phenytoin has been researched along with Pheochromocytoma in 3 studies
Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
Excerpt | Relevance | Reference |
---|---|---|
"The mechanism of calcium channel antagonism by phenytoin was studied by comparing the effects of phenytoin and classical calcium channel antagonists on K+-stimulated 45Ca uptake and [3H]nitrendipine binding in the PC12 pheochromocytoma cell line." | 3.67 | Mechanism of calcium channel inhibition by phenytoin: comparison with classical calcium channel antagonists. ( Carpenter, CL; Greenberg, DA; Messing, RO, 1985) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (100.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Chalfie, M | 2 |
Perlman, RL | 2 |
Hoadley, D | 1 |
Pastan, S | 1 |
Messing, RO | 1 |
Carpenter, CL | 1 |
Greenberg, DA | 1 |
3 other studies available for phenytoin and Pheochromocytoma
Article | Year |
---|---|
Inhibition of catecholamine synthesis and tyrosine 3-monooxygenase activation in pheochromocytoma cells by diphenylhydantoin.
Topics: Adrenal Gland Neoplasms; Animals; Catecholamines; Cells, Cultured; Depression, Chemical; Dose-Respon | 1977 |
Calcium uptake into rat pheochromocytoma cells.
Topics: Animals; Calcium; Catecholamines; Drug Interactions; In Vitro Techniques; Phenytoin; Pheochromocytom | 1976 |
Mechanism of calcium channel inhibition by phenytoin: comparison with classical calcium channel antagonists.
Topics: Adrenal Gland Neoplasms; Animals; Binding Sites; Calcium; Calcium Channel Blockers; Carbachol; Cell | 1985 |