Page last updated: 2024-09-27

Splenosis

The spontaneous transplantation of splenic tissue to unusual sites after open splenic trauma, e.g., after automobile accidents, gunshot or stab wounds. The splenic pulp implants appear as red-blue nodules on the peritoneum, omentum, and mesentery, morphologically similar to multifocal pelvic endometriosis. (Segen, Dictionary of Modern Medicine, 1992)

Synonyms(1)

Synonym
Splenosis

Research Excerpts

Overview

ExcerptReference
"The development of splenosis is a known consequence of splenic rupture."( al-Ahmadi, M; Brody, F; Brundage, S; Jacobs, L; Sackier, JM, 1998)
"Thoracic splenosis is the autotransplantation of splenic tissue into the pleural cavity, usually following traumatic injury that simultaneously involves the spleen and diaphragm."( Fidvi, SA; Klein, SA; Kroop, SA, 1999)
"Splenosis is autotransplantation of splenic tissue that usually follows traumatic rupture of the spleen and/or splenectomy."( Kohno, N; Mishina, A; Ota, T; Sakamoto, T; Tsugawa, T, 2001)
"Intrathoracic splenosis is a rare diagnosis that is usually made following an invasive procedure."( Hagman, TF; Jennings, SG; Meyer, CA; Winer-Muram, HT, 2001)
"Splenosis is defined as the autotransplantation of splenic tissue to abnormal locations after splenic injury."( Barbari, A; Yammine, JN; Yatim, A, 2003)
"Since renal splenosis is quite rare and has previously been reported only in the left kidney, we did not consider splenosis in our differential diagnosis during the evaluation of the renal mass."( Lenz, DL; Page, JB; Wong, C, 2006)
"Splenosis is a condition in which splenic tissue is present in a non-anatomical position."( Attinà, GM; Galatà, G; Garaci, FG; Grande, M; Konda, D; Mancino, S; Simonetti, G; Villa, M, 2009)
"Most cases of splenosis are intra-abdominal due to direct seeding of surrounding structures, although these ectopic rests may occur almost anywhere in the body, and its diffuse nature may raise the suspicion of metastatic cancer."( Bhargava, P; Hayes, TG; Short, NJ, 2011)
"Although hepatic splenosis is a rare condition, this diagnosis should be considered in patients with previous history of abdominal trauma and then the diagnosis of splenosis may be confirmed by Tc-99m-DRBC scintigraphy, avoiding biopsy or further surgery."( Inchingolo, R; Karani, J; Peddu, P, 2013)
"Splenosis is a rare condition defined as seeding and autotransplantation of splenic tissue, typically after blunt abdominal trauma (e."( Cheung, KK; Dvorkin, L; Hall, M; Wagner, T, 2014)

Research

Studies (56)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's11 (19.64)12.5806
2000's31 (55.36)18.1394
2010's14 (25.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
iohexol0low10
iopromide0low10
edetic acid0low10
penicillin v0low10
sulfur hexafluoride0low20
technetium0low190
cefazolin0low10
amoxicillin0low10
deoxyglucose0low10
edotreotide0low10
gadolinium dtpa0low10
technetium tc 99m diphosphonate0low10
technetium tc 99m exametazime0low20
sodium pertechnetate tc 99m0low30
tuftsin0low10
technetium tc 99m sulfur colloid0low170
68ga-dotanoc0low10
concanavalin a0low10

Protein Targets (100)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, Beta-lactamase1001
Chain A, 2-oxoglutarate Oxygenase1001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
AR protein2002
apical membrane antigen 1, AMA12002
estrogen nuclear receptor alpha2002
Beta-lactamase 0001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
DNA polymerase kappa isoform 11001
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40203
Bile salt export pump0101
Bile salt export pump0303
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Cytochrome P450 2C9 0101
Beta-lactamase0001
Kappa-type opioid receptor0001
Solute carrier family 15 member 10303
Solute carrier family 15 member 10101
Cytochrome P450 2J20101
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Canalicular multispecific organic anion transporter 10202
Cytochrome P450 2D60101
Sodium-dependent serotonin transporter0202
Sigma non-opioid intracellular receptor 10202
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Luciferase1001
thioredoxin reductase1001
phosphopantetheinyl transferase1001
RAR-related orphan receptor gamma2002
Smad31001
glucocorticoid receptor [Homo sapiens]1001
cytochrome P450 2D61001
vitamin D3 receptor isoform VDRA1001
nuclear factor erythroid 2-related factor 2 isoform 12002
lamin isoform A-delta101001
Solute carrier family 22 member 60101
Solute carrier family 22 member 60101
Solute carrier family 22 member 80101
Solute carrier family 22 member 110101
Solute carrier family 22 member 80101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
hypoxia-inducible factor 1 alpha subunit1001
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor1001
retinoic acid nuclear receptor alpha variant 11001
estrogen-related nuclear receptor alpha1001
euchromatic histone-lysine N-methyltransferase 21001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
Histone H2A.x1001
Eyes absent homolog 20101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Voltage-dependent calcium channel gamma-2 subunit1001
Cellular tumor antigen p531001
Amyloid-beta precursor protein0101
Angiotensin-converting enzyme 0101
Glutamate receptor 21001
Histamine H2 receptor1001
Metallo-beta-lactamase VIM-130101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase VIM-1 0101
Somatostatin receptor type 10101
Somatostatin receptor type 20101
Somatostatin receptor type 40101
Somatostatin receptor type 30101
Somatostatin receptor type 50101
ATAD5 protein, partial1001
geminin1001
Spike glycoprotein2002
USP1 protein, partial1001
farnesoid X nuclear receptor1001
pregnane X nuclear receptor1001
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
nuclear receptor ROR-gamma isoform 11001
Solute carrier family 22 member 80101
Replicase polyprotein 1ab0101
Beta-lactamase OXA-70001
Chain D, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)0101
Chain A, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)0101
Chain A, Beta-arrestin 10011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]