selenonorcholesterol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Selenonorcholesterol is a synthetic steroidal analog of cholesterol that contains selenium in place of sulfur. It is synthesized through a multi-step process involving the introduction of selenium into the steroidal scaffold. Selenonorcholesterol has been shown to exhibit a range of biological effects, including inhibition of cholesterol biosynthesis, antioxidant activity, and anti-inflammatory properties. Its ability to inhibit cholesterol biosynthesis makes it a potential therapeutic agent for hypercholesterolemia and atherosclerosis. Selenonorcholesterol is also being investigated for its potential to protect against oxidative stress and inflammation in various tissues. The unique chemical structure and biological activities of selenonorcholesterol have made it a subject of ongoing research, with the aim of understanding its full therapeutic potential and developing novel drugs based on its structure.'

selenonorcholesterol: adrenal radioisotope scanning agents [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	122051
MeSH ID	M0066925

Synonyms (24)

Synonym
scintadren
(75)selenonorcholesterol
6-methyl-(75)selenomethyl-19-norcholest-5(10)-en-3beta-ol
19-norcholest-5(10)-en-3-ol, 6-((methylseleno-(75)se)methyl) (3beta,6beta)
xwr21tj99h ,
unii-xwr21tj99h
63795-61-9
selenonorcholesterol
j40.704f ,
19-norcholest-5(10)-en-3-ol, 6-((methylseleno-75se)methyl)-, (3.beta.,6.beta.)-
72521-77-8
6.beta.-(methyl(75se)selenomethyl)-19-norcholest-5(10)-en-3.beta.-ol
6-methyl-(75)selenomethyl-19-norcholest-5(10)-en-3.beta.-ol
scintadren se-75
selenonorcholesterol (75 se) [who-dd]
selenonorcholesterol (75 se)
selenium se-75 norcholesterol
selenium (75se) norcholesterol
(3.beta.,6.beta.)-6-((methyl(75se)selanyl)methyl)-19-norcholest-5(10)-en-3-ol
DB13622
DTXSID30980361
6-{[methyl(~75~se)selanyl]methyl}-19-norcholest-5(10)-en-3-ol
Q27294031
(3s,6r,8s,9s,13r,14s,17r)-13-methyl-6-(methyl(75se)selanylmethyl)-17-[(2r)-6-methylheptan-2-yl]-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-ol

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (22)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	15 (68.18)	18.7374
1990's	4 (18.18)	18.2507
2000's	3 (13.64)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.84

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	10.84 (24.57)
Research Supply Index	3.30 (2.92)
Research Growth Index	4.14 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (10.84)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (4.00%)	5.53%
Reviews	4 (16.00%)	6.00%
Case Studies	6 (24.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	14 (56.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
pentetic acid Pentetic Acid: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.	1.97	1	pentacarboxylic acid	copper chelator
aldosterone [no description available]	1.97	1	11beta-hydroxy steroid; 18-oxo steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid hormone; mineralocorticoid; primary alpha-hydroxy ketone; steroid aldehyde	human metabolite; mouse metabolite
technetium Technetium: The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, and atomic number 43. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.	1.96	1	manganese group element atom
3-iodobenzylguanidine 3-Iodobenzylguanidine: A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.	3.77	3	organoiodine compound
adosterol Adosterol: A sterol usually substituted with radioactive iodine. It is an adrenal cortex scanning agent with demonstrated high adrenal concentration and superior adrenal imaging.	3.75	3
technetium tc 99m pentetate Technetium Tc 99m Pentetate: A technetium imaging agent used in renal scintigraphy, computed tomography, lung ventilation imaging, gastrointestinal scintigraphy, and many other procedures which employ radionuclide imaging agents.	1.97	1
cortodoxone Cortodoxone: 17,21-Dihydroxypregn-4-ene-3,20-dione. A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities.. 11-deoxycortisol : A deoxycortisol that is cortisol in which the hydroxy group at position 11 has been replaced by a hydrogen.	1.96	1	deoxycortisol; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	human metabolite; mouse metabolite
succimer Succimer: A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.. succimer : A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.	1.96	1	dicarboxylic acid; dithiol; sulfur-containing carboxylic acid	chelator
selenium Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.	3.9	13	chalcogen; nonmetal atom	micronutrient
19-iodocholesterol 19-Iodocholesterol: 19-Iodocholest-5-en-3 beta-ol. A cholesterol derivative usually substituted with radioactive iodine in the 19 position. The compound is an adrenal cortex scanning agent used in the assessment of patients suspected of having Cushing's syndrome, hyperaldosteronism, pheochromocytoma and adrenal remnants following total adrenalectomy.	2.38	2
6-iodomethylcholesterol 6-iodomethylcholesterol: RN given refers to (123)I-labeled cpd (3 beta,6 beta)-isomer	2.38	2
technetium tc 99m dimercaptosuccinic acid Technetium Tc 99m Dimercaptosuccinic Acid: A nontoxic radiopharmaceutical that is used in the diagnostic imaging of the renal cortex.	1.96	1

Condition	Relationship Strength	Studies	Trials
Aldosteronism [description not available]	5.77	8	1
Hyperaldosteronism A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.	5.77	8	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	3.8	2	1
Adenoma, Basal Cell [description not available]	3.07	5	0
Cushing's Syndrome [description not available]	4.49	9	0
Adrenal Cortex Cancer [description not available]	3.22	6	0
Adenoma A benign epithelial tumor with a glandular organization.	3.07	5	0
Adrenal Cortex Neoplasms Tumors or cancers of the ADRENAL CORTEX.	3.22	6	0
Cushing Syndrome A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.	4.49	9	0
Cancer of Liver [description not available]	1.96	1	0
Liver Neoplasms Tumors or cancer of the LIVER.	1.96	1	0
Congenital Adrenal Hyperplasia [description not available]	2.37	2	0
Adrenal Hyperplasia, Congenital A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.	2.37	2	0
Adrenal Cancer [description not available]	3.99	5	0
Hyperplasia An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.	2.38	2	0
Adrenal Gland Diseases Pathological processes of the ADRENAL GLANDS.	3.98	5	0
Aldosteronism with Hyperplasia of the Adrenal Cortex [description not available]	1.96	1	0
Blood Pressure, High [description not available]	1.95	1	0
Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	1.95	1	0
Adenoma, Adrenal Cortical [description not available]	2.01	1	0
Gangliocytoma [description not available]	1.98	1	0
Cancer of Pituitary [description not available]	1.98	1	0
Adenoma, Prolactin-Secreting, Pituitary [description not available]	1.98	1	0
Adenomatosis, Familial Endocrine [description not available]	1.98	1	0
Abdominal Neoplasms New abnormal growth of tissue in the ABDOMEN.	1.98	1	0
Pituitary Neoplasms Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.	1.98	1	0
Pheochromocytoma, Extra-Adrenal [description not available]	1.96	1	0
Pheochromocytoma A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)	1.96	1	0
Adrenal Cortex Diseases Pathological processes of the ADRENAL CORTEX.	1.96	1	0

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