Deficiency, Protein C

An absence or deficiency in PROTEIN C which leads to impaired regulation of blood coagulation. It is associated with an increased risk of severe or premature thrombosis. (Stedman's Med. Dict., 26th ed.)

Synonym
Protein C Deficiency
Hereditary Thrombophilia Due To Protein C Deficiency
Deficiency, Protein C

Excerpt	Reference
"Protein C deficiency is found in 6 to 7% of thromboembolic manifestations."	( Bierme, R; Cambus, JP; Jonot, F; Leophonte, P; Pouchelon, E, 1990)
"Homozygous protein C deficiency is a rare disorder, but one in which early recognition and intervention may be lifesaving."	( Bower, DJ; Hartman, KR; Manco-Johnson, M; Marlar, RA; Rawlings, JS, 1989)
"The inheritance of protein C deficiency is discussed and the importance of warfarin (Coumadin) treatment in this conditions is emphasized."	( Cengiz, B; Karabent, A; Ozsoylu, S, 1988)
"Inherited protein C deficiency is often associated with a high risk for venous thromboembolism."	( Koide, T; Tokunaga, F; Tsukamoto, T, 1996)
"Protein C deficiency is an inherited thrombophilia presented in adults with venous thrombosis at different sites."	( Saleh, AA, 2002)
"Severe genetic protein C deficiency is rare and is associated with severe, often fatal thrombosis."	( Knapp-Clevenger, R; Manco-Johnson, MJ, 2004)
"Protein C deficiency is a common thrombophilic condition that affects an estimated 1 in 400 Americans."	( Bruley, DF; Jagannath, SB; Streiff, MB, 2011)
"Neonatal severe protein C deficiency is a serious disease."	( Debillon, T; Douchin, S; Epiard, C; Milleret, C; Pernod, G, 2017)
"Patients with protein C deficiency are at increased risk for thrombolic diseases."	( Alchi, R; Bloomfield, D; Lai, J; Ramai, D, 2017)
"Congenital protein C deficiency is an important cause of thrombosis in humans but is not described in dogs."	( Juvet, F; Kelly, D; Moore, G, 2020)
"Protein C deficiency is a rare form of hereditary thrombophilia."	( Ashizawa, T; China, T; Horie, S; Ikehata, Y; Ishikawa, K; Isotani, S; Kawano, H; Maiguma, M; Muto, S; Nagashima, Y; Nagata, M; Nagaya, N; Nakagawa, Y; Nakamura, S; Shimizu, F; Shirakawa, T; Suzuki, Y; Yoshiyama, A; Yuzawa, K, 2022)
"Protein C deficiency is a rare form of hereditary thrombophilia."	( Ashizawa, T; China, T; Horie, S; Ikehata, Y; Ishikawa, K; Isotani, S; Kawano, H; Maiguma, M; Muto, S; Nagashima, Y; Nagata, M; Nagaya, N; Nakagawa, Y; Nakamura, S; Shimizu, F; Shirakawa, T; Suzuki, Y; Yoshiyama, A; Yuzawa, K, 2022)
"Protein C deficiency is a rare form of hereditary thrombophilia."	( Ashizawa, T; China, T; Horie, S; Ikehata, Y; Ishikawa, K; Isotani, S; Kawano, H; Maiguma, M; Muto, S; Nagashima, Y; Nagata, M; Nagaya, N; Nakagawa, Y; Nakamura, S; Shimizu, F; Shirakawa, T; Suzuki, Y; Yoshiyama, A; Yuzawa, K, 2022)

Excerpt	Reference
"In the two men the protein C deficiency was diagnosed only after the onset of severe thromboembolic complications (cavernous sinus thrombosis; pulmonary embolism) during heparin treatment."	( Korsten, S; Reis, HE, 1992)
"This syndrome occurs when acquired protein C deficiency during warfarin treatment of HIT and deep venous thrombosis leads to the inability to regulate thrombin generation in the microvasculature."	( Warkentin, TE, 1999)
"In the setting of protein C deficiency, skin necrosis, which occurs most often at the initial phase of oral anticoagulants therapy, is a rare side effect."	( Alhene Gelas, M; Avril, MF; Beqqal, K; Dupin, N; Flaujac, C; Gorin, I; Hassam, B; Horellou, MH; Jacobelli, S; Philippe, A, 2014)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	42 (14.79)	23.3326
1990's	111 (39.08)	12.5806
2000's	72 (25.35)	18.1394
2010's	51 (17.96)	28.8240
2020's	8 (2.82)	9.53

Drug	Relationship Strength	Studies	Trials
adenine	low	2	0
beta-alanine	low	1	0
citric acid, anhydrous	low	1	0
coumarin	low	14	0
cytosine	low	1	0
glycine	low	3	0
dalteparin	low	14	0
aspirin	low	8	0
citalopram	low	1	0
clonazepam	low	1	0
valproic acid	low	1	0
fluorouracil	low	1	0
2-propanol	low	1	0
apnea	medium	2	1
phenindione	low	2	0
sulfasalazine	low	1	0
ticlopidine	low	1	0
prednisolone	low	1	0
prednisone	low	3	0
alanine	low	2	0
serine	low	3	0
aspartic acid	low	1	0
glutamine	low	3	0
lysine	low	2	0
ethinyl estradiol	low	2	0
phenylephrine	low	1	0
tyrosine	low	2	0
leucine	low	1	0
methionine	low	2	0
cytarabine	low	3	0
asparagine	low	1	0
histidine	low	4	0
valine	low	2	0
threonine	low	4	0
methandrostenolone	low	1	0
tryptophan	low	1	0
isoleucine	low	1	0
arginine	low	11	0
methylprednisolone	low	2	0
penicillanic acid	low	1	0
thiophenes	low	2	0
fluocortolone	low	1	0
thiazoles	low	2	0
ephedrine	low	1	0
homocystine	low	2	0
hesperidin	low	1	0
fluorescein-5-isothiocyanate	low	1	0
stanozolol	low	2	0
danazol	low	3	0
glutamic acid	low	2	0
amoxicillin	low	1	0
etoposide	low	1	0
ribavirin	low	1	0
1-carboxyglutamic acid	low	2	0
desogestrel	low	1	0
idarubicin	low	2	0
propiconazole	low	2	0
piperacillin	low	1	0
clopidogrel	low	1	0
tirofiban	low	1	0
5-methylcytosine	low	1	0
fluindione	low	2	0
nsc-172755	low	1	0
fibrinogen	medium	19	1
homocysteine	low	9	0
mci 9038	low	1	0
imidazoleacetic acid	low	1	0
methotrexate	low	1	0
proline	low	3	0
docetaxel anhydrous	low	1	0
biotin	low	1	0
dabigatran	medium	3	1
carboplatin	low	2	0
fibrin	low	11	0
tretinoin	low	1	0
cocaine	low	1	0
aclarubicin	low	1	0
leuprolide	low	1	0
propylthiouracil	low	1	0
tamoxifen	low	1	0
dermatan sulfate	low	2	0
gestodene	low	1	0
alpha-chymotrypsin	low	1	0
bilirubin	low	2	0
vitamin k semiquinone radical	low	24	0
vitamin k1 oxide	low	1	0
diosmin	low	1	0
cyproterone	low	1	0
vitamin k 1	low	1	0
cysteine	low	3	0
rivaroxaban	low	4	0
s 5682	low	1	0
edoxaban	low	2	0
(4-24)-ply(a)	low	1	0
piperacillin, tazobactam drug combination	low	1	0
fibrinopeptide a	low	3	0
heparitin sulfate	low	1	0
acenocoumarol	low	6	0
warfarin	medium	113	1
phenprocoumon	low	4	0
epidermal growth factor	low	2	0
kaolinite	low	1	0
hirudin	low	3	0
refludan	low	3	0
technetium tc 99m medronate	low	1	0
thromboplastin	low	5	0
chondroitin sulfates	low	1	0
guanine	low	3	0
eye	low	1	0

Protein Targets (995)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	11	0	0	11
RAR-related orphan receptor gamma	23	0	0	23
GLI family zinc finger 3	21	0	0	21
AR protein	31	0	0	31
aldehyde dehydrogenase 1 family, member A1	16	0	0	16
retinoic acid nuclear receptor alpha variant 1	25	0	0	25
retinoid X nuclear receptor alpha	15	0	0	15
estrogen nuclear receptor alpha	37	0	0	37
peroxisome proliferator-activated receptor delta	13	0	0	13
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	16	0	0	16
activating transcription factor 6	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
Histone H2A.x	12	0	0	12
thyroid hormone receptor beta isoform a	10	0	0	10
heat shock protein beta-1	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 1	22	0	0	22
lamin isoform A-delta10	19	0	0	19
Voltage-dependent calcium channel gamma-2 subunit	13	0	0	13
Glutamate receptor 2	14	2	1	17
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	14	0	0	14
Luciferase	9	0	0	9
G	13	0	0	13
peroxisome proliferator activated receptor gamma	19	0	0	19
euchromatic histone-lysine N-methyltransferase 2	23	0	0	23
thyroid stimulating hormone receptor	11	0	0	11
chromobox protein homolog 1	16	0	0	16
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
geminin	20	0	0	20
muscleblind-like protein 1 isoform 1	7	0	0	7
Interferon beta	19	0	0	19
HLA class I histocompatibility antigen, B alpha chain	13	0	0	13
Guanine nucleotide-binding protein G	2	0	0	2
Inositol hexakisphosphate kinase 1	13	0	0	13
cytochrome P450 2C9, partial	13	0	0	13
72 kDa type IV collagenase	0	1	0	1
5-hydroxytryptamine receptor 2B	0	8	0	8
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
TDP1 protein	23	0	0	23
nuclear receptor subfamily 1, group I, member 3	17	0	0	17
cytochrome P450 family 3 subfamily A polypeptide 4	16	0	0	16
glucocorticoid receptor [Homo sapiens]	26	0	0	26
estrogen-related nuclear receptor alpha	26	0	0	26
pregnane X nuclear receptor	22	0	0	22
nuclear factor erythroid 2-related factor 2 isoform 2	10	0	0	10
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Bile salt export pump	0	26	0	26
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	4	0	0	4
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	12	0	0	12
Ataxin-2	16	0	0	16
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
Carbonic anhydrase 1	0	5	0	15
Carbonic anhydrase 2	0	5	1	16
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	3
Glutamate receptor ionotropic, NMDA 1	0	9	2	15
Proton-coupled amino acid transporter 1	0	7	0	8
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	3
Chain A, Beta-lactamase	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
apical membrane antigen 1, AMA1	3	0	0	3
Beta-lactamase	0	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	8	0	0	8
DNA polymerase eta isoform 1	6	0	0	6
DNA polymerase iota isoform a (long)	15	0	0	15
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
DNA polymerase kappa isoform 1	10	0	0	10
ATP-binding cassette sub-family C member 3	0	19	0	19
Multidrug resistance-associated protein 4	0	19	0	20
Bile salt export pump	0	4	0	4
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase SHV-1	0	0	0	2
Cytochrome P450 2C9	0	8	1	9
Beta-lactamase	0	0	0	2
Kappa-type opioid receptor	0	0	0	2
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Cytochrome P450 2J2	0	6	0	6
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Canalicular multispecific organic anion transporter 1	0	19	0	20
thioredoxin reductase	14	0	0	14
ATAD5 protein, partial	8	0	0	8
Microtubule-associated protein tau	12	0	0	12
arylsulfatase A	9	0	0	9
Bloom syndrome protein isoform 1	8	0	0	8
D(1A) dopamine receptor	5	0	0	5
neuropeptide S receptor isoform A	1	0	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
phosphopantetheinyl transferase	14	0	0	14
NFKB1 protein, partial	3	0	0	3
GLS protein	8	0	0	8
thyroid stimulating hormone receptor	10	0	0	10
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	4	0	0	4
flap endonuclease 1	8	0	0	8
muscarinic acetylcholine receptor M1	5	0	0	5
lethal factor (plasmid)	7	0	0	7
Cytochrome P450 3A4	0	6	1	8
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
ATP-dependent phosphofructokinase	13	0	0	13
Neutral amino acid transporter A	0	4	0	4
Neutral amino acid transporter B(0)	0	4	0	4
Carbonic anhydrase-like protein, putative	0	0	0	7
Amino acid transporter	0	4	0	4
Chain A, Ferritin light chain	9	0	0	9
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	7	2	13
Glutamate receptor ionotropic, NMDA 2B	0	7	2	13
Glutamate receptor ionotropic, NMDA 2C	0	7	2	13
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Glutamate receptor ionotropic, NMDA 2D	0	7	2	13
Glutamate receptor ionotropic, NMDA 3B	0	7	2	13
Glutamate receptor ionotropic, NMDA 3A	0	7	2	13
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	5	0	0	5
hypothetical protein, conserved	1	0	0	1
EWS/FLI fusion protein	12	0	0	12
cytochrome P450 2D6	7	0	0	7
glucocerebrosidase	2	0	0	2
Rac1 protein	0	0	1	1
IDH1	7	0	0	7
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	3	0	3
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	3	2	2	8
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	3	2	2	8
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Adenosine receptor A1	0	1	0	3
Adenosine receptor A2a	0	1	0	3
Substance-P receptor	0	3	0	4
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	5	1	1	7
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	8	3	1	12
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	8	1	9
Sigma non-opioid intracellular receptor 1	0	1	1	2
regulator of G-protein signaling 4	6	0	0	6
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, Cruzipain	2	0	0	2
USP1 protein, partial	12	0	0	12
vitamin D3 receptor isoform VDRA	10	0	0	10
caspase-1 isoform alpha precursor	2	0	0	2
Caspase-7	2	0	0	2
Inositol monophosphatase 1	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	6	0	8
Solute carrier organic anion transporter family member 1B1	0	4	0	5
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	6	0	0	6
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
acetylcholinesterase	9	0	0	9
estrogen receptor 2 (ER beta)	12	0	0	12
histone-lysine N-methyltransferase 2A isoform 2 precursor	5	0	0	5
histone acetyltransferase KAT2A isoform 1	7	0	0	7
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
survival motor neuron protein isoform d	6	0	0	6
Solute carrier family 22 member 1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
5-hydroxytryptamine receptor 4	0	4	0	4
Aldo-keto reductase family 1 member B1	0	9	0	9
Tryptophan 5-hydroxylase 1	0	2	0	2
Angiotensin-converting enzyme	0	4	0	4
Aldo-keto reductase family 1 member B1	0	1	0	1
5-hydroxytryptamine receptor 1A	0	5	0	5
Acetylcholinesterase	0	2	0	2
Aromatase	0	1	0	1
Sodium-dependent noradrenaline transporter	0	10	0	10
Sodium-dependent dopamine transporter	0	3	0	3
Alpha-1D adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2C	0	4	0	4
Sodium-dependent serotonin transporter	0	12	1	13
Sodium-dependent serotonin transporter	0	3	0	4
Histamine H1 receptor	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Spike glycoprotein	7	0	2	9
Sodium-dependent dopamine transporter	0	9	0	9
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Sigma intracellular receptor 2	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	3	0	3
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Transporter	0	4	0	4
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
farnesoid X nuclear receptor	13	0	0	13
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	1	0	2
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	8	2	1	11
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-1	8	2	1	11
Gamma-aminobutyric acid receptor subunit beta-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit delta	8	2	1	11
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	8	2	1	11
Gamma-aminobutyric acid receptor subunit alpha-5	8	2	1	11
Gamma-aminobutyric acid receptor subunit alpha-3	8	2	1	11
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	8	2	1	11
Gamma-aminobutyric acid receptor subunit alpha-2	8	2	1	11
Gamma-aminobutyric acid receptor subunit alpha-4	8	2	1	11
Gamma-aminobutyric acid receptor subunit beta-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-3	8	2	1	11
Gamma-aminobutyric acid receptor subunit alpha-6	8	2	1	11
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-3	8	2	1	11
Gamma-aminobutyric acid receptor subunit beta-2	8	2	1	11
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
GABA theta subunit	8	2	1	11
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	8	2	1	11
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
nonstructural protein 1	7	0	0	7
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2B6	0	5	0	5
Liver carboxylesterase 1	0	1	0	3
Cytochrome P450 2C19	0	4	1	5
Rap guanine nucleotide exchange factor 4	1	0	0	1
P2Y purinoceptor 12	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Amyloid-beta precursor protein	2	2	0	4
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
5-hydroxytryptamine receptor 2C	0	3	0	4
5-hydroxytryptamine receptor 2A	0	3	0	3
D	0	1	0	1
Alpha-2B adrenergic receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
5-hydroxytryptamine receptor 1B	0	3	0	3
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
pregnane X receptor	8	0	0	8
GALC protein	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	12	0	0	12
nuclear receptor subfamily 1, group I, member 2	7	0	0	7
peripheral myelin protein 22	10	0	0	10
glycogen synthase kinase-3 alpha	0	0	0	1
Exportin-1	0	1	0	1
Carbonic anhydrase 12	0	1	0	5
Glyceraldehyde-3-phosphate dehydrogenase	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	3
Carbonic anhydrase 3	0	1	0	4
Cytochrome P450 2A6	0	1	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	3
UDP-glucuronosyltransferase 1-6	0	1	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Cytochrome P450 2A5	0	0	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	4
UDP-glucuronosyltransferase 1A4	0	1	0	2
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	0	1	0	1
Carbonic anhydrase 4	0	1	0	4
Carbonic anhydrase 6	0	1	0	4
Carbonic anhydrase 5A, mitochondrial	0	1	0	4
UDP-glucuronosyltransferase 2B10	0	1	0	1
Carbonic anhydrase 7	0	1	0	4
Quinone oxidoreductase	0	0	0	1
Beta-secretase 1	0	1	0	1
Sorbitol dehydrogenase	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Carbonic anhydrase 9	0	1	0	5
Zn finger protein	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Carbonic anhydrase 13	0	1	0	2
Carbonic anhydrase 15	0	1	0	4
Carbonic anhydrase 13	0	1	0	3
Carbonic anhydrase 14	0	1	0	4
Carbonic anhydrase 5B, mitochondrial	0	1	0	4
endonuclease IV	3	0	0	3
glp-1 receptor, partial	8	0	0	8
67.9K protein	8	0	0	8
LMP1 [Human herpesvirus 4]	0	0	0	3
thyroid hormone receptor beta isoform 2	18	0	0	18
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	1
Cellular tumor antigen p53	19	0	0	19
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	3	0	4
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
D(1A) dopamine receptor	3	0	0	3
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Thymidine kinase	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Solute carrier family 22 member 2	0	2	0	2
Prothrombin	0	5	2	8
Coagulation factor X	0	7	0	7
Plasminogen	0	2	0	2
Coagulation factor XII	0	2	0	2
Tissue-type plasminogen activator	0	2	0	2
Vitamin K-dependent protein C	0	1	0	1
Serine protease hepsin	0	1	0	1
Trypsin-1	0	2	0	2
Trypsin-2	0	2	0	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Trypsin-3	0	2	0	2
Multidrug and toxin extrusion protein 2	0	2	0	2
Multidrug and toxin extrusion protein 1	0	2	0	2
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
progesterone receptor	16	0	0	16
Rap guanine nucleotide exchange factor 3	4	0	0	4
Estrogen receptor	0	10	2	13
Glucocorticoid receptor	0	10	2	17
Sex hormone-binding globulin	0	0	3	3
Cytochrome P450 1A2	0	1	1	2
Glycine receptor subunit alpha-1	0	10	0	10
Alpha-2A adrenergic receptor	0	7	1	8
Adenosine receptor A3	0	11	0	11
Beta-3 adrenergic receptor	0	4	1	5
Androgen receptor	0	13	0	13
Alpha-1B adrenergic receptor	0	11	0	11
Alpha-2B adrenergic receptor	0	7	0	7
Alpha-2C adrenergic receptor	0	5	1	6
Muscarinic acetylcholine receptor M3	0	4	0	4
Glycine receptor subunit beta	0	10	0	10
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	4	0	4
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
5-hydroxytryptamine receptor 2A	0	4	0	4
Mu-type opioid receptor	0	6	0	6
D(3) dopamine receptor	0	4	0	4
Kappa-type opioid receptor	0	6	0	6
Alpha-1A adrenergic receptor	0	11	0	11
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
PPM1D protein	8	0	0	8
aryl hydrocarbon receptor	7	0	0	7
DNA polymerase beta	4	0	0	4
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	1	0	1
Lysine-specific histone demethylase 1A	0	2	0	2
Aurora kinase B	0	1	0	1
caspase 7, apoptosis-related cysteine protease	4	0	0	4
caspase-3	4	0	0	4
Serum paraoxonase/arylesterase 1	0	2	0	2
Kinesin-like protein KIF11	0	1	0	1
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Fumarate hydratase	2	0	0	2
polyprotein	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
lysosomal alpha-glucosidase preproprotein	1	0	0	1
Vpr	2	0	0	2
cytochrome P450 3A4 isoform 1	8	0	0	8
Cytochrome P450 2B1	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	2	0	2
Adenosine receptor A2a	0	5	0	5
Sulfotransferase 1A1	0	2	1	4
Aldehyde oxidase	0	1	0	1
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Estrogen receptor beta	0	5	2	7
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	4	2	7
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	1	7
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Caspase-3	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
thyrotropin-releasing hormone receptor	3	0	0	3
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
Thrombopoietin	2	0	0	2
peripheral myelin protein 22 isoform 1	5	0	0	5
hemoglobin subunit beta	1	0	0	1
huntingtin isoform 2	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	4	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Glutamate receptor 1	1	2	1	4
Glutamate receptor 3	1	2	1	4
Glutamate receptor 4	1	2	1	4
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	2	0	0	2
Asc-type amino acid transporter 1	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	8	0	8
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
Neuraminidase	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	1	0	1
Calmodulin-1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Nischarin	0	1	0	1
Substance-K receptor	0	1	0	1
Heparanase	0	0	1	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	0	0	3
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
DNA polymerase III, partial	2	0	0	2
NPYLR7B	0	0	1	1
Parkin	2	0	0	2
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
mitogen-activated protein kinase 1	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
ras-related protein Rab-9A	3	0	0	3
eyes absent homolog 2 isoform a	1	0	0	1
nuclear receptor ROR-gamma isoform 1	5	0	0	5
M-phase phosphoprotein 8	5	0	0	5
Single-stranded DNA cytosine deaminase	1	0	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
Gonadotropin-releasing hormone receptor	0	1	0	1
Gonadotropin-releasing hormone receptor	0	2	0	2
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Prothrombin	0	1	0	1
Cationic trypsin	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	2	0	0	2
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
thioredoxin glutathione reductase	5	0	0	5
Gag-Pol polyprotein	0	1	0	1
Cytochrome P450 2D6	0	3	1	4
Gag-Pol polyprotein	0	1	0	1
Protease	0	3	0	3
Alpha-1B adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	0	1	1
Beta-1 adrenergic receptor	0	2	1	3
POU domain, class 2, transcription factor 1	0	0	0	1
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	2	1	3
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Beta-lactamase OXA-7	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
BlaVIM-1	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
luciferase	0	0	0	1
Progesterone receptor	0	3	0	4
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Histamine H2 receptor	3	0	0	3
heat shock protein 90, putative	0	0	0	1
NADH-cytochrome b5 reductase 3	0	1	0	1
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
NS5	0	0	1	1
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	3	3
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Transmembrane protease serine 2	0	0	2	2
Polymerase basic protein 2	0	0	1	1
RNA-directed RNA polymerase catalytic subunit	0	0	1	1
Polymerase acidic protein	0	0	1	1
Procathepsin L	0	0	2	2
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Adenosylhomocysteinase	0	0	0	2
Adenosine receptor A1	0	3	0	3
Adenosine receptor A1	0	1	0	1
Genome polyprotein	0	0	1	1
Angiotensin-converting enzyme 2	0	0	2	2
Chain A, Activated Factor Xa Heavy Chain	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Cholinesterase	0	1	0	1
Chain A, Glutathione S-transferase	0	1	0	1
cytochrome P450 2C9 precursor	1	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Tumor necrosis factor	0	0	1	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Thromboxane-A synthase	0	2	0	2
Mitogen-activated protein kinase 1	0	2	0	2
Caspase-1	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Sodium/bile acid cotransporter	0	1	0	1
Cystine/glutamate transporter	0	1	0	1
Chain A, CES1 protein	0	1	0	1
Caspase-7	2	0	0	2
cytochrome P450 2D6 isoform 1	2	0	0	2
interferon gamma precursor	0	0	0	1
caspase-3	2	0	0	2
ubiquitin-conjugating enzyme E2 N	0	1	0	1
streptokinase A precursor	0	0	1	1
Serine/threonine-protein kinase D3	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor	0	0	1	2
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
D(2) dopamine receptor	0	2	0	2
Protein kinase C alpha type	0	1	0	1
D(4) dopamine receptor	0	2	0	2
Protein kinase C eta type	0	1	0	1
Histamine H2 receptor	0	2	0	2
Substance-P receptor	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Alpha-synuclein	1	2	0	3
Delta-type opioid receptor	0	2	0	2
Protein kinase C iota type	0	1	0	1
Melanocortin receptor 3	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Integrin subunit alpha 2b	0	1	0	1
Integrin beta-1	0	1	0	1
Integrin alpha-V	0	1	0	1
Integrin alpha-5	0	1	0	1
Integrin beta-3	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
60 kDa heat shock protein, mitochondrial	0	1	0	1
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
10 kDa heat shock protein, mitochondrial	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Stromelysin-1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	2
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Polyphenol oxidase 2	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Chain A, Arginase 1	0	1	0	1
Cocaine esterase	0	1	0	1
Histone deacetylase 3	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	0	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Histone deacetylase 4	0	2	0	2
Histone deacetylase 1	0	2	0	2
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	2	0	2
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
Vitamin K epoxide reductase complex subunit 1	0	0	0	1
Albumin	0	0	1	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (284)

Protein Targets (995)

Deficiency, Protein C

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (284)

Drugs Studied (123)

Protein Targets (995)