Page last updated: 2024-09-28

Conjunctivitis, Acute Hemorrhagic

A highly contagious disease characterized by subconjunctival hemorrhage, sudden swelling of the eyelids and congestion, redness, and pain in the eye. Epidemic conjunctivitis caused by Enterovirus 70 (EV-70) was first described in Africa in 1969. It is caused also by Coxsackievirus A24 variant (CA24v). Epidemics by this organism have appeared most frequently in Asia.

Synonyms(1)

Synonym
Conjunctivitis, Acute Hemorrhagic

Research Excerpts

Overview

ExcerptReference
"Acute hemorrhagic conjunctivitis is associated with enteroviruses."( Bilaiya, H; Deolankar, RP; Fulmali, PV; Gopalkrishna, V; Kolhapure, RM; Patil, PR, 2007)

Treatment

ExcerptReference
"Use of topical corticosteroids to treat acute hemorrhagic conjunctivitis may predispose an already compromised cornea to develop microbial keratitis and such a practice should be discouraged."( Anand, JR; Chand, M; Sharma, N; Tabin, GC; Vajpayee, M; Vajpayee, RB, 1998)

Research

Studies (28)

TimeframeStudies, This Condition (%)All Conditions %
pre-19906 (21.43)23.3326
1990's10 (35.71)12.5806
2000's5 (17.86)18.1394
2010's5 (17.86)28.8240
2020's2 (7.14)9.53
DrugIndicatedRelationship StrengthStudiesTrials
pleconaril0low10
framycetin0low10
oxazoles0low10
chlorine0low10
amoxicillin0low10
arildone0low10
zoledronic acid0low10
biotin0low10
n-acetylneuraminic acid0low20
cefotaxime0low10
viroxime0low10
enviradene0low10
amoxicillin-potassium clavulanate combination0low10
oxadiazoles0low10
clove0low10
ro13-99040low10
piroxicam0medium11
exudates0low10
eye0low20

Protein Targets (300)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Beta-lactamase2002
Chain A, 2-oxoglutarate Oxygenase2002
Beta-lactamase 0001
Beta-lactamase 0002
Beta-lactamase 0002
Beta-lactamase 0002
AR protein2002
apical membrane antigen 1, AMA12002
estrogen nuclear receptor alpha4004
Beta-lactamase 0002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
DNA polymerase kappa isoform 11001
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Bile salt export pump0101
Bile salt export pump0505
Beta-lactamase SHV-10002
Beta-lactamase SHV-10002
Cytochrome P450 2C9 0404
Beta-lactamase0002
Kappa-type opioid receptor0002
Solute carrier family 15 member 10202
Solute carrier family 15 member 10101
Cytochrome P450 2J20303
B2 metallo-beta-lactamase 0002
Solute carrier family 15 member 20202
Beta-lactamase 0002
Beta-lactamase 0002
Solute carrier family 15 member 20202
Beta-lactamase 0002
Beta-lactamase 0002
Canalicular multispecific organic anion transporter 10404
Chain A, Avidin0011
Chain A, Protein (streptavidin)0011
Chain B, Protein (streptavidin)0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin Complex With Biotin0011
Chain D, Circularly Permuted Core-streptavidin E51/a460011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Avidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, JmjC domain-containing histone demethylation protein 3A2002
RAR-related orphan receptor gamma2002
nonstructural protein 10101
green fluorescent protein, partial0101
vitamin D3 receptor isoform VDRA1001
insulin-degrading enzyme isoform 10011
Streptavidin0011
Receptor-type tyrosine-protein phosphatase beta0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0101
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0101
Solute carrier family 22 member 60202
Albumin0022
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Beta-lactamase Toho-10001
Solute carrier family 22 member 60303
Solute carrier family 22 member 70101
Metallo-beta-lactamase0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
BlaVIM-1 0001
Beta-lactamase 0001
Solute carrier family 22 member 80202
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Histamine H3 receptor0001
Beta-lactamase class B VIM-2 0001
Solute carrier family 22 member 110202
Solute carrier family 22 member 80101
Beta-lactamase VIM-1 0001
Solute carrier family 22 member 70101
Motilin receptor0011
acid sphingomyelinase1001
TDP1 protein2002
GLI family zinc finger 31001
estrogen-related nuclear receptor alpha2002
thyroid hormone receptor beta isoform 22002
low molecular weight phosphotyrosine protein phosphatase isoform c0101
serine/threonine-protein kinase PLK11001
geminin2002
streptokinase A precursor0011
Motilin receptor0112
Rap guanine nucleotide exchange factor 31001
30S ribosomal protein S60213
30S ribosomal protein S70213
50S ribosomal protein L150213
ATP-dependent translocase ABCB10202
ATP-dependent translocase ABCB10202
Cytochrome P450 3A40303
60 kDa chaperonin0101
50S ribosomal protein L100213
50S ribosomal protein L110213
50S ribosomal protein L7/L120213
50S ribosomal protein L190213
50S ribosomal protein L10213
50S ribosomal protein L200213
50S ribosomal protein L270213
50S ribosomal protein L280213
50S ribosomal protein L290213
50S ribosomal protein L310213
50S ribosomal protein L31 type B0213
50S ribosomal protein L320213
50S ribosomal protein L330213
50S ribosomal protein L340213
50S ribosomal protein L350213
50S ribosomal protein L360213
30S ribosomal protein S100213
30S ribosomal protein S110213
30S ribosomal protein S120213
30S ribosomal protein S130213
30S ribosomal protein S160213
30S ribosomal protein S180213
30S ribosomal protein S190213
30S ribosomal protein S200213
30S ribosomal protein S20213
30S ribosomal protein S30213
30S ribosomal protein S40213
30S ribosomal protein S50213
30S ribosomal protein S80213
30S ribosomal protein S90213
50S ribosomal protein L130213
50S ribosomal protein L140213
50S ribosomal protein L160213
50S ribosomal protein L230213
30S ribosomal protein S150213
50S ribosomal protein L170213
50S ribosomal protein L210213
50S ribosomal protein L300213
50S ribosomal protein L60213
30S ribosomal protein S140213
30S ribosomal protein S170213
30S ribosomal protein S10213
50S ribosomal protein L180213
60 kDa heat shock protein, mitochondrial0101
Chitinase B0101
ATP-dependent translocase ABCB10202
Low molecular weight phosphotyrosine protein phosphatase0101
50S ribosomal protein L20213
50S ribosomal protein L30213
50S ribosomal protein L240213
50S ribosomal protein L40213
50S ribosomal protein L220213
10 kDa heat shock protein, mitochondrial0101
50S ribosomal protein L50213
30S ribosomal protein S210213
50S ribosomal protein L250213
Potassium voltage-gated channel subfamily H member 20101
Cytochrome P450 1B10101
Thiosulfate sulfurtransferase0101
Lanosterol 14-alpha demethylase0101
50S ribosomal protein L36 20213
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Multidrug and toxin extrusion protein 10101
Menin0011
Lecithin retinol acyltransferase0101
Lethal factor0101
Protein Rev 0011
Aminoglycoside 3'-phosphotransferase 0001
Tyrosyl-DNA phosphodiesterase 10101
Sialidase-40101
Sialidase-10101
Sialidase-30101
Sialidase-20101
Luciferase1001
thioredoxin reductase1001
15-lipoxygenase, partial1001
phosphopantetheinyl transferase1001
ATAD5 protein, partial1001
NFKB1 protein, partial1001
GLS protein1001
nuclear receptor subfamily 1, group I, member 32002
EWS/FLI fusion protein2002
nonstructural protein 11001
retinoic acid nuclear receptor alpha variant 12002
pregnane X nuclear receptor2002
G2002
Parkin1001
bromodomain adjacent to zinc finger domain 2B1001
arylsulfatase A1001
euchromatic histone-lysine N-methyltransferase 21001
aryl hydrocarbon receptor1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
Bloom syndrome protein isoform 11001
cytochrome P450 2D6 isoform 11001
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
chromobox protein homolog 11001
potassium voltage-gated channel subfamily H member 2 isoform d1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
nuclear factor erythroid 2-related factor 2 isoform 11001
cytochrome P450 3A4 isoform 11001
muscleblind-like protein 1 isoform 11001
histone acetyltransferase KAT2A isoform 11001
muscarinic acetylcholine receptor M11001
Gamma-aminobutyric acid receptor subunit pi1001
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Prostaglandin G/H synthase 10101
Polyunsaturated fatty acid 5-lipoxygenase0101
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Prostaglandin G/H synthase 10101
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Prostaglandin G/H synthase 20101
Prostaglandin G/H synthase 2 0101
Alpha-synuclein1001
Histamine H2 receptor1001
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Disintegrin and metalloproteinase domain-containing protein 171001
TAR DNA-binding protein 431001
Prostaglandin G/H synthase 1 0101
GABA theta subunit1001
Inositol hexakisphosphate kinase 12002
Gamma-aminobutyric acid receptor subunit epsilon1001
cytochrome P450 2C9, partial2002
ATP-dependent phosphofructokinase1001
progesterone receptor1001
cytochrome P450 family 3 subfamily A polypeptide 41001
cytochrome P450 2D61001
peroxisome proliferator-activated receptor delta1001
thyroid stimulating hormone receptor1001
Nuclear receptor subfamily 1 group I member 20011
Cytochrome P450 1A20101
Cytochrome P450 2D60101
Cytochrome P450 2C190101
Genome polyprotein 0012
Genome polyprotein0011
Genome polyprotein 0011
Fumarate hydratase1001
polyprotein1001
lamin isoform A-delta101001
Butyrophilin subfamily 3 member A10012
Carbonic anhydrase 120101
Geranylgeranyl pyrophosphate synthase0203
Carbonic anhydrase 10101
Carbonic anhydrase 20101
72 kDa type IV collagenase0101
Farnesyl pyrophosphate synthase0202
Matrix metalloproteinase-90101
Neutrophil collagenase0101
Farnesyl diphosphate synthase0101
Matrix metalloproteinase-140101
Farnesyl pyrophosphate synthase 0202
Geranylgeranyl pyrophosphate synthase0202
Carbonic anhydrase 90101
Farnesyl pyrophosphate synthase 0101
H0101
Carbonic anhydrase 140101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]