Caspase-2	0	0	1	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase OXA-1	0	1	0	1
Metallo-beta-lactamase type 2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Beta-lactamase TEM	0	2	0	2
Beta-lactamase	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	1	0	1
Collagenase 3	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
serine/threonine-protein kinase PLK1	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(20)

Research Excerpts

Overview

Context

Treatment

Research

Studies (474)

Protein Targets (1,317)

Acquired Encephalocele

Synonyms(20)

Research Excerpts

Overview

Context

Treatment

Research

Studies (474)

Drugs Studied (201)

Protein Targets (1,317)