mitotane has been researched along with Pheochromocytoma in 11 studies
Mitotane: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pheochromocytomas are present in approximately 4-7% of patients with adrenal incidentalomas." | 2.58 | Primary malignant tumors of the adrenal glands. ( Almeida, MQ; Bezerra-Neto, JE; Fragoso, MCBV; Latronico, AC; Mendonça, BB, 2018) |
| "Pheochromocytomas are derived from the adrenal medulla and present with symptoms caused by high secretion of catecholamines." | 2.50 | Rare adrenal tumors in children. ( Mihai, R, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nowak, KM | 1 |
| Łebek-Szatańska, A | 1 |
| Samsel, R | 1 |
| Roszkowska-Purska, K | 1 |
| Ćwikła, JB | 1 |
| Papierska, L | 1 |
| Almeida, MQ | 1 |
| Bezerra-Neto, JE | 1 |
| Mendonça, BB | 1 |
| Latronico, AC | 1 |
| Fragoso, MCBV | 1 |
| Mihai, R | 1 |
| Berruti, A | 1 |
| Baudin, E | 1 |
| Gelderblom, H | 1 |
| Haak, HR | 1 |
| Porpiglia, F | 1 |
| Fassnacht, M | 1 |
| Pentheroudakis, G | 1 |
| Brauckhoff, M | 1 |
| Dralle, H | 1 |
| Favia, G | 1 |
| Lumachi, F | 1 |
| Carraro, P | 1 |
| D'Amico, DF | 1 |
| Bennett, PF | 1 |
| Norman, EJ | 1 |
| Schott, M | 1 |
| Scherbaum, WA | 1 |
| Feldkamp, J | 1 |
| Besser, GM | 1 |
| Jeffcoate, WJ | 1 |
| Schwartz, RW | 1 |
| Sloan, DA | 1 |
| Kenady, DE | 1 |
| Schein, PS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mitotane With or Without Cisplatin and Etoposide After Surgery in Treating Participants With Stage I-III Adrenocortical Cancer With High Risk of Recurrence[NCT03723941] | Phase 3 | 240 participants (Anticipated) | Interventional | 2018-07-01 | Recruiting | ||
| Activity of Abiraterone Acetate in the Management of Cushing's Syndrome in Patients With Adrenocortical Carcinoma[NCT03145285] | Phase 2 | 10 participants (Anticipated) | Interventional | 2017-04-18 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for mitotane and Pheochromocytoma
| Article | Year |
|---|---|
Primary malignant tumors of the adrenal glands.
Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Antineoplastic Agents, | 2018 |
Rare adrenal tumors in children.
Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenal Hyperplasia, Congenital; Adrenalectomy; A | 2014 |
[Recurrent operations on the adrenal glands].
Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Adult; Anti | 2005 |
Adrenocortical carcinoma. Our experience.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Aged; Antineoplastic Combined Chemothera | 1995 |
[Drug therapy of endocrine neoplasms. Part I: Thyroid neoplasms, adrenal neoplasms and parathyroid neoplasms].
Topics: Adrenal Gland Neoplasms; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Proto | 2000 |
Diagnosis and treatment of primary adrenal tumors.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Carcinoma; Cushing Syndrome; Diagnosis | 1991 |
Chemotherapeutic management of the hormone-secreting endocrine malignancies.
Topics: Adenoma, Islet Cell; Adrenal Gland Neoplasms; Aminoglutethimide; Aniline Compounds; Antibiotics, Ant | 1972 |
4 other studies available for mitotane and Pheochromocytoma
| Article | Year |
|---|---|
Adrenocortical carcinoma mimicking pheochromocytoma on iodine 123-labeled metaiodobenzylguanidine scintigraphy.
Topics: Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Adult; Antineoplastic Agents, Hormonal; Four-Dime | 2019 |
Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; A | 2012 |
Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; A | 2012 |
Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; A | 2012 |
Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Antineoplastic Agents, Hormonal; A | 2012 |
Mitotane (o,p'-DDD) resistance in a dog with pituitary-dependent hyperadrenocorticism and phaeochromocytoma.
Topics: Adrenal Cortex Function Tests; Adrenal Gland Neoplasms; Adrenal Medulla; Adrenocortical Hyperfunctio | 1998 |
Endocrine and metabolic diseases. Adrenal diseases.
Topics: Adenoma; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenal Gland Neoplasms; Adrenal Insuffici | 1976 |