Ectopic Junctional Tachycardia

A rare form of supraventricular tachycardia caused by automatic, not reentrant, conduction initiated from sites at the atrioventricular junction, but not the ATRIOVENTRICULAR NODE. It usually occurs during myocardial infarction, after heart surgery, or in digitalis intoxication with a HEART RATE ranging from 140 to 250 beats per minute.

Synonym
Ectopic Junctional Tachycardia
Tachycardia, Ectopic Junctional
Junctional Ectopic Tachycardia

Excerpt	Reference
"Junctional ectopic tachycardia is associated with a poor prognosis when it occurs in newborns and young infants."	( Kallfelz, HC; Paul, T; Reimer, A, 1992)
"Postoperative junctional ectopic tachycardia is associated with a poor prognosis in patients after open-heart surgery."	( Kallfelz, HC; Paul, T; Wilken, M; Ziemer, G, 1993)
"Junctional ectopic tachycardia is favored by high levels of sympathomimetic catecholamines after surgery."	( Cabrera Duro, A; Galdeano Miranda, JM; Macua Biurrun, P; Martínez Corrales, P; Pastor Menchaca, E; Pilar Orive, J; Rodrigo Carbonero, D, 2002)
"Junctional ectopic tachycardia is recognized predominantly as a postoperative arrhythmia after surgery for congenital heart disease."	( Cloutier, RL; Lin, RJ; Mehr, MF; Tanel, RE, 2002)
"Post-operative junctional ectopic tachycardia is a transient, but potentially life threatening, rapid automatic tachyarrhythmia that requires urgent and adequate treatment."	( Haas, N; Justo, R; Plumpton, K, 2005)
"Postoperative junctional ectopic tachycardia is a potentially life-threatening arrhythmia that is often resistant to conventional antiarrhythmic drugs."	( Dobos, D; Hakacova, N; Kovacikova, L; Skrak, P; Zahorec, M, 2009)
"Junctional ectopic tachycardia is common after pediatric heart surgery."	( Dossey, AM; Garcia, X; Imamura, M; Jaquiss, RD; Shinkawa, T, 2012)
"Congenital junctional ectopic tachycardia is a rare tachyarrhythmia with high mortality."	( Imamura, T; Ninomiya, Y; Tanaka, Y; Yoshinaga, M, 2015)
"Postoperative junctional ectopic tachycardia is one of the most serious arrhythmias that occur after pediatric cardiac surgery, difficult to treat and better to be prevented."	( El Amrousy, DM; El-Feky, W; El-Kashlan, M; Elrifaey, S; Elsanosy, M; Elshmaa, NS; Hablas, N; Hassan, S, 2017)
"Junctional ectopic tachycardia is a supraventricular tachyarrhythmia with atrioventricular dissociation that causes life-threatening postsurgical conditions in pediatric heart patients."	( Hiramatsu, Y; Kato, H; Mathis, BJ; Nakajima, T; Sakamoto, H; Tokunaga, C; Yoneyama, F, 2018)
"Junctional ectopic tachycardia is a serious tachyarrhythmic complication following pediatric cardiac surgery."	( Chou, FS; Ghimire, LV, 2018)

Excerpt	Reference
"Like other automatic tachyarrhythmias, junctional ectopic tachycardia has been shown to be very resistant to medical treatment."	( Kallfelz, HC; Paul, T; Reimer, A, 1992)
"An infant with junctional ectopic tachycardia diagnosed at three weeks of age was treated with oral sotalol."	( Davignon, A; Fournier, A; Maragnès, P, 1992)
"Chaotic atrial tachycardia (n = 3) and junctional ectopic tachycardia (n = 2) were controlled after successful intravenous therapy."	( Kallfelz, HC; Paul, T; Reimer, A, 1991)
"For treatment of chronic atrial and junctional ectopic tachycardia, standard antiarrhythmic therapy has been shown to be ineffective in most patients."	( Duckeck, W; Kuck, KH; Kunze, KP; Schlüter, M, 1988)
"To evaluate treatment of junctional ectopic tachycardia after cardiac surgery."	( Cabrera Duro, A; Galdeano Miranda, JM; Macua Biurrun, P; Martínez Corrales, P; Pastor Menchaca, E; Pilar Orive, J; Rodrigo Carbonero, D, 2002)
"Post-operative junctional ectopic tachycardia is a transient, but potentially life threatening, rapid automatic tachyarrhythmia that requires urgent and adequate treatment."	( Haas, N; Justo, R; Plumpton, K, 2005)
"Congenital junctional ectopic tachycardia (JET) is a rare arrhythmia that can be refractory to medical therapy with high morbidity and mortality rates."	( Abello, M; Benjamín, MN; Infante, J; Moltedo, JM; Olmedo, J, 2011)
"Treatment of congenital junctional ectopic tachycardia (JET) is often challenging."	( Dieks, JK; Klehs, S; Krause, U; Müller, MJ; Paul, T, 2016)
"Postoperative junctional ectopic tachycardia is one of the most serious arrhythmias that occur after pediatric cardiac surgery, difficult to treat and better to be prevented."	( El Amrousy, DM; El-Feky, W; El-Kashlan, M; Elrifaey, S; Elsanosy, M; Elshmaa, NS; Hablas, N; Hassan, S, 2017)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	11 (9.82)	23.3326
1990's	30 (26.79)	12.5806
2000's	25 (22.32)	18.1394
2010's	34 (30.36)	28.8240
2020's	12 (10.71)	9.53

Drug	Relationship Strength	Studies	Trials
hydrogen carbonate	low	1	0
urea	low	4	0
amiodarone	medium	36	4
verapamil	low	7	0
chlorpromazine	low	1	0
disopyramide	low	1	0
fentanyl	low	1	0
flecainide	low	8	0
lidocaine	low	1	0
isoproterenol	low	1	0
ketanserin	low	1	0
mexiletine	medium	1	1
milrinone	low	1	0
nifedipine	low	1	0
potassium chloride	low	1	0
procainamide	low	2	0
propafenone	medium	9	1
propranolol	medium	5	1
sotalol	low	8	0
phentolamine	low	1	0
magnesium sulfate	medium	2	1
amoxicillin	low	1	0
moricizine	low	1	0
dobutamine	low	1	0
encainide	low	1	0
esmolol	low	2	0
adenosine	low	8	0
ethacizine	medium	1	1
fingolimod hydrochloride	low	1	0
landiolol	low	4	0
nifekalant hydrochloride	low	1	0
ivabradine	medium	13	1
atropine	low	1	0
quinidine	low	1	0
digitoxin	medium	2	1
digoxin	medium	9	1
sphingosine	low	1	0
dexmedetomidine	medium	8	1
beta-acetyldigoxin	low	1	0
ro13-9904	low	1	0
cardiovascular agents	low	4	0
allapinin	medium	1	1
aconitine	medium	1	1
pyrimidinones	low	1	0

Protein Targets (702)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	9	0	0	9
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
AR protein	19	0	0	19
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	10	0	0	10
glucocorticoid receptor [Homo sapiens]	13	0	0	13
retinoid X nuclear receptor alpha	10	0	0	10
estrogen nuclear receptor alpha	19	0	0	19
NPYLR7B	0	0	2	2
arylsulfatase A	7	0	0	7
IDH1	7	0	0	7
Histone H2A.x	8	0	0	8
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	8	0	0	8
flap endonuclease 1	4	0	0	4
nuclear receptor ROR-gamma isoform 1	6	0	0	6
peripheral myelin protein 22	10	0	0	10
survival motor neuron protein isoform d	5	0	0	5
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Rap guanine nucleotide exchange factor 3	2	0	0	2
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	3	0	3
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	3	0	3
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	7	3	11
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Glutamate receptor 2	4	0	0	4
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	1	1	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	3	3	7
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	4	2	7
Adenosine receptor A2a	0	2	2	4
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
acetylcholinesterase	6	0	0	6
phosphopantetheinyl transferase	8	0	0	8
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
RAR-related orphan receptor gamma	10	0	0	10
SMAD family member 2	6	0	0	6
ATAD5 protein, partial	8	0	0	8
Fumarate hydratase	5	0	0	5
USP1 protein, partial	6	0	0	6
NFKB1 protein, partial	3	0	0	3
PPM1D protein	2	0	0	2
SMAD family member 3	6	0	0	6
TDP1 protein	18	0	0	18
Thrombopoietin	3	0	0	3
caspase 7, apoptosis-related cysteine protease	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
thyroid stimulating hormone receptor	6	0	0	6
estrogen receptor 2 (ER beta)	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	11	0	0	11
progesterone receptor	7	0	0	7
EWS/FLI fusion protein	10	0	0	10
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
estrogen-related nuclear receptor alpha	11	0	0	11
farnesoid X nuclear receptor	6	0	0	6
pregnane X nuclear receptor	11	0	0	11
G	7	0	0	7
cytochrome P450 2D6	14	0	0	14
polyprotein	5	0	0	5
peroxisome proliferator-activated receptor delta	8	0	0	8
peroxisome proliferator activated receptor gamma	9	0	0	9
caspase-3	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	15	0	0	15
thyroid stimulating hormone receptor	9	0	0	9
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
cytochrome P450 2D6 isoform 1	5	0	0	5
cellular tumor antigen p53 isoform a	5	0	0	5
cytochrome P450 2C9 precursor	4	0	0	4
D(1A) dopamine receptor	10	0	0	10
chromobox protein homolog 1	11	0	0	11
thyroid hormone receptor beta isoform a	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	14	0	0	14
thyroid hormone receptor beta isoform 2	11	0	0	11
heat shock protein beta-1	3	0	0	3
huntingtin isoform 2	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
geminin	14	0	0	14
cytochrome P450 3A4 isoform 1	8	0	0	8
muscarinic acetylcholine receptor M1	6	0	0	6
lethal factor (plasmid)	4	0	0	4
lamin isoform A-delta10	19	0	0	19
Gamma-aminobutyric acid receptor subunit pi	8	1	1	10
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
ATP-binding cassette sub-family C member 3	0	17	0	17
Multidrug resistance-associated protein 4	0	17	0	17
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Solute carrier organic anion transporter family member 1A4	0	3	0	4
Voltage-dependent L-type calcium channel subunit alpha-1F	0	11	0	11
5-hydroxytryptamine receptor 4	0	18	0	18
Lysine-specific demethylase PHF2	0	1	0	1
Bile salt export pump	0	22	0	22
Interferon beta	9	0	0	9
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Thyroid hormone receptor alpha	0	1	0	1
Cellular tumor antigen p53	10	0	0	10
Integrin beta-3	4	0	0	4
Tyrosine-protein kinase Fyn	0	3	0	3
ATP-dependent translocase ABCB1	0	4	0	4
Aldo-keto reductase family 1 member B1	0	10	0	10
Muscarinic acetylcholine receptor M2	0	7	2	13
Muscarinic acetylcholine receptor M4	0	6	1	10
ATP-dependent translocase ABCB1	0	15	3	28
Integrin alpha-IIb	4	0	0	4
Beta-1 adrenergic receptor	0	16	4	20
Muscarinic acetylcholine receptor M5	0	6	1	10
Alpha-2A adrenergic receptor	0	12	4	18
Cytochrome P450 2C8	0	3	0	3
Thyroid hormone receptor alpha	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Muscarinic acetylcholine receptor M1	0	7	2	13
Beta-3 adrenergic receptor	0	10	4	14
D(2) dopamine receptor	0	10	1	12
Androgen receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	8	1	1	10
Alpha-1B adrenergic receptor	0	13	4	17
Lethal factor	0	1	0	1
Alpha-2B adrenergic receptor	0	10	2	14
Thyroid hormone receptor beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	8	1	1	10
Gamma-aminobutyric acid receptor subunit gamma-2	8	1	1	10
Gamma-aminobutyric acid receptor subunit alpha-5	8	1	1	10
Gamma-aminobutyric acid receptor subunit alpha-3	8	1	1	10
Muscarinic acetylcholine receptor M3	0	7	2	12
ATP-dependent translocase ABCB1	0	4	0	5
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	8	1	10
D(4) dopamine receptor	0	7	0	8
Gamma-aminobutyric acid receptor subunit gamma-1	8	1	1	10
Gamma-aminobutyric acid receptor subunit alpha-2	8	1	1	10
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Sodium-dependent noradrenaline transporter	0	11	0	11
Histamine H2 receptor	0	6	0	6
Endothelin-1 receptor	0	3	1	4
5-hydroxytryptamine receptor 2A	0	16	2	20
5-hydroxytryptamine receptor 2C	0	20	1	22
Gamma-aminobutyric acid receptor subunit alpha-4	8	1	1	10
Gamma-aminobutyric acid receptor subunit gamma-3	8	1	1	10
Lysine-specific demethylase 5A	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	8	1	1	10
B2 bradykinin receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	13	0	13
Melanocortin receptor 4	0	4	0	4
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	4	0	4
Mu-type opioid receptor	0	7	2	9
D(3) dopamine receptor	0	12	0	13
Sodium channel protein type 1 subunit alpha	0	4	0	4
Sodium channel protein type 4 subunit alpha	0	5	0	5
Squalene synthase	0	1	0	1
Delta-type opioid receptor	0	7	1	8
Kappa-type opioid receptor	0	7	1	8
5-hydroxytryptamine receptor 2B	0	18	1	20
C-C chemokine receptor type 2	0	4	0	4
Melanocortin receptor 3	0	4	0	4
Alpha-1A adrenergic receptor	0	14	4	18
Histamine H2 receptor	5	0	1	8
D(1A) dopamine receptor	5	0	0	5
5-hydroxytryptamine receptor 6	0	11	1	12
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
C-C chemokine receptor type 4	0	2	0	2
Spike glycoprotein	11	1	1	13
Gamma-aminobutyric acid receptor subunit alpha-1	8	1	1	10
Gamma-aminobutyric acid receptor subunit beta-3	8	1	1	10
Gamma-aminobutyric acid receptor subunit beta-2	8	1	1	10
Sodium channel protein type 7 subunit alpha	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	11	0	11
Sodium-dependent dopamine transporter	0	10	0	10
Potassium voltage-gated channel subfamily H member 2	0	18	0	18
Voltage-dependent L-type calcium channel subunit alpha-1S	0	11	0	11
Voltage-dependent L-type calcium channel subunit alpha-1C	0	12	0	13
Sodium channel protein type 5 subunit alpha	0	10	0	10
Squalene monooxygenase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	6	0	6
Lysine-specific demethylase 7A	0	1	0	1
GABA theta subunit	8	1	1	10
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Inositol hexakisphosphate kinase 1	7	0	0	7
Canalicular multispecific organic anion transporter 1	0	17	0	17
Sodium channel protein type 2 subunit alpha	0	4	0	4
Ataxin-2	12	0	0	12
Sigma non-opioid intracellular receptor 1	0	14	0	14
Gamma-aminobutyric acid receptor subunit epsilon	8	1	1	10
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	1	1
Sodium channel protein type 3 subunit alpha	0	5	0	5
Sodium channel protein type 11 subunit alpha	0	4	0	4
Histone lysine demethylase PHF8	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	4	0	4
Sodium channel protein type 10 subunit alpha	0	4	0	4
cytochrome P450 2C9, partial	7	0	0	7
ATP-dependent phosphofructokinase	9	0	0	9
Chain A, Beta-lactamase	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
apical membrane antigen 1, AMA1	3	0	0	3
Beta-lactamase	0	0	0	1
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	5	0	0	5
DNA polymerase kappa isoform 1	3	0	0	3
Bile salt export pump	0	6	0	6
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Cytochrome P450 2C9	0	9	0	9
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	3	0	4
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 1	0	2	0	2
Cytochrome P450 2J2	0	8	0	8
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
GLI family zinc finger 3	15	0	0	15
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	2	0	0	2
short transient receptor potential channel 6 isoform 1	0	0	2	2
Solute carrier family 22 member 1	0	13	0	15
Muscarinic acetylcholine receptor M1	0	3	1	6
Muscarinic acetylcholine receptor M3	0	3	1	6
Muscarinic acetylcholine receptor M4	0	3	1	6
Muscarinic acetylcholine receptor M5	0	3	1	6
Muscarinic acetylcholine receptor M2	0	3	1	7
Muscarinic acetylcholine receptor M1	0	0	0	1
Alpha-1D adrenergic receptor	0	11	3	15
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 7	0	8	0	8
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
Microtubule-associated protein tau	8	0	0	8
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
lysosomal alpha-glucosidase preproprotein	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
Toll-like receptor 4	0	1	0	1
Solute carrier family 22 member 2	0	3	0	3
Potassium channel subfamily K member 2	0	5	1	6
Amyloid-beta precursor protein	0	1	0	1
Beta-2 adrenergic receptor	0	12	5	18
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Angiotensin-converting enzyme	0	7	0	7
Alpha-2C adrenergic receptor	0	8	4	14
5-hydroxytryptamine receptor 1A	0	11	1	13
UDP-glucuronosyltransferase 1A1	0	2	0	2
5-hydroxytryptamine receptor 1B	0	11	0	11
Potassium channel subfamily K member 10	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	6	0	6
Multidrug and toxin extrusion protein 1	0	5	0	5
Proteasome subunit beta type-11	0	0	0	1
thioredoxin reductase	9	0	0	9
Smad3	4	0	0	4
NADPH oxidase 1	0	1	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	12	0	0	12
67.9K protein	4	0	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	9	0	0	9
Snq2p	0	0	0	1
Adenylate cyclase type 1	0	2	0	2
Caspase-7	1	0	0	1
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
vitamin D3 receptor isoform VDRA	4	0	0	4
caspase-3	1	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
ras-related protein Rab-9A	3	0	0	3
M-phase phosphoprotein 8	2	0	0	2
histone acetyltransferase KAT2A isoform 1	4	0	0	4
Proteasome subunit alpha type-7	0	0	0	1
Transmembrane protease serine 2	0	1	1	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Albumin	0	1	3	4
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Major prion protein	0	0	1	1
Cytochrome P450 1A2	0	3	1	4
Procathepsin L	0	1	1	2
5-hydroxytryptamine receptor 1A	0	3	1	4
5-hydroxytryptamine receptor 2C	0	3	1	4
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Replicase polyprotein 1ab	0	3	1	4
Cytochrome P450 2D6	0	6	1	7
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
5-hydroxytryptamine receptor 2A	0	5	1	6
Sphingomyelin phosphodiesterase	0	1	0	1
D	0	3	0	3
D(3) dopamine receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	7	3	10
D(2) dopamine receptor	0	1	0	1
Proteasome subunit beta type-1	0	0	0	1
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	7	3	10
UDP-glucuronosyltransferase 1A4	0	1	0	2
Alpha-2A adrenergic receptor	0	7	3	10
Alpha-1D adrenergic receptor	0	9	4	14
Sodium-dependent dopamine transporter	0	2	0	2
D(1B) dopamine receptor	0	2	0	2
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	2	0	2
D(4) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	3	1	4
Histamine H1 receptor	0	2	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 7	0	3	1	4
Histamine H1 receptor	0	5	0	5
Glutamate receptor ionotropic, NMDA 1	0	1	1	2
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	2
D(2) dopamine receptor	0	5	0	6
Calmodulin	0	1	1	2
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	1	2
Glutamate receptor ionotropic, NMDA 2B	0	1	1	2
Glutamate receptor ionotropic, NMDA 2C	0	1	1	2
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Aldehyde oxidase	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	1	2
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	1	2
D	0	1	0	1
Proteasome subunit beta type-7	0	0	0	1
Angiotensin-converting enzyme 2	0	2	1	3
Glutamate receptor ionotropic, NMDA 3A	0	1	1	2
Histamine H3 receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	0	1	1
cytochrome P450 2C19 precursor	5	0	0	5
Alpha-1A adrenergic receptor	0	1	1	2
Chain A, Cruzipain	3	0	0	3
STAT3, partial	0	2	0	2
activating transcription factor 6	9	0	0	9
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	3	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	2	0	2
Sodium/potassium-transporting ATPase subunit gamma	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
ATPase family AAA domain-containing protein 5	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
interleukin 8	1	0	0	1
PAX8	0	0	0	1
thioredoxin glutathione reductase	1	0	0	1
alpha-galactosidase	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
tumor necrosis factor	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Cytochrome P450 3A4	0	5	0	5
Nuclear receptor ROR-gamma	2	1	1	4
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	3	0	3
nonstructural protein 1	2	0	0	2
Bloom syndrome protein isoform 1	4	0	0	4
peripheral myelin protein 22 isoform 1	2	0	0	2
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
Solute carrier family 22 member 1	0	5	0	6
Multidrug and toxin extrusion protein 2	0	1	0	1
Solute carrier family 22 member 2	0	5	0	5
dopamine D1 receptor	2	0	0	2
glp-1 receptor, partial	6	0	0	6
GALC protein	1	0	0	1
GLS protein	6	0	0	6
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
aryl hydrocarbon receptor	4	0	0	4
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Carbonic anhydrase 12	0	1	0	1
Carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Tyrosine-protein kinase Lck	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
POU domain, class 2, transcription factor 1	0	0	0	2
Carbonic anhydrase 4	0	3	0	3
Carbonic anhydrase 6	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase 9	0	2	0	2
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 15	0	2	0	2
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
endonuclease IV	2	0	0	2
Angiotensin-converting enzyme	0	1	0	1
Type-2 angiotensin II receptor	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Angiotensin-converting enzyme	0	1	0	1
Beta-1 adrenergic receptor	0	1	3	6
Luciferase	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Delta-type opioid receptor	0	3	0	3
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	3	1	4
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Sphingosine 1-phosphate receptor 1	0	0	1	1
RCG53912, isoform CRA_a	0	0	0	1
Sphingosine kinase 1	0	0	0	1
Sphingosine kinase 2	0	1	0	2
Sphingosine kinase 1	0	1	0	2
Potassium voltage-gated channel subfamily A member 5	0	4	0	4
Potassium voltage-gated channel subfamily A member 1	0	2	0	2
Potassium voltage-gated channel subfamily D member 2	0	3	0	3
Carbonic anhydrase	0	1	0	1
beta-2 adrenergic receptor	2	0	0	2
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Beta-2 adrenergic receptor	0	4	1	6
Beta-1 adrenergic receptor	0	4	2	8
Beta-2 adrenergic receptor	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	3	1	4
Vasopressin V1a receptor	0	0	1	1
Beta-1 adrenergic receptor	0	2	1	3
Alpha-1A adrenergic receptor	0	3	4	8
Alpha-1B adrenergic receptor	0	2	3	6
Beta-2 adrenergic receptor	0	3	0	3
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	2	2
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	2	2
Oxytocin receptor	0	0	1	1
Beta-2 adrenergic receptor	0	1	2	3
Taste receptor type 2 member 42	0	0	1	1
Beta-2 adrenergic receptor	0	1	3	6
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	2	2
Taste receptor type 2 member 13	0	0	2	2
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	2	2
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	2	2
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	0	0	1	1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	0	0	1	1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1B	0	3	1	4
5-hydroxytryptamine receptor 5A	0	1	0	1
Synaptic vesicular amine transporter	0	2	0	2
Vesicular acetylcholine transporter	0	1	0	1
Potassium channel subfamily K member 3	0	3	0	3
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Potassium channel subfamily K member 18	0	1	0	1
Phosphodiesterase	0	1	0	1
Vpr	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Aurora kinase A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Dual specificity protein kinase TTK	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Aurora kinase B	0	1	0	1
Inner centromere protein	0	1	0	1
Phosphodiesterase	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
pregnane X receptor	1	0	0	1
hypothetical protein, conserved	1	0	0	1
Parkin	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Phospholipase A2, membrane associated	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Leukotriene B4 receptor 1	0	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Potassium channel subfamily K member 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	1	3
ClpP	1	0	0	1
Hsf1 protein	0	0	1	1
estrogen receptor beta isoform 1	0	1	0	1
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	1	0	1
Nischarin	0	1	0	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Sodium/potassium/calcium exchanger 2	0	1	1	2
Solute carrier family 22 member 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Acetylcholinesterase	0	2	0	2
Acetylcholinesterase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 4	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
ATP-binding cassette sub-family C member 9	0	1	0	1
ATP-sensitive inward rectifier potassium channel 11	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	3	3
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Cytochrome P450 2C19	0	1	0	1
Vasopressin V1a receptor	0	1	1	2
Sodium/bile acid cotransporter	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Cholinesterase	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Cholinesterase	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Multidrug resistance protein 1a	0	0	0	1
Chain A, Ferritin light chain	1	0	0	1
acid sphingomyelinase	1	0	0	1
glucocerebrosidase	2	0	0	2
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
bcl-2-related protein A1	0	1	0	1
streptokinase A precursor	0	0	1	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor beta	0	0	1	1
Protein kinase C eta type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Catechol O-methyltransferase	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Multidrug resistance-associated protein 1	0	2	1	4
Chloroquine resistance transporter	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ectopic Junctional Tachycardia

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (112)

Protein Targets (702)

Ectopic Junctional Tachycardia

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (112)

Drugs Studied (51)

Protein Targets (702)