19-iodocholesterol profile

## 19-IodoCholesterol: A Tracer for Steroid Hormone Research

19-IodoCholesterol (19-IC) is a radiolabeled analog of cholesterol that is used as a tracer in medical imaging and research. Here's why it's important:

**1. Targeting Steroid Hormone Production:**

* 19-IC is specifically designed to mimic cholesterol, the precursor for all steroid hormones. It is readily taken up by cells that produce these hormones, including the adrenal glands, ovaries, and testes.
* The iodine atom attached to the 19th carbon allows for radiolabeling, making it visible through imaging techniques like scintigraphy.

**2. Studying Steroid Hormone Synthesis and Function:**

* **Imaging Steroid Hormone Production:** By tracking the distribution of 19-IC in the body, researchers can visualize and assess the activity of steroid hormone-producing organs. This provides valuable information about the function of these organs in health and disease.
* **Evaluating the Impact of Treatments:** 19-IC can be used to monitor the effectiveness of treatments that target steroid hormone production, such as those used for adrenal or ovarian tumors.
* **Understanding Disease Mechanisms:** 19-IC imaging helps in understanding the underlying mechanisms of various diseases associated with steroid hormone imbalances, such as Cushing's syndrome, congenital adrenal hyperplasia, or polycystic ovary syndrome.

**3. Research Applications:**

* 19-IC has been instrumental in characterizing the role of steroid hormones in various biological processes, including:
* Regulation of metabolism
* Growth and development
* Reproduction
* Immune function
* Stress response
* It has been used to study the effects of various medications, environmental factors, and genetic variations on steroid hormone production and function.

**4. Limitations:**

* 19-IC is a relatively complex molecule, and its metabolism can vary between individuals.
* The radiation exposure associated with the radioactive iodine can be a concern, limiting its use in certain cases.

**Overall, 19-IodoCholesterol continues to play a significant role in advancing our understanding of steroid hormone synthesis, function, and related diseases. Its ability to provide insights into the dynamics of these complex processes makes it a valuable tool for research and clinical applications.**

19-Iodocholesterol: 19-Iodocholest-5-en-3 beta-ol. A cholesterol derivative usually substituted with radioactive iodine in the 19 position. The compound is an adrenal cortex scanning agent used in the assessment of patients suspected of having Cushing's syndrome, hyperaldosteronism, pheochromocytoma and adrenal remnants following total adrenalectomy. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	21150757
CHEMBL ID	2110675
SCHEMBL ID	378862
MeSH ID	M0023184

Synonym
4a4e6exb6u ,
iodocholesterol
unii-4a4e6exb6u
cholest-5-en-3-ol, 19-iodo-, (3beta)-
37414-03-2
19-iodocholest-5-en-3beta-ol
einecs 253-499-4
19-iodocholesterol
cholest-5-en-3-ol, 19-iodo-, (3.beta.)-
SCHEMBL378862
CHEMBL2110675
DTXSID80190857
Q4557701
(3s,8s,9s,10s,13r,14s,17r)-10-(iodomethyl)-13-methyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-ol

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	62 (60.19)	18.7374
1990's	15 (14.56)	18.2507
2000's	17 (16.50)	29.6817
2010's	7 (6.80)	24.3611
2020's	2 (1.94)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	6 (5.26%)	5.53%
Reviews	8 (7.02%)	6.00%
Case Studies	30 (26.32%)	4.05%
Observational	1 (0.88%)	0.25%
Other	69 (60.53%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
dihydroxyphenylalanine Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.. dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.	3.14	1	0	hydroxyphenylalanine; non-proteinogenic alpha-amino acid; tyrosine derivative	human metabolite
niacin Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.. vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).. nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.	1.96	1	0	pyridine alkaloid; pyridinemonocarboxylic acid; vitamin B3	antidote; antilipemic drug; EC 3.5.1.19 (nicotinamidase) inhibitor; Escherichia coli metabolite; human urinary metabolite; metabolite; mouse metabolite; plant metabolite; vasodilator agent
bisacodyl Bisacodyl: A diphenylmethane stimulant laxative used for the treatment of CONSTIPATION and for bowel evacuation. (From Martindale, The Extra Pharmacopoeia, 30th ed, p871)	1.96	1	0	diarylmethane
glutaral Glutaral: One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.. glutaraldehyde : A dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5.	2.44	2	0	dialdehyde	cross-linking reagent; disinfectant; fixative
mitotane Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.	2.67	3	0	diarylmethane
potassium iodide Potassium Iodide: An inorganic compound that is used as a source of iodine in thyrotoxic crisis and in the preparation of thyrotoxic patients for thyroidectomy. (From Dorland, 27th ed). potassium iodide : A metal iodide salt with a K(+) counterion. It is a scavenger of hydroxyl radicals.	1.95	1	0	potassium salt	expectorant; radical scavenger
spironolactone Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827). spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.	1.96	1	0	3-oxo-Delta(4) steroid; oxaspiro compound; steroid lactone; thioester	aldosterone antagonist; antihypertensive agent; diuretic; environmental contaminant; xenobiotic
aldosterone [no description available]	2.68	3	0	11beta-hydroxy steroid; 18-oxo steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid hormone; mineralocorticoid; primary alpha-hydroxy ketone; steroid aldehyde	human metabolite; mouse metabolite
dehydroepiandrosterone Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.. dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.	1.96	1	0	17-oxo steroid; 3beta-hydroxy-Delta(5)-steroid; androstanoid	androgen; human metabolite; mouse metabolite
iodohippuric acid Iodohippuric Acid: An iodine-containing compound used in pyelography as a radiopaque medium. If labeled with radioiodine, it can be used for studies of renal function.. 2-iodohippuric acid : A member of the class of benzamides resulting from the formal condensation of the carboxy group of 2-iodobenzoic acid with the amino group of glycine.	1.95	1	0	benzamides; N-acylglycine; organoiodine compound
technetium Technetium: The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, and atomic number 43. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.	2.37	2	0	manganese group element atom
fluorodopa f 18 fluorodopa F 18: RN given refers to (L)-isomer	3.14	1	0	(18)F radiopharmaceutical; 6-fluoro-L-dopa
3-iodobenzylguanidine 3-Iodobenzylguanidine: A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.	6.6	9	1	organoiodine compound
colestipol Colestipol: Highly crosslinked and insoluble basic anion exchange resin used as anticholesteremic. It may also may reduce triglyceride levels.. colestipol : A high molecular weight copolymer of diethylenetriamine and epichlorohydrin (hydrochloride), with approximately 1 out of 5 amine nitrogens protonated. Due to the highly cross-linked and insoluble nature of the material, no structural formula has been assigned and no specific molecular weight information is available. A basic anion exchange resin, it is used as its hydrochloride for binding bile acids in the intestine, inhibiting their reabsorption.	1.96	1	0
fluorodeoxyglucose f18 Fluorodeoxyglucose F18: The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)	5.78	6	1	2-deoxy-2-((18)F)fluoro-D-glucose; 2-deoxy-2-fluoro-aldehydo-D-glucose
adosterol Adosterol: A sterol usually substituted with radioactive iodine. It is an adrenal cortex scanning agent with demonstrated high adrenal concentration and superior adrenal imaging.	4.31	6	0
selenonorcholesterol selenonorcholesterol: adrenal radioisotope scanning agents	2.38	2	0
19-iodocholesterol 3-acetate 19-iodocholesterol 3-acetate: RN given refers to (3beta)-isomer	7.36	2	0
succimer Succimer: A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.. succimer : A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.	1.96	1	0	dicarboxylic acid; dithiol; sulfur-containing carboxylic acid	chelator
17-ketosteroids 17-Ketosteroids: Steroids that contain a ketone group at position 17.. 17-oxo steroid : Any oxo steroid carrying the oxo group at position 17.	2.37	2	0
cholesteryl oleate cholesteryl oleate: RN given refers to ((Z)-isomer). cholesteryl oleate : The (Z)-stereoisomer of cholesteryl octadec-9-enoate.	1.95	1	0	CE(18:1); cholesteryl octadec-9-enoate	mouse metabolite
thallium Thallium: A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.. thallium : A metallic element first identified and named from the brilliant green line in its flame spectrum (from Greek thetaalphalambdalambdaomicronsigma, a green shoot).	3.06	1	0	boron group element atom
selenium Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.	7.37	2	0	chalcogen; nonmetal atom	micronutrient
beta-escin [no description available]	1.95	1	0
6-iodomethylcholesterol 6-iodomethylcholesterol: RN given refers to (123)I-labeled cpd (3 beta,6 beta)-isomer	8.79	35	3
chitosan [no description available]	2.72	3	0
technetium tc 99m dimercaptosuccinic acid Technetium Tc 99m Dimercaptosuccinic Acid: A nontoxic radiopharmaceutical that is used in the diagnostic imaging of the renal cortex.	2.39	2	0
phosphorus radioisotopes Phosphorus Radioisotopes: Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.	1.96	1	0

Condition	Relationship Strength	Studies	Trials
Adrenal Cancer [description not available]	9.09	37	5
Adenoma, Basal Cell [description not available]	8.31	27	3
Aldosteronism [description not available]	7.23	23	1
Adenoma A benign epithelial tumor with a glandular organization.	8.31	27	3
Hyperaldosteronism A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.	7.23	23	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	6.2	9	4
Adrenal Gland Hypofunction [description not available]	2.1	1	0
Cushing's Syndrome [description not available]	12.47	27	2
Adrenal Insufficiency Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS.	2.1	1	0
Cushing Syndrome A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.	7.47	27	2
Asymptomatic Conditions [description not available]	2.5	2	0
Adenoma, Adrenal Cortical [description not available]	4.51	5	1
Adrenal Cortex Cancer [description not available]	6.58	19	1
Adrenal Cortex Neoplasms Tumors or cancers of the ADRENAL CORTEX.	6.58	19	1
Pheochromocytoma, Extra-Adrenal [description not available]	5.78	8	1
Pheochromocytoma A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)	5.78	8	1
Hyperplasia An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.	4.87	8	1
Multiple Primary Neoplasms [description not available]	2.07	1	0
Adrenocortical Carcinoma A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.	2.07	1	0
Cancer of Liver [description not available]	2.07	1	0
Liver Neoplasms Tumors or cancer of the LIVER.	2.07	1	0
Adolescent Gynecomastia [description not available]	2.01	1	0
Gynecomastia Enlargement of the BREAST in the males, caused by an excess of ESTROGENS. Physiological gynecomastia is normally observed in NEWBORNS; ADOLESCENT; and AGING males.	2.01	1	0
Urination Disorders Abnormalities in the process of URINE voiding, including bladder control, frequency of URINATION, as well as the volume and composition of URINE.	2.02	1	0
Adrenal Gland Diseases Pathological processes of the ADRENAL GLANDS.	4.27	7	0
Breast Cancer [description not available]	2.39	2	0
Cancer of Sigmoid [description not available]	2.02	1	0
Breast Neoplasms Tumors or cancer of the human BREAST.	2.39	2	0
Gangliocytoma [description not available]	2.67	3	0
Foreign-Body Reaction Chronic inflammation and granuloma formation around irritating foreign bodies.	2.03	1	0
Innate Inflammatory Response [description not available]	2.03	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.03	1	0
Metastase [description not available]	2.67	3	0
Experimental Mammary Neoplasms [description not available]	2.03	1	0
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2.67	3	0
Hirsutism A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth.	2.36	2	0
Chemodectoma [description not available]	1.95	1	0
Postpartum Amenorrhea [description not available]	1.96	1	0
Cancer of Ovary [description not available]	2.65	3	0
Theca Cell Tumor [description not available]	1.96	1	0
Amenorrhea Absence of menstruation.	1.96	1	0
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	2.65	3	0
Addison's Disease [description not available]	1.96	1	0
Blood Pressure, High [description not available]	1.96	1	0
Addison Disease An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.	1.96	1	0
Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	1.96	1	0
Adrenal Cortex Diseases Pathological processes of the ADRENAL CORTEX.	2.87	4	0
Corpus Luteum Cyst [description not available]	1.96	1	0
Ovarian Cysts General term for CYSTS and cystic diseases of the OVARY.	1.96	1	0
Androgenization [description not available]	1.96	1	0
Hematoma A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.	1.96	1	0
Bone Fractures [description not available]	1.96	1	0
Fractures, Closed Fractures in which the break in bone is not accompanied by an external wound.	1.96	1	0
Fractures, Bone Breaks in bones.	1.96	1	0
Adrenal Gland Hyperfunction [description not available]	2.65	3	0
Adrenocortical Hyperfunction Excess production of ADRENAL CORTEX HORMONES such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE. Hyperadrenal syndromes include CUSHING SYNDROME; HYPERALDOSTERONISM; and VIRILISM.	2.65	3	0
Carcinoma, Anaplastic [description not available]	3.34	7	0
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	3.34	7	0
Cancer of Lung [description not available]	2.36	2	0
Lung Neoplasms Tumors or cancer of the LUNG.	2.36	2	0
Adenocarcinoma Of Kidney [description not available]	2.68	3	0
Neurilemoma [description not available]	2.37	2	0
Myelolipoma A rare benign tumor of the adrenal gland, several centimeters in diameter, composed in varying proportions of adipose tissue, lymphocytes, and primitive myeloid cells, probably a developmental abnormality. (Dorland, 27th ed)	1.98	1	0
Carcinoma, Renal Cell A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.	2.68	3	0
Neurilemmoma A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)	2.37	2	0
Empty Sella Syndrome A condition when the SELLA TURCICA is not filled with pituitary tissue. The pituitary gland is either compressed, atrophied, or removed. There are two types: (1) primary empty sella is due a defect in the sella diaphragm leading to arachnoid herniation into the sellar space; (2) secondary empty sella is associated with the removal or treatment of PITUITARY NEOPLASMS.	1.99	1	0
Cancer of Kidney [description not available]	2.4	2	0
Kidney Neoplasms Tumors or cancers of the KIDNEY.	2.4	2	0
Diseases of Endocrine System [description not available]	2	1	0
Endocrine System Diseases Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.	2	1	0
Germinoblastoma [description not available]	1.95	1	0
Lymphoma A general term for various neoplastic diseases of the lymphoid tissue.	1.95	1	0
Remission, Spontaneous A spontaneous diminution or abatement of a disease over time, without formal treatment.	1.95	1	0
Lymph Node Metastasis [description not available]	1.95	1	0
Recrudescence [description not available]	2.37	2	0
Brain Disorders [description not available]	1.95	1	0
Adenohypophyseal Diseases [description not available]	1.95	1	0
Brain Diseases Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.	1.95	1	0
Pituitary Diseases Disorders involving either the ADENOHYPOPHYSIS or the NEUROHYPOPHYSIS. These diseases usually manifest as hypersecretion or hyposecretion of PITUITARY HORMONES. Neoplastic pituitary masses can also cause compression of the OPTIC CHIASM and other adjacent structures.	1.95	1	0
Sertoli Cell Tumor Gonadal neoplasm composed entirely of SERTOLI CELLS or may have a component of GRANULOSA CELLS. Some of the Sertoli cell tumors produce ESTROGEN or ANDROGENS, but seldom in sufficient quantity to cause clinical symptoms such as FEMINIZATION or masculinization (VIRILISM).	1.95	1	0
Androgen Insensitivity Syndrome [description not available]	1.95	1	0
Cancer of Testis [description not available]	1.95	1	0
Testicular Neoplasms Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.	1.95	1	0
Complication, Postoperative [description not available]	1.96	1	0
Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.	1.96	1	0
Congenital Adrenal Hyperplasia [description not available]	1.96	1	0
Adrenal Hyperplasia, Congenital A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.	1.96	1	0
Ectopic ACTH Syndrome [description not available]	1.97	1	0
Ectopic Hormone Syndromes [description not available]	1.97	1	0
ACTH Syndrome, Ectopic Symptom complex due to ACTH production by non-pituitary neoplasms.	1.97	1	0
Cyst [description not available]	1.97	1	0
Parathyroid Disorders [description not available]	2.88	1	0
Hyperparathyroidism A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.	2.88	1	0
Parathyroid Diseases Pathological processes of the PARATHYROID GLANDS. They usually manifest as hypersecretion or hyposecretion of PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.	2.88	1	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	1.96	1	0
Elevated Cholesterol [description not available]	1.96	1	0
Hypercholesterolemia A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.	1.96	1	0
Interstitial Cell Tumor [description not available]	1.96	1	0

19-iodocholesterol

Description

Cross-References

Synonyms (14)

Research

Studies (103)

Study Types