oroxin-b and Pheochromocytoma

oroxin-b has been researched along with Pheochromocytoma* in 1 studies

Other Studies

1 other study(ies) available for oroxin-b and Pheochromocytoma

Article	Year
Orexin signaling in recombinant neuron-like cells. FEBS letters, 2002, Aug-28, Volume: 526, Issue:1-3 To assess the role of orexin receptor signaling in neuron-like cells, Neuro-2a murine neuroblastoma and PC12 human pheochromocytoma cells were stably transfected with human OX(1) or OX(2) receptors. Activation of both receptors strongly elevated cellular inositol phosphates and Ca(2+). A difference in the potency between orexin-A and -B was seen for OX(1), but not OX(2) receptors. Dependence of the orexin-mediated Ca(2+) response on extracellular Ca(2+) and the observed Ba(2+) influx indicate that in addition to phospholipase C, orexin receptors also may couple to similar non-voltage-gated Ca(2+) channels in neuronal cells as previously characterized in non-neuronal cells. Topics: Animals; Calcium; Carrier Proteins; Humans; Inositol Phosphates; Intracellular Signaling Peptides and Proteins; Neuroblastoma; Neurons; Neuropeptides; Neurotransmitter Agents; Orexin Receptors; Orexins; PC12 Cells; Pheochromocytoma; Rats; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Recombinant Proteins; Transfection; Tumor Cells, Cultured	2002

Article

Year

Orexin signaling in recombinant neuron-like cells.

FEBS letters, 2002, Aug-28, Volume: 526, Issue:1-3

To assess the role of orexin receptor signaling in neuron-like cells, Neuro-2a murine neuroblastoma and PC12 human pheochromocytoma cells were stably transfected with human OX(1) or OX(2) receptors. Activation of both receptors strongly elevated cellular inositol phosphates and Ca(2+). A difference in the potency between orexin-A and -B was seen for OX(1), but not OX(2) receptors. Dependence of the orexin-mediated Ca(2+) response on extracellular Ca(2+) and the observed Ba(2+) influx indicate that in addition to phospholipase C, orexin receptors also may couple to similar non-voltage-gated Ca(2+) channels in neuronal cells as previously characterized in non-neuronal cells.

Topics: Animals; Calcium; Carrier Proteins; Humans; Inositol Phosphates; Intracellular Signaling Peptides and Proteins; Neuroblastoma; Neurons; Neuropeptides; Neurotransmitter Agents; Orexin Receptors; Orexins; PC12 Cells; Pheochromocytoma; Rats; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Recombinant Proteins; Transfection; Tumor Cells, Cultured

2002