dihydroxyphenylalanine and Pheochromocytoma studies

Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.

Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)

Research Excerpts

Excerpt	Relevance	Reference
"Two patients with nonmetastatic adrenal pheochromocytoma, and 9 patients with extraadrenal abdominal paraganglioma (1 nonmetastatic, 8 metastatic), underwent whole-body CT, MRI, baseline (18)F-DOPA PET, and (18)F-DOPA PET with oral preadministration of 200 mg of carbidopa."	9.12	The effects of carbidopa on uptake of 6-18F-Fluoro-L-DOPA in PET of pheochromocytoma and extraadrenal abdominal paraganglioma. ( Adams, KT; Carrasquillo, JA; Chen, CC; Eisenhofer, G; Hadi, M; Ling, A; Martiniova, L; Pacak, K; Timmers, HJ; Whatley, M, 2007)
"(18)F-fluorodihydroxyphenylalanine (FDOPA) is a powerful tool for the diagnosis and detection of neuroendocrine tumors when planning and monitoring surgical and oncologic therapies."	8.90	18F-fluorodihydroxyphenylalanine in the diagnosis of neuroendocrine tumors. ( Forsback, S; Kauhanen, S; Kemppainen, J; Minn, H; Seppänen, M, 2014)
"In recent years, 6-l-18F-fluorodihydroxyphenylalanine (18F-DOPA) PET has emerged as a new diagnostic tool for the imaging of neuroendocrine tumors."	8.84	6-L-18F-fluorodihydroxyphenylalanine PET in neuroendocrine tumors: basic aspects and emerging clinical applications. ( Brouwers, AH; Chirakal, R; Gulenchyn, KY; Jager, PL; Koopmans, KP; Marriott, CJ, 2008)
"In detecting pheochromocytoma (PHEO), positron emission tomography (PET) with the radiolabelled amine precursor (18)F-fluorodihydroxyphenylalanine ((18)F-DOPA) offers excellent specificity, while computed tomography (CT) provides high sensitivity and ability to localize lesions; therefore, the combination of these modalities could be advantageous in this setting."	7.76	Clinical value of 18F-fluorodihydroxyphenylalanine positron emission tomography/computed tomography (18F-DOPA PET/CT) for detecting pheochromocytoma. ( Buck, AK; Dralle, H; Glatting, G; Karges, W; Luster, M; Mottaghy, FM; Neumaier, B; Pauls, S; Reske, SN; Solbach, C; Verburg, FA; Zeich, K, 2010)
"Pheochromocytomas (PHEOs) and paragangliomas (PGLs) may be better detected by (18)F-fluorodihydroxyphenylalanine-positron emission tomography (FDOPA-PET) than (123)I-metaiodobenzyl-guanidine (123-I-MIBG) scintigraphy."	7.76	6-18F-fluoro-L-dihydroxyphenylalanine positron emission tomography is superior to 123I-metaiodobenzyl-guanidine scintigraphy in the detection of extraadrenal and hereditary pheochromocytomas and paragangliomas: correlation with vesicular monoamine transpo ( Anlauf, M; Bartenstein, P; Fottner, C; Helisch, A; Klöppel, G; Kreft, A; Lackner, KJ; Musholt, TJ; Rossmann, H; Schadmand-Fischer, S; Schreckenberger, M; Weber, MM, 2010)
"Flow-cytometric analysis of nuclear DNA and measurements of tissue levels of dihydroxyphenylalanine (dopa) and catecholamines were performed using fresh samples of tissue taken from 17 patients with pheochromocytoma."	7.69	Nuclear DNA ploidy pattern and tissue levels of dihydroxyphenylalanine and catecholamines in pheochromocytoma. ( Ishigooka, M; Kubota, Y; Nakada, T; Sasagawa, I; Sawamura, T; Suzuki, Y, 1995)
"In PC12 rat pheochromocytoma cells differentiated with nerve growth factor (NGF), neuropeptide Y inhibited depolarization-stimulated catecholamine synthesis as determined by in situ measurement of 3,4-dihydroxyphenylalanine (DOPA) production in the presence of the decarboxylase inhibitor m-hydroxybenzylhydrazine (NSD-1015)."	7.69	Neuropeptide Y inhibits depolarization-stimulated catecholamine synthesis in rat pheochromocytoma cells. ( McCullough, LA; Westfall, TC, 1995)
"A suppression of norepinephrine, epinephrine, and its metabolites in malignant pheochromocytoma by metyrosine was associated with an increase in tyrosine, plasma DOPA, and sulfate esters of DOPA and dopamine, followed, with continuing metyrosine administration, by a further rise of both DOPA sulfate and dopamine sulfate."	7.68	Alternative catecholamine pathways after tyrosine hydroxylase inhibition in malignant pheochromocytoma. ( Buu, NT; Edwards, DJ; Kuchel, O, 1990)
"Pheochromocytoma tyrosine hydroxylase was reported to have unusual catalytic properties, which might be unique to the tumor enzyme (Dix, T."	7.68	The hydroxylation of phenylalanine and tyrosine by tyrosine hydroxylase from cultured pheochromocytoma cells. ( Kaufman, S; Pigeon, D; Ribeiro, P, 1991)
"Effects of the 1-methyl-4-phenylpyridinium ion (MPP+) on DOPA formation and phosphorylation of tyrosine hydroxylase (TH) of rat pheochromocytoma PC12h cells were examined after the cells were cultured with MPP+."	7.67	Effect of the 1-methyl-4-phenylpyridinium ion on phosphorylation of tyrosine hydroxylase in rat pheochromocytoma PC12h cells. ( Hagiwara, M; Hidaka, H; Kiuchi, K; Nagatsu, T, 1988)
"Pheochromocytoma cells (clone PC-12) were treated with 6-aminonicotinamide."	7.67	Inhibition of biopterin synthesis and DOPA production in PC-12 pheochromocytoma cells induced by 6-aminonicotinamide. ( Herken, H; Jung, W, 1989)
"Incubation of pheochromocytoma cells with 56 mM K+ or with cholera toxin increases the conversion of [14C]tyrosine to [14C]catecholamines (Chalfie, M."	7.66	Tyrosine 3-monooxygenase regulates catecholamine synthesis in pheochromocytoma cells. ( Liang, BT; Perelle, BA; Perlman, RL; Vaccaro, KK, 1980)
"Adenosine increases the activity of tyrosine 3-monooxygenase in intact pheochromocytoma cells."	7.66	Activation of tyrosine 3-monooxygenase in pheochromocytoma cells by adenosine. ( Berezo, MW; Erny, RE; Perlman, RL, 1981)
"The carboxylic ionophore monensin inhibits the activity of tyrosine 3-monooxygenase and decreases the rate of catecholamine synthesis in pheochromocytoma cells incubated in vitro."	7.66	Monensin inhibits catecholamine synthesis in pheochromocytoma cells. ( Liang, BT; Perlman, RL; Sheard, BE; Vaccaro, KK, 1982)
"Two patients with nonmetastatic adrenal pheochromocytoma, and 9 patients with extraadrenal abdominal paraganglioma (1 nonmetastatic, 8 metastatic), underwent whole-body CT, MRI, baseline (18)F-DOPA PET, and (18)F-DOPA PET with oral preadministration of 200 mg of carbidopa."	5.12	The effects of carbidopa on uptake of 6-18F-Fluoro-L-DOPA in PET of pheochromocytoma and extraadrenal abdominal paraganglioma. ( Adams, KT; Carrasquillo, JA; Chen, CC; Eisenhofer, G; Hadi, M; Ling, A; Martiniova, L; Pacak, K; Timmers, HJ; Whatley, M, 2007)
"(18)F-fluorodihydroxyphenylalanine (FDOPA) is a powerful tool for the diagnosis and detection of neuroendocrine tumors when planning and monitoring surgical and oncologic therapies."	4.90	18F-fluorodihydroxyphenylalanine in the diagnosis of neuroendocrine tumors. ( Forsback, S; Kauhanen, S; Kemppainen, J; Minn, H; Seppänen, M, 2014)
"In recent years, 6-l-18F-fluorodihydroxyphenylalanine (18F-DOPA) PET has emerged as a new diagnostic tool for the imaging of neuroendocrine tumors."	4.84	6-L-18F-fluorodihydroxyphenylalanine PET in neuroendocrine tumors: basic aspects and emerging clinical applications. ( Brouwers, AH; Chirakal, R; Gulenchyn, KY; Jager, PL; Koopmans, KP; Marriott, CJ, 2008)
"To evaluate the clinical value of (18) F-fluorodihydroxyphenylalanine ((18) F-FDOPA) PET in relation to tumour localization and the patient's genetic status in a large series of pheochromocytoma/paraganglioma (PHEO/PGL) patients and to discuss in detail false-negative results."	3.79	Functional characterization of nonmetastatic paraganglioma and pheochromocytoma by (18) F-FDOPA PET: focus on missed lesions. ( Barlier, A; Blanchet, EM; Chen, CC; Deveze, A; Fakhry, N; Gabriel, S; Morange, I; Pacak, K; Sebag, F; Taïeb, D, 2013)
"To define the appropriate scan time for fluorine-18-labeled dihydroxyphenylalanine (F-18 DOPA) PET in oncological imaging of pheochromocytomas and paragangliomas."	3.78	Is there an optimal scan time for 6-[F-18]fluoro-L-DOPA PET in pheochromocytomas and paragangliomas? ( Boedeker, CC; Brink, I; Hentschel, M; Neumann, HP; Rottenburger, C, 2012)
"In detecting pheochromocytoma (PHEO), positron emission tomography (PET) with the radiolabelled amine precursor (18)F-fluorodihydroxyphenylalanine ((18)F-DOPA) offers excellent specificity, while computed tomography (CT) provides high sensitivity and ability to localize lesions; therefore, the combination of these modalities could be advantageous in this setting."	3.76	Clinical value of 18F-fluorodihydroxyphenylalanine positron emission tomography/computed tomography (18F-DOPA PET/CT) for detecting pheochromocytoma. ( Buck, AK; Dralle, H; Glatting, G; Karges, W; Luster, M; Mottaghy, FM; Neumaier, B; Pauls, S; Reske, SN; Solbach, C; Verburg, FA; Zeich, K, 2010)
"Pheochromocytomas (PHEOs) and paragangliomas (PGLs) may be better detected by (18)F-fluorodihydroxyphenylalanine-positron emission tomography (FDOPA-PET) than (123)I-metaiodobenzyl-guanidine (123-I-MIBG) scintigraphy."	3.76	6-18F-fluoro-L-dihydroxyphenylalanine positron emission tomography is superior to 123I-metaiodobenzyl-guanidine scintigraphy in the detection of extraadrenal and hereditary pheochromocytomas and paragangliomas: correlation with vesicular monoamine transpo ( Anlauf, M; Bartenstein, P; Fottner, C; Helisch, A; Klöppel, G; Kreft, A; Lackner, KJ; Musholt, TJ; Rossmann, H; Schadmand-Fischer, S; Schreckenberger, M; Weber, MM, 2010)
"Besides (123)I-metaiodobenzylguanidine (MIBG), positron emission tomography (PET) agents are available for the localization of paraganglioma (PGL), including (18)F-3,4-dihydroxyphenylalanine (DOPA), (18)F-fluoro-2-deoxy-D-glucose ((18)F-FDG), and (18)F-fluorodopamine ((18)F-FDA)."	3.75	Comparison of 18F-fluoro-L-DOPA, 18F-fluoro-deoxyglucose, and 18F-fluorodopamine PET and 123I-MIBG scintigraphy in the localization of pheochromocytoma and paraganglioma. ( Adams, KT; Carrasquillo, JA; Chen, CC; Eisenhofer, G; Havekes, B; Ling, A; Martiniova, L; Pacak, K; Timmers, HJ; Whatley, M, 2009)
"To evaluate fluorine 18 ((18)F) dihydroxyphenylalanine (DOPA) whole-body positron emission tomography (PET) as a biochemical imaging approach for detection of pheochromocytomas."	3.71	Pheochromocytomas: detection with 18F DOPA whole body PET--initial results.. ( Altehoefer, C; Brink, I; Ghanem, N; Hoegerle, S; Manz, T; Moser, E; Neumann, HP; Nitzsche, E; Reincke, M, 2002)
"Flow-cytometric analysis of nuclear DNA and measurements of tissue levels of dihydroxyphenylalanine (dopa) and catecholamines were performed using fresh samples of tissue taken from 17 patients with pheochromocytoma."	3.69	Nuclear DNA ploidy pattern and tissue levels of dihydroxyphenylalanine and catecholamines in pheochromocytoma. ( Ishigooka, M; Kubota, Y; Nakada, T; Sasagawa, I; Sawamura, T; Suzuki, Y, 1995)
"In PC12 rat pheochromocytoma cells differentiated with nerve growth factor (NGF), neuropeptide Y inhibited depolarization-stimulated catecholamine synthesis as determined by in situ measurement of 3,4-dihydroxyphenylalanine (DOPA) production in the presence of the decarboxylase inhibitor m-hydroxybenzylhydrazine (NSD-1015)."	3.69	Neuropeptide Y inhibits depolarization-stimulated catecholamine synthesis in rat pheochromocytoma cells. ( McCullough, LA; Westfall, TC, 1995)
"Pheochromocytoma tyrosine hydroxylase was reported to have unusual catalytic properties, which might be unique to the tumor enzyme (Dix, T."	3.68	The hydroxylation of phenylalanine and tyrosine by tyrosine hydroxylase from cultured pheochromocytoma cells. ( Kaufman, S; Pigeon, D; Ribeiro, P, 1991)
"A suppression of norepinephrine, epinephrine, and its metabolites in malignant pheochromocytoma by metyrosine was associated with an increase in tyrosine, plasma DOPA, and sulfate esters of DOPA and dopamine, followed, with continuing metyrosine administration, by a further rise of both DOPA sulfate and dopamine sulfate."	3.68	Alternative catecholamine pathways after tyrosine hydroxylase inhibition in malignant pheochromocytoma. ( Buu, NT; Edwards, DJ; Kuchel, O, 1990)
"The inhibitory effect of apomorphine on tyrosine hydroxylase (TH) was tested using enzyme preparations from rat striatum, neuroblastoma clone N1E-115 and pheochromocytoma clone PC-12."	3.67	Inhibition of striatal tyrosine hydroxylase by low concentrations of apomorphine. ( Bräutigam, M; Kittner, B; Laschinski, G, 1984)
"Pheochromocytoma cells (clone PC-12) were treated with 6-aminonicotinamide."	3.67	Inhibition of biopterin synthesis and DOPA production in PC-12 pheochromocytoma cells induced by 6-aminonicotinamide. ( Herken, H; Jung, W, 1989)
"Vasoactive intestinal peptide (VIP) acutely increases tyrosine hydroxylase (TH) activity in cultures of dispersed normal adult rat chromaffin cells and of PC12 rat pheochromocytoma cells."	3.67	Vasoactive intestinal peptide increases tyrosine hydroxylase activity in normal and neoplastic rat chromaffin cell cultures. ( Costopoulos, D; Horwitz, J; Perlman, RL; Tischler, AS, 1985)
"Effects of the 1-methyl-4-phenylpyridinium ion (MPP+) on DOPA formation and phosphorylation of tyrosine hydroxylase (TH) of rat pheochromocytoma PC12h cells were examined after the cells were cultured with MPP+."	3.67	Effect of the 1-methyl-4-phenylpyridinium ion on phosphorylation of tyrosine hydroxylase in rat pheochromocytoma PC12h cells. ( Hagiwara, M; Hidaka, H; Kiuchi, K; Nagatsu, T, 1988)
"The carboxylic ionophore monensin inhibits the activity of tyrosine 3-monooxygenase and decreases the rate of catecholamine synthesis in pheochromocytoma cells incubated in vitro."	3.66	Monensin inhibits catecholamine synthesis in pheochromocytoma cells. ( Liang, BT; Perlman, RL; Sheard, BE; Vaccaro, KK, 1982)
"Adenosine increases the activity of tyrosine 3-monooxygenase in intact pheochromocytoma cells."	3.66	Activation of tyrosine 3-monooxygenase in pheochromocytoma cells by adenosine. ( Berezo, MW; Erny, RE; Perlman, RL, 1981)
"Incubation of pheochromocytoma cells with 56 mM K+ or with cholera toxin increases the conversion of [14C]tyrosine to [14C]catecholamines (Chalfie, M."	3.66	Tyrosine 3-monooxygenase regulates catecholamine synthesis in pheochromocytoma cells. ( Liang, BT; Perelle, BA; Perlman, RL; Vaccaro, KK, 1980)
"Cells prepared from a transplantable rat pheochromocytoma synthesize norepinephrine from 14C-tyrosine, at a rate of 9."	3.65	Regulation of catecholamine biosynthesis in a transplantable rat pheochromocytoma. ( Chalfie, M; Perlman, RL, 1977)
"Paragangliomas are tumours that arise within the sympathetic nervous system originating from the neural crest."	2.43	Imaging of pheochromocytoma and paraganglioma. ( Bley, TA; Brink, I; Hoegerle, S; Klisch, J, 2005)
"Pheochromocytoma is a rare but clinically important tumor of catecholamine-secreting chromaffin cells."	2.41	Diagnostic localization of pheochromocytoma: the coming of age of positron emission tomography. ( Carrasquillo, JA; Chen, CC; Eisenhofer, G; Goldstein, DS; Pacak, K; Whatley, M, 2002)
"All pheochromocytomas were detected by both PET/CT and MRI."	1.40	(18)F-DOPA PET/CT and MRI: description of 12 histologically-verified pheochromocytomas. ( Dudczak, R; Hacker, M; Javor, D; Karanikas, G; Khameneh, A; Magnaldi, S; Mayerhoefer, ME; Mitterhauser, M; Schuetz, M, 2014)
"Paragangliomas and pheochromocytomas are genetically heterogeneous diseases."	1.38	Correlation of the genotype of paragangliomas and pheochromocytomas with their metabolic phenotype on 3,4-dihydroxy-6-18F-fluoro-L-phenylalanin PET. ( Benz, MR; Campbell, D; Dumont, RA; Mix, M; Neumann, HP; Rischke, HC; Rössler, J; Seufert, J; Weber, WA; Wiech, T; Wild, D, 2012)
"Successful treatment of pheochromocytoma requires accurate diagnosis and localization of tumors."	1.35	18F-FDOPA PET and PET/CT accurately localize pheochromocytomas. ( Agopian, VG; Auerbach, MS; Benz, MR; Czernin, JG; Dumont, RA; Imani, F; Lai, CK; Walter, MA; Yeh, MW, 2009)
"Neuroblastoma was the most common cause of elevated dopamine in children's specimens, although other associations are described."	1.33	Elevated urinary dopamine in adults and children. ( Davidson, DF, 2005)

Timeframe	Studies, this research(%)	All Research%
pre-1990	43 (40.95)	18.7374
1990's	11 (10.48)	18.2507
2000's	20 (19.05)	29.6817
2010's	29 (27.62)	24.3611
2020's	2 (1.90)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Diagnosis, Pathophysiology, and Molecular Biology of Pheochromocytoma and Paraganglioma[NCT00004847]	Phase 1	3,000 participants (Anticipated)	Interventional	2000-03-22	Recruiting
The Use of Fluorodopa F 18 Positron Emission Tomography Combined With Computed Tomography in Congenital Hyperinsulinism and Insulinoma[NCT02021604]	Phase 1	250 participants (Anticipated)	Interventional	2013-10-09	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
18F-fluorodihydroxyphenylalanine in the diagnosis of neuroendocrine tumors. PET clinics, 2014, Volume: 9, Issue:1 Topics: Adrenal Gland Neoplasms; Carcinoma, Neuroendocrine; Dihydroxyphenylalanine; Humans; Intestinal Neopl	2014
Role of (18) F-FDOPA PET/CT imaging in endocrinology. Clinical endocrinology, 2014, Volume: 81, Issue:6 Topics: Adrenal Gland Neoplasms; Carbidopa; Carcinoid Tumor; Carcinoma, Neuroendocrine; Dihydroxyphenylalani	2014
PET/Computed Tomography in Neuroendocrine Tumor: Value to Patient Management and Survival Outcomes. PET clinics, 2015, Volume: 10, Issue:3 Topics: Adrenal Gland Neoplasms; Dihydroxyphenylalanine; Fluorodeoxyglucose F18; Gallium Radioisotopes; Gast	2015
[Adrenal incidentaloma and nuclear medicine examination]. Journal de radiologie, 2009, Volume: 90, Issue:3 Pt 2 Topics: 19-Iodocholesterol; 3-Iodobenzylguanidine; Adenoma; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasm	2009
Diagnostic localization of pheochromocytoma: the coming of age of positron emission tomography. Annals of the New York Academy of Sciences, 2002, Volume: 970 Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Dihydroxyphenylalanine; Fluorine Radioisotopes; Huma	2002
RECENT ADVANCES IN THE BIOCHEMICAL, PHARMACOLOGICAL AND CLINICAL ASPECTS OF PHEOCHROMOCYTOMA. The Journal of the Arkansas Medical Society, 1963, Volume: 60 Topics: Biochemical Phenomena; Biochemistry; Catecholamines; Dihydroxyphenylalanine; Dopamine; Epinephrine;	1963
Imaging of pheochromocytoma and paraganglioma. Familial cancer, 2005, Volume: 4, Issue:1 Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Dihydroxyphenylalanine; Fluorodeoxyglucose F18; Huma	2005
[3,4-Dihydroxyphenyl alanine (DOPA)]. Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 8 Topics: Adrenal Gland Neoplasms; Biomarkers; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; H	2005
6-L-18F-fluorodihydroxyphenylalanine PET in neuroendocrine tumors: basic aspects and emerging clinical applications. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2008, Volume: 49, Issue:4 Topics: Adenoma, Islet Cell; Dihydroxyphenylalanine; Humans; Hyperinsulinism; Neuroendocrine Tumors; Pancrea	2008
[Pheochromocytoma]. Przeglad lekarski, 1982, Volume: 39, Issue:6 Topics: Adrenal Gland Neoplasms; Dihydroxyphenylalanine; Epinephrine; Humans; Norepinephrine; Pheochromocyto	1982

Article	Year
Prospective comparison of (68)Ga-DOTATATE and (18)F-FDOPA PET/CT in patients with various pheochromocytomas and paragangliomas with emphasis on sporadic cases. European journal of nuclear medicine and molecular imaging, 2016, Volume: 43, Issue:7 Topics: Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Dihydroxyphenylalanine; False Positive Reac	2016
The effects of carbidopa on uptake of 6-18F-Fluoro-L-DOPA in PET of pheochromocytoma and extraadrenal abdominal paraganglioma. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2007, Volume: 48, Issue:10 Topics: Abdominal Neoplasms; Adrenal Gland Neoplasms; Carbidopa; Dihydroxyphenylalanine; Female; Humans; Ima	2007
[Evaluation of the usefulness for measuring catecholamines and their principle metabolites in the diagnosis of pheochromocytoma]. Przeglad lekarski, 1997, Volume: 54, Issue:11 Topics: Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Catecholamines; Dihydroxyphenylalanine; Dop	1997

Article	Year
Recurrence of a Pheochromocytoma With TNEM127 Mutation Negative on 18F-FDOPA and 18F-FDG but Positive on 123I-MIBG and 68Ga-DOTATOC Imaging. Clinical nuclear medicine, 2022, Mar-01, Volume: 47, Issue:3 Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Aged; Dihydroxyphenylalanine; Female; Fluorodeoxyglu	2022
Comparison of 18 F-FDOPA and 18 F-MFBG PET/CT Images of Metastatic Pheochromocytoma. Clinical nuclear medicine, 2023, Jul-01, Volume: 48, Issue:7 Topics: Adrenal Gland Neoplasms; Adult; Dihydroxyphenylalanine; Humans; Male; Neoplasms, Second Primary; Per	2023
Synchronous bilateral pheochromocytomas and bilobar medullary thyroid carcinoma revealed by Endocrine, 2019, Volume: 66, Issue:3 Topics: Adrenal Gland Neoplasms; Adult; Carcinoma, Neuroendocrine; Dihydroxyphenylalanine; Female; Humans; M	2019
FDOPA Patterns in Adrenal Glands: A Pictorial Essay. Clinical nuclear medicine, 2017, Volume: 42, Issue:5 Topics: Adrenal Gland Neoplasms; Adrenal Glands; Aged; Dihydroxyphenylalanine; Female; Fluorine Radioisotope	2017
Quantitative analysis of normal and pathologic adrenal glands with 18F-FDOPA PET/CT: focus on pheochromocytomas. Nuclear medicine communications, 2017, Volume: 38, Issue:9 Topics: Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Diagnosis, Differential; Dihydroxyphenylalan	2017
18F-FDOPA PET/CT Imaging of MAX-Related Pheochromocytoma. The Journal of clinical endocrinology and metabolism, 2018, 04-01, Volume: 103, Issue:4 Topics: Adrenal Gland Neoplasms; Adult; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Dihydro	2018
False-positive findings on 6-[18F]fluor-l-3,4-dihydroxyphenylalanine PET ( European journal of endocrinology, 2018, Volume: 179, Issue:2 Topics: Adrenal Gland Neoplasms; Adult; Aged; Dihydroxyphenylalanine; False Positive Reactions; Female; Huma	2018
18F-FDOPA PET/CT Uptake Parameters Correlate with Catecholamine Secretion in Human Pheochromocytomas. Neuroendocrinology, 2018, Volume: 107, Issue:3 Topics: Adrenal Gland Neoplasms; Adult; Aged; Catecholamines; Dihydroxyphenylalanine; Female; Humans; Male;	2018
18F-FDOPA PET Compared With 123I-Metaiodobenzylguanidine Scintigraphy and 18F-FDG PET in Secreting Sporadic Pheochromocytoma. Clinical nuclear medicine, 2019, Volume: 44, Issue:9 Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Dihydroxyphenylalanine; Fluorodeoxyglucose F18; Huma	2019
18F-DOPA PET/CT in the evaluation of hereditary SDH-deficiency paraganglioma-pheochromocytoma syndromes. Clinical nuclear medicine, 2014, Volume: 39, Issue:1 Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Dihydroxyphenylalanine; Female; Humans; Male; Middle Age	2014
(18)F-DOPA PET/CT and MRI: description of 12 histologically-verified pheochromocytomas. Anticancer research, 2014, Volume: 34, Issue:2 Topics: Adrenal Gland Neoplasms; Adult; Aged; Dihydroxyphenylalanine; Female; Fluorine Radioisotopes; Humans	2014
Renaissance of (18)F-FDG positron emission tomography in the imaging of pheochromocytoma/paraganglioma. The Journal of clinical endocrinology and metabolism, 2014, Volume: 99, Issue:7 Topics: Adrenal Gland Neoplasms; Dihydroxyphenylalanine; Fluorodeoxyglucose F18; History, 20th Century; Hist	2014
Fetal and maternal absorbed dose estimates for positron-emitting molecular imaging probes. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014, Volume: 55, Issue:9 Topics: Dihydroxyphenylalanine; Female; Fetus; Fluorodeoxyglucose F18; Humans; Molecular Imaging; Pheochromo	2014
Multimodality imaging of bilateral pheochromocytoma. A case report. Annali italiani di chirurgia, 2015, Jun-22, Volume: 86, Issue:ePub Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Adrenalectomy; Aged; Dihydroxyphenylalanine; False N	2015
Adrenal Metastasis of a Poorly Differentiated Adenocarcinoma Mimicking a Pheochromocytoma on 18F-FDOPA PET/CT. Clinical nuclear medicine, 2016, Volume: 41, Issue:9 Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Adult; Diagnosis, Differential; Dihydroxyphenylalanine; Fat	2016
Catecholamine-Induced Chest Pain Mimicking Infarction Due to an MIBG-Negative and DOPA-Positive Succinate Dehydrogenase Syndrome Subunit B-Related Pheochromocytoma. Clinical nuclear medicine, 2017, Volume: 42, Issue:6 Topics: 3-Iodobenzylguanidine; Adolescent; Adrenal Gland Neoplasms; Catecholamines; Chest Pain; Dihydroxyphe	2017
Image in endocrinology. Localization of an adrenocorticotropin-producing pheochromocytoma using 18F-dihydroxyphenylalanine positron emission tomography. The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:3 Topics: Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aged; Dihydroxyphenylalanine; Humans; Male; Ph	2009
18F-FDOPA PET and PET/CT accurately localize pheochromocytomas. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2009, Volume: 50, Issue:4 Topics: Adrenal Gland Neoplasms; Adult; Aged; Dihydroxyphenylalanine; Female; Humans; Image Enhancement; Mal	2009
6-[F-18]Fluoro-L-dihydroxyphenylalanine positron emission tomography is superior to conventional imaging with (123)I-metaiodobenzylguanidine scintigraphy, computer tomography, and magnetic resonance imaging in localizing tumors causing catecholamine exces The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:10 Topics: 3-Iodobenzylguanidine; Adolescent; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Aged; Biomarkers;	2009
Animal model of metastatic pheochromocytoma: evaluation by MRI and PET. Endocrine regulations, 2009, Volume: 43, Issue:2 Topics: Adrenal Gland Neoplasms; Animals; Dihydroxyphenylalanine; Disease Models, Animal; Dopamine; Female;	2009
Clinical value of 18F-fluorodihydroxyphenylalanine positron emission tomography/computed tomography (18F-DOPA PET/CT) for detecting pheochromocytoma. European journal of nuclear medicine and molecular imaging, 2010, Volume: 37, Issue:3 Topics: Adolescent; Adult; Aged; Biological Transport; Child; Dihydroxyphenylalanine; Endocrine Gland Neopla	2010
Comparison of 18F-fluoro-L-DOPA, 18F-fluoro-deoxyglucose, and 18F-fluorodopamine PET and 123I-MIBG scintigraphy in the localization of pheochromocytoma and paraganglioma. The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:12 Topics: 3-Iodobenzylguanidine; Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Dihydroxyphenylalanine; Dop	2009
Diagnosis: imaging of pheochromocytomas and paragangliomas. Nature reviews. Endocrinology, 2010, Volume: 6, Issue:4 Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Contrast Media; Diagnostic Imaging; Dihydroxyphenyla	2010
6-18F-fluoro-L-dihydroxyphenylalanine positron emission tomography is superior to 123I-metaiodobenzyl-guanidine scintigraphy in the detection of extraadrenal and hereditary pheochromocytomas and paragangliomas: correlation with vesicular monoamine transpo The Journal of clinical endocrinology and metabolism, 2010, Volume: 95, Issue:6 Topics: 3-Iodobenzylguanidine; Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Biomarkers; Data Interpreta	2010
I-123 MIBG scintigraphy and 68Ga-DOTANOC PET/CT negative but F-18 DOPA PET/CT positive pheochromocytoma: a case report. Clinical nuclear medicine, 2011, Volume: 36, Issue:2 Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Adult; Dihydroxyphenylalanine; False Negative Reacti	2011
Comparison of 123I-MIBG SPECT-CT and 18F-DOPA PET-CT in the evaluation of patients with known or suspected recurrent paraganglioma. Nuclear medicine communications, 2011, Volume: 32, Issue:7 Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Adult; Aged; Dihydroxyphenylalanine; Female; Humans;	2011
Novel use of F-DOPA PET/CT imaging in a child with paraganglioma/pheochromocytoma syndrome. Pediatric radiology, 2011, Volume: 41, Issue:10 Topics: Adolescent; Adrenal Gland Neoplasms; Dihydroxyphenylalanine; Female; Humans; Kidney Neoplasms; Multi	2011
Usefulness of [18F]-DA and [18F]-DOPA for PET imaging in a mouse model of pheochromocytoma. Nuclear medicine and biology, 2012, Volume: 39, Issue:2 Topics: Adrenal Gland Neoplasms; Animals; Contrast Media; Dihydroxyphenylalanine; Dopamine; Female; Liver Ne	2012
Is there an optimal scan time for 6-[F-18]fluoro-L-DOPA PET in pheochromocytomas and paragangliomas? Clinical nuclear medicine, 2012, Volume: 37, Issue:2 Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Dihydroxyphenylalanine; Female;	2012
Correlation of the genotype of paragangliomas and pheochromocytomas with their metabolic phenotype on 3,4-dihydroxy-6-18F-fluoro-L-phenylalanin PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2012, Volume: 53, Issue:9 Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Biological Transport; Child; Di	2012
(18)F-DOPA PET/CT revealed synchronous neuroendocrine tumors in two sisters with MEN2A syndrome. Endocrine, 2013, Volume: 43, Issue:2 Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Carcinoma, Medullary; Dihydroxyphenylalanine; Female;	2013
Functional characterization of nonmetastatic paraganglioma and pheochromocytoma by (18) F-FDOPA PET: focus on missed lesions. Clinical endocrinology, 2013, Volume: 79, Issue:2 Topics: Abdominal Neoplasms; Adrenal Gland Neoplasms; Dihydroxyphenylalanine; False Negative Reactions; Head	2013
Biochemical observations of a chromaffine tumour. Revue canadienne de biologie, 1957, Volume: 16, Issue:4 Topics: Adenosine Triphosphate; Animals; Dihydroxyphenylalanine; Dog Diseases; Dogs; Epinephrine; Pheochromo	1957
Observations on the substrate specificity of DOPA decarboxylase from ox adrenal medulla, human phaeochromocytoma and human argentaffinoma. British journal of pharmacology and chemotherapy, 1962, Volume: 18 Topics: 5-Hydroxytryptophan; Adrenal Medulla; Carcinoid Tumor; Dihydroxyphenylalanine; Dopa Decarboxylase; H	1962
[PHEOCHROMOCYTOMA AS A CAUSE OF CURABLE ARTERIAL HYPERTENSION. PRESENTATION OF A NEW CASE]. Revista clinica espanola, 1963, Aug-31, Volume: 90 Topics: Adolescent; Angiography; Antihypertensive Agents; Dihydroxyphenylalanine; Hypertension; Methyldopa;	1963
QUANTITATIVE DETERMINATION OF METANEPHRINE AND NORMETANEPHRINE IN URINE. The Journal of laboratory and clinical medicine, 1964, Volume: 64 Topics: Amines; Chromatography; Dihydroxyphenylalanine; Epinephrine; Fluorescence; Fluorometry; Humans; Indi	1964
STUDY ON THE BIOGENESIS OF CATECHOLAMINES IN PHEOCHROMOCYTOMA TISSUE CULTURE. Archives of biochemistry and biophysics, 1964, Jul-20, Volume: 106 Topics: Adenosine Triphosphate; Adrenocorticotropic Hormone; Catecholamines; Dihydroxyphenylalanine; Dopamin	1964
STUDIES OF FUNCTIONAL NEURAL TUMORS. VI. BIOCHEMICAL DIAGNOSIS. Scandinavian journal of clinical and laboratory investigation, 1964, Volume: 16 Topics: Abdominal Neoplasms; Adolescent; Adrenal Gland Neoplasms; Amino Acids; Child; Dihydroxyphenylalanine	1964
TUMORS OF NEURAL CREST ORIGIN; BIOCHEMICAL AND PATHOLOGICAL CORRELATION. Archives of neurology, 1965, Volume: 13 Topics: Biochemical Phenomena; Biochemistry; Catecholamines; Child; Dihydroxyphenylalanine; Dopamine; Epinep	1965
Cardiac uptake-1 inhibition by high circulating norepinephrine levels in patients with pheochromocytoma. Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:6 Topics: Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Binding, Competitive; Dihydroxyphenylalanin	2004
Visualization of the gall bladder on F-18 FDOPA PET imaging: a potential pitfall. Clinical nuclear medicine, 2005, Volume: 30, Issue:1 Topics: Artifacts; Diagnosis, Differential; Diagnostic Errors; Dihydroxyphenylalanine; Gallbladder; Humans;	2005
Biochemical and clinical manifestations of dopamine-producing paragangliomas: utility of plasma methoxytyramine. The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:4 Topics: Adrenal Gland Neoplasms; Adult; Dihydroxyphenylalanine; Dopamine; Female; Humans; Male; Middle Aged;	2005
Elevated urinary dopamine in adults and children. Annals of clinical biochemistry, 2005, Volume: 42, Issue:Pt 3 Topics: Adrenal Gland Neoplasms; Adult; Antidepressive Agents; Catecholamines; Child; Dihydroxyphenylalanine	2005
The use of 18-fluoro-dihydroxyphenylalanine and 18-fluorodeoxyglucose positron emission tomography scanning in the assessment of metaiodobenzylguanidine-negative phaeochromocytoma. European journal of endocrinology, 2007, Volume: 157, Issue:4 Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Adult; Dihydroxyphenylalanine; Fluorine Radioisotope	2007
The role of 18F-FDOPA and 18F-FDG-PET in the management of malignant and multifocal phaeochromocytomas. Clinical endocrinology, 2008, Volume: 69, Issue:4 Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Adult; Aged; Dihydroxyphenylalanine; Disease Progres	2008
Dihydroxyphenylalanine secretion in a malignant pheochromocytoma. The American journal of medicine, 1967, Volume: 42, Issue:3 Topics: Adult; Diagnosis, Differential; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; Fluorometry;	1967
Tyrosine 3-monooxygenase regulates catecholamine synthesis in pheochromocytoma cells. The Journal of biological chemistry, 1980, Jul-25, Volume: 255, Issue:14 Topics: Biological Transport; Catecholamines; Cholera Toxin; Dihydroxyphenylalanine; Enzyme Activation; Huma	1980
Activation of tyrosine 3-monooxygenase in pheochromocytoma cells by adenosine. The Journal of biological chemistry, 1981, Feb-10, Volume: 256, Issue:3 Topics: 2-Chloroadenosine; Adenosine; Adrenal Gland Neoplasms; Calcium; Cholera Toxin; Cyclic AMP; Dihydroxy	1981
Monensin inhibits catecholamine synthesis in pheochromocytoma cells. The Journal of pharmacology and experimental therapeutics, 1982, Volume: 221, Issue:3 Topics: Adrenal Gland Neoplasms; Animals; Catecholamines; Cells, Cultured; Chromaffin Granules; Dihydroxyphe	1982
Adenosine-dependent activation of tyrosine hydroxylase is defective in adenosine kinase-deficient PC12 cells. Proceedings of the National Academy of Sciences of the United States of America, 1984, Volume: 81, Issue:15 Topics: Adenosine; Adenosine Kinase; Animals; Cells, Cultured; Cholera Toxin; Cyclic AMP; Dihydroxyphenylala	1984
Inhibition of striatal tyrosine hydroxylase by low concentrations of apomorphine. Naunyn-Schmiedeberg's archives of pharmacology, 1984, Volume: 327, Issue:2 Topics: Animals; Apomorphine; Biopterins; Cells, Cultured; Corpus Striatum; Dihydroxyphenylalanine; In Vitro	1984
Glucocorticoids increase catecholamine synthesis and storage in PC12 pheochromocytoma cell cultures. Journal of neurochemistry, 1983, Volume: 40, Issue:2 Topics: Adrenal Gland Neoplasms; Animals; Cell Line; Cholera Toxin; Corticosterone; Dexamethasone; Dihydroxy	1983
Malignant phaeochromocytoma with high circulating DOPA, and clonidine-suppressible noradrenaline. Blood pressure, 1995, Volume: 4, Issue:4 Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Agonists; Aged; Clonidine; Dihydroxyphenylalanine; Humans;	1995
Nuclear DNA ploidy pattern and tissue levels of dihydroxyphenylalanine and catecholamines in pheochromocytoma. Urologia internationalis, 1995, Volume: 54, Issue:4 Topics: Adrenal Gland Neoplasms; Adult; Aged; Catecholamines; Cell Nucleus; Chromatography, High Pressure Li	1995
TOPA quinone, a kainate-like agonist and excitotoxin is generated by a catecholaminergic cell line. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:4 Topics: Adrenal Gland Neoplasms; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Catecholamines; Chro	1995
Co-induction of tetrahydrobiopterin (BH4) levels and tyrosine hydroxylase activity in cultured PC12 cells. Advances in experimental medicine and biology, 1993, Volume: 338 Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Gland Neoplasms; Analysis of Variance; Animals; Biopterins;	1993
Neuropeptide Y inhibits depolarization-stimulated catecholamine synthesis in rat pheochromocytoma cells. European journal of pharmacology, 1995, Dec-20, Volume: 287, Issue:3 Topics: Adrenal Gland Neoplasms; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aro	1995
[Surgical treatment of a patient with giant pheochromocytoma]. Khirurgiia, 2001, Issue:10 Topics: Adrenal Gland Neoplasms; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; Humans; Middle Aged;	2001
Dopamine and dopa urinary excretion in patients with pheochromocytoma--diagnostic implications. Blood pressure, 2001, Volume: 10, Issue:4 Topics: Adult; Biomarkers, Tumor; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; Homovanillic Acid;	2001
Pheochromocytomas: detection with 18F DOPA whole body PET--initial results.. Radiology, 2002, Volume: 222, Issue:2 Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Dihydroxyphenylalanine; Female; Fluorine Radioisot	2002
Regulation of catecholamine biosynthesis in a transplantable rat pheochromocytoma. The Journal of pharmacology and experimental therapeutics, 1977, Volume: 200, Issue:3 Topics: Animals; Brocresine; Calcium; Cells, Cultured; Chromaffin System; Cycloheximide; Dihydroxyphenylalan	1977
A selective Ca2+/calmodulin-dependent protein kinase II inhibitor, KN-62, inhibits the enhanced phosphorylation and the activation of tyrosine hydroxylase by 56 mM K+ in rat pheochromocytoma PC12h cells. Biochemical and biophysical research communications, 1991, May-15, Volume: 176, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Gland Neoplasms; Animals; Calcium-Calmodulin-	1991
Reduction of enzymatic activity of tyrosine hydroxylase by a heterocyclic amine, 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole (Trp-P-1), was due to reduced affinity to a cofactor biopterin. Neuroscience letters, 1991, Apr-15, Volume: 125, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Gland Neoplasms; Animals; Biopterins; Carbolines; Cell Line;	1991
The hydroxylation of phenylalanine and tyrosine by tyrosine hydroxylase from cultured pheochromocytoma cells. The Journal of biological chemistry, 1991, Aug-25, Volume: 266, Issue:24 Topics: Animals; Biopterins; Catalysis; Dihydroxyphenylalanine; Electrophoresis, Polyacrylamide Gel; Hydroge	1991
Alternative catecholamine pathways after tyrosine hydroxylase inhibition in malignant pheochromocytoma. The Journal of laboratory and clinical medicine, 1990, Volume: 115, Issue:4 Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Catecholamines; Dihydroxyphenylalanine; Dopamine; Epi	1990
Mimicry and inhibition of nerve growth factor effects: interactions of staurosporine, forskolin, and K252a in PC12 cells and normal rat chromaffin cells in vitro. Journal of neurochemistry, 1990, Volume: 55, Issue:4 Topics: Adrenal Gland Neoplasms; Adrenal Medulla; Alkaloids; Animals; Animals, Newborn; Axons; Carbazoles; C	1990
PC12 cells: a model system for studying drug effects on dopamine synthesis and release. Archives internationales de pharmacodynamie et de therapie, 1987, Volume: 286, Issue:2 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e	1987
[Clinical significance of 3,4-dihydroxyphenylalanine analysis in endocrine tests of the adrenal medulla and sympathetic nervous system]. Nihon rinsho. Japanese journal of clinical medicine, 1989, Volume: 48 Suppl Topics: Adolescent; Adrenal Gland Neoplasms; Adrenal Medulla; Adult; Aged; Child; Child, Preschool; Chromato	1989
Inhibition of biopterin synthesis and DOPA production in PC-12 pheochromocytoma cells induced by 6-aminonicotinamide. Naunyn-Schmiedeberg's archives of pharmacology, 1989, Volume: 339, Issue:4 Topics: 6-Aminonicotinamide; Alcohol Oxidoreductases; Animals; Biopterins; Chromatography, High Pressure Liq	1989
Regulation of tyrosine hydroxylase activity in rat PC12 cells by neuropeptides of the secretin family. Molecular pharmacology, 1989, Volume: 36, Issue:6 Topics: Adrenal Gland Neoplasms; Animals; Calcium; Colforsin; Cyclic AMP; Dihydroxyphenylalanine; Enzyme Act	1989
Vasoactive intestinal peptide increases tyrosine hydroxylase activity in normal and neoplastic rat chromaffin cell cultures. Neuroscience letters, 1985, Oct-24, Volume: 61, Issue:1-2 Topics: Adrenal Gland Neoplasms; Adrenal Medulla; Animals; Cell Line; Cells, Cultured; Cyclic AMP; Dihydroxy	1985
Effect of the 1-methyl-4-phenylpyridinium ion on phosphorylation of tyrosine hydroxylase in rat pheochromocytoma PC12h cells. Neuroscience letters, 1988, Jun-29, Volume: 89, Issue:2 Topics: 1-Methyl-4-phenylpyridinium; Adrenal Gland Neoplasms; Animals; Dihydroxyphenylalanine; Pheochromocyt	1988
Plasma 3,4-dihydroxyphenylalanine (dopa) and catecholamines in neuroblastoma or pheochromocytoma. Annals of internal medicine, 1986, Volume: 105, Issue:6 Topics: Adrenal Gland Neoplasms; Catecholamines; Chromatography, High Pressure Liquid; Dihydroxyphenylalanin	1986
Effect of apomorphine, alpha-methylparatyrosine, haloperidol and reserpine on DOPA production in clonal cell lines (PC-12 and N1E-115). Biochemical pharmacology, 1985, Apr-01, Volume: 34, Issue:7 Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Animals; Apomorphine; Cell Line; Dihydroxyphenylalani	1985
Clinical and biochemical aspects of pheochromocytoma. Report of 110 cases. Cardiology, 1985, Volume: 72 Suppl 1 Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Child; Circadian Rhythm; Dihydroxyphenylalanine; D	1985
Dopa decarboxylase in medullary carcinoma of the thyroid. The New England journal of medicine, 1973, Sep-13, Volume: 289, Issue:11 Topics: Adrenal Gland Neoplasms; Amine Oxidase (Copper-Containing); Aromatic Amino Acid Decarboxylase Inhibi	1973
Orthohydroxyhippuric (salicyluric) acid--its physiologic and clinical significance. Clinical pharmacology and therapeutics, 1974, Volume: 15, Issue:2 Topics: Anemia; Animals; Cattle; Dihydroxyphenylalanine; Dogs; Down Syndrome; Fever; Glycine; Humans; Hypert	1974
[Autoradiographic examinations of the metabolic activity of the carotid body]. Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde, 1970, Volume: 196, Issue:2 Topics: Animals; Carotid Body; Catecholamines; Dihydroxyphenylalanine; Ganglia, Autonomic; Humans; Mice; Par	1970
Quantitative fluorimetric determination of urinary dopa and its significance for the diagnosis of neural crest tumours. Clinica chimica acta; international journal of clinical chemistry, 1971, Volume: 32, Issue:1 Topics: Adult; Child; Chromatography, Ion Exchange; Dihydroxyphenylalanine; Fluorometry; Ganglioneuroma; Hum	1971
Circular thin-layer chromatography for diagnosis and follow-up of neural crest tumours. Journal of chromatography, 1973, Jul-18, Volume: 82, Issue:1 Topics: Catecholamines; Catechols; Chromatography, Gas; Chromatography, Thin Layer; Diagnosis, Differential;	1973
[Biochemical tumor diagnosis in childhood]. Schweizerische medizinische Wochenschrift, 1974, May-04, Volume: 104, Issue:18 Topics: Adenoma, Islet Cell; Adrenal Gland Neoplasms; Carcinoma, Hepatocellular; Child; Cushing Syndrome; De	1974
Secretion of dopa in phaeochromocytoma. British medical journal, 1972, Nov-11, Volume: 4, Issue:5836 Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; H	1972
[Biochemical diagnosis of pheochromocytoma, neuroblastoma and other neuro-ectodermal neoplasms]. Helvetica paediatrica acta, 1972, Volume: 29 Topics: Adolescent; Adult; Catecholamines; Child; Child, Preschool; Dihydroxyphenylalanine; Dopamine; Electr	1972
The management of hypertension during pregnancy. The Journal of reproductive medicine, 1972, Volume: 8, Issue:2 Topics: Adolescent; Adult; Blood Pressure; Clinical Laboratory Techniques; Diagnosis, Differential; Dihydrox	1972
Phaeochromocytoma in childhood: report of 3 cases. Archives of disease in childhood, 1973, Volume: 48, Issue:2 Topics: Adolescent; Adrenal Gland Neoplasms; Blood Pressure; Catecholamines; Child; Dihydroxyphenylalanine;	1973
Pheochromocytoma. Archives of surgery (Chicago, Ill. : 1960), 1972, Volume: 104, Issue:2 Topics: Adrenal Gland Neoplasms; Adrenal Medulla; Catecholamines; Chromaffin System; Dihydroxyphenylalanine;	1972
Evaluation of increased norepinephrine excretion in hypertension using L-dopa-3H. Circulation research, 1971, Volume: 28, Issue:1 Topics: Adrenal Glands; Adult; Aged; Diagnosis, Differential; Dihydroxyphenylalanine; Epinephrine; Female; H	1971
[Catecholamine metabolism in the tissue of malignant and benign tumors of the sympathetic nervous system]. Schweizerische medizinische Wochenschrift, 1971, Apr-03, Volume: 101, Issue:13 Topics: Catecholamines; Dihydroxyphenylalanine; Dopamine; Epinephrine; Humans; Microscopy, Electron; Neurobl	1971
The role of catecholamines in producing arrhythmias. The American journal of the medical sciences, 1971, Volume: 262, Issue:1 Topics: Anesthetics; Antidepressive Agents; Arrhythmias, Cardiac; Atropine; Catecholamines; Digitalis Glycos	1971
Catecholamine metabolism in neuroblastoma. Journal of pediatric surgery, 1968, Volume: 3, Issue:1 Topics: Adolescent; Adult; Catecholamines; Child; Child, Preschool; Chromatography, Paper; Dihydroxyphenylal	1968
[Presence of dopamine in human adrenal glands]. Revue francaise d'etudes cliniques et biologiques, 1969, Volume: 14, Issue:3 Topics: Adolescent; Adrenal Glands; Adult; Aged; Dihydroxyphenylalanine; Dopamine; Epinephrine; Humans; Midd	1969
Paper chromatographic identification of catecholamines. Journal of applied physiology, 1966, Volume: 21, Issue:6 Topics: Adrenal Medulla; Adult; Animals; Catecholamines; Child; Chromatography, Paper; Dihydroxyphenylalanin	1966

dihydroxyphenylalanine and Pheochromocytoma

Research Excerpts

Research

Studies (105)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Cottereau, AS	1
Garcia, C	1
Dousset, B	1
Libe, R	1
Tenenbaum, F	2
Wei, F	1
Wu, B	1
Ling, X	1
Gong, J	1
Xu, H	1
Rotania, M	1
Chabrier, G	1
Imperiale, A	2
Moreau, A	2
Giraudet, AL	2
Kryza, D	2
Borson-Chazot, F	2
Bournaud-Salinas, C	1
Mognetti, T	2
Lifante, JC	2
Combemale, P	2
Giammarile, F	2
Houzard, C	2
Bournaud, C	1
Taïeb, D	7
Jha, A	1
Guerin, C	3
Pang, Y	1
Adams, KT	4
Chen, CC	5
Romanet, P	1
Roche, P	1
Essamet, W	1
Ling, A	3
Quezado, MM	1
Castinetti, F	2
Sebag, F	5
Pacak, K	11
Berends, AMA	1
Kerstens, MN	2
Bolt, JW	1
Links, TP	2
Korpershoek, E	1
de Krijger, RR	1
Walenkamp, AME	1
Noordzij, W	1
van Etten, B	1
Kats-Ugurlu, G	1
Brouwers, AH	4
van der Horst-Schrivers, ANA	1
Moog, S	1
Houy, S	1
Chevalier, E	1
Ory, S	1
Weryha, G	1
Rame, M	1
Klein, M	1
Brunaud, L	1
Gasman, S	1
Cuny, T	1
Lugat, A	1
Drui, D	1
Mirallié, E	1
Kraeber-Bodéré, F	1
Ansquer, C	1
Marzola, MC	1
Chondrogiannis, S	1
Grassetto, G	1
Rampin, L	1
Maffione, AM	1
Ferretti, A	2
Opocher, G	1
Schiavi, F	1
Colletti, PM	2
Rubello, D	2
Magnaldi, S	1
Mayerhoefer, ME	1
Khameneh, A	1
Schuetz, M	1
Javor, D	1
Mitterhauser, M	1
Dudczak, R	1
Hacker, M	1
Karanikas, G	1
Timmers, HJ	3
Shulkin, BL	1
Xie, T	1
Zaidi, H	1
Minn, H	1
Kemppainen, J	1
Kauhanen, S	1
Forsback, S	1
Seppänen, M	1
Santhanam, P	1
Shamim, SA	1
Kumar, A	1
Kumar, R	1
Paladino, NC	1
Lowery, A	1
Archier, A	1
Varoquaux, A	1
Garrigue, P	1
Montava, M	1
Gabriel, S	2
Beschmout, E	1
Morange, I	3
Fakhry, N	2
Barlier, A	3
Loundou, A	1
Guillet, B	1
Heimburger, C	1
Averous, G	1
Charlin, E	1
Lang, H	1
Kurtz, JE	1
Mazza, A	1
Sacco, AP	1
Fiebrich, HB	2
van Bergeijk, L	1
van den Berg, G	1
Imani, F	2
Agopian, VG	1
Auerbach, MS	1
Walter, MA	1
Benz, MR	2
Dumont, RA	2
Lai, CK	1
Czernin, JG	1
Yeh, MW	1
Pijl, ME	1
Kema, IP	1
de Jong, JR	1
Jager, PL	2
Elsinga, PH	1
Dierckx, RA	1
van der Wal, JE	1
Sluiter, WJ	1
de Vries, EG	1
Martiniova, L	4
Lai, EW	3
Thomasson, D	2
Kiesewetter, DO	2
Seidel, J	2
Merino, MJ	1
Kvetnansky, R	2
Luster, M	1
Karges, W	1
Zeich, K	1
Pauls, S	1
Verburg, FA	1
Dralle, H	1
Glatting, G	1
Buck, AK	1
Solbach, C	1
Neumaier, B	1
Reske, SN	1
Mottaghy, FM	1
Carrasquillo, JA	3
Whatley, M	3
Havekes, B	1
Eisenhofer, G	7
Chew, SL	1
Fottner, C	1
Helisch, A	1
Anlauf, M	1
Rossmann, H	1
Musholt, TJ	1
Kreft, A	1
Schadmand-Fischer, S	1
Bartenstein, P	1
Lackner, KJ	1
Klöppel, G	1
Schreckenberger, M	1
Weber, MM	1
Grassi, I	1
Nanni, C	1
Vicennati, V	1
Castellucci, P	1
Allegri, V	1
Montini, GC	1
Pagotto, U	1
di Dalmazi, G	1
Pasquali, R	1
Fanti, S	2
Rufini, V	2
Treglia, G	2
Castaldi, P	2
Perotti, G	1
Calcagni, ML	1
Corsello, SM	1
Galli, G	1
Giordano, A	1
Levine, DS	1
Metzger, DL	1
Nadel, HR	1
Oviedo, A	1
Adam, MJ	1
Skarsgard, E	1
Cleary, S	1
Dawson, LF	1
Phillips, JK	1
Chen, X	1
Powers, JF	1
Hentschel, M	1
Rottenburger, C	1
Boedeker, CC	1
Neumann, HP	3
Brink, I	3
Rischke, HC	1
Wild, D	1
Mix, M	1
Campbell, D	1
Seufert, J	1
Wiech, T	1
Rössler, J	1
Weber, WA	1
Blanchet, EM	1
Deveze, A	1
Goldstein, DS	4
GELINAS, R	1
PELLERIN, J	1
D'IORIO, A	1
HAGEN, P	1
ATKINSON, GA	1
RAPADOERRAZTI, A	1
JIMENEZCASADO, M	1
RODRIGUEZSANTOS, A	1
NAVARRO, V	1
TANIGUCHI, K	1
KAKIMOTO, Y	1
ARMSTRONG, MD	1
CABANA, BE	1
PROKESCH, JC	1
CHRISTIANSEN, GS	1
GJESSING, LR	1
GREER, M	2
ANTON, AH	2
WILLIAMS, CM	2
ECHEVARRIA, RA	1
Eldadah, BA	1
Holmes, C	1
Kopin, IJ	1
Balan, KK	2
Sullivan, P	1
Csako, G	1
Brouwers, FM	1
Hoegerle, S	2
Klisch, J	1
Bley, TA	1
Davidson, DF	1
Yatabe, J	1
Sanada, H	1
Hadi, M	1
Mackenzie, IS	1
Gurnell, M	1
Simpson, H	1
Chatterjee, K	1
Brown, MJ	1
Chirakal, R	1
Marriott, CJ	1
Koopmans, KP	1
Gulenchyn, KY	1
Tessonnier, L	1
Niccoli-Sire, P	1
Colavolpe, C	1
De Micco, C	1
Palazzo, FF	1
Henry, JF	1
Mundler, O	1
Sayre, DF	1
Vaccaro, KK	2
Liang, BT	2
Perelle, BA	1
Perlman, RL	7
Erny, RE	1
Berezo, MW	1
Sheard, BE	2
Erny, R	1
Wagner, JA	1
Laschinski, G	2
Kittner, B	3
Bräutigam, M	3
Tischler, AS	3
Morse, GM	1
Majeswka, Z	1
Wocial, B	4
McClean, DR	1
Sinclair, LM	1
Yandle, TG	1
Nicholls, MG	1
Sasagawa, I	1
Nakada, T	1
Kubota, Y	1
Ishigooka, M	1
Sawamura, T	1
Suzuki, Y	1
Newcomer, TA	1
Rosenberg, PA	1
Aizenman, E	1
Anastasiadis, PZ	1
States, JC	1
Kuhn, DM	1
Levine, RA	1
McCullough, LA	1
Westfall, TC	1
Januszewicz, W	3
Gryglas, P	2
Januszewicz, A	2
Feltynowski, T	1
Lapiński, M	1
Gavrilenko, AV	1
Sheremet'eva, GF	1
Skrylev, SI	1
Zolicheva, NIu	1
Lisitskiĭ, DA	1
Siniavin, GV	1
Prejbisz, A	1
Nitzsche, E	1
Altehoefer, C	1
Ghanem, N	1
Manz, T	1
Reincke, M	1
Moser, E	1
Chalfie, M	1
Ishii, A	1
Kiuchi, K	2
Kobayashi, R	1
Sumi, M	1
Hidaka, H	2
Nagatsu, T	3
Maruyama, W	1
Minami, M	1
Ota, A	1
Takahashi, T	1
Takahashi, A	1
Naoi, M	1
Ribeiro, P	1
Pigeon, D	1
Kaufman, S	1
Kuchel, O	1
Buu, NT	1
Edwards, DJ	1
Ruzicka, LA	1
Herken, H	3
Shigetomi, S	1
Jung, W	1
Roskoski, R	1
White, L	1
Knowlton, R	1
Roskoski, LM	1
Costopoulos, D	1
Horwitz, J	1
Hagiwara, M	1
Stull, R	1
Sisson, JC	1
Weder, A	1
Averbuch, SD	1
Keiser, HR	2
Atkins, FL	1
Beaven, MA	1
Altschule, MD	1
Hegedus, ZL	1
Helpap, B	1
Türler, K	2
Käser, H	5
Wagner, HP	1
Zuppinger, K	1
Zurbrügg, R	1
Louis, WJ	1
Doyle, AE	1
Heath, WC	1
Robinson, MJ	2
Wilber, JA	1
Kent, M	1
Stocks, J	1
Sullivan, JM	1
DeQuattro, V	1
Burri, PH	1
Leon, AS	1
Abrams, WB	1
Bohuon, C	1
Vandermeulen, R	1
Cession-Fossion, A	1
Lecomte, J	1
Orban, F	1
Lejeune, G	1
Laasberg, LH	1
Shimosato, S	1