Compounds > kelfiprim
Page last updated: 2024-09-23

kelfiprim

Description

kelfiprim: combination of trimethoprim & sulfametopyrazine [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID64934
MeSH IDM0087922

Synonyms (7)

Synonym
sulfalene + trimethoprim
benzenesulfonamide, 4-amino-n-(3-methoxypyrazinyl)-, mixt. with 5-((3,4,5-trimethoxyphenyl)methyl)-2,4-pyrimidinediamine
kelfiprim
trimed
50933-06-7
DTXSID50198966
4-amino-n-(3-methoxypyrazin-2-yl)benzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine

Research Excerpts

Overview

ExcerptReference
"Kelfiprim (KP) is a new bactericidal agent containing trimethoprim (T) and sulfametopyrazine (S), a long-acting sulfonamide (ratio 5:4). "( Cantaluppi, A; Chiarini, C; Graziani, G; Limido, D; Locatelli, F; Marai, P; Piaia, F; Pincella, G; Ponticelli, C; Zucchelli, P, 1987)

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-199018 (94.74)18.7374
1990's1 (5.26)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials8 (42.11%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (5.26%)4.05%
Observational0 (0.00%)0.25%
Other10 (52.63%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
sulfalene[no description available]medium198pyrazines;
sulfonamide antibiotic;
sulfonamide
trimethoprim[no description available]medium198aminopyrimidine;
methoxybenzenes		antibacterial drug;
diuretic;
drug allergen;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
environmental contaminant;
xenobiotic
ampicillin[no description available]medium22beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
trimethoprim, sulfamethoxazole drug combination[no description available]medium44
sulfamethoxazole[no description available]medium44isoxazoles;
substituted aniline;
sulfonamide antibiotic;
sulfonamide		antibacterial agent;
antiinfective agent;
antimicrobial agent;
drug allergen;
EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
epitope;
P450 inhibitor;
xenobiotic
tetracycline[no description available]medium11
amoxicillin[no description available]medium11penicillin allergen;
penicillin		antibacterial drug
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Bacterial Prostatitis0low20
Acute Disease0medium42
Agranulocytosis0low10
Anemia0low10
Asymptomatic Inflammatory Prostatitis0low20
Bacterial Disease0low40
Bacterial Infection0low40
Bacterial Infections0low40
Bronchial Pneumonia0medium11
Bronchitis0medium11
Bronchopneumonia0medium11
Chronic Bacterial Prostatitis0low20
Chronic Disease0low20
Chronic Illness0low20
Chronic Prostatitis with Chronic Pelvic Pain Syndrome0low20
Chronically Ill0low20
Cronobacter Infections0low10
Cystitis0low20
E coli Infections0low10
E. coli Infection0low10
ENT Diseases0low10
Enterobacteriaceae Infections0low10
Enterobacterial Infections0low10
Escherichia coli Infections0low10
Experimental Lung Inflammation0medium11
Granulocytopenia0low10
Infection, Bacterial0low40
Infections, Bacterial0low40
Infections, E coli0low10
Infections, Enterobacteriaceae0low10
Infections, Enterobacterial0low10
Infections, Escherichia coli0low10
Infections, Klebsiella0low10
Infections, Respiratory0medium33
Infections, Respiratory Tract0medium33
Infections, Upper Respiratory0medium33
Infections, Upper Respiratory Tract0medium33
Kidney Diseases0low10
Klebsiella Infections0low10
Lobar Pneumonia0medium11
Lung Inflammation0medium11
Middle Ear Inflammation0low10
Nasal Catarrh0low10
Otitis Media0low10
Otolaryngologic Diseases0low10
Otolaryngological Diseases0low10
Otorhinolaryngologic Disease0low10
Otorhinolaryngologic Diseases0low10
Otorhinolaryngological Disease0low10
Pneumonia0medium11
Pneumonia, Lobar0medium11
Pneumonitis0medium11
Prostatitis0low20
Pulmonary Inflammation0medium11
Recrudescence0medium31
Recurrence0medium31
Relapse0medium31
Respiratory Infections0medium33
Respiratory Tract Infections0medium33
Rhinitis0low10
Sinus Infections0medium32
Sinusitis0medium32
Tonsillitis0low10
Upper Respiratory Infections0medium33
Upper Respiratory Tract Infection0medium33
Upper Respiratory Tract Infections0medium33
Urinary Tract Infections0medium73

Research Highlights

Pharmacokinetics (1)

ArticleYear
Pharmacokinetic study of the new sulfamethopyrazine-trimethoprim combination (kelfiprim) in renal insufficiency.
European journal of clinical pharmacology, Volume: 27, Issue: 3		1984
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (1)

ArticleYear
A multi-centre trial comparing a sulfamethopyrazine/trimethoprim combination with co-trimoxazole in respiratory tract infections.
Pharmatherapeutica, Volume: 3, Issue: 8		1984
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]