Conjunctivitis, Acute Hemorrhagic

A highly contagious disease characterized by subconjunctival hemorrhage, sudden swelling of the eyelids and congestion, redness, and pain in the eye. Epidemic conjunctivitis caused by Enterovirus 70 (EV-70) was first described in Africa in 1969. It is caused also by Coxsackievirus A24 variant (CA24v). Epidemics by this organism have appeared most frequently in Asia.

Synonyms(1)

Synonym
Conjunctivitis, Acute Hemorrhagic

Research Excerpts

Overview

Excerpt	Reference
"Acute hemorrhagic conjunctivitis is associated with enteroviruses."	( Bilaiya, H; Deolankar, RP; Fulmali, PV; Gopalkrishna, V; Kolhapure, RM; Patil, PR, 2007)

Treatment

Excerpt	Reference
"Use of topical corticosteroids to treat acute hemorrhagic conjunctivitis may predispose an already compromised cornea to develop microbial keratitis and such a practice should be discouraged."	( Anand, JR; Chand, M; Sharma, N; Tabin, GC; Vajpayee, M; Vajpayee, RB, 1998)

Research

Studies (28)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	6 (21.43)	23.3326
1990's	10 (35.71)	12.5806
2000's	5 (17.86)	18.1394
2010's	5 (17.86)	28.8240
2020's	2 (7.14)	9.53

Drug	Relationship Strength	Studies	Trials
pleconaril	low	1	0
framycetin	low	1	0
oxazoles	low	1	0
chlorine	low	1	0
amoxicillin	low	1	0
arildone	low	1	0
zoledronic acid	low	1	0
biotin	low	1	0
n-acetylneuraminic acid	low	2	0
cefotaxime	low	1	0
viroxime	low	1	0
enviradene	low	1	0
amoxicillin-potassium clavulanate combination	low	1	0
oxadiazoles	low	1	0
clove	low	1	0
ro13-9904	low	1	0
piroxicam	medium	1	1
exudates	low	1	0
eye	low	2	0

Protein Targets (300)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, Beta-lactamase	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
AR protein	2	0	0	2
apical membrane antigen 1, AMA1	2	0	0	2
estrogen nuclear receptor alpha	4	0	0	4
Beta-lactamase	0	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Bile salt export pump	0	1	0	1
Bile salt export pump	0	5	0	5
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase SHV-1	0	0	0	2
Cytochrome P450 2C9	0	4	0	4
Beta-lactamase	0	0	0	2
Kappa-type opioid receptor	0	0	0	2
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Cytochrome P450 2J2	0	3	0	3
B2 metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Canalicular multispecific organic anion transporter 1	0	4	0	4
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
RAR-related orphan receptor gamma	2	0	0	2
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Albumin	0	0	2	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Solute carrier family 22 member 6	0	3	0	3
Solute carrier family 22 member 7	0	1	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	2	0	2
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Solute carrier family 22 member 11	0	2	0	2
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase VIM-1	0	0	0	1
Solute carrier family 22 member 7	0	1	0	1
Motilin receptor	0	0	1	1
acid sphingomyelinase	1	0	0	1
TDP1 protein	2	0	0	2
GLI family zinc finger 3	1	0	0	1
estrogen-related nuclear receptor alpha	2	0	0	2
thyroid hormone receptor beta isoform 2	2	0	0	2
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
geminin	2	0	0	2
streptokinase A precursor	0	0	1	1
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
30S ribosomal protein S6	0	2	1	3
30S ribosomal protein S7	0	2	1	3
50S ribosomal protein L15	0	2	1	3
ATP-dependent translocase ABCB1	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
Cytochrome P450 3A4	0	3	0	3
60 kDa chaperonin	0	1	0	1
50S ribosomal protein L10	0	2	1	3
50S ribosomal protein L11	0	2	1	3
50S ribosomal protein L7/L12	0	2	1	3
50S ribosomal protein L19	0	2	1	3
50S ribosomal protein L1	0	2	1	3
50S ribosomal protein L20	0	2	1	3
50S ribosomal protein L27	0	2	1	3
50S ribosomal protein L28	0	2	1	3
50S ribosomal protein L29	0	2	1	3
50S ribosomal protein L31	0	2	1	3
50S ribosomal protein L31 type B	0	2	1	3
50S ribosomal protein L32	0	2	1	3
50S ribosomal protein L33	0	2	1	3
50S ribosomal protein L34	0	2	1	3
50S ribosomal protein L35	0	2	1	3
50S ribosomal protein L36	0	2	1	3
30S ribosomal protein S10	0	2	1	3
30S ribosomal protein S11	0	2	1	3
30S ribosomal protein S12	0	2	1	3
30S ribosomal protein S13	0	2	1	3
30S ribosomal protein S16	0	2	1	3
30S ribosomal protein S18	0	2	1	3
30S ribosomal protein S19	0	2	1	3
30S ribosomal protein S20	0	2	1	3
30S ribosomal protein S2	0	2	1	3
30S ribosomal protein S3	0	2	1	3
30S ribosomal protein S4	0	2	1	3
30S ribosomal protein S5	0	2	1	3
30S ribosomal protein S8	0	2	1	3
30S ribosomal protein S9	0	2	1	3
50S ribosomal protein L13	0	2	1	3
50S ribosomal protein L14	0	2	1	3
50S ribosomal protein L16	0	2	1	3
50S ribosomal protein L23	0	2	1	3
30S ribosomal protein S15	0	2	1	3
50S ribosomal protein L17	0	2	1	3
50S ribosomal protein L21	0	2	1	3
50S ribosomal protein L30	0	2	1	3
50S ribosomal protein L6	0	2	1	3
30S ribosomal protein S14	0	2	1	3
30S ribosomal protein S17	0	2	1	3
30S ribosomal protein S1	0	2	1	3
50S ribosomal protein L18	0	2	1	3
60 kDa heat shock protein, mitochondrial	0	1	0	1
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
50S ribosomal protein L2	0	2	1	3
50S ribosomal protein L3	0	2	1	3
50S ribosomal protein L24	0	2	1	3
50S ribosomal protein L4	0	2	1	3
50S ribosomal protein L22	0	2	1	3
10 kDa heat shock protein, mitochondrial	0	1	0	1
50S ribosomal protein L5	0	2	1	3
30S ribosomal protein S21	0	2	1	3
50S ribosomal protein L25	0	2	1	3
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
50S ribosomal protein L36 2	0	2	1	3
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
Lethal factor	0	1	0	1
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
Luciferase	1	0	0	1
thioredoxin reductase	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
ATAD5 protein, partial	1	0	0	1
NFKB1 protein, partial	1	0	0	1
GLS protein	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
EWS/FLI fusion protein	2	0	0	2
nonstructural protein 1	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	2	0	0	2
pregnane X nuclear receptor	2	0	0	2
G	2	0	0	2
Parkin	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
arylsulfatase A	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	1	0	0	1
aryl hydrocarbon receptor	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
chromobox protein homolog 1	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Alpha-synuclein	1	0	0	1
Histamine H2 receptor	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
TAR DNA-binding protein 43	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
GABA theta subunit	1	0	0	1
Inositol hexakisphosphate kinase 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
cytochrome P450 2C9, partial	2	0	0	2
ATP-dependent phosphofructokinase	1	0	0	1
progesterone receptor	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	1	0	0	1
cytochrome P450 2D6	1	0	0	1
peroxisome proliferator-activated receptor delta	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Genome polyprotein	0	0	1	2
Genome polyprotein	0	0	1	1
Genome polyprotein	0	0	1	1
Fumarate hydratase	1	0	0	1
polyprotein	1	0	0	1
lamin isoform A-delta10	1	0	0	1
Butyrophilin subfamily 3 member A1	0	0	1	2
Carbonic anhydrase 12	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	3
Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Matrix metalloproteinase-9	0	1	0	1
Neutrophil collagenase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Carbonic anhydrase 9	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
Carbonic anhydrase 14	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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