(4-fluoro-3-iodobenzyl)guanidine

Description

(4-Fluoro-3-iodobenzyl)guanidine is a **small molecule** that acts as a **potent and selective inhibitor** of the enzyme **protein arginine methyltransferase 5 (PRMT5)**.

**Here's a breakdown of its significance in research:**

**What is PRMT5?**

* PRMT5 is an enzyme that plays a crucial role in **modifying proteins** by adding a methyl group to arginine residues.
* This process, known as **methylation**, can significantly alter a protein's function and interaction with other molecules.
* PRMT5 is implicated in various cellular processes, including:
* **Transcriptional regulation**
* **RNA splicing**
* **DNA replication**
* **Cell cycle progression**
* **Immune response**

**Why is (4-fluoro-3-iodobenzyl)guanidine important?**

* **PRMT5 as a Drug Target:** PRMT5 has emerged as a potential therapeutic target for various diseases, including:
* **Cancer:** PRMT5 is often overexpressed in cancer cells and contributes to their growth and survival.
* **Autoimmune disorders:** Dysregulation of PRMT5 has been linked to autoimmune diseases like lupus.
* **Neurological disorders:** PRMT5 is involved in processes related to neurodevelopment and synaptic function, making it relevant for neurological disorders.

* **(4-fluoro-3-iodobenzyl)guanidine as a Research Tool:** This molecule acts as a potent and selective inhibitor of PRMT5, providing researchers with a valuable tool to:
* **Investigate PRMT5 function:** Studying how PRMT5 inhibition affects various cellular processes can shed light on its role in health and disease.
* **Develop new drugs:** By understanding how (4-fluoro-3-iodobenzyl)guanidine interacts with PRMT5, scientists can design and develop more effective and specific inhibitors for therapeutic applications.

**Key Features of (4-fluoro-3-iodobenzyl)guanidine:**

* **Potency:** It effectively inhibits PRMT5 activity at low concentrations.
* **Selectivity:** It primarily targets PRMT5, minimizing off-target effects.
* **Chemical Structure:** Its specific structure allows for binding to the active site of PRMT5, inhibiting its enzymatic activity.

**Overall, (4-fluoro-3-iodobenzyl)guanidine is a valuable research tool for understanding PRMT5 function and developing new therapeutic strategies for diseases where PRMT5 dysregulation plays a role.**

(4-fluoro-3-iodobenzyl)guanidine: a potential MIBG analog for positron emission tomography; structure given in first source; RN refers to (18F)-labelled compound [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]