Iodotyrosine deiodinase 1

An iodotyrosine deiodinase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6PHW0]

IYD-1;
EC 1.21.1.1;
Iodotyrosine dehalogenase 1

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2-iodophenol	Homo sapiens (human)	Kd	738.5000	1	2
monoiodotyrosine	Homo sapiens (human)	Kd	4.1450	1	2

This protein enables 4 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
FMN binding	molecular function	Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:tb]
iodotyrosine deiodinase activity	molecular function	Catalyzes the reaction: 2 iodide + L-tyrosine + 2 NADP+ = 3,5-diiodo-L-tyrosine + H+ + 2 NADPH. Note that this activity has only been demonstrated in the direction of 3-deiodination. 3-bromo-L-tyrosine and 3-chloro-L-tyrosine can also be used as substrates. [PMID:15289438, PMID:18434651, PMID:25395621, PMID:27643701, RHEA:32479]
oxidoreductase activity	molecular function	Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. [GOC:go_curators]

This protein is located in 3 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cytoplasmic vesicle membrane	cellular component	The lipid bilayer surrounding a cytoplasmic vesicle. [GOC:mah]

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is involved in 2 target(s):

Target	Category	Definition
tyrosine metabolic process	biological process	The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. [GOC:go_curators]
thyroid hormone metabolic process	biological process	The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. [GOC:jl, ISBN:0198506732]