succinic acid has been researched along with Pheochromocytoma in 16 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Paraganglioma and pheochromocytoma are examples, whose etiology and therapy are complicated by the absence of representative cell lines or animal models." | 1.51 | Modeling succinate dehydrogenase loss disorders in C. elegans through effects on hypoxia-inducible factor. ( Braun, MM; Chen, C; Damjanac, T; Hu, J; Maher, LJ; Zhang, Y, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 9 (56.25) | 2.80 |
| Authors | Studies |
|---|---|
| Armstrong, N | 1 |
| Storey, CM | 1 |
| Noll, SE | 1 |
| Margulis, K | 1 |
| Soe, MH | 1 |
| Xu, H | 1 |
| Yeh, B | 1 |
| Fishbein, L | 1 |
| Kebebew, E | 1 |
| Howitt, BE | 1 |
| Zare, RN | 1 |
| Sage, J | 1 |
| Annes, JP | 1 |
| Lamy, C | 1 |
| Tissot, H | 1 |
| Faron, M | 1 |
| Baudin, E | 1 |
| Lamartina, L | 1 |
| Pradon, C | 1 |
| Al Ghuzlan, A | 1 |
| Leboulleux, S | 1 |
| Perfettini, JL | 1 |
| Paci, A | 1 |
| Hadoux, J | 1 |
| Broutin, S | 1 |
| Gudgeon, N | 1 |
| Munford, H | 1 |
| Bishop, EL | 1 |
| Hill, J | 1 |
| Fulton-Ward, T | 1 |
| Bending, D | 1 |
| Roberts, J | 1 |
| Tennant, DA | 1 |
| Dimeloe, S | 1 |
| Branzoli, F | 3 |
| Salgues, B | 3 |
| Marjańska, M | 3 |
| Laloi-Michelin, M | 3 |
| Herman, P | 3 |
| Le Collen, L | 3 |
| Delemer, B | 3 |
| Riancho, J | 3 |
| Kuhn, E | 3 |
| Jublanc, C | 3 |
| Burnichon, N | 4 |
| Amar, L | 4 |
| Favier, J | 4 |
| Gimenez-Roqueplo, AP | 4 |
| Buffet, A | 4 |
| Lussey-Lepoutre, C | 4 |
| Bancel, LP | 1 |
| Masso, V | 1 |
| Dessein, AF | 1 |
| Aubert, S | 1 |
| Leteurtre, E | 1 |
| Coppin, L | 1 |
| Odou, MF | 1 |
| Cao, CD | 1 |
| Cardot-Bauters, C | 1 |
| Pigny, P | 1 |
| Wang, Y | 2 |
| Liu, B | 1 |
| Li, F | 1 |
| Zhang, Y | 2 |
| Gao, X | 1 |
| Zhou, H | 1 |
| Braun, MM | 1 |
| Damjanac, T | 1 |
| Chen, C | 1 |
| Hu, J | 1 |
| Maher, LJ | 1 |
| Matlac, DM | 1 |
| Hadrava Vanova, K | 1 |
| Bechmann, N | 1 |
| Richter, S | 2 |
| Folberth, J | 1 |
| Ghayee, HK | 1 |
| Ge, GB | 1 |
| Abunimer, L | 1 |
| Wesley, R | 1 |
| Aherrahrou, R | 1 |
| Dona, M | 1 |
| Martínez-Montes, ÁM | 1 |
| Calsina, B | 1 |
| Merino, MJ | 1 |
| Schwaninger, M | 1 |
| Deen, PMT | 1 |
| Zhuang, Z | 1 |
| Neuzil, J | 1 |
| Pacak, K | 5 |
| Lehnert, H | 1 |
| Fliedner, SMJ | 1 |
| Hirose, R | 1 |
| Tsurutani, Y | 1 |
| Sugisawa, C | 1 |
| Inoue, K | 1 |
| Suematsu, S | 1 |
| Nagata, M | 1 |
| Hasegawa, N | 1 |
| Kakuta, Y | 1 |
| Yonamine, M | 1 |
| Takekoshi, K | 1 |
| Kimura, N | 1 |
| Saito, J | 1 |
| Nishikawa, T | 1 |
| Taïeb, D | 2 |
| Sulkowski, PL | 1 |
| Sundaram, RK | 1 |
| Oeck, S | 1 |
| Corso, CD | 1 |
| Liu, Y | 1 |
| Noorbakhsh, S | 1 |
| Niger, M | 1 |
| Boeke, M | 1 |
| Ueno, D | 1 |
| Kalathil, AN | 1 |
| Bao, X | 1 |
| Li, J | 1 |
| Shuch, B | 1 |
| Bindra, RS | 1 |
| Glazer, PM | 1 |
| Eijkelenkamp, K | 1 |
| Osinga, TE | 1 |
| Links, TP | 1 |
| van der Horst-Schrivers, ANA | 1 |
| Rao, JU | 2 |
| Engelke, UF | 1 |
| Rodenburg, RJ | 1 |
| Wevers, RA | 1 |
| Eisenhofer, G | 2 |
| Qin, N | 2 |
| Kusters, B | 1 |
| Goudswaard, AG | 1 |
| Lenders, JW | 2 |
| Hermus, AR | 1 |
| Mensenkamp, AR | 1 |
| Kunst, HP | 1 |
| Sweep, FC | 1 |
| Timmers, HJ | 2 |
| Peitzsch, M | 1 |
| Rapizzi, E | 1 |
| de Cubas, AA | 1 |
| Schiavi, F | 1 |
| Beuschlein, F | 1 |
| Quinkler, M | 1 |
| Opocher, G | 1 |
| Mannelli, M | 1 |
| Robledo, M | 1 |
| Imperiale, A | 1 |
| Moussallieh, FM | 1 |
| Roche, P | 1 |
| Battini, S | 1 |
| Cicek, AE | 1 |
| Sebag, F | 1 |
| Brunaud, L | 1 |
| Barlier, A | 1 |
| Elbayed, K | 1 |
| Loundou, A | 1 |
| Bachellier, P | 1 |
| Goichot, B | 1 |
| Stratakis, CA | 1 |
| Namer, IJ | 1 |
| Bellucci, A | 1 |
| Morin, A | 1 |
| Janin, M | 1 |
| Ottolenghi, C | 1 |
| Zinzindohoué, F | 1 |
| Autret, G | 1 |
| Robidel, E | 1 |
| Banting, B | 1 |
| Fontaine, S | 1 |
| Cuenod, CA | 1 |
| Benit, P | 1 |
| Rustin, P | 1 |
| Halimi, P | 1 |
| Fournier, L | 1 |
| Tavitian, B | 1 |
3 reviews available for succinic acid and Pheochromocytoma
| Article | Year |
|---|---|
The connection between tricarboxylic acid cycle enzyme mutations and pseudohypoxic signaling in pheochromocytoma and paraganglioma.
Topics: Adrenal Gland Neoplasms; Citric Acid Cycle; Dioxygenases; Fumarates; Humans; Ketoglutaric Acids; Mut | 2023 |
New Insights into the Nuclear Imaging Phenotypes of Cluster 1 Pheochromocytoma and Paraganglioma.
Topics: Adrenal Gland Neoplasms; Catecholamines; Fluorodeoxyglucose F18; Humans; Paraganglioma; Phenotype; P | 2017 |
Clinical implications of the oncometabolite succinate in SDHx-mutation carriers.
Topics: Adrenal Gland Neoplasms; Biomarkers, Tumor; Carcinoma, Renal Cell; Genetic Predisposition to Disease | 2020 |
13 other studies available for succinic acid and Pheochromocytoma
| Article | Year |
|---|---|
SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas.
Topics: Adrenal Gland Neoplasms; Animals; Carcinogenesis; Cell Transformation, Neoplastic; Dioxygenases; Mic | 2022 |
Succinate: A Serum Biomarker of SDHB-Mutated Paragangliomas and Pheochromocytomas.
Topics: Adrenal Gland Neoplasms; Biomarkers, Tumor; Germ-Line Mutation; Humans; Mutation; Paraganglioma; Phe | 2022 |
Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation.
Topics: Adrenal Gland Neoplasms; CD8-Positive T-Lymphocytes; Cytokines; Glucose; Humans; Paraganglioma; Pheo | 2022 |
SDHx mutation and pituitary adenoma: can in vivo 1H-MR spectroscopy unravel the link?
Topics: Adenoma; Adrenal Gland Neoplasms; Germ-Line Mutation; Humans; Magnetic Resonance Spectroscopy; Mutat | 2023 |
SDHx mutation and pituitary adenoma: can in vivo 1H-MR spectroscopy unravel the link?
Topics: Adenoma; Adrenal Gland Neoplasms; Germ-Line Mutation; Humans; Magnetic Resonance Spectroscopy; Mutat | 2023 |
SDHx mutation and pituitary adenoma: can in vivo 1H-MR spectroscopy unravel the link?
Topics: Adenoma; Adrenal Gland Neoplasms; Germ-Line Mutation; Humans; Magnetic Resonance Spectroscopy; Mutat | 2023 |
SDHx mutation and pituitary adenoma: can in vivo 1H-MR spectroscopy unravel the link?
Topics: Adenoma; Adrenal Gland Neoplasms; Germ-Line Mutation; Humans; Magnetic Resonance Spectroscopy; Mutat | 2023 |
Serum Succinate/Fumarate Ratio in Patients With Paraganglioma/Pheochromocytoma Attending an Endocrine Oncogenetic Unit.
Topics: Adrenal Gland Neoplasms; Carcinogenesis; Cell Transformation, Neoplastic; Fumarates; Germ-Line Mutat | 2023 |
Modeling succinate dehydrogenase loss disorders in C. elegans through effects on hypoxia-inducible factor.
Topics: Adrenal Gland Neoplasms; Amino Acids, Dicarboxylic; Animals; Animals, Genetically Modified; Caenorha | 2019 |
Succinate Mediates Tumorigenic Effects
Topics: Animals; Humans; Mice; Mutation; Paraganglioma; Pheochromocytoma; Protein Subunits; Rats; Receptors, | 2021 |
Hereditary pheochromocytoma/paraganglioma syndrome with a novel mutation in the succinate dehydrogenase subunit B gene in a Japanese family: two case reports.
Topics: Adrenal Gland Neoplasms; Adult; Female; Humans; Japan; Mutation; Neoplasm Recurrence, Local; Paragan | 2021 |
Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair.
Topics: Adrenal Gland Neoplasms; Cell Line; Cell Line, Tumor; Citric Acid Cycle; DNA Breaks, Double-Stranded | 2018 |
Genotype-specific abnormalities in mitochondrial function associate with distinct profiles of energy metabolism and catecholamine content in pheochromocytoma and paraganglioma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Catecholamines; Electron Transport Complex II; Energy Me | 2013 |
Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas/paragangliomas due to succinate dehydrogenase deficiency.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Citric Acid Cycle; Female; Follow-Up Studies; Fuma | 2014 |
Metabolome profiling by HRMAS NMR spectroscopy of pheochromocytomas and paragangliomas detects SDH deficiency: clinical and pathophysiological implications.
Topics: Female; Humans; Immunohistochemistry; Male; Metabolic Networks and Pathways; Metabolome; Metabolomic | 2015 |
In Vivo Detection of Succinate by Magnetic Resonance Spectroscopy as a Hallmark of SDHx Mutations in Paraganglioma.
Topics: Animals; Electron Transport Complex II; Genetic Predisposition to Disease; Germ-Line Mutation; Human | 2016 |