communic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

communic acid: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	637125
CHEMBL ID	498097
SCHEMBL ID	2406902
MeSH ID	M0434389

Synonyms (21)

Synonym
trans-communic acid
1231-35-2
communic acid
CHEMBL498097
(1s,4ar,5s,8ar)-1,4a-dimethyl-6-methylidene-5-[(2e)-3-methylpenta-2,4-dienyl]-3,4,5,7,8,8a-hexahydro-2h-naphthalene-1-carboxylic acid
SCHEMBL2406902
2761-77-5
(+)-communic acid
1-naphthalenecarboxylic acid, decahydro-1,4a-dimethyl-6-methylene-5-(3-methyl-2,4-pentadienyl)-, (1s,4ar,5s,8ar)-
DTXSID20348411
10178-32-2
FS-9702
1-naphthalenecarboxylic acid, decahydro-1,4a-dimethyl-6-methylene-5-((2e)-3-methyl-2,4-pentadien-1-yl)-, (1s,4ar,5s,8ar)-
communic acid, (+)-(e)-
ser34y2er9 ,
(1s,4ar,5s,8ar)-decahydro-1,4a-dimethyl-6-methylene-5-((2e)-3-methyl-2,4-pentadien-1-yl)-1-naphthalenecarboxylic acid
communic acid, (e)-
unii-ser34y2er9
labda-8(20),12,14-trien-19-oic acid, (e)-
cis-communic acid
AKOS040736447

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay ID	Title	Year	Journal	Article
AID750855	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Diterpenoids from the twigs and leaves of Fokienia hodginsii.
AID398025	Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 500 mol ratio relative to TPA	2002	Journal of natural products, Dec, Volume: 65, Issue:12	Potential antitumor-promoting diterpenes from the cones of Pinus luchuensis.
AID398027	Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 10 mol ratio relative to TPA	2002	Journal of natural products, Dec, Volume: 65, Issue:12	Potential antitumor-promoting diterpenes from the cones of Pinus luchuensis.
AID398028	Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio after 48 hours relative to TPA	2002	Journal of natural products, Dec, Volume: 65, Issue:12	Potential antitumor-promoting diterpenes from the cones of Pinus luchuensis.
AID398026	Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 100 mol ratio relative to TPA	2002	Journal of natural products, Dec, Volume: 65, Issue:12	Potential antitumor-promoting diterpenes from the cones of Pinus luchuensis.
AID750851	Cytotoxicity against human SW480 cells after 48 hrs by MTT assay	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Diterpenoids from the twigs and leaves of Fokienia hodginsii.
AID398024	Inhibition of 12-O-tetradecanoylphorbol 13-acetate-induced Epstein-Barr virus early antigen activation in human Raji cells assessed as EA induction at 1000 mol ratio relative to TPA	2002	Journal of natural products, Dec, Volume: 65, Issue:12	Potential antitumor-promoting diterpenes from the cones of Pinus luchuensis.
AID750854	Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Diterpenoids from the twigs and leaves of Fokienia hodginsii.
AID750853	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Diterpenoids from the twigs and leaves of Fokienia hodginsii.
AID750852	Cytotoxicity against human A549 cells after 48 hrs by MTT assay	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Diterpenoids from the twigs and leaves of Fokienia hodginsii.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (4.76)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (28.57)	29.6817
2010's	8 (38.10)	24.3611
2020's	6 (28.57)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.88

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	24.88 (24.57)
Research Supply Index	3.09 (2.92)
Research Growth Index	4.63 (4.65)
Search Engine Demand Index	26.67 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (24.88)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (4.76%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	20 (95.24%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
mercaptoethanol Mercaptoethanol: A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.	2.11	1	alkanethiol; primary alcohol	geroprotector
abietic acid abietic acid : An abietane diterpenoid that is abieta-7,13-diene substituted by a carboxy group at position 18.	2.51	2	abietane diterpenoid; monocarboxylic acid	plant metabolite
podophyllotoxin Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.	2.07	1	furonaphthodioxole; lignan; organic heterotetracyclic compound	antimitotic; antineoplastic agent; keratolytic drug; microtubule-destabilising agent; plant metabolite; tubulin modulator
amoxicillin Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.. amoxicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.	2.41	1	penicillin allergen; penicillin	antibacterial drug
homocysteine Homocysteine: A thiol-containing amino acid formed by a demethylation of METHIONINE.. homocysteine : A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.. L-homocysteine : A homocysteine that has L configuration.	2.02	1	amino acid zwitterion; homocysteine; serine family amino acid	fundamental metabolite; mouse metabolite
totarol totarol: structure given in first source; isolated from the bark of Podocarpus nagi	2.04	1	diterpenoid	metabolite
sugiol sugiol: diterpene with anti-inflammatory activity from Calocedrus formosana bark; structure in first source. sugiol : An abietane diterpenoid that is ferruginol in which the methylene group para to the phenolic hydroxy group has been substituted by an oxo group.	2.47	2	abietane diterpenoid; carbotricyclic compound; cyclic terpene ketone; meroterpenoid; phenols	antineoplastic agent; antioxidant; antiviral agent; plant metabolite; radical scavenger
dehydroabietic acid dehydroabietic acid: major aquatic toxicant in effluent of pulp and paper mills. dehydroabietic acid : An abietane diterpenoid that is abieta-8,11,13-triene substituted at position 18 by a carboxy group.. dehydroabietate : A monocarboxylic acid anion that is the conjugate base of dehydroabietic acid, obtained by deprotonation of the carboxy group.	2.45	2	abietane diterpenoid; carbotricyclic compound; monocarboxylic acid	allergen; metabolite
sl-mercaptoethanol SL-mercaptoethanol: structure given in first source	2.11	1
sandaracopimaric acid sandaracopimaric acid: a terpenoid from Sagittaria sanittifolia L.. sandaracopimaric acid : A pimarane diterpenoid that is (1S,4aS,4bS,7R,10aS)-1,4a,7-trimethyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene carrying a carboxy group at position 1 and a vinyl group at position 7. It is a natural product found in several plant species.	2.96	4	monocarboxylic acid; pimarane diterpenoid; tricyclic diterpenoid	plant metabolite
anthricin anthricin: antitumor constituent from Anthriscus sylvestris (L.) Hoffm; structure in first source. deoxypodophyllotoxin : A member of the class of furonaphthodioxoles that is (5R,5aR,8aR)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one substituted at position 5 by a 3,4,5-trimethoxyphenyl group.	2.07	1	furonaphthodioxole; gamma-lactone; lignan; methoxybenzenes	antineoplastic agent; apoptosis inducer; plant metabolite
ferruginol ferruginol: structure in first source. ferruginol : An abietane diterpenoid that is abieta-8,11,13-triene substituted by a hydroxy group at positions 12.	2.46	2	abietane diterpenoid; carbotricyclic compound; meroterpenoid; phenols	antibacterial agent; antineoplastic agent; plant metabolite; protective agent
abieta-7(8),13(14)-diene abieta-7(8),13(14)-diene: structure in first source. abietadiene : A diterpene consisting of abietane having two C=C double bonds at unspecified positions.	2.04	1	abietadiene
sesquiterpenes [no description available]	2.11	1
beta carotene beta Carotene: A carotenoid that is a precursor of VITAMIN A. Beta carotene is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC).. provitamin A : A provitamin that can be converted into vitamin A by enzymes from animal tissues.	2.01	1	carotenoid beta-end derivative; cyclic carotene	antioxidant; biological pigment; cofactor; ferroptosis inhibitor; human metabolite; mouse metabolite; plant metabolite; provitamin A
isocupressic acid isocupressic acid: a labdane that induces premature LABOR	2.81	3
pimarane pimarane: from Croton joufra; structure in first source	2.04	1	diterpene; terpenoid fundamental parent
labdane labdane: from Croton joufra; structure in first source	2.04	1	diterpene; terpenoid fundamental parent
imbricatolic acid imbricatolic acid: isolated from Araucaria araucana resin; structure in first source	2.1	1

Condition	Relationship Strength	Studies
Acute Confusional Senile Dementia [description not available]	2.25	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.25	1
Blood Pressure, High [description not available]	2.31	1
Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	2.31	1
Abnormalities, Multiple Congenital abnormalities that affect more than one organ or body structure.	2.02	1
Amblyopia, Developmental [description not available]	2.02	1
Nearsightedness [description not available]	2.02	1
Symptom Cluster [description not available]	2.02	1
Eye Diseases, Hereditary Transmission of gene defects or chromosomal aberrations/abnormalities which are expressed in extreme variation in the structure or function of the eye. These may be evident at birth, but may be manifested later with progression of the disorder.	2.02	1
Amblyopia A nonspecific term referring to impaired vision. Major subcategories include stimulus deprivation-induced amblyopia and toxic amblyopia. Stimulus deprivation-induced amblyopia is a developmental disorder of the visual cortex. A discrepancy between visual information received by the visual cortex from each eye results in abnormal cortical development. STRABISMUS and REFRACTIVE ERRORS may cause this condition. Toxic amblyopia is a disorder of the OPTIC NERVE which is associated with ALCOHOLISM, tobacco SMOKING, and other toxins and as an adverse effect of the use of some medications.	2.02	1
Connective Tissue Diseases A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.	2.02	1
Myopia A refractive error in which rays of light entering the EYE parallel to the optic axis are brought to a focus in front of the RETINA when accommodation (ACCOMMODATION, OCULAR) is relaxed. This results from an overly curved CORNEA or from the eyeball being too long from front to back. It is also called nearsightedness.	2.02	1
Retinal Degeneration A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)	2.02	1
Syndrome A characteristic symptom complex.	2.02	1
Cancer of Colon [description not available]	2.01	1
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	2.01	1
Cancer of Lung [description not available]	2.01	1
Malignant Melanoma [description not available]	2.01	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.01	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.01	1
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	2.01	1

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