pd 98059 has been researched along with Pheochromocytoma in 6 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a previous study, we show that stimulation of chemotaxis in rat pheochromocytoma PC12 cells by nerve growth factor (NGF) and epidermal growth factor (EGF) requires activation of the RAS-ERK signaling pathway." | 3.73 | Threshold levels of ERK activation for chemotactic migration differ for NGF and EGF in rat pheochromocytoma PC12 cells. ( Chan, BM; Ho, WC; Morris, VL; Uniyal, S; Zhou, H, 2005) |
| "Prosaposin treatment induced pheochromocytoma cells (PC12) to enter the S phase of the cell cycle; this effect was inhibited by the MEK inhibitor PD98059, indicating that prosaposin-induced ERK phosphorylation is required for stimulation of DNA synthesis." | 1.31 | Prosaposin treatment induces PC12 entry in the S phase of the cell cycle and prevents apoptosis: activation of ERKs and sphingosine kinase. ( Campana, WM; Cifone, MG; Di Marzio , L; Misasi, R; Molinari, S; O'Brien, JS; Pavan, A; Pontieri, GM; Sorice, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Luo, P | 1 |
| Zhao, Y | 1 |
| Li, D | 1 |
| Chen, T | 1 |
| Li, S | 1 |
| Chao, X | 1 |
| Liu, W | 1 |
| Zhang, L | 1 |
| Qu, Y | 1 |
| Jiang, X | 1 |
| Lu, G | 1 |
| Poon, W | 1 |
| Fei, Z | 1 |
| Cerioni, L | 1 |
| Palomba, L | 1 |
| Cantoni, O | 1 |
| Ho, WC | 1 |
| Uniyal, S | 1 |
| Zhou, H | 1 |
| Morris, VL | 1 |
| Chan, BM | 1 |
| Nanmoku, T | 1 |
| Takekoshi, K | 1 |
| Fukuda, T | 1 |
| Ishii, K | 1 |
| Isobe, K | 1 |
| Kawakami, Y | 1 |
| Misasi, R | 1 |
| Sorice, M | 1 |
| Di Marzio , L | 1 |
| Campana, WM | 1 |
| Molinari, S | 1 |
| Cifone, MG | 1 |
| Pavan, A | 1 |
| Pontieri, GM | 1 |
| O'Brien, JS | 1 |
| Yip, PM | 1 |
| Siu, CH | 1 |
6 other studies available for pd 98059 and Pheochromocytoma
| Article | Year |
|---|---|
Protective effect of Homer 1a on tumor necrosis factor-α with cycloheximide-induced apoptosis is mediated by mitogen-activated protein kinase pathways.
Topics: Adrenal Gland Neoplasms; Animals; Anthracenes; Apoptosis; Brain-Derived Neurotrophic Factor; Carrier | 2012 |
The Raf/MEK inhibitor PD98059 enhances ERK1/2 phosphorylation mediated by peroxynitrite via enforced mitochondrial formation of reactive oxygen species.
Topics: Adrenal Gland Neoplasms; Animals; Enzyme Inhibitors; Flavonoids; Kinetics; Mitochondria; Mitogen-Act | 2003 |
Threshold levels of ERK activation for chemotactic migration differ for NGF and EGF in rat pheochromocytoma PC12 cells.
Topics: Adrenal Gland Neoplasms; Animals; Cell Movement; Cell Proliferation; Chemotaxis; Chromones; Differen | 2005 |
Stimulation of catecholamine biosynthesis via the PKC pathway by prolactin-releasing peptide in PC12 rat pheochromocytoma cells.
Topics: Animals; Catecholamines; Cell Line, Tumor; Cyclic AMP-Dependent Protein Kinases; Flavonoids; Hypotha | 2005 |
Prosaposin treatment induces PC12 entry in the S phase of the cell cycle and prevents apoptosis: activation of ERKs and sphingosine kinase.
Topics: Adrenal Gland Neoplasms; Animals; Apoptosis; Cell Cycle; DNA, Neoplasm; Enzyme Activation; Enzyme In | 2001 |
PC12 cells utilize the homophilic binding site of L1 for cell-cell adhesion but L1-alphavbeta3 interaction for neurite outgrowth.
Topics: Adrenal Gland Neoplasms; Animals; Cell Adhesion; Cell Aggregation; Enzyme Inhibitors; Flavonoids; Hu | 2001 |