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phenytoin and Pheochromocytoma

phenytoin has been researched along with Pheochromocytoma in 3 studies

Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)

Research Excerpts

ExcerptRelevanceReference
"The mechanism of calcium channel antagonism by phenytoin was studied by comparing the effects of phenytoin and classical calcium channel antagonists on K+-stimulated 45Ca uptake and [3H]nitrendipine binding in the PC12 pheochromocytoma cell line."3.67Mechanism of calcium channel inhibition by phenytoin: comparison with classical calcium channel antagonists. ( Carpenter, CL; Greenberg, DA; Messing, RO, 1985)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19903 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chalfie, M2
Perlman, RL2
Hoadley, D1
Pastan, S1
Messing, RO1
Carpenter, CL1
Greenberg, DA1

Other Studies

3 other studies available for phenytoin and Pheochromocytoma

ArticleYear
Inhibition of catecholamine synthesis and tyrosine 3-monooxygenase activation in pheochromocytoma cells by diphenylhydantoin.
    Journal of neurochemistry, 1977, Volume: 29, Issue:4

    Topics: Adrenal Gland Neoplasms; Animals; Catecholamines; Cells, Cultured; Depression, Chemical; Dose-Respon

1977
Calcium uptake into rat pheochromocytoma cells.
    Journal of neurochemistry, 1976, Volume: 27, Issue:6

    Topics: Animals; Calcium; Catecholamines; Drug Interactions; In Vitro Techniques; Phenytoin; Pheochromocytom

1976
Mechanism of calcium channel inhibition by phenytoin: comparison with classical calcium channel antagonists.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Adrenal Gland Neoplasms; Animals; Binding Sites; Calcium; Calcium Channel Blockers; Carbachol; Cell

1985