apalcillin profile

ID Source	ID
PubMed CID	6602341
CHEMBL ID	3306902
CHEBI ID	51691
SCHEMBL ID	33854
MeSH ID	M0058939

Synonym
apalcilline [inn-french]
apalcilina [inn-spanish]
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((2r)-(((4-hydroxy-1,5-naphthyridin-3-yl)carbonyl)amino)phenylacetyl)amino)-3,3-dimethyl-7-oxo-, (2s,5r,6r)-
(6r)-6-((r)-2-(4-hydroxy-1,5-naphthyridin-3-carboxamido)-2-phenylacetamido)penicillansaeure
(2s,5r,6r)-6-((r)-2-(4-hydroxy-1,5-naphthyridin-3-carboxamido)-2-phenylacetamido)-3,3-dimethyl-7-oxo-5-thia-1-azabicyclo(3.2.0)heptan-2-carboxylic acid
apalcillinum [inn-latin]
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((((4-hydroxy-1,5-naphthyridin-3-yl)carbonyl)amino)phenylacetyl)amino)-3,3-dimethyl-7-oxo-, (2s-(2-alpha,5-alpha,6-beta(s*)))-
apalcillin
brn 6030446
(2s,5r,6r)-6-((r)-2-(4-hydroxy-1,5-naphthyridin-3-carboxamido)-2-phenylacetamido)-3,3-dimethyl-7-oxo-5-thia-1-azabicyclo(3.2.0)heptan-2-carbonsaeure
apalcillinum
63469-19-2
CHEBI:51691 ,
apalcilline
(2s,5r,6r)-6-{[(2r)-2-{[(4-hydroxy-1,5-naphthyridin-3-yl)carbonyl]amino}-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
apalcilina
6beta-{(2r)-2-[(4-hydroxy-1,5-naphthyridin-3-yl)carboxamido]-2-phenylacetamido}-2,2-dimethylpenam-3alpha-carboxylic acid
(2s,5r,6r)-3,3-dimethyl-7-oxo-6-[[2-[(4-oxo-1h-1,5-naphthyridine-3-carbonyl)amino]-2-phenylacetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2s,5r,6r)-3,3-dimethyl-7-oxo-6-[[(2r)-2-[(4-oxo-1h-1,5-naphthyridine-3-carbonyl)amino]-2-phenylacetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
apalcillin [inn]
unii-3373rt9u7a
3373rt9u7a ,
apalcillin [who-dd]
apalcillin [mi]
SCHEMBL33854
CHEMBL3306902
(2s,5r,6r)-6-(2-(4-hydroxy-1,5-naphthyridine-3-carboxamido)-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Q15633259
DTXSID601016509
pc904
gtpl10759
wy-44,417
wy-44417
diethyl5,5-methylenebis(4-ethyl-3-methyl-2-pyrrolecarboxylate)

Research Excerpts

Overview

Apalcillin is a semi-synthetic broad-spectrum penicillin which is particularly active against Pseudomonas. Apalcillin appears to be a safe, although marginally effective single agent antibiotic for the treatment of complicated urinary tract infections.

Excerpt	Reference	Relevance
"Apalcillin is a new semi-synthetic penicillin of the uridino-penicillin group. "	( [Pharmacokinetic study of apalcillin after infusion]. Akbaraly, JP; Auzerie, J; Bebear, C; Brachet-Liermain, A; Coux, C; Guyot, M; Quentin, C, 1983)	2.01
"Apalcillin is a new semi-synthetic penicillin active on the positive Gram bacteria, and on the enterobacteria, with a particular activity on Pseudomonas and Acinetobacter. "	( [Pharmacokinetics of apalcillin. Study of linearity]. Akbaraly, JP; Auzerie, J; Bebear, C; Brachet-Liermain, A; Coux, C; Guyot, M; Heinzel, G; Quentin, C, 1984)	2.03
"Apalcilline is a new semi-synthetic penicillin. "	( [Apalcillin and renal function]. Fillastre, JP; Frelon, JH; Josse, S; Moulin, B, 1988)	2.63
"Apalcillin appears to be a safe, although marginally effective single agent antibiotic for the treatment of complicated urinary tract infections."	( Apalcillin treatment of complicated urinary tract infections. Lee, M; Ojeda, L; Sharifi, R, 1987)	2.44
"Apalcillin is a new semisynthetic penicillin used as a sodium salt. "	( Is apalcillin nephrotoxic? Fillastre, JP; Frelon, JH; Godin, M; Moulin, B, 1988)	2.34
"Apalcillin is a Pseudomonas-active penicillin with a broad spectrum of antibacterial activity similar to that of piperacillin, except for the greater potency of apalcillin against Acinetobacter spp. "	( Apalcillin [PC-904]: spectrum of activity and beta-lactamase hydrolysis/inhibition. Barry, AL; Jones, RN; Thornsberry, C, 1985)	3.15
"Apalcillin is a semi-synthetic broad-spectrum penicillin which is particularly active against Pseudomonas. "	( [Pharmacokinetics of apalcillin in pediatrics]. Akbaraly, JP; Heinzel, G; Martin, C; Peyraud, J; Sarlangue, J; Sautarel, M, 1985)	2.03

Pharmacokinetics

A pharmacokinetic study of apalcillin was performed in 12 patients in an intensive-care unit. 26 subjects were given increasing doses (500, 1 000, 2 000, 3 000 mg) by the venous route.

Excerpt	Reference	Relevance
" Pharmacokinetic studies were carried out after slow (3 mn) intravenous administration of a single dose of 20 or 30 mg/kg in five categories of infants: premature, dysmature, full term newborn up to 8 days of age, infant aged 8 days to 1 month and infant beyond 1 month."	( [Pharmacokinetics of apalcillin in pediatrics]. Akbaraly, JP; Heinzel, G; Martin, C; Peyraud, J; Sarlangue, J; Sautarel, M, 1985)	0.59
"A pharmacokinetic study of apalcillin was performed in 12 patients in an intensive-care unit."	( Pharmacokinetics of apalcillin in intensive-care patients: study of penetration into the respiratory tract. Akbaraly, JP; Bergogne-Berezin, E; Chastre, J; Gibert, C; Heinzel, G; Pierre, J, 1984)	0.89
" Pharmacokinetic parameters were calculated according to a two-compartment open model."	( Comparative pharmacokinetics of apalcillin and piperacillin. Borner, K; Elvers, A; Koeppe, P; Lode, H, 1984)	0.55
" The linearity study of the pharmacokinetic was carried out on 26 subjects who were given increasing doses (500, 1 000, 2 000, 3 000 mg) of apalcillin by the venous route."	( [Pharmacokinetics of apalcillin. Study of linearity]. Akbaraly, JP; Auzerie, J; Bebear, C; Brachet-Liermain, A; Coux, C; Guyot, M; Heinzel, G; Quentin, C, 1984)	0.79

Compound-Compound Interactions

Excerpt	Reference	Relevance
"The in-vitro synergistic activity of YTR 830, a new beta-lactamase inhibitor, combined with four extended-spectrum penicillins (ticarcillin, piperacillin, mezlocillin and apalcillin) against ticarcillin-resistant clinical isolates of Gram-negative enteric bacilli was compared with that of clavulanate and sulbactam."	( Comparative activities of the beta-lactamase inhibitors YTR 830, clavulanate and sulbactam combined with extended-spectrum penicillins against ticarcillin-resistant Enterobacteriaceae and pseudomonads. Aronoff, SC; Jacobs, MR; Johenning, S; Yamabe, S, 1986)	0.47

Dosage Studied

Excerpt	Relevance	Reference
" At moderate and high dosage levels, PC 904'S efficacy was comparable to carbenicillin's but much less than gentamicin's."	( In vitro and in vivo effect of PC 904, a new broad-spectrum penicillin, on ocular strains of Pseudomonas aeruginosa. Dy-Liacco, J; Mintsioulis, G; Ohno, S; Okumoto, M; Smolin, G, 1978)	0.26
" From these results the recommended dosage is: 20 mg/kg twice daily for premature, dysmature and full term neonates up to 8 days, 30 mg/kg twice daily for infants from 8 days to one month of age, and 30 mg/kg three or four times a day for infants above one month of age."	( [Pharmacokinetics of apalcillin in pediatrics]. Akbaraly, JP; Heinzel, G; Martin, C; Peyraud, J; Sarlangue, J; Sautarel, M, 1985)	0.59
" A dosage of 200 mg/kg/day should allow the treatment of meningitis due to sensitive bacteria and in particular due to Pseudomonas aeruginosa."	( Meningeal penetration of apalcillin in man. Akbaraly, R; Auzerie, J; Bedjaoui, A; Casanova, P; Gallias, H; Raoult, D, 1985)	0.57
" The results obtained show that increasing the dosage has no effect on apalcillin pharmacokinetics, which appear linear."	( [Pharmacokinetics of apalcillin. Study of linearity]. Akbaraly, JP; Auzerie, J; Bebear, C; Brachet-Liermain, A; Coux, C; Guyot, M; Heinzel, G; Quentin, C, 1984)	0.82

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Class	Description
penicillin	Any member of the group of substituted penams containing two methyl substituents at position 2, a carboxylate substituent at position 3 and a carboxamido group at position 6.
1,5-naphthyridine derivative	Any naphthyridine derivative that is a derivative of 1,5-naphthyridine.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	58 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	6 (10.17%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	3 (5.08%)	4.05%
Observational	0 (0.00%)	0.25%
Other	50 (84.75%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
p-aminohippuric acid p-Aminohippuric Acid: The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.. p-aminohippurate : A hippurate that is the conjugate base of p-aminohippuric acid, arising from deprotonation of the carboxy group.. p-aminohippuric acid : An N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow.	1.97	1	0	N-acylglycine	Daphnia magna metabolite
gentamicin Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.	7.88	4	0
penicillin g Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.	2.36	2	0	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope
kanamycin a Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.	1.96	1	0	kanamycins	bacterial metabolite
ampicillin Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.	8.29	58	6	beta-lactam antibiotic; penicillin allergen; penicillin	antibacterial drug
penicillanic acid Penicillanic Acid: A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed). penicillanic acid : A penam that consists of 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane bearing a carboxy group at position 2 and having (2S,5R)-configuration.	1.96	1	0	penicillanic acids
carbenicillin Carbenicillin: Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.. carbenicillin : A penicillin antibiotic having a 6beta-2-carboxy-2-phenylacetamido side-chain.	3.06	5	0	penicillin allergen; penicillin	antibacterial drug
cefazolin Cefazolin: A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.. cefazolin : A first-generation cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups at positions 3 and 7 respectively.	2.36	2	0	beta-lactam antibiotic allergen; cephalosporin; tetrazoles; thiadiazoles	antibacterial drug
amoxicillin Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.. amoxicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.	1.96	1	0	penicillin allergen; penicillin	antibacterial drug
tobramycin Tobramycin: An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.. tobramycin : A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.	1.96	1	0	amino cyclitol glycoside	antibacterial agent; antimicrobial agent; toxin
ticarcillin Ticarcillin: An antibiotic derived from penicillin similar to CARBENICILLIN in action.. ticarcillin : A penicillin compound having a 6beta-[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino side-group.	8.21	6	0	penicillin allergen; penicillin	antibacterial drug
amikacin Amikacin: A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.. amikacin : An amino cyclitol glycoside that is kanamycin A acylated at the N-1 position by a 4-amino-2-hydroxybutyryl group.	1.96	1	0	alpha-D-glucoside; amino cyclitol glycoside; aminoglycoside; carboxamide	antibacterial drug; antimicrobial agent; nephrotoxin
sulbenicillin Sulbenicillin: Semisynthetic penicillin-type antibiotic.. sulbenicillin : A penicillin antibiotic having a 6beta-[phenyl(sulfo)acetamido] side-chain.	1.96	1	0	penicillin
vecuronium bromide Vecuronium Bromide: Monoquaternary homolog of PANCURONIUM. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents.. vecuronium bromide : The organic bromide salt of a 5alpha-androstane compound having 3alpha-acetoxy-, 17beta-acetoxy-, 2beta-piperidinino- and 16beta-N-methylpiperidinium substituents.	3.35	1	1	organic bromide salt; quaternary ammonium salt	muscle relaxant; neuromuscular agent; nicotinic antagonist
piperacillin Piperacillin: Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.. piperacillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carboxamido]-2-phenylacetamido group.	5.85	13	2	penicillin allergen; penicillin	antibacterial drug
cefoperazone Cefoperazone: Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It may be used to treat Pseudomonas infections.. cefoperazone : A semi-synthetic parenteral cephalosporin with a tetrazolyl moiety that confers beta-lactamase resistance.	6.96	1	0	cephalosporin	antibacterial drug
cephalosporin c cephalosporin C: RN given refers to parent cpd; structure in Merck, 9th ed, #1937. cephalosporin C : A cephalosporin antibiotic carrying a 3-acetoxymethyl substituent and a 6-oxo-N(6)-L-lysino group at position 7.	3.66	10	0	cephalosporin	fungal metabolite
glycidyl nitrate glycidyl nitrate: a nitric oxide donor; structure in first source. peptidoglycan : A peptidoglycosaminoglycan formed by alternating residues of beta-(1->4)-linked N-acetylglucosamine and N-acetylmuramic acid {2-amino-3-O-[(S)-1-carboxyethyl]-2-deoxy-D-glucose} residues. Attached to the carboxy group of the muramic acid is a peptide chain of three to five amino acids.	1.96	1	0
imipenem, anhydrous Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.. imipenem : A broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup.	1.96	1	0	beta-lactam antibiotic allergen; carbapenems; zwitterion	antibacterial drug
sulbactam [no description available]	1.96	1	0	penicillanic acids
beta-lactams 2-azetidinone: structure in first source. azetidin-2-one : An unsubstituted beta-lactam compound.. beta-lactam : A lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon.	1.96	1	0	beta-lactam antibiotic allergen; beta-lactam
cefoxitin Cefoxitin: A semisynthetic cephamycin antibiotic resistant to beta-lactamase.. cefoxitin : A semisynthetic cephamycin antibiotic which, in addition to the methoxy group at the 7alpha position, has 2-thienylacetamido and carbamoyloxymethyl side-groups. It is resistant to beta-lactamase.	1.96	1	0	beta-lactam antibiotic allergen; cephalosporin; cephamycin; semisynthetic derivative	antibacterial drug
pancuronium Pancuronium: A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than CURARE but has less effect on the circulatory system and on histamine release.. pancuronium : A steroid ester in which a 5alpha-androstane skeleton is C-3alpha- and C-17beta-disubstituted with acetoxy groups and 2beta- and 16beta-disubstituted with 1-methylpiperidinium-1-yl groups. It is a non-depolarizing curare-mimetic muscle relaxant.	3.35	1	1	acetate ester; steroid ester	cholinergic antagonist; muscle relaxant; nicotinic antagonist
netilmicin Netilmicin: Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity.	1.96	1	0
cefpiramide cefpiramide: antipseudomonal cephalosporin derivative. cefpiramide : A third-generation cephalosporin antibiotic with [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl and (R)-2-{[(4-hydroxy-6-methylpyridin-3-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It has a broad spectrum of antibacterial activity.	2.88	4	0	carboxylic acid; cephalosporin	antibacterial drug
mezlocillin Mezlocillin: Semisynthetic ampicillin-derived acylureido penicillin. It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections.. mezlocillin : A penicillin in which the substituent at position 6 of the penam ring is a (2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido group.	9.6	6	1	penicillin allergen; penicillin	antibacterial drug
cefsulodin Cefsulodin: A pyridinium-substituted semisynthetic, broad-spectrum antibacterial used especially for Pseudomonas infections in debilitated patients.. cefsulodin : A pyridinium-substituted semi-synthetic, broad-spectrum, cephalosporin antibiotic.	2.37	2	0	cephalosporin; organosulfonic acid; primary carboxamide	antibacterial drug
clavulanic acid Clavulanic Acid: A beta-lactam antibiotic produced by the actinobacterium Streptomyces clavuligerus. It is a suicide inhibitor of bacterial beta-lactamase enzymes. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.. clavulanate : The conjugate base of clavulanic acid.. clavulanic acid : Antibiotic isolated from Streptomyces clavuligerus. It acts as a suicide inhibitor of bacterial beta-lactamase enzymes.	1.96	1	0	oxapenam	antibacterial drug; anxiolytic drug; bacterial metabolite; EC 3.5.2.6 (beta-lactamase) inhibitor
azlocillin Azlocillin: A semisynthetic ampicillin-derived acylureido penicillin.. azlocillin : A semisynthetic penicillin having a 6beta-{(2R)-2-[(2-oxoimidazolidine-1-carbonyl)amino]-2-phenylacetyl}amino side-group. It is an antibiotic used in treating infections caused by Pseudomonas aeruginosa, Escherichia coli and Haemophilus influenzae.	4.27	4	1	penicillin allergen; penicillin; semisynthetic derivative	antibacterial drug
ceftazidime monobactam ceftazidime monobactam: ceftazidime monobactam analog; structure given in first source	1.96	1	0
ro13-9904 Ceftriaxone: A broad-spectrum cephalosporin antibiotic and cefotaxime derivative with a very long half-life and high penetrability to meninges, eyes and inner ears.. ceftriaxone : A third-generation cephalosporin compound having 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetylamino and [(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl side-groups.	3.35	1	1

Condition	Relationship Strength	Studies	Trials
Infections, Respiratory [description not available]	1.96	1	0
Respiratory Tract Infections Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.	1.96	1	0
Bacteroides Infections Infections with bacteria of the genus BACTEROIDES.	1.96	1	0
Bacterial Disease [description not available]	2.65	3	0
Bacterial Infections Infections by bacteria, general or unspecified.	2.65	3	0
Biliary Tract Diseases Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.	2.65	3	0
Experimental Pneumococcal Meningitis [description not available]	6.96	1	0
Meningitis, Pneumococcal An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with OTITIS MEDIA; MASTOIDITIS; SINUSITIS; RESPIRATORY TRACT INFECTIONS; sickle cell disease (ANEMIA, SICKLE CELL); skull fractures; and other disorders. Clinical manifestations include FEVER; HEADACHE; neck stiffness; and somnolence followed by SEIZURES; focal neurologic deficits (notably DEAFNESS); and COMA. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)	1.96	1	0
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.36	2	0
Infections, Pseudomonas [description not available]	4.26	4	1
Pseudomonas Infections Infections with bacteria of the genus PSEUDOMONAS.	4.26	4	1
Cystitis Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.	1.95	1	0
Empyema, Gall Bladder [description not available]	1.95	1	0
Cholangitis Inflammation of the biliary ductal system (BILE DUCTS); intrahepatic, extrahepatic, or both.	1.95	1	0
Cholecystitis Inflammation of the GALLBLADDER; generally caused by impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, or other diseases.	1.95	1	0
Thyroiditis Inflammatory diseases of the THYROID GLAND. Thyroiditis can be classified into acute (THYROIDITIS, SUPPURATIVE), subacute (granulomatous and lymphocytic), chronic fibrous (Riedel's), chronic lymphocytic (HASHIMOTO DISEASE), transient (POSTPARTUM THYROIDITIS), and other AUTOIMMUNE THYROIDITIS subtypes.	1.95	1	0
Acute Disease Disease having a short and relatively severe course.	1.95	1	0
Bronchitis Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.	1.95	1	0
Urinary Tract Infections Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.	8.75	2	1
Electrolytes Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)	2.37	2	0
Recrudescence [description not available]	3.35	1	1
E coli Infections [description not available]	3.35	1	1
Infections, Proteus [description not available]	3.35	1	1
Escherichia coli Infections Infections with bacteria of the species ESCHERICHIA COLI.	3.35	1	1
Kidney Diseases Pathological processes of the KIDNEY or its component tissues.	1.97	1	0
Bile Duct Diseases Diseases in any part of the ductal system of the BILIARY TRACT from the smallest BILE CANALICULI to the largest COMMON BILE DUCT.	3.35	1	1
Gallstone Disease [description not available]	3.35	1	1
Complication, Postoperative [description not available]	3.35	1	1
Cholelithiasis Presence or formation of GALLSTONES in the BILIARY TRACT, usually in the gallbladder (CHOLECYSTOLITHIASIS) or the common bile duct (CHOLEDOCHOLITHIASIS).	3.35	1	1
Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.	3.35	1	1
Thrombopenia [description not available]	1.97	1	0
Thrombocytopenia A subnormal level of BLOOD PLATELETS.	6.97	1	0
Blood Poisoning [description not available]	1.96	1	0
Neutropenia A decrease in the number of NEUTROPHILS found in the blood.	1.96	1	0
Sepsis Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.	1.96	1	0
Infection, Wound [description not available]	1.96	1	0
Burns Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.	1.96	1	0
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	1.96	1	0

apalcillin

Cross-References

Synonyms (34)

Research Excerpts

Overview

Pharmacokinetics

Compound-Compound Interactions

Dosage Studied

Drug Classes (2)

Research

Studies (58)

Study Types

apalcillin

Cross-References

Synonyms (34)

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