Page last updated: 2024-09-27

Hospital Acquired Pneumonia

Synonyms(2)

Synonym
Nosocomial Pneumonia
Hospital Acquired Pneumonia

Research Excerpts

Treatment

ExcerptReference
"Carbapenems have shown efficacy in treating nosocomial pneumonias in clinical trials despite a reported low lung penetration compared with other β-lactams."( Jett, R; Lopez, J; O'Donnell, JN; Rhodes, NJ; Scheetz, MH, 2018)

Research

Studies (63)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's22 (34.92)28.8240
2020's41 (65.08)9.53
DrugIndicatedRelationship StrengthStudiesTrials
dalteparin0low10
citalopram0low10
hydroxychloroquine0low10
penicillin g0low10
methylprednisolone0low10
gentian violet0low10
vancomycin0low30
amoxicillin0low10
sisomicin0medium11
cefoperazone0medium41
octenidine0low10
oseltamivir0low10
cephalosporin c0medium124
tazobactam0medium52
sulbactam0medium51
carbapenems0low110
beta-lactams0low30
levofloxacin0low10
meropenem0medium87
linezolid0low20
zithromax0low20
mezlocillin0low10
ranitidine0medium11
telavancin0low20
cefepime0medium41
chlorhexidine0low10
ppi-09030low10
piperacillin, tazobactam drug combination0low20
achn 4900medium11
colistin0medium72
fr 2642050low20
tigecycline0low30
cefiderocol0medium32
daptomycin0low10
clozapine0low20
ceftobiprole0low10

Protein Targets (582)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Beta-lactamase1001
Chain A, 2-oxoglutarate Oxygenase3003
Beta-lactamase 0103
Beta-lactamase 0104
Beta-lactamase 0003
Beta-lactamase 0205
AR protein8008
apical membrane antigen 1, AMA11001
estrogen nuclear receptor alpha110011
Beta-lactamase 0002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)3003
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
DNA polymerase kappa isoform 13003
ATP-binding cassette sub-family C member 3011011
Multidrug resistance-associated protein 4011011
Bile salt export pump0303
Bile salt export pump013013
Beta-lactamase SHV-10103
Beta-lactamase SHV-10308
Cytochrome P450 2C9 0305
Beta-lactamase0207
Kappa-type opioid receptor0003
Solute carrier family 15 member 10303
Solute carrier family 15 member 10101
Cytochrome P450 2J20203
B2 metallo-beta-lactamase 0004
Solute carrier family 15 member 20303
Beta-lactamase 0103
Beta-lactamase 0003
Solute carrier family 15 member 20303
Beta-lactamase 0103
Beta-lactamase 0003
Canalicular multispecific organic anion transporter 1011011
Beta-lactamase 0104
Beta-lactamase 0204
Beta-lactamase 0003
Beta-lactamase 0002
Beta-lactamase 0104
Metallo-beta-lactamase type 20014
Metallo-beta-lactamase VIM-11 0003
Metallo-beta-lactamase VIM-20003
Metallo-beta-lactamase VIM-19 0003
Beta-lactamase 0204
Beta-lactamase 0104
Metallo-beta-lactamase0003
Beta-lactamase 0002
Beta-lactamase0003
Solute carrier family 22 member 50101
Beta-lactamase0205
Beta-lactamase0308
Beta-lactamase0003
Beta-lactamase TEM0509
Beta-lactamase0104
Metallo-beta-lactamase VIM-130003
Beta-lactamase 0204
Metallo-beta-lactamase VIM-20003
Metallo-beta-lactamase0002
Beta-lactamase 0004
Beta-lactamase 0014
Metallo-b-lactamase 0005
BlaVIM-1 0003
Beta-lactamase 0003
Beta-lactamase 0105
Beta-lactamase class B VIM-2 0017
Beta-lactamase VIM-1 0003
Solute carrier family 22 member 60303
Glutathione reductase, mitochondrial0203
Glutathione peroxidase 10101
Microsomal glutathione S-transferase 10101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70101
Solute carrier family 22 member 80202
Solute carrier family 22 member 110101
Solute carrier family 22 member 80203
Solute carrier family 22 member 70101
MecA 0101
TDP1 protein7007
Smad31001
67.9K protein3003
interferon gamma precursor0001
flap endonuclease 12002
Alpha-synuclein2002
Chain A, JmjC domain-containing histone demethylation protein 3A4004
Chain A, BCL-2-RELATED PROTEIN A10011
Chain A, Cruzipain2002
Luciferase3003
acid sphingomyelinase1001
interleukin 82002
acetylcholinesterase6006
PAX80001
glp-1 receptor, partial2002
15-lipoxygenase, partial1001
pregnane X receptor2002
phosphopantetheinyl transferase2002
hypoxia-inducible factor 1 alpha subunit4004
RAR-related orphan receptor gamma4004
SMAD family member 22002
USP1 protein, partial3003
SMAD family member 32002
GLI family zinc finger 35005
caspase 7, apoptosis-related cysteine protease3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
PINK11001
thyroid stimulating hormone receptor5005
estrogen receptor 2 (ER beta)5005
nuclear receptor subfamily 1, group I, member 34004
progesterone receptor5005
cytochrome P450 family 3 subfamily A polypeptide 45005
glucocorticoid receptor [Homo sapiens]6006
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha5005
estrogen-related nuclear receptor alpha7007
farnesoid X nuclear receptor3003
pregnane X nuclear receptor3003
G6006
cytochrome P450 2D65005
glucocerebrosidase3003
Parkin1001
peroxisome proliferator-activated receptor delta6006
peroxisome proliferator activated receptor gamma3003
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
heat shock protein 900011
caspase-33003
IDH14004
euchromatic histone-lysine N-methyltransferase 26006
calcineurin A1, putative0011
aryl hydrocarbon receptor3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
thyroid stimulating hormone receptor4004
activating transcription factor 63003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x4004
cytochrome P450 2D6 isoform 13003
hepatocyte nuclear factor 4-alpha isoform 20101
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C19 precursor3003
cytochrome P450 2C9 precursor2002
perilipin-50101
thyroid hormone receptor beta isoform a2002
perilipin-10101
nuclear factor erythroid 2-related factor 2 isoform 22002
potassium voltage-gated channel subfamily H member 2 isoform d4004
transcriptional regulator ERG isoform 31001
thyroid hormone receptor beta isoform 25005
heat shock protein beta-12002
huntingtin isoform 22002
importin subunit beta-1 isoform 11001
mitogen-activated protein kinase 13003
ubiquitin-conjugating enzyme E2 N0101
nuclear factor NF-kappa-B p105 subunit isoform 12002
protein AF-9 isoform a0001
snurportin-11001
melanocortin receptor 40101
nuclear factor erythroid 2-related factor 2 isoform 17007
CAAX prenyl protease0001
bcl-2-related protein A10101
nuclear receptor ROR-gamma isoform 13003
geminin5005
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
peripheral myelin protein 224004
cytochrome P450 3A4 isoform 14004
glycogen synthase kinase-3 alpha0001
hexokinase HKDC10101
DNA repair protein RAD52 homolog isoform a0001
bcl-2-like protein 11 isoform 10011
lethal factor (plasmid)4004
lamin isoform A-delta107007
Gamma-aminobutyric acid receptor subunit pi4105
Synaptojanin-20101
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0304
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
Synaptojanin-10101
Solute carrier family 22 member 30101
Voltage-dependent calcium channel gamma-2 subunit3003
Interferon beta7007
HLA class I histocompatibility antigen, B alpha chain 6006
Cellular tumor antigen p533003
Integrin beta-32002
72 kDa type IV collagenase0101
Integrin alpha-IIb2002
Matrix metalloproteinase-90101
Gamma-aminobutyric acid receptor subunit beta-14105
Gamma-aminobutyric acid receptor subunit delta4105
Gamma-aminobutyric acid receptor subunit gamma-24105
Glutamate receptor 23003
Gamma-aminobutyric acid receptor subunit alpha-54105
Gamma-aminobutyric acid receptor subunit alpha-34105
Gamma-aminobutyric acid receptor subunit gamma-14105
Gamma-aminobutyric acid receptor subunit alpha-24105
Gamma-aminobutyric acid receptor subunit alpha-44105
Gamma-aminobutyric acid receptor subunit gamma-34105
Trypanothione reductase0101
Gamma-aminobutyric acid receptor subunit alpha-64105
Histamine H2 receptor3003
Nuclear receptor ROR-gamma3003
Spike glycoprotein7018
Gamma-aminobutyric acid receptor subunit alpha-14105
Gamma-aminobutyric acid receptor subunit beta-34105
Gamma-aminobutyric acid receptor subunit beta-24105
TAR DNA-binding protein 432002
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase0101
Multidrug and toxin extrusion protein 20101
Rap guanine nucleotide exchange factor 41001
GABA theta subunit4105
Inositol hexakisphosphate kinase 16006
Multidrug and toxin extrusion protein 10202
ATPase family AAA domain-containing protein 54004
Ataxin-25005
Gamma-aminobutyric acid receptor subunit epsilon4105
Spermine oxidase0101
cytochrome P450 2C9, partial6006
thioredoxin reductase3003
aldehyde dehydrogenase 1 family, member A12002
EWS/FLI fusion protein6006
NPC intracellular cholesterol transporter 1 precursor1001
D(1A) dopamine receptor3003
survival motor neuron protein isoform d3003
Sodium-dependent noradrenaline transporter0101
5-hydroxytryptamine receptor 40606
Aldo-keto reductase family 1 member B10404
Tryptophan 5-hydroxylase 10101
Angiotensin-converting enzyme0404
Aldo-keto reductase family 1 member B10101
5-hydroxytryptamine receptor 1A0606
Acetylcholinesterase0303
Aromatase0101
Sodium-dependent noradrenaline transporter 0404
Sodium-dependent dopamine transporter0303
Alpha-1D adrenergic receptor0808
5-hydroxytryptamine receptor 2C0617
Sodium-dependent serotonin transporter0415
Sodium-dependent serotonin transporter0303
Histamine H1 receptor0428
5-hydroxytryptamine receptor 2B0617
5-hydroxytryptamine receptor 70202
Sodium-dependent dopamine transporter 0404
Potassium voltage-gated channel subfamily H member 20707
Sigma intracellular receptor 20101
Sodium-dependent serotonin transporter0101
Sodium-dependent dopamine transporter0101
Nuclear receptor subfamily 3 group C member 3 0404
Sigma non-opioid intracellular receptor 10404
Sigma non-opioid intracellular receptor 10202
Transporter0404
ATP-dependent phosphofructokinase4004
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
5-hydroxytryptamine receptor 3E0112
ATAD5 protein, partial1001
Fumarate hydratase1001
NFKB1 protein, partial2002
GLS protein2002
Microtubule-associated protein tau2003
polyprotein1001
Beta-1 adrenergic receptor 0101
bromodomain adjacent to zinc finger domain 2B2002
Adenylate cyclase type 1 0101
Bloom syndrome protein isoform 12002
peripheral myelin protein 22 isoform 11001
chromobox protein homolog 13003
DNA polymerase beta2002
atrial natriuretic peptide receptor 2 precursor1001
short transient receptor potential channel 6 isoform 10011
M-phase phosphoprotein 81001
transient receptor potential cation channel subfamily V member 11001
muscarinic acetylcholine receptor M13003
Voltage-dependent L-type calcium channel subunit alpha-1F0202
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 3B0112
Albumin0022
Muscarinic acetylcholine receptor M20617
Muscarinic acetylcholine receptor M40516
ATP-dependent translocase ABCB10104
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40202
Cytochrome P450 3A40406
5-hydroxytryptamine receptor 1A0202
5-hydroxytryptamine receptor 2C0303
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M50505
Alpha-2A adrenergic receptor0808
Calmodulin-10101
Beta-2 adrenergic receptor0202
Cytochrome P450 2D60406
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M10516
D(2) dopamine receptor0609
5-hydroxytryptamine receptor 2A0303
Alpha-1B adrenergic receptor0617
Alpha-2B adrenergic receptor0505
Beta-1 adrenergic receptor0101
Alpha-2C adrenergic receptor0505
D0303
D(3) dopamine receptor0303
Alpha-2B adrenergic receptor0415
D(2) dopamine receptor0303
Muscarinic acetylcholine receptor M30516
Endothelin receptor type B0101
D(1A) dopamine receptor0405
D(4) dopamine receptor0204
D(1B) dopamine receptor0102
Adenylate cyclase type 30101
Alpha-2C adrenergic receptor0415
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0415
Alpha-1D adrenergic receptor0415
5-hydroxytryptamine receptor 3A0202
Endothelin receptor type B0101
Histamine H2 receptor0404
Adenosine receptor A10101
D(1B) dopamine receptor0303
Beta-3 adrenergic receptor0101
Adenylate cyclase type 20101
Adenylate cyclase type 40101
5-hydroxytryptamine receptor 2A0608
5-hydroxytryptamine receptor 1B0303
5-hydroxytryptamine receptor 1D0303
D(4) dopamine receptor0303
5-hydroxytryptamine receptor 1F0303
5-hydroxytryptamine receptor 2B0314
Histamine H1 receptor0101
Histamine H1 receptor0202
5-hydroxytryptamine receptor 7 0101
Cytochrome P450 2C190103
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70101
Alpha-1A adrenergic receptor0101
5-hydroxytryptamine receptor 2A0101
Alpha-1B adrenergic receptor0101
D(3) dopamine receptor0608
5-hydroxytryptamine receptor 3A0303
Adenylate cyclase type 80101
Alpha-1A adrenergic receptor0617
5-hydroxytryptamine receptor 3A0112
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 60203
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
D(2) dopamine receptor0101
D(3) dopamine receptor0101
Gastrin/cholecystokinin type B receptor0101
D(2) dopamine receptor0101
D(2) dopamine receptor0404
Calmodulin 0011
Inositol monophosphatase 12002
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
5-hydroxytryptamine receptor 2B0101
Adenylate cyclase type 60101
Adenylate cyclase type 50101
5-hydroxytryptamine receptor 40101
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Transporter0101
Cholecystokinin receptor type A0101
5-hydroxytryptamine receptor 1A0101
5-hydroxytryptamine receptor 3D0112
Adenylyl cyclase 7 0101
5-hydroxytryptamine receptor 3C0112
D0202
Histamine H4 receptor0213
5-hydroxytryptamine receptor 3B0303
Histamine H3 receptor0101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Ferritin light chain1001
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]1001
alpha synuclein, partial1001
hypothetical protein, conserved1001
luciferase1001
thyrotropin-releasing hormone receptor1001
nuclear receptor subfamily 1, group I, member 23003
Caspase-71001
tumor necrosis factor1001
polyunsaturated fatty acid lipoxygenase ALOX121001
vitamin D3 receptor isoform VDRA1001
caspase-31001
histone deacetylase 9 isoform 31001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Epidermal growth factor receptor0101
Tyrosine-protein kinase Fyn0101
60 kDa chaperonin0101
Adenosine receptor A30202
60 kDa heat shock protein, mitochondrial0202
Androgen receptor0404
Substance-K receptor0202
Glutamate receptor ionotropic, kainate 11001
Adenosine receptor A2a0202
Mu-type opioid receptor0202
Kappa-type opioid receptor0202
Glutamate receptor ionotropic, kainate 21001
Glutamate receptor ionotropic, kainate 31001
10 kDa heat shock protein, mitochondrial0202
Disintegrin and metalloproteinase domain-containing protein 171001
Fatty-acid amide hydrolase 11102
Glutamate receptor ionotropic, kainate 41001
Leukotriene B4 receptor 11001
Thiosulfate sulfurtransferase0202
60 kDa chaperonin 0202
Glutamate receptor ionotropic, kainate 51001
10 kDa chaperonin 0202
Leukotriene B4 receptor 21001
Genome polyprotein 0101
Spike glycoprotein0011
Replicase polyprotein 1ab0112
Transmembrane protease serine 20011
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0213
Sigma intracellular receptor 20101
Cyclic GMP-AMP synthase0101
Angiotensin-converting enzyme 2 0011
Toll-like receptor 90101
Toll-like receptor 70101
CAAX prenyl protease 2 isoform 20001
histone acetyltransferase KAT2A isoform 12002
streptokinase A precursor0055
Tubulin beta-4A chain0101
Tubulin beta chain0101
Tubulin alpha-3C chain0101
Tubulin alpha-1B chain0101
Tubulin alpha-4A chain0101
Tubulin beta-4B chain0101
DNA gyrase subunit A0101
DNA primase0101
Tubulin beta-3 chain0101
Tubulin beta-2A chain0101
Tubulin beta-8 chain0101
Tubulin alpha-3E chain0101
Tubulin alpha-1A chain0101
Tubulin alpha-1C chain0101
Tubulin beta-6 chain0101
Tubulin beta-2B chain0101
Tubulin beta-1 chain0101
30S ribosomal protein S60202
30S ribosomal protein S70202
50S ribosomal protein L150202
Cytochrome P450 1A20102
Estrogen receptor0011
50S ribosomal protein L100202
50S ribosomal protein L110202
50S ribosomal protein L7/L120202
50S ribosomal protein L190202
50S ribosomal protein L10202
50S ribosomal protein L200202
50S ribosomal protein L270202
50S ribosomal protein L280202
50S ribosomal protein L290202
50S ribosomal protein L310202
50S ribosomal protein L31 type B0202
50S ribosomal protein L320202
50S ribosomal protein L330202
50S ribosomal protein L340202
50S ribosomal protein L350202
50S ribosomal protein L360202
30S ribosomal protein S100202
30S ribosomal protein S110202
30S ribosomal protein S120202
30S ribosomal protein S130202
30S ribosomal protein S160202
30S ribosomal protein S180202
30S ribosomal protein S190202
30S ribosomal protein S200202
30S ribosomal protein S20202
30S ribosomal protein S30202
30S ribosomal protein S40202
30S ribosomal protein S50202
30S ribosomal protein S80202
30S ribosomal protein S90202
50S ribosomal protein L130202
50S ribosomal protein L140202
50S ribosomal protein L160202
50S ribosomal protein L230202
30S ribosomal protein S150202
DNA gyrase subunit A0101
DNA gyrase subunit B0101
50S ribosomal protein L170202
50S ribosomal protein L210202
50S ribosomal protein L300202
50S ribosomal protein L60202
30S ribosomal protein S140202
30S ribosomal protein S170202
30S ribosomal protein S10202
50S ribosomal protein L180202
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] A0202
Prostaglandin G/H synthase 10101
Amine oxidase [flavin-containing] B0101
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial0101
50S ribosomal protein L20202
50S ribosomal protein L30202
50S ribosomal protein L240202
50S ribosomal protein L40202
50S ribosomal protein L220202
50S ribosomal protein L50202
30S ribosomal protein S210202
50S ribosomal protein L250202
50S ribosomal protein L36 20202
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
Estrogen receptor beta0011
Renin0101
Beta-lactamase 0102
Beta-lactamase 0002
Beta-lactamase 0203
Beta-lactamase IMP-1 0002
Carbapenem-hydrolyzing beta-lactamase KPC0305
Histamine H3 receptor0001
Beta-lactamase 0002
PPM1D protein2002
nonstructural protein 11001
muscleblind-like protein 1 isoform 11001
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Nuclear receptor subfamily 1 group I member 20011
Myeloperoxidase0101
6-phosphogluconate dehydrogenase, decarboxylating0101
Lactoperoxidase0101
5-hydroxytryptamine receptor 4 0102
5-hydroxytryptamine receptor 3B0101
Beta-lactamase OXA-70001
Neuraminidase 0202
Neuraminidase 0202
Neuraminidase 0202
Neuraminidase0202
Neuraminidase0101
Neuraminidase0202
Sialidase0101
Acyl-CoA desaturase 10101
Liver carboxylesterase 10001
Neuraminidase 0202
Neuraminidase 0202
Neuraminidase0101
Neuraminidase0101
Sialidase-40101
Sialidase-10101
Sialidase-30101
Sialidase-20101
Beta-lactamase 0203
Solute carrier family 22 member 80102
Beta-lactamase 10001
Beta-lactamase OXA-100001
Guanine nucleotide-binding protein G1001
Beta-lactamase 0001
Efflux transporter 0001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Class D beta-lactamase0203
Beta-lactamase 0102
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Beta-lactamase 0202
Beta-lactamase0202
Beta-lactamase OXA-10203
Metallo-beta-lactamase type 20202
Angiotensin-converting enzyme0202
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0101
B2 bradykinin receptor0101
Beta-lactamase0101
Beta-lactamase0101
Cytochrome P450 2B60101
Metallo-beta-lactamase L1 type 30101
Beta-lactamase 0101
Beta-lactamase 0101
Albumin0011
D-alanyl-D-alanine dipeptidase0101
twin arginine protein translocation system - TatA protein0001
Protein-arginine deiminase type-40101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]