3,4-dihydroxyphenylacetic acid has been researched along with Pheochromocytoma in 13 studies
3,4-Dihydroxyphenylacetic Acid: A deaminated metabolite of LEVODOPA.
(3,4-dihydroxyphenyl)acetic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine.
dihydroxyphenylacetic acid : A dihydroxy monocarboxylic acid consisting of phenylacetic acid having two phenolic hydroxy substituents.
Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of an organophosphate (OP) pesticide, fenthion (FEN), on the release and metabolism of dopamine were evaluated in a clonal line of rat pheochromocytoma (PC12) cells." | 7.67 | Release and metabolism of dopamine in a clonal line of pheochromocytoma (PC12) cells exposed to fenthion. ( Bowen, JM; Hazen, AA; Tuler, SM, 1989) |
| "The effects of an organophosphate (OP) pesticide, fenthion (FEN), on the release and metabolism of dopamine were evaluated in a clonal line of rat pheochromocytoma (PC12) cells." | 3.67 | Release and metabolism of dopamine in a clonal line of pheochromocytoma (PC12) cells exposed to fenthion. ( Bowen, JM; Hazen, AA; Tuler, SM, 1989) |
| " Our data show that opioid drugs (heroin and morphine) are more toxic than stimulant drugs (d-amphetamine and cocaine)." | 1.31 | Toxic effects of opioid and stimulant drugs on undifferentiated PC12 cells. ( Macedo, TR; Morgadinho, MT; Oliveira, CR; Oliveira, MT; Rego, AC, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Serra, PA | 1 |
| Rocchitta, G | 1 |
| Delogu, MR | 1 |
| Migheli, R | 1 |
| Taras, MG | 1 |
| Mura, MP | 1 |
| Esposito, G | 1 |
| Miele, E | 1 |
| Desole, MS | 1 |
| Miele, M | 1 |
| PETRASEK, J | 1 |
| DUBOVSKY, J | 1 |
| VICH, Z | 1 |
| Fornai, F | 1 |
| Lenzi, P | 1 |
| Gesi, M | 1 |
| Ferrucci, M | 1 |
| Lazzeri, G | 1 |
| Busceti, CL | 1 |
| Ruffoli, R | 1 |
| Soldani, P | 1 |
| Ruggieri, S | 1 |
| Alessandri, MG | 1 |
| Paparelli, A | 1 |
| Sasaki, M | 1 |
| Sanada, H | 1 |
| Joseph, MH | 1 |
| Kadam, BV | 1 |
| Risby, D | 1 |
| Anastasiadis, PZ | 1 |
| States, JC | 1 |
| Kuhn, DM | 1 |
| Levine, RA | 1 |
| Oliveira, MT | 1 |
| Rego, AC | 1 |
| Morgadinho, MT | 1 |
| Macedo, TR | 1 |
| Oliveira, CR | 1 |
| Peyrin, L | 1 |
| Cottet-Emard, JM | 1 |
| Claustre, B | 1 |
| Smythe, GA | 1 |
| Edwards, G | 1 |
| Graham, P | 1 |
| Lazarus, L | 1 |
| Maruyama, W | 1 |
| Minami, M | 1 |
| Ota, A | 1 |
| Takahashi, T | 1 |
| Takahashi, A | 1 |
| Nagatsu, T | 1 |
| Naoi, M | 1 |
| Kanthasamy, AG | 1 |
| Maduh, EU | 1 |
| Peoples, RW | 1 |
| Borowitz, JL | 1 |
| Isom, GE | 1 |
| Shigetomi, S | 1 |
| Tuler, SM | 1 |
| Hazen, AA | 1 |
| Bowen, JM | 1 |
1 review available for 3,4-dihydroxyphenylacetic acid and Pheochromocytoma
| Article | Year |
|---|---|
[3,4-Dihydroxyphenylacetic acid (DOPAC)].
Topics: 3,4-Dihydroxyphenylacetic Acid; Addison Disease; Adrenal Gland Neoplasms; Alzheimer Disease; Biomark | 2005 |
12 other studies available for 3,4-dihydroxyphenylacetic acid and Pheochromocytoma
| Article | Year |
|---|---|
Role of the nitric oxide/cyclic GMP pathway and extracellular environment in the nitric oxide donor-induced increase in dopamine secretion from PC12 cells: a microdialysis in vitro study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Ascorbic Acid; Calcium; Calcium Channel Blockers; Cell Surv | 2003 |
[EXCRETION OF 3,4-DIHYDROXYPHENYLACETIC ACID (DOPAC) IN PATIENTS WITH NEUROBLASTOMA AND PHEOCHROMOCYTOMA].
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Gland Neoplasms; Chromatography; Humans; Neuroblastoma; Phen | 1964 |
Fine structure and biochemical mechanisms underlying nigrostriatal inclusions and cell death after proteasome inhibition.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Animals; Cell Death; Corpus Striatum; Cysteine Endop | 2003 |
Simple high-performance liquid chromatographic method for the concurrent determination of the amine metabolites vanillylmandelic acid, 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid, dihydroxyphenylacetic acid and homovanillic acid in urine u
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Gland Neoplasms; Carbidopa; Chromatography, High Pressure Li | 1981 |
Co-induction of tetrahydrobiopterin (BH4) levels and tyrosine hydroxylase activity in cultured PC12 cells.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Gland Neoplasms; Analysis of Variance; Animals; Biopterins; | 1993 |
Toxic effects of opioid and stimulant drugs on undifferentiated PC12 cells.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Surviva | 2002 |
Studies on urinary DOPAC in man by means of a sensitive automated procedure.
Topics: 3,4-Dihydroxyphenylacetic Acid; Addison Disease; Adrenal Gland Neoplasms; Adult; Aged; Autoanalysis; | 1978 |
Biochemical diagnosis of pheochromocytoma by simultaneous measurement of urinary excretion of epinephrine and norepinephrine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Gland Neoplasms; Dopamine; Epinephrine; Gas Chromatography-M | 1992 |
Reduction of enzymatic activity of tyrosine hydroxylase by a heterocyclic amine, 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole (Trp-P-1), was due to reduced affinity to a cofactor biopterin.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Gland Neoplasms; Animals; Biopterins; Carbolines; Cell Line; | 1991 |
Calcium mediation of cyanide-induced catecholamine release: implications for neurotoxicity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Gland Neoplasms; Animals; Calcium; Cell Line; Cerebral Corte | 1991 |
[Clinical significance of 3,4-dihydroxyphenyl acetic acid analysis in endocrine tests of the adrenal medulla and sympathetic nervous system].
Topics: 3,4-Dihydroxyphenylacetic Acid; Addison Disease; Adrenal Gland Neoplasms; Adrenal Medulla; Adult; Ag | 1989 |
Release and metabolism of dopamine in a clonal line of pheochromocytoma (PC12) cells exposed to fenthion.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Gland Neoplasms; Animals; Dopamine; Fenthion; Homovanillic A | 1989 |