Acyl-protein thioesterase 2

An acyl-protein thioesterase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O95372]

APT-2;
EC 3.1.2.-;
Lysophospholipase II;
LPL-II;
LysoPLA II

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
benzo(b)thiophene-2-boronic acid	Homo sapiens (human)	IC50	1.4145	1	2
benzeneboronic acid	Homo sapiens (human)	IC50	19.9500	1	2
1,1'-biphenyl-4-yl-boronic acid	Homo sapiens (human)	IC50	10.2250	1	2
palmostatin b	Homo sapiens (human)	IC50	0.0377	1	1
palmostatin b	Homo sapiens (human)	Ki	0.0340	1	1
palmostatin m	Homo sapiens (human)	IC50	0.0196	1	1

This protein enables 5 target(s):

Target	Category	Definition
lysophospholipase activity	molecular function	Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine. [EC:3.1.1.5]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
palmitoyl-(protein) hydrolase activity	molecular function	Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. [EC:3.1.2.22]
cadherin binding	molecular function	Binding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf]
carboxylic ester hydrolase activity	molecular function	Catalysis of the hydrolysis of a carboxylic ester bond. [GOC:curators]

This protein is located in 5 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
Golgi stack	cellular component	The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. [GOC:mah, ISBN:0815316194]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

This protein is involved in 5 target(s):

Target	Category	Definition
protein depalmitoylation	biological process	The removal of palymitoyl groups from a lipoprotein. [GOC:hjd]
fatty acid metabolic process	biological process	The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198547684]
axon guidance	biological process	The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [ISBN:0878932437]
acylglycerol catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. [GOC:ai]
prostaglandin catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of prostaglandin. [GO_REF:0000068, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25290914]