w 7 has been researched along with Pheochromocytoma in 2 studies
W 7: RN given refers to parent cpd; structure; calmodulin antagonist
Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pheochromocytoma cells were incubated for 90 minutes with W-7 (calmodulin antagonist), calphostin C (protein kinase C inhibitor), Sp-cAMPS (cAMP agonist), Rp-cAMPS (cAMP antagonist), forskolin (activator of adenylyl cyclase), or lead nitrate." | 3.69 | A study of the cellular mechanism by which lead affects catecholamine secretion. ( Porter, JC; Ramin, SM, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ramin, SM | 1 |
| Porter, JC | 1 |
| Kittner, B | 1 |
| Bräutigam, M | 1 |
| Herken, H | 1 |
2 other studies available for w 7 and Pheochromocytoma
| Article | Year |
|---|---|
A study of the cellular mechanism by which lead affects catecholamine secretion.
Topics: Adenylyl Cyclases; Animals; Calmodulin; Catecholamines; Colforsin; Cyclic AMP; Enzyme Activation; En | 1997 |
PC12 cells: a model system for studying drug effects on dopamine synthesis and release.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1987 |