Page last updated: 2024-10-21

homovanillic acid and Pheochromocytoma

homovanillic acid has been researched along with Pheochromocytoma in 49 studies

Homovanillic Acid: A 3-O-methyl ETHER of (3,4-dihydroxyphenyl)acetic acid.
homovanillate : A hydroxy monocarboxylic acid anion which is obtained by deprotonation of the carboxy group of homovanillic acid.
homovanillic acid : A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.

Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)

Research Excerpts

ExcerptRelevanceReference
"The effects of an organophosphate (OP) pesticide, fenthion (FEN), on the release and metabolism of dopamine were evaluated in a clonal line of rat pheochromocytoma (PC12) cells."7.67Release and metabolism of dopamine in a clonal line of pheochromocytoma (PC12) cells exposed to fenthion. ( Bowen, JM; Hazen, AA; Tuler, SM, 1989)
"High performance liquid chromatography (HPLC) with electrochemical detection (ED) was applied for the monitoring of catecholamines (epinephrine - E, norepinephrine - NE, dopamine - DA) and their main metabolites (homovanillic acid - HVA, vanillylmandelic acid - VMA) in urine samples of patients with the pheochromocytoma diagnosis."3.69HPLC-ED determination of catecholamines and their metabolites in urine. ( Balazovjech, I; Brandsteterová, E; Kubalec, P; Skacáni, I, 1994)
"The effects of an organophosphate (OP) pesticide, fenthion (FEN), on the release and metabolism of dopamine were evaluated in a clonal line of rat pheochromocytoma (PC12) cells."3.67Release and metabolism of dopamine in a clonal line of pheochromocytoma (PC12) cells exposed to fenthion. ( Bowen, JM; Hazen, AA; Tuler, SM, 1989)
"The interference of various foodstuffs on methods to determine epinephrine (E), norepinephrine (NE), vanillylmandelic acid (VMA), metanephrines (MN), homovanillic acid (HVA), and 6-hydroxyindole acetic acid (5-HIA) in the 24 h urine for diagnosis of pheochromocytoma and carcinoid syndrome, respectively, was investigated."3.66[The influence of different diets and smoking on the clinical chemical diagnosis of pheochromocytoma, neuroblastoma, and carcinoid syndrome (author's transl)]. ( Eberhagen, D; Heinemann, G; Rahlfs, V; Schievelbein, H, 1981)
"Neuroblastoma is the most common extracranial solid tumour in childhood (8% of all childhood cancers), the most frequently diagnosed in infancy, and has one of the highest death rates, while chromaffin tumours rarely present in childhood."1.37Age-related medical decision limits for urinary free (unconjugated) metadrenalines, catecholamines and metabolites in random urine specimens from children. ( Carachi, R; Davidson, DF; Hammond, PJ; Murphy, D, 2011)
"Treatment of this pheochromocytoma is surgical and resolves the hypertensive symptoms in 80% of the benign forms."1.26[Non-hypertensive pheochromocytoma. Description of 2 clinical cases]. ( Buzzatti, A; Cagol, PP; De Marchi, F; Zavagno, G, 1982)

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-199029 (59.18)18.7374
1990's8 (16.33)18.2507
2000's10 (20.41)29.6817
2010's2 (4.08)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Díaz-Soto, G1
Serrano Morte, A1
Rodríguez Martín, C1
García-Talavera, P1
Abril, CM1
Puig-Domingo, M1
Manickum, T1
Davidson, DF3
Hammond, PJ1
Murphy, D1
Carachi, R1
Serra, PA1
Rocchitta, G1
Delogu, MR1
Migheli, R1
Taras, MG1
Mura, MP1
Esposito, G1
Miele, E1
Desole, MS1
Miele, M1
PETRASEK, J2
DUBOVSKY, J2
SANKOFF, I1
SOURKES, TL1
RUTHVEN, CR1
SANDLER, M1
Jähnel, M1
Tajiri, S1
Grosset, K1
Grosset, D1
Bockenhauer, D1
Rees, L1
Neumann, H1
Foo, Y1
Joseph, MH1
Kadam, BV1
Risby, D1
Soldin, SJ3
Jacob, K1
Vogt, W1
Schwertfeger, G1
Tuchman, M1
Crippin, PJ1
Krivit, W1
Zavagno, G1
Cagol, PP1
Buzzatti, A1
De Marchi, F1
Heinemann, G1
Schievelbein, H1
Eberhagen, D1
Rahlfs, V1
Hill, JG2
Grobler, SM1
Potgieter, GM1
Stefănescu, AM1
Stumvoll, M1
Radjaipour, M1
Seif, F1
Anastasiadis, PZ1
States, JC1
Kuhn, DM1
Levine, RA1
Brandsteterová, E1
Kubalec, P1
Skacáni, I1
Balazovjech, I1
Robertson, WS1
Stewart, MF1
Reed, P1
Weinkove, C1
Moriarty, KJ1
Ralston, AJ1
Kanesaka, Y1
Tomita, K1
Joseph, JV1
Harrison, R1
Davis, RS1
Tormey, WP1
Fitzgerald, RJ1
Thomas, G1
Kay, EW1
Leader, MB1
Januszewicz, W1
Wocial, B1
Januszewicz, A1
Gryglas, P1
Prejbisz, A1
Imashuku, S1
Takada, H1
Sawada, T1
Nakamura, T1
LaBrosse, EH1
Feldman, JM3
Blalock, JA1
Zern, RT1
Shelburne, JD1
Gaede, JT1
Farrell, RE1
Wells, SA1
Morrisey, JL1
Shihabi, ZK1
Peyrin, L1
Cottet-Emard, JM1
Claustre, B1
Muskiet, FA1
Jeuring, HJ1
Nagel, GT1
de Bruyn, HW1
Wolthers, BG1
Yoshida, A1
Yoshioka, M1
Yamazaki, T1
Sakai, T1
Tamura, Z1
Wisser, H1
Knoll, E1
Hanson, MW1
Beam, CA1
Leight, GS1
Coleman, RE1
Mannelli, M1
Tuler, SM1
Hazen, AA1
Bowen, JM1
Price, S1
Davenport, K1
Berg, JD1
Tippett, PA1
West, RS1
McEwan, AJ1
Middleton, JE1
Ackery, DM1
Buu, NT1
Kuchel, O1
Manger, W1
Hulse, MC1
Chute, RN1
Vorbrodt, B1
Krause, E1
Weinert, D1
Fenech, C1
Guyon, F1
Dauchy, P1
Pertsemlidis, D1
Gitlow, SE1
Kark, AE1
Butler, SS1
Chapman, BA1
Bivens, CE1

Reviews

6 reviews available for homovanillic acid and Pheochromocytoma

ArticleYear
[Vanillylmandelic acid (VMA) and homovanillic acid (HVA)].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 8

    Topics: Adrenal Gland Neoplasms; Biomarkers; Chromatography, High Pressure Liquid; Chronic Disease; Depressi

2005
Diagnostic considerations in pheochromocytoma and chronic hemodialysis: case report and review of the literature.
    American journal of nephrology, 1995, Volume: 15, Issue:2

    Topics: Adrenal Gland Neoplasms; Adult; Catecholamines; Homovanillic Acid; Humans; Kidney Failure, Chronic;

1995
[Vanillylmandelic acid (VMA) and homovanillic acid (HVA)].
    Nihon rinsho. Japanese journal of clinical medicine, 1999, Volume: 57 Suppl

    Topics: Adolescent; Child; Child, Preschool; Homovanillic Acid; Humans; Infant; Neuroblastoma; Pheochromocyt

1999
Catecholamine secretion and ploidy in phaeochromocytoma.
    International journal of clinical practice, 2000, Volume: 54, Issue:8

    Topics: Adrenal Gland Neoplasms; Biomarkers, Tumor; Catecholamines; Chromatography, High Pressure Liquid; Fl

2000
Diagnostic problems in pheochromocytoma.
    Journal of endocrinological investigation, 1989, Volume: 12, Issue:10

    Topics: Adrenal Gland Neoplasms; Epinephrine; Homovanillic Acid; Humans; Magnetic Resonance Imaging; Metanep

1989
Pheochromocytoma: advances in diagnosis and treatment.
    Surgery annual, 1972, Volume: 4

    Topics: Adrenal Gland Neoplasms; Catecholamines; Child; Creatinine; Diagnosis, Differential; Epinephrine; Fe

1972

Trials

1 trial available for homovanillic acid and Pheochromocytoma

ArticleYear
Parkinson's disease: the effect of L-dopa therapy on urinary free catecholamines and metabolites.
    Annals of clinical biochemistry, 2007, Volume: 44, Issue:Pt 4

    Topics: Adolescent; Adult; Aged; Antiparkinson Agents; Catecholamines; Creatinine; Dopamine; Female; Homovan

2007

Other Studies

42 other studies available for homovanillic acid and Pheochromocytoma

ArticleYear
[Familial paraganglioma syndrome: phenotype and relevance of a new SDHB mutation].
    Medicina clinica, 2013, May-13, Volume: 140, Issue:10

    Topics: Adult; Aged, 80 and over; Catecholamines; Exons; Female; Genotype; Homovanillic Acid; Humans; Hypert

2013
Simultaneous analysis of neuroendocrine tumor markers by HPLC-electrochemical detection.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Dec-15, Volume: 877, Issue:32

    Topics: Adrenal Gland Neoplasms; Adult; Biomarkers, Tumor; Child; Child, Preschool; Chromatography, High Pre

2009
Age-related medical decision limits for urinary free (unconjugated) metadrenalines, catecholamines and metabolites in random urine specimens from children.
    Annals of clinical biochemistry, 2011, Volume: 48, Issue:Pt 4

    Topics: Adolescent; Age Factors; Catecholamines; Child, Preschool; Decision Making; Diagnosis, Differential;

2011
Phaeochromocytoma with normal urinary catecholamines: the potential value of urinary free metadrenalines.
    Annals of clinical biochemistry, 2002, Volume: 39, Issue:Pt 6

    Topics: Adult; Aged; Catecholamines; Chromatography, High Pressure Liquid; Female; Homovanillic Acid; Humans

2002
Role of the nitric oxide/cyclic GMP pathway and extracellular environment in the nitric oxide donor-induced increase in dopamine secretion from PC12 cells: a microdialysis in vitro study.
    Journal of neurochemistry, 2003, Volume: 86, Issue:6

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Ascorbic Acid; Calcium; Calcium Channel Blockers; Cell Surv

2003
[Elimination of 3-methoxy-4-hydroxyphenylacetic acid (homovanillic acid). II. Clinical applications].
    Sbornik lekarsky, 1963, Volume: 65

    Topics: Homovanillic Acid; Humans; Neuroblastoma; Paraganglioma; Phenylacetates; Pheochromocytoma

1963
[Isolation of 3-methoxy-4-hydroxymandelic acid (vanillin-mandelic acid) and 3-methoxy-4-hydroxphenylacetic acid (homovanillic acid) in tumors of the sympathoadrenal system].
    Casopis lekaru ceskych, 1962, Dec-07, Volume: 101

    Topics: Benzaldehydes; Homovanillic Acid; Humans; Mandelic Acids; Neuroblastoma; Paraganglioma; Phenylacetat

1962
Determination by thin-layer chromatography of urinary homovanillic acid in normal and disease states.
    Canadian journal of biochemistry and physiology, 1963, Volume: 41

    Topics: Chorea; Chromatography, Thin Layer; Ganglioneuroma; Hepatolenticular Degeneration; Homovanillic Acid

1963
ESTIMATION OF HOMOVANILLIC ACID IN URINE.
    Analytical biochemistry, 1964, Volume: 8

    Topics: Chromatography; Clinical Laboratory Techniques; Colorimetry; Dopamine; Ganglioneuroma; Homovanillic

1964
[Pseudopheochromocytoma in Parkinson disease and depression].
    Psychiatrische Praxis, 2003, Volume: 30 Suppl 2

    Topics: Adrenal Gland Neoplasms; Antidepressive Agents; Antiparkinson Agents; Catecholamines; Depressive Dis

2003
A sporadic case of paraganglioma undetected by urine metabolite screening.
    Pediatric nephrology (Berlin, Germany), 2008, Volume: 23, Issue:10

    Topics: Adrenal Gland Neoplasms; Child; Genetic Testing; Homovanillic Acid; Humans; Male; Pheochromocytoma;

2008
Simple high-performance liquid chromatographic method for the concurrent determination of the amine metabolites vanillylmandelic acid, 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid, dihydroxyphenylacetic acid and homovanillic acid in urine u
    Journal of chromatography, 1981, Dec-11, Volume: 226, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Gland Neoplasms; Carbidopa; Chromatography, High Pressure Li

1981
High-performance liquid chromatography: applications in a children's hospital.
    Advances in chromatography, 1982, Volume: 20

    Topics: Adolescent; Anticonvulsants; Catecholamines; Child; Child, Preschool; Chromatography, High Pressure

1982
Sensitive mass fragmentographic determination of acidic catecholamine metabolites in human body fluids.
    Journal of chromatography, 1984, May-04, Volume: 290

    Topics: Adrenal Gland Neoplasms; Body Fluids; Gas Chromatography-Mass Spectrometry; Homovanillic Acid; Human

1984
Capillary gas-chromatographic determination of urinary homovanillic acid and vanillylmandelic acid.
    Clinical chemistry, 1983, Volume: 29, Issue:5

    Topics: Adolescent; Adrenal Gland Neoplasms; Child; Child, Preschool; Chromatography, Gas; Female; Homovanil

1983
[Non-hypertensive pheochromocytoma. Description of 2 clinical cases].
    Chirurgia italiana, 1982, Volume: 34, Issue:2

    Topics: Adrenal Gland Neoplasms; Adult; Catecholamines; Homovanillic Acid; Humans; Male; Middle Aged; Pheoch

1982
[The influence of different diets and smoking on the clinical chemical diagnosis of pheochromocytoma, neuroblastoma, and carcinoid syndrome (author's transl)].
    Klinische Wochenschrift, 1981, Oct-15, Volume: 59, Issue:20

    Topics: Adrenal Gland Neoplasms; Adult; Diagnosis, Differential; Epinephrine; Feeding Behavior; Homovanillic

1981
Simultaneous liquid-chromatographic analysis for 4-hydroxy-3-methoxymandelic acid and 4-hydroxy-3-methoxyphenylacetic acid in urine.
    Clinical chemistry, 1980, Volume: 26, Issue:2

    Topics: Adrenal Gland Neoplasms; Chromatography, High Pressure Liquid; Homovanillic Acid; Humans; Neuroblast

1980
A screening test for pheochromocytoma and neuroblastoma using high voltage electrophoresis.
    Clinica chimica acta; international journal of clinical chemistry, 1980, Feb-14, Volume: 101, Issue:1

    Topics: Catecholamines; Electrophoresis, Paper; Homovanillic Acid; Humans; Methoxyhydroxyphenylglycol; Pheoc

1980
Liquid-chromatographic analysis for urinary 4-hydroxy-3-methoxymandelic acid and 4-hydroxy-3-methoxyphenylacetic acid, and its use in investigation of neural crest tumors.
    Clinical chemistry, 1981, Volume: 27, Issue:3

    Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Child; Child, Preschool; Chromatography, Liquid; Female;

1981
An improvement of the endocrine diagnosis by high-performance liquid chromatography.
    Romanian journal of endocrinology, 1993, Volume: 31, Issue:3-4

    Topics: Adrenal Gland Neoplasms; Adult; Catecholamines; Chromatography, High Pressure Liquid; Chromatography

1993
Co-induction of tetrahydrobiopterin (BH4) levels and tyrosine hydroxylase activity in cultured PC12 cells.
    Advances in experimental medicine and biology, 1993, Volume: 338

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Gland Neoplasms; Analysis of Variance; Animals; Biopterins;

1993
HPLC-ED determination of catecholamines and their metabolites in urine.
    Neoplasma, 1994, Volume: 41, Issue:4

    Topics: Catecholamines; Chromatography, High Pressure Liquid; Detergents; Electrochemistry; Homovanillic Aci

1994
Laboratory diagnosis of phaeochromocytoma.
    Annals of clinical biochemistry, 1993, Volume: 30 ( Pt 5)

    Topics: Adrenal Gland Neoplasms; Homovanillic Acid; Humans; Lactates; Pheochromocytoma

1993
Biochemical diagnosis of phaeochromocytoma: two instructive case reports.
    Journal of clinical pathology, 1993, Volume: 46, Issue:3

    Topics: Adrenal Gland Neoplasms; Adult; Dopamine; Epinephrine; Female; Homovanillic Acid; Humans; Lactates;

1993
Multiple endocrine neoplasia type IIA (Sipple's syndrome) presenting in pregnancy.
    The Australian & New Zealand journal of obstetrics & gynaecology, 2000, Volume: 40, Issue:4

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Antihypertensive Agents; Calcitonin; Drug Monitoring;

2000
Dopamine and dopa urinary excretion in patients with pheochromocytoma--diagnostic implications.
    Blood pressure, 2001, Volume: 10, Issue:4

    Topics: Adult; Biomarkers, Tumor; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; Homovanillic Acid;

2001
Studies on tyrosine hydroxylase in neuroblastoma in relation to urinary levels of catecholamine metabolites.
    Cancer, 1975, Volume: 36, Issue:2

    Topics: Adolescent; Adrenal Gland Neoplasms; Adrenal Glands; Bone Neoplasms; Chromatography, Paper; Chromato

1975
Deficiency of dopamine-beta-hydroxylase. A new mechanism for normotensive pheochromocytomas.
    American journal of clinical pathology, 1979, Volume: 72, Issue:2

    Topics: Adrenal Gland Neoplasms; Adult; Blood Pressure; Catecholamines; Dopamine beta-Hydroxylase; Female; H

1979
Assay of 4-hydroxy-3-methoxyphenylacetic (homovanillic) acid by liquid chromatography with electrochemical detection.
    Clinical chemistry, 1979, Volume: 25, Issue:12

    Topics: Adult; Chromatography, Liquid; Electrochemistry; Homovanillic Acid; Humans; Neuroblastoma; Parkinson

1979
Studies on urinary DOPAC in man by means of a sensitive automated procedure.
    Biochemical medicine, 1978, Volume: 19, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Addison Disease; Adrenal Gland Neoplasms; Adult; Aged; Autoanalysis;

1978
Mass-fragmentographic determination of catecholamine metabolites in amniotic fluid and its possible clinical usefulness.
    Clinical chemistry, 1978, Volume: 24, Issue:11

    Topics: Adrenal Gland Neoplasms; Amniotic Fluid; Catecholamines; Creatinine; Female; Fetal Diseases; Gas Chr

1978
Urinary levels of vanilmandelic acid and homovanillic acid determined by high-speed liquid chromatography.
    Clinica chimica acta; international journal of clinical chemistry, 1976, Dec-01, Volume: 73, Issue:2

    Topics: Adult; Child; Child, Preschool; Chromatography, High Pressure Liquid; Diet; Homovanillic Acid; Human

1976
[Results of a study on the circadian rhythm of catecholamine excretion on normal subjects and those with high excretion levels (author's transl)].
    Clinica chimica acta; international journal of clinical chemistry, 1975, Feb-22, Volume: 59, Issue:1

    Topics: Adult; Catecholamines; Circadian Rhythm; Dopamine; Epinephrine; Homovanillic Acid; Humans; Male; Mid

1975
Iodine 131-labeled metaiodobenzylguanidine scintigraphy and biochemical analyses in suspected pheochromocytoma.
    Archives of internal medicine, 1991, Volume: 151, Issue:7

    Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Adult; Aged; Dopamine; Epinephrine; Female; Homovani

1991
Release and metabolism of dopamine in a clonal line of pheochromocytoma (PC12) cells exposed to fenthion.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1989, Volume: 13, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Gland Neoplasms; Animals; Dopamine; Fenthion; Homovanillic A

1989
Determination of urinary 3-methoxy-4-hydroxymandelic and 3-methoxy-4-hydroxyphenylacetic acids by fused silica capillary gas chromatography.
    Annals of clinical biochemistry, 1986, Volume: 23 ( Pt 3)

    Topics: Adrenal Gland Neoplasms; Adult; Chromatography, Gas; Homovanillic Acid; Humans; Hypertension; Pheoch

1986
A comparison of dopamine and homovanillic acid excretion, as prognostic indicators in malignant phaeochromocytoma.
    Clinica chimica acta; international journal of clinical chemistry, 1987, Jul-15, Volume: 166, Issue:2-3

    Topics: Adult; Dopamine; Female; Homovanillic Acid; Humans; Male; Middle Aged; Neoplasm Metastasis; Pheochro

1987
Metabolism and storage of catecholamines in rats with pheochromocytoma implants.
    Hypertension (Dallas, Tex. : 1979), 1986, Volume: 8, Issue:10

    Topics: Adrenal Gland Neoplasms; Animals; Dopamine; Homovanillic Acid; Hypertension; Male; Monoamine Oxidase

1986
[Circadian rhythm of 3-methoxy-4-hydroxymandelic acid and 3-methoxy-4-hydroxyphenylacetic acid in the urine].
    Die Pharmazie, 1985, Volume: 40, Issue:4

    Topics: Adrenal Gland Neoplasms; Adult; Circadian Rhythm; Female; Homovanillic Acid; Humans; Male; Phenylace

1985
Liquid chromatographic analysis of 4-hydroxy-3-methoxymandelic acid (VMA) and 4-hydroxy-3-methoxyphenylacetic acid (HVA) in urine.
    Clinica chimica acta; international journal of clinical chemistry, 1985, Nov-29, Volume: 153, Issue:1

    Topics: Adrenal Gland Neoplasms; Chromatography, High Pressure Liquid; Homovanillic Acid; Humans; Neuroblast

1985
Catecholamine metabolism in the carcinoid syndrome.
    Clinica chimica acta; international journal of clinical chemistry, 1974, Feb-28, Volume: 51, Issue:1

    Topics: Catecholamines; Creatine; Diagnosis, Differential; Epinephrine; Female; Homovanillic Acid; Humans; H

1974