Tick Paralysis

Paralysis caused by a neurotropic toxin secreted by the salivary glands of ticks.

Synonym
Tick Paralysis

Excerpt	Reference
"Tick paralysis is a preventable cause of morbidity and death that, when diagnosed promptly, requires a simple low-cost intervention."	( Greenstein, P, 2002)
"Tick paralysis is an acute, progressive, and potentially fatal muscle paralysis secondary to a toxin secreted by a pregnant tick during a bite."	( Burke, MS; Fordham, LA; Hamrick, HJ, 2005)

Excerpt	Reference
"Tick paralysis has not been reported in horses in North America."	( Camp, JW; Lewis, MJ; Parsley, AL; Taylor, SD; Trumpp, KM, 2019)

Excerpt	Reference
"Questions referred to dogs and cats treated for tick paralysis over a period of three years: the number treated, treatment protocols and adverse systemic reactions to tick antitoxin serum."	( Atwell, RB; Campbell, FE, 2001)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	13 (34.21)	23.3326
1990's	4 (10.53)	12.5806
2000's	9 (23.68)	18.1394
2010's	9 (23.68)	28.8240
2020's	3 (7.89)	9.53

Drug	Relationship Strength	Studies	Trials
carbamates	low	1	0
salicylic acid	low	3	0
urea	low	1	0
mercaptoethanol	low	1	0
fenthion	low	1	0
fipronil	low	2	0
phenoxybenzamine	low	1	0
promethazine	low	1	0
theobromine	low	1	0
tubocurarine	low	1	0
acepromazine	low	1	0
cloxacillin	low	1	0
ethyl chloride	low	1	0
isoxazoles	medium	2	1
amoxicillin	low	1	0
amitraz	low	1	0
permethrin	low	2	0
fomesafen	low	1	0
fluphenacur	low	1	0
tebuconazole	low	1	0
foxes	low	1	0
atropine	low	1	0
fibrin	low	1	0
strychnine	low	1	0
bilirubin	low	1	0
clavulanic acid	low	1	0
thallium	low	1	0
methoprene	low	1	0
flumethrin	medium	1	1
le 135	low	1	0
dextrothyroxine	low	1	0
ants	low	1	0
natriuretic peptide, brain	low	1	0
pyrethrins	medium	2	1
muramidase	low	1	0
imidacloprid	medium	1	1

Protein Targets (354)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
thyroid stimulating hormone receptor	3	0	0	3
cytochrome P450 2D6 isoform 1	1	0	0	1
geminin	6	0	0	6
lethal factor (plasmid)	3	0	0	3
lamin isoform A-delta10	9	0	0	9
Bile salt export pump	0	9	0	9
Major prion protein	0	0	2	2
Trypanothione reductase	0	3	0	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
RAR-related orphan receptor gamma	8	0	0	8
GLI family zinc finger 3	8	0	0	8
AR protein	10	0	0	10
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
progesterone receptor	7	0	0	7
cytochrome P450 family 3 subfamily A polypeptide 4	6	0	0	6
glucocorticoid receptor [Homo sapiens]	8	0	0	8
retinoic acid nuclear receptor alpha variant 1	9	0	0	9
retinoid X nuclear receptor alpha	10	0	0	10
estrogen-related nuclear receptor alpha	10	0	0	10
farnesoid X nuclear receptor	4	0	0	4
pregnane X nuclear receptor	11	0	0	11
estrogen nuclear receptor alpha	11	0	0	11
cytochrome P450 2D6	4	0	0	4
peroxisome proliferator activated receptor gamma	5	0	0	5
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
aryl hydrocarbon receptor	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	8	0	0	8
thyroid hormone receptor beta isoform a	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	8	0	0	8
thyroid hormone receptor beta isoform 2	5	0	0	5
heat shock protein beta-1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	12	0	0	12
cytochrome P450 3A4 isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	6	0	0	6
Cellular tumor antigen p53	5	0	0	5
Alpha-2A adrenergic receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit delta	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-2	6	0	0	6
Peroxisome proliferator-activated receptor alpha	1	0	0	1
GABA theta subunit	6	0	0	6
Gamma-aminobutyric acid receptor subunit epsilon	6	0	0	6
Chain A, Beta-lactamase	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
apical membrane antigen 1, AMA1	2	0	0	2
Beta-lactamase	0	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	3	0	0	3
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
DNA polymerase kappa isoform 1	3	0	0	3
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Bile salt export pump	0	4	0	4
Beta-lactamase SHV-1	0	1	0	2
Beta-lactamase SHV-1	0	2	0	3
Cytochrome P450 2C9	0	1	0	1
Beta-lactamase	0	1	0	2
Kappa-type opioid receptor	0	0	0	1
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	4	0	4
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	2	0	0	2
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	3	0	3
5-hydroxytryptamine receptor 4	0	4	0	4
Muscarinic acetylcholine receptor M2	0	4	1	8
Muscarinic acetylcholine receptor M4	0	4	1	7
Muscarinic acetylcholine receptor M1	0	2	1	5
Muscarinic acetylcholine receptor M3	0	2	1	5
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M5	0	2	1	5
Muscarinic acetylcholine receptor M5	0	4	1	7
Muscarinic acetylcholine receptor M2	0	2	1	6
Muscarinic acetylcholine receptor M1	0	4	1	8
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	4	1	7
Alpha-1D adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2C	0	4	0	4
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	1	0	0	2
5-hydroxytryptamine receptor 7	0	3	0	3
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, Cruzipain	3	0	0	3
phosphopantetheinyl transferase	2	0	0	2
USP1 protein, partial	6	0	0	6
Microtubule-associated protein tau	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	8	0	0	8
vitamin D3 receptor isoform VDRA	4	0	0	4
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Beta-lactamase	0	1	0	1
Beta-lactamase	0	2	0	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Neutrophil elastase	0	1	0	1
Beta-lactamase OXA-1	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Beta-lactamase TEM	0	3	0	4
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Class D beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Metallo-b-lactamase	0	0	0	2
Beta-lactamase	0	1	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	2	0	2
Beta-lactamase class B VIM-2	0	0	0	2
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase OXA-7	0	0	0	1
Efflux transporter	0	1	0	1
Beta-lactamase	0	1	0	1
Chain A, Ferritin light chain	2	0	0	2
endonuclease IV	1	0	0	1
thioredoxin reductase	3	0	0	3
nonstructural protein 1	1	0	0	1
glucocerebrosidase	3	0	0	3
Bloom syndrome protein isoform 1	2	0	0	2
peripheral myelin protein 22 isoform 1	2	0	0	2
mitogen-activated protein kinase 1	3	0	0	3
M-phase phosphoprotein 8	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Spike glycoprotein	4	1	1	6
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Luciferase	2	0	0	2
acetylcholinesterase	2	0	0	2
G	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	5	0	0	5
thyroid stimulating hormone receptor	7	0	0	7
chromobox protein homolog 1	7	0	0	7
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
peripheral myelin protein 22	6	0	0	6
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Interferon beta	5	0	0	5
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Glutamate receptor 2	4	0	0	4
Guanine nucleotide-binding protein G	1	0	0	1
Inositol hexakisphosphate kinase 1	5	0	0	5
cytochrome P450 2C9, partial	5	0	0	5
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
TDP1 protein	5	0	0	5
estrogen receptor 2 (ER beta)	3	0	0	3
peroxisome proliferator-activated receptor delta	5	0	0	5
histone deacetylase 9 isoform 3	1	0	0	1
nuclear receptor ROR-gamma isoform 1	3	0	0	3
survival motor neuron protein isoform d	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
15-lipoxygenase, partial	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Histone H2A.x	3	0	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Retinoic acid receptor alpha	0	1	0	1
Retinoic acid receptor beta	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
pregnane X receptor	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Nuclear receptor ROR-gamma	2	0	0	2
Atrial natriuretic peptide receptor 1	0	1	0	1
serine-protein kinase ATM isoform a	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
EWS/FLI fusion protein	2	0	0	2
arylsulfatase A	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
flap endonuclease 1	1	0	0	1
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 3	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
D(2) dopamine receptor	0	1	0	1
ATP-dependent phosphofructokinase	3	0	0	3
GLS protein	3	0	0	3
regulator of G-protein signaling 4	2	0	0	2
Snq2p	0	0	0	1
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
D(1A) dopamine receptor	1	0	0	1
huntingtin isoform 2	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
Transmembrane protease serine 2	0	1	1	2
Procathepsin L	0	1	1	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Calmodulin-1	0	1	0	1
Replicase polyprotein 1ab	0	1	1	2
D(2) dopamine receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Histamine H2 receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
Histamine H1 receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Calmodulin	0	0	1	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Ataxin-2	1	0	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Angiotensin-converting enzyme 2	0	1	1	2
Chloroquine resistance transporter	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Polyphenol oxidase 2	0	1	0	2
Carbonic anhydrase 12	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Albumin	0	1	0	1
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase 9	0	1	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	0	1
Glycine receptor subunit alpha-1	0	1	0	1
Glycine receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	0	1
Glycine receptor subunit beta	0	1	0	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 10	0	0	1	2
Cytochrome P450 14alpha-demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	0	1
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Fumarate hydratase	1	0	0	1
polyprotein	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
Adenosine receptor A1	0	1	0	1
Adenosine receptor A2b	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (38)

Protein Targets (354)

Tick Paralysis

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (38)

Drugs Studied (45)

Protein Targets (354)