Acyl-protein thioesterase 1

An acyl-protein thioesterase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75608]

Synonyms

APT-1;
hAPT1;
EC 3.1.2.-;
Lysophospholipase 1;
Lysophospholipase I;
LPL-I;
LysoPLA I

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (5)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
benzo(b)thiophene-2-boronic acid	Homo sapiens (human)	IC50	1.4145	1	2
benzeneboronic acid	Homo sapiens (human)	IC50	19.9500	1	2
1,1'-biphenyl-4-yl-boronic acid	Homo sapiens (human)	IC50	10.2250	1	2
palmostatin b	Homo sapiens (human)	IC50	0.3377	2	2
palmostatin m	Homo sapiens (human)	IC50	0.0025	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
phospholipase activity	molecular function	Catalysis of the hydrolysis of a glycerophospholipid. [ISBN:0198506732]
lysophospholipase activity	molecular function	Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine. [EC:3.1.1.5]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
palmitoyl-(protein) hydrolase activity	molecular function	Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. [EC:3.1.2.22]
lipase activity	molecular function	Catalysis of the hydrolysis of a lipid or phospholipid. [GOC:mah, ISBN:0198506732]
carboxylic ester hydrolase activity	molecular function	Catalysis of the hydrolysis of a carboxylic ester bond. [GOC:curators]

Located In

This protein is located in 7 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
nuclear membrane	cellular component	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 5 target(s):

Target	Category	Definition
protein depalmitoylation	biological process	The removal of palymitoyl groups from a lipoprotein. [GOC:hjd]
fatty acid metabolic process	biological process	The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198547684]
fatty acid transport	biological process	The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [GOC:ai]
negative regulation of Golgi to plasma membrane protein transport	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. [GOC:jl]
negative regulation of aggrephagy	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of aggrephagy. [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25686248]