1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine has been researched along with Pheochromocytoma in 8 studies
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine : A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Polymer-encapsulated PC12 cells, a dopaminergic cell line derived from a rat pheochromocytoma, were transplanted in five Macaca fascicularis monkeys which had been previously rendered hemiparkinsonian by a unilateral carotid injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine." | 3.69 | Functional recovery in hemiparkinsonian primates transplanted with polymer-encapsulated PC12 cells. ( Aebischer, P; Goddard, M; Signore, AP; Timpson, RL, 1994) |
| "The toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine (2'Et-MPTP), and their corresponding pyridinium species was studied in the rat pheochromocytoma PC12 cell line." | 3.68 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced toxicity in PC12 cells: role of monoamine oxidase A. ( Basma, AN; Geller, HM; Giovanni, A; Heikkila, RE; Nicklas, WJ, 1990) |
| "5 mM MPTP for 72 h resulted in a 50% cell loss with respect to the control cells, and clorgyline, a MAO-A inhibitor, antagonized this toxic effect." | 1.27 | Evaluation of the toxicity of the dopaminergic neurotoxins MPTP and MPP+ in PC12 pheochromocytoma cells: binding and biological studies. ( Bernardi, F; Corsini, GU; Del Zompo, M; Marongiu, ME; Piccardi, MP, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Denton, T | 2 |
| Howard, BD | 4 |
| Aebischer, P | 1 |
| Goddard, M | 1 |
| Signore, AP | 1 |
| Timpson, RL | 1 |
| Andersen, JK | 1 |
| Zhang, MB | 2 |
| Zhong, XH | 1 |
| Rozenberg, YY | 1 |
| Basma, AN | 1 |
| Heikkila, RE | 1 |
| Nicklas, WJ | 1 |
| Giovanni, A | 1 |
| Geller, HM | 1 |
| Naoi, M | 1 |
| Takahashi, T | 1 |
| Nagatsu, T | 1 |
| Marongiu, ME | 1 |
| Piccardi, MP | 1 |
| Bernardi, F | 1 |
| Corsini, GU | 1 |
| Del Zompo, M | 1 |
| Bitler, CM | 1 |
8 other studies available for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and Pheochromocytoma
| Article | Year |
|---|---|
Inhibition of dopamine uptake by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a cause of parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Gland Neoplasms; Animals; Biological Transport | 1984 |
Functional recovery in hemiparkinsonian primates transplanted with polymer-encapsulated PC12 cells.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Gland Neoplasms; Adrenal Medulla; Animals; Cap | 1994 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-resistant, flat-cell PC12 variants having a partial loss of transformed phenotype.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Gland Neoplasms; Animals; Cell Transformation, | 1990 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced toxicity in PC12 cells: role of monoamine oxidase A.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Gland Neoplasms; Animals; Cell Survival; Clorg | 1990 |
Metabolism of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in a rat pheochromocytoma cell line, PC12h.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Chromatography, | 1987 |
Evaluation of the toxicity of the dopaminergic neurotoxins MPTP and MPP+ in PC12 pheochromocytoma cells: binding and biological studies.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adrenal Gland Neoplasms; | 1988 |
PC12 variants deficient in catecholamine transport.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Gland Neoplasms; Animals; Biological Transport | 1986 |
A dopaminergic cell line variant resistant to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenosine Triphosphate; Adrenal Gland Neoplasms; Anima | 1987 |