Deficiency of GP 2b 3a Complex

A congenital bleeding disorder with prolonged bleeding time, absence of aggregation of platelets in response to most agents, especially ADP, and impaired or absent clot retraction. Platelet membranes are deficient in or have a defect in the glycoprotein IIb-IIIa complex (PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX).

Synonym
Thrombasthenia of Glanzmann and Naegeli
Thrombasthenia
Platelet Glycoprotein IIb-IIIa Deficiency
Platelet Glycoprotein 2b-3a Deficiency
Platelet Fibrinogen Receptor, Deficiency of
Glanzmann Thrombasthenia, Type A
Deficiency of GP 2b 3a Complex
GP IIb-IIIa Complex, Deficiency Of
Glycoprotein Complex IIb-IIIa, Deficiency Of
Glanzmann Thrombasthenia

Excerpt	Reference
"Glanzmann's Thrombasthenia is a rare inherited disorder of platelet aggregation with normal platelet count and humoral coagulation."	( Berger, K; Dörr, HG; Klinge, J; Merkle, E; Schnell, K; Wenzel, D, 1992)
"Glanzmann thrombasthenia is an autosomal recessive bleeding disorder characterized by a decrease or absence of functional platelet glycoprotein (GP) IIb-IIIa (alpha IIb beta 3) integrin receptors."	( Coller, BS; Lyman, S; Newman, PJ; Seligsohn, U, 1991)
"Glanzmann's thrombasthenia is characterized by the absence of platelet aggregation and reduced levels of GP IIb-IIIa complexes and platelet fibrinogen."	( Bouillot, C; Disdier, M; Dubernard, V; Legrand, C; Nurden, AT; Pidard, D, 1989)
"Glanzmann's thrombasthenia is a congenital bleeding abnormality characterized by absent platelet aggregation due to the failure of fibrinogen to bind to activated thrombasthenic platelets."	( Berndt, MC; Castaldi, PA; Fournier, DJ; Kabral, A, 1989)
"Glanzmann's thrombasthenia is an inherited bleeding disorder that results from a deficit of glycoprotein (GP) IIb-IIIa complexes in platelets."	( Diaz-Ricart, M; Jallu, V; Nurden, AT; Ordinas, A; Pico, M; Vezon, G, 1994)
"Glanzmann's thrombasthenia is an autosomal recessive, inherited platelet function disorder."	( Choudhry, VP; Kashyap, R; Kriplani, A; Saxena, R; Takkar, D, 1997)
"Glanzmann thrombasthenia is an inherited bleeding disorder due to a functional reduction or absence of platelet GPIIb/IIIa (alphaIIbbeta3) integrin receptors."	( Chen, F; Coller, BS; French, DL; Grimaldi, CM; Weiss, HJ; Wu, C, 1998)
"Glanzmann thrombasthenia is an inherited bleeding disorder characterized by qualitative or quantitative defects of the platelet-specific integrin, alphaIIbbeta(3)."	( Bell, WR; Bray, PF; French, DL; Griffith, M; Ishizawa, L; Olsen, JC; Steeber, DA; White, GC; Wilcox, DA, 2000)
"Type I Glanzmann's thrombasthenia is a rare congenital platelet function disorder, characterized by undetectable platelet membrane glycoprotein IIb-IIIa (GPIIb-IIIa)."	( Charpentier, B; D'Oiron, R; Debré, M; Dreyfus, M; Fressinaud, E; Guillet, B; Kaplan, C; Kriaa, F; Lambert, T; Laurian, Y; Martin, I; Proulle, V; Tchernia, G, 2002)
"Glanzmann's thrombasthenia is a congenitally acquired platelet disorder with an autosomal recessive mode of inheritance."	( Chanana, C; Deka, D; Malhotra, N, 2006)
"Glanzmann's thrombasthenia is a congenital hemorrhagic disorder transmitted as an autosomal recessive trait and characterized by altered production and/or assembly of the platelet membrane glycoprotein IIb/IIIa receptor."	( Barbato, L; Casati, V; D'Angelo, A; Grasso, MA; Panzeri, E; Rossi, E; Spagnolo, S, 2006)
"Glanzmann thrombasthenia is a rare congenital platelet disorder characterized by spontaneous mucocutaneous bleeding and severe bleeding complications during major surgery."	( Heindl, B; Lison, S; Spannagl, M, 2009)
"Glanzmann thrombasthenia is a rare autosomal recessive genetic disease characterized by platelet aggregation dysfunction caused by a congenital defect of platelet membrane glycoprotein IIb/IIIa (integrin αIIbβ3)."	( Xu, M; Xu, Q; Zhang, L; Zhang, X; Zhou, M, 2021)
"Thrombasthenia is a disease in which bleeding occurs in the mucosa and skin due to platelet dysfunction."	( Aoki, Y; Fukuta, M; Kanno, S; Kato, H; Nakamura, Y; Ohtaki, J, 2023)

Excerpt	Reference
"She was diagnosed with thrombasthenia and was being treated with oral tranexamic acid and carbazochrome."	( Aoki, Y; Fukuta, M; Kanno, S; Kato, H; Nakamura, Y; Ohtaki, J, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	44 (14.43)	23.3326
1990's	108 (35.41)	12.5806
2000's	92 (30.16)	18.1394
2010's	46 (15.08)	28.8240
2020's	15 (4.92)	9.53

Drug	Relationship Strength	Studies	Trials
phosphoserine	low	1	0
citric acid, anhydrous	low	1	0
aminocaproic acid	low	3	0
cytosine	low	2	0
glycine	low	3	0
dalteparin	low	2	0
niacinamide	low	1	0
palmitic acid	low	1	0
urea	low	1	0
aspirin	medium	8	1
azathioprine	low	1	0
caffeine	low	1	0
dipyridamole	low	1	0
flumazenil	low	4	0
thalidomide	low	1	0
ticlopidine	low	2	0
tranexamic acid	low	15	0
prednisolone	low	1	0
lynestrenol	low	1	0
prednisone	low	1	0
alanine	low	3	0
serine	low	4	0
aspartic acid	low	2	0
glutamine	low	2	0
lysine	low	2	0
ethinyl estradiol	low	1	0
adenosine diphosphate	medium	34	1
galactose	low	1	0
edetic acid	low	5	0
tyrosine	low	8	0
leucine	low	6	0
ethyl methanesulfonate	low	1	0
egtazic acid	low	1	0
norethindrone	low	2	0
asparagine	low	2	0
histidine	low	2	0
medroxyprogesterone acetate	low	1	0
valine	low	2	0
tryptophan	low	2	0
isoleucine	low	3	0
arginine	low	4	0
thiazoles	low	1	0
thiazolidines	low	1	0
levonorgestrel	low	1	0
fluorescein-5-isothiocyanate	low	1	0
mannose	low	1	0
manganese	low	2	0
technetium	low	1	0
gold	low	1	0
barium sulfate	low	1	0
tetradecanoylphorbol acetate	low	7	0
phosphotyrosine	low	5	0
phenyl acetate	low	1	0
amoxicillin	low	1	0
1,3,4,6-tetrachloro-3 alpha,6 alpha-diphenylglycoluril	low	1	0
clopidogrel	low	2	0
tirofiban	low	2	0
adenosine	low	1	0
leupeptin	low	1	0
fibrinogen	low	92	0
arginyl-glycyl-aspartic acid	low	9	0
arginyl-glycyl-aspartyl-serine	low	12	0
1-hexadecyl-2-acetyl-glycero-3-phosphocholine	low	3	0
thromboxanes	low	1	0
glycyl-arginyl-glycyl-aspartyl-seryl-proline	low	1	0
rges peptide	low	1	0
imatinib mesylate	low	1	0
glycyl-prolyl-arginyl-proline	low	1	0
glycyl-arginyl-glycyl-aspartyl-serine	low	1	0
methotrexate	low	1	0
d-arg-gly-asp-trp	low	2	0
thrombin receptor peptide sfllrnp	low	1	0
fk 633	low	1	0
5'-(4-fluorosulfonylbenzoyl)adenosine	low	1	0
proline	low	8	0
biotin	low	1	0
gr 144053	low	1	0
bortezomib	medium	1	1
leupeptins	low	1	0
fibrin	low	17	0
adenosine 5'-o-(3-thiotriphosphate)	low	1	0
arachidonic acid	low	7	0
tacrolimus	low	1	0
mycophenolic acid	low	1	0
eptifibatide	low	7	0
ag-213	low	1	0
cystine	low	1	0
lamifiban	low	1	0
arginyl-glycyl-aspartyl-phenylalanine	low	1	0
sodium dodecyl sulfate	low	1	0
alpha-chymotrypsin	low	3	0
dinoprostone	low	1	0
vitamin k semiquinone radical	low	1	0
thromboxane a2	low	4	0
alprostadil	low	1	0
thromboxane b2	low	3	0
deamino arginine vasopressin	low	9	0
enprostil	low	1	0
cytochalasin b	low	1	0
15-hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic acid	low	2	0
cysteine	low	5	0
latrunculin b	low	1	0
beraprost	low	1	0
phosphocreatine	low	1	0
chlorhexidine	low	1	0
jasplakinolide	low	1	0
acebutolol	low	1	0
losartan potassium	low	1	0
calcimycin	low	6	0
sepharose	low	1	0
thrombin receptor peptide (42-55)	low	1	0
oligonucleotides	low	2	0
ristocetin	low	19	0
calpain	low	3	0
piperidines	low	1	0
warfarin	low	4	0
epidermal growth factor	low	1	0
kaolinite	low	1	0
hirudin	low	1	0
sta 2	low	1	0
cyclosporine	low	1	0
cytochalasin d	low	6	0
apyrase	low	2	0
thromboplastin	low	9	0
dacarbazine	low	1	0
ferric carboxymaltose	low	1	0
concanavalin a	low	2	0

Protein Targets (1,045)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	23	0	0	23
Chain A, Cruzipain	8	0	0	8
regulator of G-protein signaling 4	8	0	0	8
Platelet-activating factor receptor	0	2	0	2
Inositol monophosphatase 1	5	0	0	5
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
AR protein	30	0	0	30
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
glucocorticoid receptor [Homo sapiens]	27	0	0	27
retinoid X nuclear receptor alpha	21	0	0	21
estrogen nuclear receptor alpha	35	0	0	35
NPYLR7B	0	0	2	2
arylsulfatase A	10	0	0	10
IDH1	13	0	0	13
Histone H2A.x	13	0	0	13
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	7	0	0	7
flap endonuclease 1	9	0	0	9
nuclear receptor ROR-gamma isoform 1	10	0	0	10
peripheral myelin protein 22	13	0	0	13
survival motor neuron protein isoform d	9	0	0	9
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	15	0	0	15
Rap guanine nucleotide exchange factor 3	6	0	0	6
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	4	0	4
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Insulin receptor	0	1	0	2
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	2	2	5
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	5	2	8
Heat shock 70 kDa protein 1A	0	2	1	3
Heat shock cognate 71 kDa protein	0	0	2	2
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	3	0	3
Endoplasmin	0	1	1	3
Glutamate receptor 2	15	1	0	16
Inosine-5'-monophosphate dehydrogenase 1	0	3	0	3
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	2	2
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	4	1	8
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	5	3	10
Adenosine receptor A2b	0	1	1	4
Adenosine receptor A2b	0	3	1	5
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	3	3	9
Adenosine receptor A2a	0	4	1	9
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	4	0	5
Adenosine receptor A1	0	1	1	2
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	4	0	5
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	4	0	4
Phosphatidylinositol 4-kinase type 2-alpha	0	4	0	5
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	4	0	5
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Chain A, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	2	2
Chain D, DNA polymerase III subunit gamma	0	0	2	2
Mu-type opioid receptor	0	2	2	4
Delta-type opioid receptor	0	0	2	2
Kappa-type opioid receptor	0	2	2	4
P2Y purinoceptor 2	0	0	2	2
P2X purinoceptor 1	0	0	2	2
P2Y purinoceptor 1	0	0	2	2
P2X purinoceptor 2	0	0	1	1
P2X purinoceptor 1	0	0	2	2
P2X purinoceptor 4	0	0	2	2
P2X purinoceptor 5	0	0	2	2
P2X purinoceptor 6	0	0	2	2
P2X purinoceptor 3	0	0	2	2
P2Y purinoceptor 11	0	0	2	2
P2Y purinoceptor 12	0	0	2	2
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
HPr kinase/phosphorylase	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Endoplasmin	0	1	1	2
P2Y purinoceptor 1	0	0	1	1
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	2	0	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, HADH2 protein	9	0	0	9
Chain B, HADH2 protein	9	0	0	9
Chain A, 2-oxoglutarate Oxygenase	12	0	0	12
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
Luciferase	6	0	0	6
RGS12	2	0	0	2
15-lipoxygenase, partial	6	0	0	6
phosphopantetheinyl transferase	11	0	0	11
NFKB1 protein, partial	3	0	0	3
TDP1 protein	24	0	0	24
Microtubule-associated protein tau	9	0	0	9
aldehyde dehydrogenase 1 family, member A1	18	0	0	18
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
thyroid stimulating hormone receptor	12	0	0	12
glucocerebrosidase	4	0	0	4
alpha-galactosidase	4	0	0	4
Bloom syndrome protein isoform 1	13	0	0	13
cytochrome P450 2D6 isoform 1	5	0	0	5
lysosomal alpha-glucosidase preproprotein	4	0	0	4
cellular tumor antigen p53 isoform a	5	0	0	5
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
cytochrome P450 2C19 precursor	7	0	0	7
cytochrome P450 2C9 precursor	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	2	0	0	2
DNA polymerase kappa isoform 1	14	0	0	14
cytochrome P450 3A4 isoform 1	10	0	0	10
muscarinic acetylcholine receptor M1	8	0	0	8
lethal factor (plasmid)	12	0	0	12
pyruvate kinase PKM isoform b	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	10	2	0	12
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
Macrophage colony-stimulating factor 1 receptor	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Dipeptidyl peptidase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	10	2	0	12
Protein kinase C alpha type	0	2	1	3
Gamma-aminobutyric acid receptor subunit delta	10	2	0	12
Gamma-aminobutyric acid receptor subunit gamma-2	10	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-5	10	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-3	10	2	0	12
Protein-glutamine gamma-glutamyltransferase 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	10	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-2	10	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-4	10	2	0	12
Gamma-aminobutyric acid receptor subunit gamma-3	10	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-6	10	2	0	12
M-phase inducer phosphatase 1	0	1	0	1
Tyrosine-protein kinase SYK	0	1	0	1
Histamine H2 receptor	5	0	0	5
Tyrosine-protein kinase JAK3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	10	3	0	13
Gamma-aminobutyric acid receptor subunit beta-3	10	2	0	12
Gamma-aminobutyric acid receptor subunit beta-2	10	2	0	12
Dynamin-1	0	1	0	1
Receptor-type tyrosine-protein phosphatase eta	0	1	0	1
Receptor protein-tyrosine kinase	0	1	0	1
GABA theta subunit	10	2	0	12
Gamma-aminobutyric acid receptor subunit epsilon	10	2	0	12
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	12	0	0	12
Carbonic anhydrase 1	0	4	0	12
Carbonic anhydrase 2	0	4	1	13
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	3
Glutamate receptor ionotropic, NMDA 1	0	5	1	9
Proton-coupled amino acid transporter 1	0	8	0	9
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	3
peroxisome proliferator activated receptor gamma	17	0	0	17
ATP-binding cassette sub-family C member 3	0	16	0	16
Multidrug resistance-associated protein 4	0	16	0	19
Bile salt export pump	0	22	0	22
Cellular tumor antigen p53	20	0	0	20
Thromboxane-A synthase	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostacyclin receptor	0	3	2	5
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Solute carrier organic anion transporter family member 2A1	0	0	0	4
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Canalicular multispecific organic anion transporter 1	0	15	0	15
Solute carrier organic anion transporter family member 2A1	0	0	0	3
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
Chain A, PLASMINOGEN	0	0	2	2
Chain A, PLASMINOGEN	0	0	2	2
Chain A, Ferritin light chain	9	0	0	9
Chain A, Apolipoprotein	0	0	1	1
ATAD5 protein, partial	9	0	0	9
cytochrome P450 family 3 subfamily A polypeptide 4	15	0	0	15
EWS/FLI fusion protein	12	0	0	12
nonstructural protein 1	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	23	0	0	23
D(1A) dopamine receptor	4	0	0	4
chromobox protein homolog 1	15	0	0	15
thyroid hormone receptor beta isoform a	9	0	0	9
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
geminin	26	0	0	26
histone acetyltransferase KAT2A isoform 1	10	0	0	10
lamin isoform A-delta10	20	0	0	20
Plasminogen	0	5	2	7
Chain A, Beta-lactamase	7	0	0	7
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
apical membrane antigen 1, AMA1	3	0	0	3
Beta-lactamase	0	0	0	1
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	16	0	0	16
urokinase-type plasminogen activator precursor	6	0	0	6
plasminogen precursor	6	0	0	6
urokinase plasminogen activator surface receptor precursor	6	0	0	6
Bile salt export pump	0	5	0	5
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Cytochrome P450 2C9	0	4	0	4
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Cytochrome P450 2J2	0	3	0	3
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
USP1 protein, partial	12	0	0	12
thioredoxin glutathione reductase	6	0	0	6
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
vitamin D3 receptor isoform VDRA	8	0	0	8
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	3	0	0	3
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	3
Trypsin	0	2	0	2
Coagulation factor VII	0	2	0	2
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Aromatase	0	1	0	1
Tissue factor	0	2	0	2
Fatty acid-binding protein, adipocyte	0	3	2	5
Prostaglandin G/H synthase 2	0	3	1	5
10 kDa heat shock protein, mitochondrial	0	1	0	1
Calmodulin	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	3	1	0	4
Prostaglandin G/H synthase 2	0	3	0	4
Fatty acid-binding protein 5	0	3	1	4
Fatty acid-binding protein 5	0	0	1	1
Thiosulfate sulfurtransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Cytosolic phospholipase A2 gamma	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	3	0	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
thioredoxin reductase	13	0	0	13
GLS protein	6	0	0	6
Cytochrome P450 3A4	0	2	1	5
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
ATP-dependent phosphofructokinase	7	0	0	7
Integrin beta-3	2	11	2	16
Integrin beta-1	0	6	0	6
Integrin alpha-V	0	5	1	6
Integrin alpha-IIb	2	11	1	15
Integrin alpha-5	0	5	0	5
Integrin beta-5	0	2	0	2
Integrin alpha-2	0	1	0	1
Integrin alpha-3	0	1	0	1
Integrin beta	0	1	0	1
Glycoprotein IIb	0	1	0	1
Neutral amino acid transporter A	0	4	0	4
Neutral amino acid transporter B(0)	0	4	0	4
Carbonic anhydrase-like protein, putative	0	0	0	6
Amino acid transporter	0	4	0	4
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	1	7
Glutamate receptor ionotropic, NMDA 2B	0	3	1	7
Glutamate receptor ionotropic, NMDA 2C	0	3	1	7
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	3	1	7
Glutamate receptor ionotropic, NMDA 3B	0	3	1	7
Glutamate receptor ionotropic, NMDA 3A	0	3	1	7
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	8	0	0	8
hypothetical protein, conserved	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	24	0	0	24
estrogen-related nuclear receptor alpha	28	0	0	28
cytochrome P450 2D6	8	0	0	8
peroxisome proliferator-activated receptor delta	16	0	0	16
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Substance-P receptor	0	2	0	2
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	6	0	0	6
Ras-related protein Rab-2A	0	0	1	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	0	1	1
acetylcholinesterase	8	0	0	8
RAR-related orphan receptor gamma	23	0	0	23
SMAD family member 2	10	0	0	10
Fumarate hydratase	5	0	0	5
SMAD family member 3	10	0	0	10
GLI family zinc finger 3	23	0	0	23
nuclear receptor subfamily 1, group I, member 3	19	0	0	19
farnesoid X nuclear receptor	19	0	0	19
pregnane X nuclear receptor	17	0	0	17
G	10	0	0	10
polyprotein	5	0	0	5
P53	1	0	0	1
aryl hydrocarbon receptor	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	13	0	0	13
thyroid stimulating hormone receptor	15	0	0	15
activating transcription factor 6	10	0	0	10
v-jun sarcoma virus 17 oncogene homolog (avian)	14	0	0	14
peripheral myelin protein 22 isoform 1	6	0	0	6
hemoglobin subunit beta	1	0	0	1
thyroid hormone receptor beta isoform 2	20	0	0	20
heat shock protein beta-1	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	21	0	0	21
M-phase phosphoprotein 8	3	0	0	3
muscleblind-like protein 1 isoform 1	4	0	0	4
Interferon beta	13	0	0	13
HLA class I histocompatibility antigen, B alpha chain	10	0	0	10
Inositol hexakisphosphate kinase 1	10	0	0	10
ATPase family AAA domain-containing protein 5	11	0	0	11
Ataxin-2	12	0	0	12
Protein-arginine deiminase type-4	0	2	0	2
cytochrome P450 2C9, partial	10	0	0	10
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Chain H, Proteasome component PUP1	0	1	0	1
Chain I, Proteasome component PUP3	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Proteasome subunit beta type-11	0	1	0	1
PPM1D protein	3	0	0	3
caspase 7, apoptosis-related cysteine protease	5	0	0	5
estrogen receptor 2 (ER beta)	11	0	0	11
progesterone receptor	18	0	0	18
vitamin D (1,25- dihydroxyvitamin D3) receptor	13	0	0	13
caspase-3	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
26S proteasome non-ATPase regulatory subunit 11	0	1	0	1
26S proteasome non-ATPase regulatory subunit 12	0	1	0	1
26S proteasome non-ATPase regulatory subunit 14	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Histone deacetylase 3	0	1	0	1
26S proteasome non-ATPase regulatory subunit 3	0	1	0	1
Carbonic anhydrase 12	0	1	0	4
Prothrombin	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Carbonic anhydrase 3	0	1	0	4
Cathepsin B	0	3	0	3
Neutrophil elastase	0	1	0	1
Cathepsin G	0	2	0	2
Lysosomal protective protein	0	1	0	1
Chymotrypsinogen B	0	1	0	1
26S proteasome regulatory subunit 6A	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Proteasome subunit beta type-1	0	1	0	2
Carbonic anhydrase 4	0	1	0	4
Carbonic anhydrase 6	0	1	0	4
Chymase	0	1	0	1
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	2	0	3
Carbonic anhydrase 5A, mitochondrial	0	1	0	4
26S proteasome regulatory subunit 7	0	1	0	1
Lon protease homolog, mitochondrial	0	1	0	1
Proteasome subunit beta type-10	0	1	0	1
Carbonic anhydrase 7	0	1	0	4
26S proteasome regulatory subunit 6B	0	1	0	1
26S proteasome non-ATPase regulatory subunit 8	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	1	0	2
26S proteasome non-ATPase regulatory subunit 7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 4	0	1	0	1
26S proteasome complex subunit SEM1	0	1	0	1
Proteasome subunit alpha type-6	0	1	0	1
26S proteasome regulatory subunit 4	0	1	0	1
26S proteasome regulatory subunit 8	0	1	0	1
26S proteasome regulatory subunit 10B	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
26S proteasome non-ATPase regulatory subunit 2	0	1	0	1
Histone deacetylase 1	0	1	0	1
26S proteasome non-ATPase regulatory subunit 6	0	1	0	1
Proteasomal ubiquitin receptor ADRM1	0	1	0	1
Carbonic anhydrase 9	0	1	0	4
ATP-dependent Clp protease proteolytic subunit	0	1	1	2
Carbonic anhydrase 13	0	1	0	2
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Histone deacetylase 2	0	1	0	1
Proteasome subunit beta type-7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	4
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Carbonic anhydrase 14	0	1	0	4
26S proteasome non-ATPase regulatory subunit 13	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	4
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
DNA polymerase beta	3	0	0	3
Potassium channel subfamily K member 2	0	0	1	1
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	2	0	2
Adenosine receptor A2a	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	4
Guanine deaminase	0	1	0	1
acid sphingomyelinase	4	0	0	4
endonuclease IV	3	0	0	3
glp-1 receptor, partial	6	0	0	6
ClpP	2	0	0	2
electroneutral potassium-chloride cotransporter KCC2	0	0	1	1
TSHR protein	1	0	0	1
Smad3	4	0	0	4
67.9K protein	7	0	0	7
Parkin	4	0	0	4
LacZ protein (plasmid)	0	0	1	1
XBP1	0	1	0	1
serine-protein kinase ATM isoform a	2	0	0	2
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
type-1 angiotensin II receptor	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	11	0	0	12
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
glucokinase regulatory protein	1	0	0	1
huntingtin isoform 2	2	0	0	2
ras-related protein Rab-9A	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
serine/threonine-protein kinase PLK1	2	0	0	2
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
DNA damage-inducible transcript 3 protein	0	1	0	1
Vpr	2	0	0	2
streptokinase A precursor	0	0	1	1
neuropeptide S receptor isoform A	3	0	0	3
Amyloid-beta precursor protein	1	1	0	2
Alpha-synuclein	4	0	0	4
D(1A) dopamine receptor	1	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
TAR DNA-binding protein 43	7	0	0	7
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
PAX8	0	0	0	1
pregnane X receptor	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	10	0	0	10
PINK1	3	0	0	3
heat shock protein 90	0	0	1	1
calcineurin A1, putative	0	0	1	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	10	0	0	10
hepatocyte nuclear factor 4-alpha isoform 2	0	2	0	2
perilipin-5	0	2	0	2
perilipin-1	0	2	0	2
transcriptional regulator ERG isoform 3	5	0	0	5
importin subunit beta-1 isoform 1	4	0	0	4
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
protein AF-9 isoform a	0	0	0	1
snurportin-1	4	0	0	4
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
bcl-2-related protein A1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	2	0	2
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	3	0	4
Solute carrier family 22 member 1	0	2	0	3
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	4
72 kDa type IV collagenase	0	1	0	1
Matrix metalloproteinase-9	0	2	0	2
Trypanothione reductase	0	1	0	1
Spike glycoprotein	9	0	0	9
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	3	0	3
Rap guanine nucleotide exchange factor 4	3	0	0	3
Multidrug and toxin extrusion protein 1	0	3	0	3
Spermine oxidase	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	2
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Cytochrome P450 2C8	0	2	0	3
Cytochrome P450 2B6	0	4	0	4
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent serotonin transporter	0	6	0	6
Cytochrome P450 2C19	0	3	0	3
P2Y purinoceptor 12	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
neutrophil cytosol factor 1	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 3	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Isocitrate lyase	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	0	1	1
Vasopressin V1a receptor	0	1	1	2
Vasopressin V1b receptor	0	1	1	2
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Solute carrier family 22 member 6	0	0	0	2
Solute carrier family 22 member 7	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 8	0	0	0	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier family 22 member 11	0	0	0	2
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
Thrombopoietin	1	0	0	1
DNA polymerase III, partial	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
LANA	0	0	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
eyes absent homolog 2 isoform a	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
kelch-like ECH-associated protein 1	0	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	2	1	0	3
Neuronal acetylcholine receptor subunit beta-2	2	1	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Caspase-7	2	0	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
Exopolyphosphatase PRUNE1	0	1	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Eyes absent homolog 2	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Cytochrome P450 2B1	0	1	0	1
Estrogen receptor	0	7	2	9
Glucocorticoid receptor	0	10	3	18
Sex hormone-binding globulin	0	0	3	3
Glycine receptor subunit alpha-1	0	10	0	10
Aldo-keto reductase family 1 member B1	0	2	0	2
Androgen receptor	0	7	0	7
Alpha-1B adrenergic receptor	0	2	0	2
Glycine receptor subunit beta	0	10	0	10
UDP-glucuronosyltransferase 1A1	0	1	0	3
Glycine receptor subunit alpha-2	0	10	0	10
Sodium-dependent noradrenaline transporter	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Glycine receptor subunit alpha-3	0	10	0	10
Alpha-1A adrenergic receptor	0	2	0	2
Sulfotransferase 1A1	0	2	1	4
Sodium-dependent dopamine transporter	0	2	0	2
Aldehyde oxidase	0	1	0	1
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Estrogen receptor beta	0	4	2	6
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Chain A, Glutamine Binding Protein	0	0	1	1
Asc-type amino acid transporter 1	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	7	0	7
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	3	3
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	1	0	4
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 13	0	0	0	2
Tyrosine-protein kinase ABL1	0	1	2	3
Mast/stem cell growth factor receptor Kit	0	1	1	2
Breakpoint cluster region protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	1	1	2
Cytochrome P450 3A5	0	2	0	3
Actin, alpha skeletal muscle	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
Cathepsin B	0	1	0	1
Prothrombin	0	1	0	1
Cationic trypsin	0	1	0	1
Papain	0	1	0	1
Serine protease hepsin	0	1	0	1
Plasminogen	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Cathepsin B	0	1	0	1
Procathepsin L	0	1	0	1
Pro-cathepsin H	0	1	0	1
Trypsin-3	0	1	0	1
Calpain-1 catalytic subunit	0	1	0	1
Cathepsin K	0	1	0	1
Hepatocyte growth factor activator	0	1	0	1
Transmembrane protease serine 6	0	1	0	1
Cysteine protease	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine protease falcipain-3	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
Progesterone receptor	0	6	4	11
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Alpha-mannosidase 2C1	0	1	0	1
Fucose-binding lectin PA-IIL	0	1	0	1
CD209 antigen	0	1	0	1
Mineralocorticoid receptor	0	3	1	4
Androgen receptor	0	4	2	6
Androgen receptor	0	0	1	1
Histamine H2 receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	1	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Estrogen receptor	0	0	1	1
Estrogen receptor beta	0	0	1	1
Chain A, Fatty acid-binding protein, adipocyte	0	1	0	1
Acetylcholinesterase	0	2	0	2
Toll-like receptor 2	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Peroxisome proliferator-activated receptor alpha	2	0	1	3
Tyrosine-protein kinase Lck	0	0	0	1
Growth factor receptor-bound protein 2	0	0	0	1
Tyrosine-protein phosphatase non-receptor type 11	0	0	0	1
luciferase	0	0	0	1
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Glutamate 5-kinase	0	0	0	1
Pyruvate kinase PKM	0	0	1	1
Cholinesterase	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Serine/threonine-protein kinase D3	0	0	1	1
Protein kinase C gamma type	0	1	1	2
Protein kinase C beta type	0	1	1	2
Luciferin 4-monooxygenase	0	0	1	1
Beta-1 adrenergic receptor	0	1	0	1
Protein kinase C eta type	0	0	1	1
Protein kinase C iota type	0	0	1	1
Protein kinase C epsilon type	0	1	1	2
Protein kinase C theta type	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	1	1	2
Serine/threonine-protein kinase D1	0	0	1	1
Ras guanyl-releasing protein 3	0	0	1	1
Cereblon isoform 4	0	2	0	2
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Alpha-2A adrenergic receptor	0	2	0	2
Cytochrome P450 2D6	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Integrin subunit alpha 2b	0	1	0	1
Integrin beta-3	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Stromelysin-1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	2
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Polyphenol oxidase 2	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Albumin	0	0	1	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Deficiency of GP 2b 3a Complex

Synonyms(10)

Research Excerpts

Overview

Treatment

Research

Studies (305)

Protein Targets (1,045)

Deficiency of GP 2b 3a Complex

Synonyms(10)

Research Excerpts

Overview

Treatment

Research

Studies (305)

Drugs Studied (148)

Protein Targets (1,045)