carbachol has been researched along with Pheochromocytoma in 44 studies
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.
Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rat PC-12 pheochromocytoma cells respond to stimulation with bradykinin, angiotensin II, and carbachol with an increased formation of labeled inositol phosphates after preincubation of the cells with [3H]inositol." | 7.67 | Stimulation by bradykinin, angiotensin II, and carbachol of the accumulation of inositol phosphates in PC-12 pheochromocytoma cells: differential effects of lithium ions on inositol mono- and polyphosphates. ( Assmann, K; Greil, W; van Calker, D, 1987) |
| "In PC12 pheochromocytoma cells whose phospholipids had been prelabelled with [3H]palmitic acid, bradykinin increased the production of [3H]phosphatidic acid." | 3.68 | Bradykinin activates a phospholipase D that hydrolyzes phosphatidylcholine in PC12 cells. ( Horwitz, J, 1991) |
| "As a measure of the transmembrane signals that they transduce, two neurotrophic agents, nerve growth factor (NGF) and basic fibroblast growth factor (bFGF), and the muscarinic agonist carbachol were compared for their ability to induce TIS (tetradecanoyl phorbol acetate-inducible sequences) transcripts, representing a family of immediate early response genes, in the rat pheochromocytoma cell line PC12 and the morphologically unresponsive variant PC12nnr5." | 3.68 | Differential induction of primary-response (TIS) genes in PC12 pheochromocytoma cells and the unresponsive variant PC12nnr5. ( Altin, JG; Bradshaw, RA; Eveleth, DD; Herschman, HR; Kujubu, DA; Raffioni, S, 1991) |
| "Both carbachol and bradykinin increased diacylglycerol formation in PC12 pheochromocytoma cells." | 3.68 | Carbachol and bradykinin increase the production of diacylglycerol from sources other than inositol-containing phospholipids in PC12 cells. ( Horwitz, J, 1990) |
| "The mechanism of calcium channel antagonism by phenytoin was studied by comparing the effects of phenytoin and classical calcium channel antagonists on K+-stimulated 45Ca uptake and [3H]nitrendipine binding in the PC12 pheochromocytoma cell line." | 3.67 | Mechanism of calcium channel inhibition by phenytoin: comparison with classical calcium channel antagonists. ( Carpenter, CL; Greenberg, DA; Messing, RO, 1985) |
| "Stimulation of rat pheochromocytoma PC12 cells with ionophore A23187, carbachol, or high K+ medium, agents which increase intracellular Ca2+, results in the phosphorylation and activation of tyrosine hydroxylase (Nose, P." | 3.67 | The multifunctional Ca2+/calmodulin-dependent protein kinase mediates Ca2+-dependent phosphorylation of tyrosine hydroxylase. ( Griffith, LC; Schulman, H, 1988) |
| "Evidence for a presynaptic neuromodulatory effect of atrial natriuretic factor (ANF) has been obtained in rat adrenal pheochromocytoma cells (PC12), a clonal line that differentiates into adrenergic neuron-like cells when treated with nerve growth factor." | 3.67 | Atrial natriuretic factor inhibits norepinephrine release in an adrenergic clonal cell line (PC12). ( Drewett, J; Marchand, G; Trachte, G; Ziegler, R, 1988) |
| " However, when applied to rat pheochromocytoma (PC12) cells at concentrations of 1 microM or higher it caused an immediate, concentration-dependent inhibition of carbachol-stimulated uptake of 86Rb+ through the nicotinic receptors, which did not appear to be related to activation of adenyl cyclase." | 3.67 | Direct anesthetic-like effects of forskolin on the nicotinic acetylcholine receptors of PC12 cells. ( McGee, R; McHugh, EM, 1986) |
| "The intracellular signals generated by carbachol activation of the muscarinic receptor [release of inositol phosphates as a consequence of phosphoinositide hydrolysis and rise of the cytosolic Ca2+ concentration ([Ca2+]i, measured by quin2)] were studied in intact PC12 pheochromocytoma cells that had been differentiated by treatment with nerve growth factor." | 3.67 | Activation of muscarinic receptors in PC12 cells. Correlation between cytosolic Ca2+ rise and phosphoinositide hydrolysis. ( Ambrosini, A; Di Virgilio, F; Meldolesi, J; Pozzan, T; Vicentini, LM, 1986) |
| "Rat PC-12 pheochromocytoma cells respond to stimulation with bradykinin, angiotensin II, and carbachol with an increased formation of labeled inositol phosphates after preincubation of the cells with [3H]inositol." | 3.67 | Stimulation by bradykinin, angiotensin II, and carbachol of the accumulation of inositol phosphates in PC-12 pheochromocytoma cells: differential effects of lithium ions on inositol mono- and polyphosphates. ( Assmann, K; Greil, W; van Calker, D, 1987) |
| "Loss of responsiveness of the neuronal-type nicotinic acetylcholine receptor (nAChR) on PC12 cells, a cell line derived from a rat pheochromocytoma, was induced by exposure to carbamylcholine (carbachol)." | 3.67 | Two components of carbamylcholine-induced loss of nicotinic acetylcholine receptor function in the neuronal cell line PC12. ( Simasko, SM; Soares, JR; Weiland, GA, 1986) |
| " Carbachol-induced PKC translocation was concentration-dependent, with a biphasic dose-response curve yielding approximate EC50 values of 10(-6) M and 10(-4) M for the high- and low-affinity components, respectively." | 1.28 | Nicotinic and muscarinic agonists stimulate rapid protein kinase C translocation in PC12 cells. ( Kiyasu, E; Messing, RO; Sneade, AB; Stevens, AM, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (65.91) | 18.7374 |
| 1990's | 15 (34.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amy, CM | 1 |
| Bennett, EL | 1 |
| Mitsuka, M | 2 |
| Hatanaka, H | 2 |
| Williams, TP | 2 |
| McGee, R | 5 |
| Siman, RG | 1 |
| Klein, WL | 1 |
| Rabe, CS | 1 |
| Chen, Y | 1 |
| Best, JA | 1 |
| Nagamoto, K | 1 |
| Tank, AW | 1 |
| Xu, S | 1 |
| Khoo, S | 1 |
| Dang, A | 1 |
| Witt, S | 1 |
| Do, V | 1 |
| Zhen, E | 1 |
| Schaefer, EM | 1 |
| Cobb, MH | 1 |
| Ritchie, AK | 1 |
| Gollasch, M | 1 |
| Hescheler, J | 1 |
| Spicher, K | 1 |
| Klinz, FJ | 1 |
| Schultz, G | 1 |
| Rosenthal, W | 1 |
| Divish, MM | 2 |
| Sheftel, G | 2 |
| Boyle, A | 1 |
| Kalasapudi, VD | 2 |
| Papolos, DF | 2 |
| Lachman, HM | 2 |
| Nishizawa, Y | 1 |
| Seamon, KB | 1 |
| Daly, JW | 1 |
| Aronstam, RS | 1 |
| Koski, G | 3 |
| Lawrence, K | 3 |
| Righi, D | 2 |
| Horwitz, J | 2 |
| Altin, JG | 2 |
| Kujubu, DA | 1 |
| Raffioni, S | 1 |
| Eveleth, DD | 1 |
| Herschman, HR | 1 |
| Bradshaw, RA | 2 |
| Kress, HG | 1 |
| Müller, J | 1 |
| Eisert, A | 1 |
| Chidgey, MA | 1 |
| Harrison, TM | 1 |
| Bönisch, H | 1 |
| Boer, R | 1 |
| Dobler, M | 1 |
| Schudt, C | 1 |
| Nose, PS | 1 |
| Griffith, LC | 2 |
| Schulman, H | 2 |
| Messing, RO | 2 |
| Carpenter, CL | 1 |
| Greenberg, DA | 1 |
| Simasko, SM | 2 |
| Durkin, JA | 1 |
| Weiland, GA | 2 |
| Matter, K | 1 |
| Dreyer, F | 1 |
| Aktories, K | 1 |
| Stevens, AM | 1 |
| Kiyasu, E | 1 |
| Sneade, AB | 1 |
| Gatti, G | 2 |
| Madeddu, L | 1 |
| Pandiella, A | 1 |
| Pozzan, T | 4 |
| Meldolesi, J | 4 |
| Ambrosini, A | 2 |
| Westhead, EW | 1 |
| Koike, T | 1 |
| Takashima, A | 1 |
| Drewett, J | 1 |
| Marchand, G | 1 |
| Ziegler, R | 1 |
| Trachte, G | 1 |
| Baizer, L | 1 |
| Weiner, N | 1 |
| McHugh, EM | 1 |
| Vicentini, LM | 2 |
| Di Virgilio, F | 2 |
| Bussolino, F | 1 |
| Tessari, F | 1 |
| Turrini, F | 1 |
| Braquet, P | 1 |
| Camussi, G | 1 |
| Prosdocimi, M | 1 |
| Bosia, A | 1 |
| DeLorme, EM | 1 |
| van Calker, D | 2 |
| Assmann, K | 1 |
| Greil, W | 1 |
| Heumann, R | 1 |
| Soares, JR | 1 |
| Kemp, G | 1 |
| Morley, BJ | 1 |
| Robinson, D | 1 |
44 other studies available for carbachol and Pheochromocytoma
| Article | Year |
|---|---|
Increased sodium ion conductance through nicotinic acetylcholine receptor channels in PC12 cells exposed to nerve growth factors.
Topics: Animals; Biological Transport, Active; Bucladesine; Bungarotoxins; Carbachol; Ion Channels; Neoplasm | 1983 |
Selective loss of acetylcholine sensitivity in a nerve cell line cultured in hormone-supplemented serum-free medium.
Topics: Acetylcholine; Animals; Biological Transport; Bungarotoxins; Calcium; Carbachol; Cell Line; Culture | 1983 |
Increase of carbamylcholine-induced 22Na+ influx into pheochromocytoma PC12h cells by nerve growth factor.
Topics: Animals; Bucladesine; Bungarotoxins; Carbachol; Clone Cells; Dexamethasone; Epidermal Growth Factor; | 1984 |
The effects of membrane fatty acid modification of clonal pheochromocytoma cells on depolarization-dependent exocytosis.
Topics: Adrenal Gland Neoplasms; Arachidonic Acid; Arachidonic Acids; Calcium; Carbachol; Cell Line; Clone C | 1982 |
Rapid recovery of nicotinic receptor-mediated sodium-22 influx following withdrawal from acute or chronic cholinergic stimulation.
Topics: Adrenal Gland Neoplasms; Animals; Biological Transport, Active; Carbachol; Cell Line; Chick Embryo; | 1982 |
Enhancement of depolarization-dependent release of norepinephrine by an inhibitor of S-adenosylmethionine-dependent transmethylations.
Topics: Adrenal Gland Neoplasms; Animals; Carbachol; Cell Line; Clone Cells; Homocysteine; Kinetics; Norepin | 1980 |
Regulation of tyrosine hydroxylase gene expression by the m1 muscarinic acetylcholine receptor in rat pheochromocytoma cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adrenal Gland Neoplasms; Animals; Atropine; Calcium; C | 1996 |
Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism.
Topics: 3T3 Cells; Aluminum Compounds; Animals; Antibodies, Monoclonal; Astrocytes; Carbachol; Cell Line; CH | 1997 |
Catecholamine secretion in a rat pheochromocytoma cell line: two pathways for calcium entry.
Topics: Adrenal Gland Neoplasms; Animals; Calcium; Carbachol; Cations, Divalent; Cell Line; Clone Cells; Dop | 1979 |
Inhibition of Ca2+ channels via alpha 2-adrenergic and muscarinic receptors in pheochromocytoma (PC-12) cells.
Topics: Adrenal Gland Neoplasms; Amino Acid Sequence; Animals; Atropine; Barium; Calcium Channel Blockers; C | 1991 |
Differential effect of lithium on fos protooncogene expression mediated by receptor and postreceptor activators of protein kinase C and cyclic adenosine monophosphate: model for its antimanic action.
Topics: Adrenal Gland Neoplasms; Animals; Antipsychotic Agents; Bipolar Disorder; Carbachol; Carbamazepine; | 1991 |
Effects of forskolin and analogues on nicotinic receptor-mediated sodium flux, voltage-dependent calcium flux, and voltage-dependent rubidium efflux in pheochromocytoma PC12 cells.
Topics: Adrenal Gland Neoplasms; Animals; Calcium; Carbachol; Colforsin; Ion Channel Gating; Ion Channels; N | 1990 |
Ethanol-induced inhibition of carbachol-stimulated uptake of calcium in PC12 pheochromocytoma cells.
Topics: Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Radioisotopes; Carbachol; Ethan | 1991 |
Bradykinin activates a phospholipase D that hydrolyzes phosphatidylcholine in PC12 cells.
Topics: Adrenal Gland Neoplasms; Animals; Bradykinin; Carbachol; Choline; Diglycerides; Enzyme Activation; G | 1991 |
Differential induction of primary-response (TIS) genes in PC12 pheochromocytoma cells and the unresponsive variant PC12nnr5.
Topics: Adrenal Gland Neoplasms; Animals; Blotting, Northern; Carbachol; Down-Regulation; Fibroblast Growth | 1991 |
Volatile anesthetics and stimulus-secretion coupling in a neural cell line.
Topics: Adrenal Gland Neoplasms; Animals; Calcium; Carbachol; Cell Line; Dopamine; Halothane; Isoflurane; Ki | 1991 |
Inhibition by ethanol of 45Ca2+ uptake in PC12 pheochromocytoma cells: interactions between alcohol and carbachol.
Topics: Adrenal Gland Neoplasms; Animals; Biological Transport, Active; Calcium; Carbachol; Cell Line; Drug | 1991 |
Lithium augments fos protoonocogene expression in PC12 pheochromocytoma cells: implications for therapeutic action of lithium.
Topics: Adrenal Gland Neoplasms; Animals; Carbachol; Gene Expression Regulation; Lithium; Pheochromocytoma; | 1990 |
Renin is sorted to the regulated secretory pathway in transfected PC12 cells by a mechanism which does not require expression of the pro-peptide.
Topics: Adrenal Gland Neoplasms; Animals; Carbachol; Enzyme Precursors; Gene Expression Regulation; Genes, R | 1990 |
Carbachol and bradykinin increase the production of diacylglycerol from sources other than inositol-containing phospholipids in PC12 cells.
Topics: Bradykinin; Calcium; Carbachol; Diglycerides; Glycerides; Inositol; Inositol Phosphates; N-Methylsco | 1990 |
Production of 1,2-diacylglycerol in PC12 cells by nerve growth factor and basic fibroblast growth factor.
Topics: Acids; Adenosine; Adrenal Gland Neoplasms; Animals; Arsenicals; Calcium; Carbachol; Culture Media; D | 1990 |
Pharmacological characterization of muscarine receptors of PC12 (rat phaeochromocytoma) cells.
Topics: Adrenal Gland Neoplasms; Animals; Binding, Competitive; Carbachol; Cell Membrane; Cerebral Cortex; G | 1990 |
Ca2+-dependent phosphorylation of tyrosine hydroxylase in PC12 cells.
Topics: Animals; Calcimycin; Calcium; Carbachol; Catecholamines; Cell Line; Cyclic AMP; Enzyme Activation; I | 1985 |
Mechanism of calcium channel inhibition by phenytoin: comparison with classical calcium channel antagonists.
Topics: Adrenal Gland Neoplasms; Animals; Binding Sites; Calcium; Calcium Channel Blockers; Carbachol; Cell | 1985 |
Effects of substance P on nicotinic acetylcholine receptor function in PC12 cells.
Topics: Adrenal Gland Neoplasms; Carbachol; Cell Line; Dose-Response Relationship, Drug; Kinetics; Pheochrom | 1987 |
Actin involvement in exocytosis from PC12 cells: studies on the influence of botulinum C2 toxin on stimulated noradrenaline release.
Topics: Actins; Adenosine Diphosphate Ribose; Adrenal Gland Neoplasms; Animals; Botulinum Toxins; Calcimycin | 1989 |
Nicotinic and muscarinic agonists stimulate rapid protein kinase C translocation in PC12 cells.
Topics: Adrenal Gland Neoplasms; Animals; Calcium; Carbachol; Cell Membrane; Dimethylphenylpiperazinium Iodi | 1989 |
Acute reduction of extracellular sodium differentially affects receptor-mediated and K+-induced calcium uptake in PC12 pheochromocytoma cells.
Topics: Animals; Calcium; Carbachol; Cell Line; Pheochromocytoma; Potassium; Rats; Sodium; Tumor Cells, Cult | 1989 |
Second-messenger generation in PC12 cells. Interactions between cyclic AMP and Ca2+ signals.
Topics: Animals; Calcium; Carbachol; Cell Differentiation; Cell Line; Clonidine; Cyclic AMP; Imidazoles; Ner | 1988 |
Second-messenger control of catecholamine release from PC12 cells. Role of muscarinic receptors and nerve-growth-factor-induced cell differentiation.
Topics: Adrenal Gland Neoplasms; Animals; Carbachol; Catecholamines; Cell Differentiation; Clonidine; Colfor | 1988 |
Cell cycle-dependent modulation of biosynthesis and stimulus-evoked release of catecholamines in PC12 pheochromocytoma cells.
Topics: Animals; Calcium; Carbachol; Catecholamines; Cell Cycle; Cell Line; Chromatography, High Pressure Li | 1986 |
The multifunctional Ca2+/calmodulin-dependent protein kinase mediates Ca2+-dependent phosphorylation of tyrosine hydroxylase.
Topics: Adenosine; Adrenal Gland Neoplasms; Animals; Calcimycin; Calcium; Calcium-Calmodulin-Dependent Prote | 1988 |
Atrial natriuretic factor inhibits norepinephrine release in an adrenergic clonal cell line (PC12).
Topics: Adrenal Gland Neoplasms; Animals; Atrial Natriuretic Factor; Carbachol; Norepinephrine; Pheochromocy | 1988 |
Regulation of dopamine release from PC12 pheochromocytoma cell cultures during stimulation with elevated potassium or carbachol.
Topics: Animals; Calcium; Carbachol; Cell Line; Colforsin; Cyclic AMP; Diterpenes; Dopamine; Drug Synergism; | 1985 |
Direct anesthetic-like effects of forskolin on the nicotinic acetylcholine receptors of PC12 cells.
Topics: Adenylyl Cyclases; Adrenal Gland Neoplasms; Anesthetics; Animals; Carbachol; Cell Line; Colforsin; C | 1986 |
Activation of muscarinic receptors in PC12 cells. Correlation between cytosolic Ca2+ rise and phosphoinositide hydrolysis.
Topics: Adrenal Gland Neoplasms; Animals; Antimetabolites; Calcium; Carbachol; Cell Line; Cytosol; Hydrolysi | 1986 |
Platelet activating factor induces dopamine release in PC-12 cell line.
Topics: Adrenal Gland Neoplasms; Animals; Atropine; Calcium; Carbachol; Cell Line; Diterpenes; Dopamine; Gin | 1988 |
Effects of prolonged depolarization on the nicotinic acetylcholine receptors of PC12 cells.
Topics: Adrenal Gland Neoplasms; Animals; Calcium; Carbachol; Membrane Potentials; Pheochromocytoma; Potassi | 1988 |
Stimulation by bradykinin, angiotensin II, and carbachol of the accumulation of inositol phosphates in PC-12 pheochromocytoma cells: differential effects of lithium ions on inositol mono- and polyphosphates.
Topics: Adrenal Gland Neoplasms; Angiotensin II; Atropine; Bradykinin; Carbachol; Cations, Monovalent; Cell | 1987 |
Nerve growth factor potentiates the agonist-stimulated accumulation of inositol phosphates in PC-12 pheochromocytoma cells.
Topics: Adrenal Gland Neoplasms; Bradykinin; Carbachol; Cells, Cultured; Chromatography, Ion Exchange; Drug | 1987 |
Activation of muscarinic receptors in PC12 cells. Stimulation of Ca2+ influx and redistribution.
Topics: Adrenal Gland Neoplasms; Animals; Biological Transport; Calcium; Carbachol; Cell Line; Ethers; Ionom | 1986 |
Two components of carbamylcholine-induced loss of nicotinic acetylcholine receptor function in the neuronal cell line PC12.
Topics: Adrenal Gland Neoplasms; Animals; Carbachol; Cell Line; Gallamine Triethiodide; L-Lactate Dehydrogen | 1986 |
Ganglionic nAChRs and high-affinity nicotinic binding sites are not equivalent.
Topics: Acetylcholine; Adrenal Gland Neoplasms; Animals; Brain Chemistry; Carbachol; Cell Line; Nicotine; Ph | 1986 |
Agonist-induced regulation of the neuronal nicotinic acetylcholine receptor of PC12 cells.
Topics: Adrenal Gland Neoplasms; Animals; Carbachol; Cell Line; Dose-Response Relationship, Drug; Mecamylami | 1985 |