Page last updated: 2024-12-08

4'-hydroxydiazepam

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID161216
CHEMBL ID111019
SCHEMBL ID11631556
MeSH IDM0141742

Synonyms (15)

Synonym
4'-hydroxydiazepam
CHEMBL111019
ro-7-3351
ro 7-3351
2h-1,4-benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-
p-hydroxydiazepam
17311-35-2
4-hydroxydiazepam
7-chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-2h-1,4-benzodiazepin-2-on
IQFWLIWUKIFGKP-UHFFFAOYSA-N
SCHEMBL11631556
7-chloro-5-(4-hydroxyphenyl)-1-methyl-1h-benzo[e][1,4]diazepin-2(3h)-one
7-chloro-5-(4-hydroxyphenyl)-1-methyl-3h-1,4-benzodiazepin-2-one
7-chloro-1-methyl-5-(4-oxocyclohexa-2,5-dien-1-ylidene)-1,3,4,5-tetrahydro-2h-1,4-benzodiazepin-2-one
DTXSID10938320

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
"The dose-response relationships of diazepam and several of its metabolites were determined in rats trained to discriminate diazepam (3 mg/kg) from saline in a two-lever operant choice task."( Potencies of diazepam metabolites in rats trained to discriminate diazepam.
Brase, DA; Dewey, WL; Glennon, RA; Young, R, 1986
)
0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID165931Inhibition of Ramos B cells death in the presence of 20 uM methylating phenol (Compound 20); Not determined2003Bioorganic & medicinal chemistry letters, Oct-06, Volume: 13, Issue:19
Structure activity studies of a novel cytotoxic benzodiazepine.
AID165934Inhibition of Ramos B cells death in the presence of FK506 (1 uM); Not determined2003Bioorganic & medicinal chemistry letters, Oct-06, Volume: 13, Issue:19
Structure activity studies of a novel cytotoxic benzodiazepine.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's1 (16.67)18.2507
2000's2 (33.33)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.52

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.52 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.46 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.52)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]