serine has been researched along with Pheochromocytoma in 9 studies
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated the effect of LB1, a small molecule inhibitor of serine/threonine protein phosphatase 2A (PP2A), on its ability to inhibit a low growth fraction and highly drug-resistant solid neuroendocrine tumor, such as metastatic pheochromocytoma (PHEO)." | 3.77 | Pharmacologic modulation of serine/threonine phosphorylation highly sensitizes PHEO in a MPC cell and mouse model to conventional chemotherapy. ( Bernardo, M; Chiang, J; Lonser, R; Lu, J; Martiniova, L; Pacak, K; Zhuang, Z, 2011) |
| "S891A mutation caused medullary thyroid cancer (MTC) in 69." | 1.36 | The clinical spectrum of multiple endocrine neoplasia type 2a caused by the rare intracellular RET mutation S891A. ( Aylwin, S; Beck-Peccoz, P; Diaz-Cano, S; Dralle, H; Fugazzola, L; Izatt, L; Machens, A; McGregor, A; Schulte, KM; Talat, N, 2010) |
| "All MEN 2A affected family members suffered from medullary thyroid carcinoma and two of ten patients for pheochromocytoma." | 1.33 | Novel germline mutation in the transmembrane region of RET gene close to Cys634Ser mutation associated with MEN 2A syndrome. ( Altaner, C; Altanerova, V; Breza, J; Kostalova, L; Poturnajova, M, 2005) |
| "The observed constellation of microcephaly, deafness, cryptorchidism, developmental delay, hypertension, and bilateral pheochromocytoma in association with a VHL mutation A451G in a patient with negative family history has not previously been described in the literature." | 1.32 | Bilateral pheochromocytomas and congenital anomalies associated with a de novo germline mutation in the von Hippel-Lindau gene. ( Assadi, F; Brackbill, EL, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schulte, KM | 1 |
| Machens, A | 1 |
| Fugazzola, L | 1 |
| McGregor, A | 1 |
| Diaz-Cano, S | 1 |
| Izatt, L | 1 |
| Aylwin, S | 1 |
| Talat, N | 1 |
| Beck-Peccoz, P | 1 |
| Dralle, H | 1 |
| Martiniova, L | 1 |
| Lu, J | 1 |
| Chiang, J | 1 |
| Bernardo, M | 1 |
| Lonser, R | 1 |
| Zhuang, Z | 1 |
| Pacak, K | 1 |
| Assadi, F | 1 |
| Brackbill, EL | 1 |
| Poturnajova, M | 1 |
| Altanerova, V | 1 |
| Kostalova, L | 1 |
| Breza, J | 1 |
| Altaner, C | 1 |
| Haycock, JW | 1 |
| Mitchell, JP | 1 |
| Hardie, DG | 1 |
| Vulliet, PR | 1 |
| Miyasaka, T | 1 |
| Miyasaka, J | 1 |
| Saltiel, AR | 1 |
| Gonzalez, GA | 1 |
| Montminy, MR | 1 |
| Pigeon, D | 1 |
| Ferrara, P | 1 |
| Gros, F | 1 |
| Thibault, J | 1 |
9 other studies available for serine and Pheochromocytoma
| Article | Year |
|---|---|
The clinical spectrum of multiple endocrine neoplasia type 2a caused by the rare intracellular RET mutation S891A.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Alanine; Amino Acid Substitutio | 2010 |
Pharmacologic modulation of serine/threonine phosphorylation highly sensitizes PHEO in a MPC cell and mouse model to conventional chemotherapy.
Topics: Adrenal Gland Neoplasms; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; | 2011 |
Bilateral pheochromocytomas and congenital anomalies associated with a de novo germline mutation in the von Hippel-Lindau gene.
Topics: Adrenal Gland Neoplasms; Amino Acid Substitution; Child; Cryptorchidism; Developmental Disabilities; | 2003 |
Novel germline mutation in the transmembrane region of RET gene close to Cys634Ser mutation associated with MEN 2A syndrome.
Topics: Adrenal Gland Neoplasms; Carcinoma, Medullary; Cysteine; Exons; Female; Gene Frequency; Genetic Link | 2005 |
Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40.
Topics: Adrenal Gland Neoplasms; Amino Acid Sequence; Animals; Cell Line; Chromatography, High Pressure Liqu | 1990 |
Site-specific phosphorylation of tyrosine hydroxylase after KCl depolarization and nerve growth factor treatment of PC12 cells.
Topics: Adrenal Gland Neoplasms; Animals; Cell Line; Cell Membrane; Chromatography, High Pressure Liquid; Is | 1990 |
Okadaic acid stimulates the activity of microtubule associated protein kinase in PC-12 pheochromocytoma cells.
Topics: Adrenal Gland Neoplasms; Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Epidermal Gro | 1990 |
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133.
Topics: Adrenal Gland Neoplasms; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Colforsin; Cyclic A | 1989 |
Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase.
Topics: Amino Acid Sequence; Animals; Electrophoresis, Polyacrylamide Gel; Peptide Fragments; Pheochromocyto | 1987 |