ro 5-4864 has been researched along with Pheochromocytoma in 1 studies
4'-chlorodiazepam: selectively binds peripheral benzodiazepine receptor
Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
| Excerpt | Relevance | Reference |
|---|---|---|
| "PC12 pheochromocytoma cells show increased binding of the peripheral type benzodiazepine Ro 5-4864 after treatment with nerve growth factor (NGF) in membrane preparations." | 3.67 | Benzodiazepine binding sites on PC12 cells: modulation by nerve growth factor and forskolin. ( Greenblatt, DJ; Jumblatt, JE; Miller, LG; Tischler, AS, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miller, LG | 1 |
| Tischler, AS | 1 |
| Jumblatt, JE | 1 |
| Greenblatt, DJ | 1 |
1 other study available for ro 5-4864 and Pheochromocytoma
| Article | Year |
|---|---|
Benzodiazepine binding sites on PC12 cells: modulation by nerve growth factor and forskolin.
Topics: Adenine; Adenosine Monophosphate; Adrenal Gland Neoplasms; Adrenal Medulla; Animals; Benzodiazepines | 1988 |