Page last updated: 2024-09-27

Ulnar Nerve Diseases

Disease involving the ULNAR NERVE from its origin in the BRACHIAL PLEXUS to its termination in the hand. Clinical manifestations may include PARESIS or PARALYSIS of wrist flexion, finger flexion, thumb adduction, finger abduction, and finger adduction. Sensation over the medial palm, fifth finger, and ulnar aspect of the ring finger may also be impaired. Common sites of injury include the AXILLA, cubital tunnel at the ELBOW, and Guyon's canal at the wrist. (From Joynt, Clinical Neurology, 1995, Ch51 pp43-5)

Synonyms(4)

Synonym
Ulnar Nerve Diseases
Ulnar Nerve Palsy
Ulnar Neuropathies
Ulnar Neuritis

Research Excerpts

Overview

ExcerptReference
"Median and Ulnar nerve palsy is a devastating condition that compromise hand function."( Brandi, C; Cuomo, R; D'Aniello, C; Grimaldi, L; Nisi, G, 2019)

Treatment

ExcerptReference
"The authors present a case of permanent ulnar nerve palsy after embolotherapy of an arteriovenous malformation around the elbow, and caution that transcatheter embolotherapy of arteriovenous malformations located close to major neurovascular structures must be carefully planned and individualized."( Cho, CH; Choi, JS, 2011)
"Here, we present a case of ulnar neuritis presenting in a patient with lepromatous leprosy four years after treatment of initial infection, with subsequent improvement after corticosteroid burst while maintained on thalidomide therapy."( Schofield, C; Wellington, T, 2019)

Research

Studies (88)

TimeframeStudies, This Condition (%)All Conditions %
pre-19902 (2.27)23.3326
1990's1 (1.14)12.5806
2000's44 (50.00)18.1394
2010's36 (40.91)28.8240
2020's5 (5.68)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
3-hydroxybutyric acid0medium11
thiamine0low10
albendazole0low10
bupivacaine0low10
carbamazepine0low10
diethylcarbamazine0low10
guaifenesin0low10
haloperidol0low10
lidocaine0medium11
thalidomide0low10
prednisolone0low20
prednisone0medium22
methylprednisolone acetate0medium22
valine0low10
perflutren0low10
triamcinolone acetonide0medium11
acrylamide0low10
methylprednisolone0medium22
streptomycin0low10
trolamine salicylate0low10
triamcinolone0low10
amoxicillin0low10
cortisone0low10
fibrin0low10
capsaicin0low10
clavulanic acid0low10
lead0low10
vendex0low10
heme0low10
minocycline0low10
acyclovir0low10
valacyclovir0low10

Protein Targets (486)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Protein skinhead-10101
Monocarboxylate transporter 20101
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
caspase 7, apoptosis-related cysteine protease3003
aldehyde dehydrogenase 1 family, member A18008
thyroid stimulating hormone receptor4004
glucocorticoid receptor [Homo sapiens]110011
retinoic acid nuclear receptor alpha variant 19009
retinoid X nuclear receptor alpha8008
estrogen-related nuclear receptor alpha100010
pregnane X nuclear receptor110011
estrogen nuclear receptor alpha160016
vitamin D (1,25- dihydroxyvitamin D3) receptor9009
caspase-33003
nuclear factor erythroid 2-related factor 2 isoform 16006
lethal factor (plasmid)2002
Alcohol dehydrogenase E chain0101
Alcohol dehydrogenase S chain0101
Cellular tumor antigen p536006
Fibroblast growth factor receptor 40101
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Ferritin light chain1001
Thymidine kinase 0101
thioredoxin reductase6006
phosphopantetheinyl transferase3003
GLS protein5005
TDP1 protein130013
Smad32002
EWS/FLI fusion protein5005
arylsulfatase A4004
euchromatic histone-lysine N-methyltransferase 2110011
activating transcription factor 61001
Histone H2A.x2002
Bloom syndrome protein isoform 13003
hemoglobin subunit beta1001
atrial natriuretic peptide receptor 1 precursor2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
lamin isoform A-delta107007
Solute carrier family 22 member 1 0204
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 40909
Solute carrier family 22 member 60102
Bile salt export pump0606
Bile salt export pump016016
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0001
POU domain, class 2, transcription factor 20001
Cytochrome P450 2C9 0707
Cytochrome P450 2J20707
Disintegrin and metalloproteinase domain-containing protein 171001
Purine nucleoside phosphorylase0011
Solute carrier family 22 member 60102
Thymidine kinase 0101
Solute carrier family 22 member 80103
Canalicular multispecific organic anion transporter 10909
Thymidine kinase0101
Chain A, Beta-lactamase6006
Luciferase1001
glp-1 receptor, partial3003
hypoxia-inducible factor 1 alpha subunit4004
RAR-related orphan receptor gamma100010
ATAD5 protein, partial4004
Fumarate hydratase2002
GLI family zinc finger 3100010
AR protein140014
nuclear receptor subfamily 1, group I, member 35005
progesterone receptor9009
farnesoid X nuclear receptor4004
polyprotein2002
67.9K protein2002
peroxisome proliferator activated receptor gamma3003
IDH16006
aryl hydrocarbon receptor3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a9009
v-jun sarcoma virus 17 oncogene homolog (avian)5005
nuclear receptor subfamily 1, group I, member 25005
cellular tumor antigen p53 isoform a1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
chromobox protein homolog 16006
nuclear factor erythroid 2-related factor 2 isoform 28008
transcriptional regulator ERG isoform 31001
thyroid hormone receptor beta isoform 24004
histone deacetylase 9 isoform 31001
heat shock protein beta-14004
mitogen-activated protein kinase 14004
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
geminin120012
Vif0001
peripheral myelin protein 223003
survival motor neuron protein isoform d4004
muscleblind-like protein 1 isoform 13003
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
neuropeptide S receptor isoform A1001
Voltage-dependent calcium channel gamma-2 subunit4004
Interferon beta4004
Integrin beta-31001
Integrin alpha-IIb1001
Methionine aminopeptidase0101
Glutamate receptor 24004
Fatty-acid amide hydrolase 10101
Inositol monophosphatase 12002
ATPase family AAA domain-containing protein 56006
Ataxin-26006
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain A, 2-oxoglutarate Oxygenase2002
Beta-lactamase 0102
Beta-lactamase 0102
Beta-lactamase 0001
Beta-lactamase 0102
apical membrane antigen 1, AMA11001
Beta-lactamase 0001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)2002
DNA polymerase kappa isoform 12002
Beta-lactamase SHV-10102
Beta-lactamase SHV-10203
Beta-lactamase0102
Kappa-type opioid receptor0102
Solute carrier family 15 member 10304
Solute carrier family 15 member 10202
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20101
Beta-lactamase 0102
Beta-lactamase 0102
Solute carrier family 15 member 20202
Beta-lactamase 0102
Beta-lactamase 0001
Potassium channel subfamily K member 30303
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20213
Potassium channel subfamily K member 90101
15-lipoxygenase, partial2002
Microtubule-associated protein tau2002
estrogen receptor 2 (ER beta)2002
glucocerebrosidase2002
peroxisome proliferator-activated receptor delta4004
nuclear receptor ROR-gamma isoform 14004
cytochrome P450 3A4 isoform 15005
transient receptor potential cation channel subfamily V member 12002
Gamma-aminobutyric acid receptor subunit pi5005
Transient receptor potential cation channel subfamily V member 10314
Lysine-specific histone demethylase 1A0101
NADH-ubiquinone oxidoreductase chain 10101
Cytochrome P450 1A20101
Polyunsaturated fatty acid 5-lipoxygenase0101
Gamma-aminobutyric acid receptor subunit beta-15005
Gamma-aminobutyric acid receptor subunit delta5005
Gamma-aminobutyric acid receptor subunit gamma-25005
Gamma-aminobutyric acid receptor subunit alpha-55005
Gamma-aminobutyric acid receptor subunit alpha-35005
Cannabinoid receptor 10101
Acetylcholinesterase0202
Prostaglandin G/H synthase 10202
Gamma-aminobutyric acid receptor subunit gamma-15005
Gamma-aminobutyric acid receptor subunit alpha-25005
Gamma-aminobutyric acid receptor subunit alpha-45005
Gamma-aminobutyric acid receptor subunit gamma-35005
Gamma-aminobutyric acid receptor subunit alpha-65005
Cannabinoid receptor 2 0101
Nuclear receptor ROR-gamma2002
Spike glycoprotein2002
D(2) dopamine receptor0213
Gamma-aminobutyric acid receptor subunit alpha-15005
Gamma-aminobutyric acid receptor subunit beta-35005
Gamma-aminobutyric acid receptor subunit beta-25005
Potassium voltage-gated channel subfamily A member 10112
Corticotropin-releasing factor receptor 20101
Transient receptor potential cation channel subfamily V member 10214
GABA theta subunit5005
Transient receptor potential cation channel subfamily V member 40112
Gamma-aminobutyric acid receptor subunit epsilon5005
Transient receptor potential cation channel subfamily V member 20112
ATP-dependent phosphofructokinase3003
acetylcholinesterase3003
USP1 protein, partial2002
thyroid hormone receptor beta isoform a2002
Vpr1001
Albumin0022
Major prion protein0022
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0202
UDP-glucuronosyltransferase 2B70103
Cytochrome P450 2B60112
Sodium channel protein type 4 subunit alpha0304
Potassium voltage-gated channel subfamily H member 20505
Sodium channel protein type 9 subunit alpha0404
Frizzled-80011
P2X purinoceptor 40101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase0101
Beta-lactamase0101
Beta-lactamase0101
Neutrophil elastase0101
Beta-lactamase OXA-10101
Beta-lactamase TEM0203
Beta-lactamase0101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0101
Class D beta-lactamase0101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase 0101
Metallo-b-lactamase 0001
Beta-lactamase 0101
Carbapenem-hydrolyzing beta-lactamase KPC0202
Beta-lactamase class B VIM-2 0001
endonuclease IV1001
dopamine D1 receptor1001
pregnane X receptor2002
regulator of G-protein signaling 42002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
peripheral myelin protein 22 isoform 13003
flap endonuclease 13003
M-phase phosphoprotein 81001
muscarinic acetylcholine receptor M13003
Glucocorticoid receptor012219
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-1012012
Corticosteroid-binding globulin0202
Glycine receptor subunit beta012012
Glycine receptor subunit alpha-2012012
Glycine receptor subunit alpha-3012012
TAR DNA-binding protein 433003
Multidrug and toxin extrusion protein 10202
SMAD family member 23003
SMAD family member 33003
Rap guanine nucleotide exchange factor 31001
NFKB1 protein, partial2002
Thrombopoietin1001
cytochrome P450 family 3 subfamily A polypeptide 47007
nonstructural protein 12002
cytochrome P450 2D64004
Adenylate cyclase type 1 0101
thyroid stimulating hormone receptor1001
cytochrome P450 2D6 isoform 11001
cytochrome P450 2C9 precursor1001
D(1A) dopamine receptor1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
serine/threonine-protein kinase mTOR isoform 11001
Cocaine esterase0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Voltage-dependent L-type calcium channel subunit alpha-1C0101
UDP-glucuronosyltransferase 1A90102
Voltage-dependent L-type calcium channel subunit alpha-1F0101
5-hydroxytryptamine receptor 40202
Vitamin D-binding protein0101
HLA class I histocompatibility antigen, A alpha chain 0011
Integrin beta-10101
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M40101
ATP-dependent translocase ABCB10203
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40202
Cytochrome P450 3A40102
5-hydroxytryptamine receptor 1A0202
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
Beta-2 adrenergic receptor0202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M10202
Angiotensin-converting enzyme0101
Integrin alpha-40101
D(2) dopamine receptor0215
5-hydroxytryptamine receptor 2A0202
Alpha-1B adrenergic receptor0202
Carbonyl reductase [NADPH] 10001
Alpha-2B adrenergic receptor0202
Beta-1 adrenergic receptor0101
Alpha-2C adrenergic receptor0202
D0202
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 1A0202
Alpha-2B adrenergic receptor0101
D(2) dopamine receptor0202
Muscarinic acetylcholine receptor M30101
D(1A) dopamine receptor0203
D(4) dopamine receptor0215
D(1B) dopamine receptor0203
Adenylate cyclase type 30101
Alpha-2C adrenergic receptor0101
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0202
Sodium-dependent noradrenaline transporter 0202
Sodium-dependent dopamine transporter0101
5-hydroxytryptamine receptor 3A0101
Histamine H2 receptor0202
Adenosine receptor A10101
Alpha-1D adrenergic receptor0202
D(1B) dopamine receptor0202
Beta-3 adrenergic receptor0101
Adenylate cyclase type 20101
Adenylate cyclase type 40101
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1D0101
D(4) dopamine receptor0202
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0202
Histamine H1 receptor0202
Sodium-dependent serotonin transporter0202
Sodium-dependent serotonin transporter0101
5-hydroxytryptamine receptor 7 0101
C-8 sterol isomerase0101
Delta-type opioid receptor0101
Mu-type opioid receptor0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70101
Kappa-type opioid receptor0101
Alpha-1A adrenergic receptor0101
5-hydroxytryptamine receptor 2A0101
Histamine H1 receptor0202
Alpha-1B adrenergic receptor0101
Mu-type opioid receptor0213
Glutamate receptor ionotropic, NMDA 1 0101
D(3) dopamine receptor0215
Sodium channel protein type 1 subunit alpha0101
Adenylate cyclase type 80101
5-hydroxytryptamine receptor 2B0202
Alpha-1A adrenergic receptor0202
Histamine H2 receptor1002
5-hydroxytryptamine receptor 2A0101
D(1A) dopamine receptor1102
5-hydroxytryptamine receptor 60101
5-hydroxytryptamine receptor 70101
D(2) dopamine receptor0101
D(3) dopamine receptor0101
Gastrin/cholecystokinin type B receptor0101
AP-2 complex subunit sigma0101
N-acetyltransferase Eis0202
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
5-hydroxytryptamine receptor 2B0101
Adenylate cyclase type 60101
Adenylate cyclase type 50101
5-hydroxytryptamine receptor 40101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0202
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Calcitonin gene-related peptide type 1 receptor0101
Genome polyprotein 0202
Sigma intracellular receptor 20101
Sigma intracellular receptor 20101
Sigma non-opioid intracellular receptor 10101
Zinc finger protein 6640101
Glutamate receptor ionotropic, NMDA 2D0101
Vesicular acetylcholine transporter0101
Transporter0101
Cholecystokinin receptor type A0101
Protease 0202
Adenylyl cyclase 7 0101
Glutamate receptor ionotropic, NMDA 3B0101
D0101
Sodium channel protein type 2 subunit alpha0101
Sigma non-opioid intracellular receptor 10202
Sodium channel protein type 3 subunit alpha0202
Sigma non-opioid intracellular receptor 10202
Glutamate receptor ionotropic, NMDA 3A0101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
PPM1D protein1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
G1001
bromodomain adjacent to zinc finger domain 2B1001
Nuclear receptor subfamily 1 group I member 20011
HLA class I histocompatibility antigen, B alpha chain 1001
Androgen receptor0303
Inositol hexakisphosphate kinase 11001
Nuclear receptor subfamily 1 group I member 20011
cytochrome P450 2C9, partial1001
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
Glucose-6-phosphate 1-dehydrogenase0101
Albumin0112
Stromelysin-10112
Matrilysin0101
Multidrug transporter MdfA0101
Matrix metalloproteinase-90101
Protein mono-ADP-ribosyltransferase PARP150101
Protein-arginine deiminase type-40404
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Prostaglandin G/H synthase 20202
Nociceptin receptor0011
Estrogen receptor beta0202
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
thioredoxin glutathione reductase3003
vitamin D3 receptor isoform VDRA3003
chaperonin-containing TCP-1 beta subunit homolog1001
histone acetyltransferase KAT2A isoform 12002
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Polyphenol oxidase 20102
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Carbonic anhydrase 10303
Carbonic anhydrase 20303
Polymerase acidic protein0011
Carbonic anhydrase 30101
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Carbonic anhydrase 40101
Carbonic anhydrase 60202
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
Enoyl-[acyl-carrier-protein] reductase [NADH]0001
Cereblon isoform 40202
Prostaglandin G/H synthase 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Prostaglandin G/H synthase 20101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0214
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Transketolase0011
Thiamine-binding periplasmic protein0011
Solute carrier family 22 member 10101
Solute carrier family 22 member 20101
procathepsin L isoform 1 preproprotein0101
Valacyclovir hydrolase0001
Chain A, Arginase 10101
Large neutral amino acids transporter small subunit 10101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]