nitrendipine has been researched along with Pheochromocytoma in 14 studies
Nitrendipine: A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
nitrendipine : A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.
Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
| Excerpt | Relevance | Reference |
|---|---|---|
| "BAY K 8644, a drug that elicits calcium-dependent muscle contraction, inhibits binding of the voltage-dependent calcium channel antagonist [3H]nitrendipine to brain and PC12 pheochromocytoma cell membranes." | 3.67 | Calcium channel 'agonist' BAY K 8644 inhibits calcium antagonist binding to brain and PC12 cell membranes. ( Carpenter, CL; Cooper, EC; Greenberg, DA, 1984) |
| "The mechanism of calcium channel antagonism by phenytoin was studied by comparing the effects of phenytoin and classical calcium channel antagonists on K+-stimulated 45Ca uptake and [3H]nitrendipine binding in the PC12 pheochromocytoma cell line." | 3.67 | Mechanism of calcium channel inhibition by phenytoin: comparison with classical calcium channel antagonists. ( Carpenter, CL; Greenberg, DA; Messing, RO, 1985) |
| "PC12 cells, a clonal rat pheochromocytoma cell line, possess voltage-dependent calcium channels that bind the high affinity dihydropyridine calcium antagonist [3H]nitrendipine and other calcium channel blockers." | 3.66 | Calcium antagonists High-affinity binding and inhibition of calcium transport in a clonal cell line. ( Toll, L, 1982) |
| " Dose-response curves to K+ show that following differentiation, cells become more sensitive, releasing transmitter at lower K+ concentrations." | 1.27 | Nerve growth factor modulates the drug sensitivity of neurotransmitter release from PC-12 cells. ( Kongsamut, S; Miller, RJ, 1986) |
| "When nitrendipine was applied, a small increase in calcium current occurred and this was followed by a decrease." | 1.27 | Dihydropyridine binding and calcium channel function in clonal rat adrenal medullary tumor cells. ( Brown, AM; Hamilton, SL; Hawkes, MJ; Kunze, DL, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (85.71) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Albus, U | 1 |
| Habermann, E | 1 |
| Ferry, DR | 1 |
| Glossmann, H | 1 |
| Greenberg, DA | 3 |
| Cooper, EC | 2 |
| Carpenter, CL | 3 |
| Toll, L | 1 |
| Kolchinskaya, LI | 1 |
| Kononenko, NI | 1 |
| Pogorelaya, NC | 1 |
| Shafer, TJ | 1 |
| Contreras, ML | 1 |
| Atchison, WD | 1 |
| Messing, RO | 1 |
| Harris, KM | 1 |
| Kongsamut, S | 2 |
| Miller, RJ | 2 |
| Kunze, DL | 1 |
| Hamilton, SL | 1 |
| Hawkes, MJ | 1 |
| Brown, AM | 1 |
| Kittner, B | 1 |
| Bräutigam, M | 1 |
| Herken, H | 1 |
| Sher, E | 1 |
| Pandiella, A | 1 |
| Clementi, F | 1 |
| Janigro, D | 1 |
| Maccaferri, G | 1 |
| Meldolesi, J | 1 |
| DeLorme, EM | 1 |
| Rabe, CS | 1 |
| McGee, R | 1 |
14 other studies available for nitrendipine and Pheochromocytoma
| Article | Year |
|---|---|
Novel 1,4-dihydropyridine (Bay K 8644) facilitates calcium-dependent [3H]noradrenaline release from PC 12 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1984 |
Calcium channel 'agonist' BAY K 8644 inhibits calcium antagonist binding to brain and PC12 cell membranes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1984 |
Calcium antagonists High-affinity binding and inhibition of calcium transport in a clonal cell line.
Topics: Adrenal Gland Neoplasms; Animals; Binding, Competitive; Biological Transport, Active; Calcium; Calci | 1982 |
Inhibition by oxytocin of voltage-activated calcium influx in cultured PC12 pheochromocytoma cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Characterization of interactions of methylmercury with Ca2+ channels in synaptosomes and pheochromocytoma cells: radiotracer flux and binding studies.
Topics: Adrenal Gland Neoplasms; Animals; Barium; Calcium; Calcium Channels; Male; Methylmercury Compounds; | 1990 |
Stimulation of calcium uptake in PC12 cells by the dihydropyridine agonist BAY K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1985 |
Mechanism of calcium channel inhibition by phenytoin: comparison with classical calcium channel antagonists.
Topics: Adrenal Gland Neoplasms; Animals; Binding Sites; Calcium; Calcium Channel Blockers; Carbachol; Cell | 1985 |
Protein kinase C mediated regulation of calcium channels in PC-12 pheochromocytoma cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1986 |
Nerve growth factor modulates the drug sensitivity of neurotransmitter release from PC-12 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1986 |
Dihydropyridine binding and calcium channel function in clonal rat adrenal medullary tumor cells.
Topics: Adrenal Gland Neoplasms; Animals; Calcium; Cell Membrane; Clone Cells; Electrophysiology; Ion Channe | 1987 |
PC12 cells: a model system for studying drug effects on dopamine synthesis and release.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |
Omega-conotoxin binding and effects on calcium channel function in human neuroblastoma and rat pheochromocytoma cell lines.
Topics: Adrenal Gland Neoplasms; Animals; Calcium; Calcium Channel Blockers; Calcium Chloride; Dihydropyridi | 1988 |
Calcium channels in undifferentiated PC12 rat pheochromocytoma cells.
Topics: Adrenal Gland Neoplasms; Animals; Calcium Channel Blockers; Calcium Channels; Cell Line; Electric Co | 1989 |
Regulation of the number of functional voltage-sensitive Ca++ channels on PC12 cells by chronic changes in membrane potential.
Topics: Adrenal Gland Neoplasms; Animals; Calcium; Calcium Channels; Ethers; Ionomycin; Membrane Potentials; | 1988 |