ATP-dependent Clp protease proteolytic subunit, mitochondrial

An ATP-dependent Clp protease proteolytic subunit, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16740]

EC 3.4.21.92;
Endopeptidase Clp

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
onc201	Homo sapiens (human)	EC50	1.0000	1	1
onc201	Homo sapiens (human)	Kd	28.2000	1	1

This protein enables 7 target(s):

Target	Category	Definition
endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
ATP-dependent peptidase activity	molecular function	Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. [GOC:mah]
serine-type endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
peptidase activity	molecular function	Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
ATPase binding	molecular function	Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. [GOC:ai]

This protein is located in 2 target(s):

Target	Category	Definition
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
mitochondrial matrix	cellular component	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732]

This protein is part of 1 target(s):

Target	Category	Definition
endopeptidase Clp complex	cellular component	A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form. [GOC:mah, PMID:11352464]

This protein is involved in 5 target(s):

Target	Category	Definition
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
membrane protein proteolysis	biological process	The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains. [GOC:pde]
mitochondrial protein catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure. [GOC:sp, PMID:21264221, PMID:21264228]
proteolysis involved in protein catabolic process	biological process	The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. [GOC:ai, GOC:dph, GOC:tb]
protein quality control for misfolded or incompletely synthesized proteins	biological process	The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. [GOC:jl]