An RNA guanine-N7 methyltransferase activating subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BTL3]
Protein FAM103A1;
RNA guanine-7 methyltransferase activating subunit;
RNMT-activating mRNA cap methyltransferase subunit;
RNMT-activating mini protein;
RAM
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| sinefungin | Homo sapiens (human) | IC50 | 0.3190 | 1 | 2 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| RNA binding | molecular function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| enzyme activator activity | molecular function | Binds to and increases the activity of an enzyme. [GOC:dph, GOC:mah, GOC:tb] |
| molecular function activator activity | molecular function | A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target. [GOC:curators] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
This protein is part of 2 target(s):
| Target | Category | Definition |
|---|---|---|
| mRNA capping enzyme complex | cellular component | A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping. [GOC:vw, PMID:10347220, PMID:12455993, PMID:9345280] |
| mRNA cap methyltransferase RNMT:RAMAC complex | cellular component | A protein complex that consists of RNA guanine-7 methyltransferase (RNMT) and RNA guanine-7 methyltransferase activating subunit (RAMAC) and is involved in mRNA cap methylation. [PMID:22099306] |
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| 7-methylguanosine mRNA capping | biological process | The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively. [GOC:mah, PMID:9266685] |
| RNA 5'-cap (guanine-N7)-methylation | biological process | The process whereby a guanine in 5-cap is methylated at the N7 position of guanine. [GOC:hjd] |
| methylation | biological process | The process in which a methyl group is covalently attached to a molecule. [GOC:mah] |