staurosporine aglycone has been researched along with Pheochromocytoma in 22 studies
staurosporine aglycone: metabolite from culture broth of Nocardiopsis sp.; a neurotrophin antag; inhibits BDNF TrkB receptor
Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nerve growth factor (NGF), basic fibroblast growth factor (bFGF), dibutyryl cAMP and forskolin, known differentiating agents for pheochromocytoma PC12 cells, induced sustained activation of sphingosine kinase, the enzyme responsible for the formation of the sphingolipid second messenger, sphingosine-1-phosphate, which mediates the mitogenic effects of certain growth factors." | 7.69 | Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors. ( Edsall, LC; Rius, RA; Spiegel, S, 1997) |
| "Nerve growth factor (NGF), basic fibroblast growth factor (bFGF), dibutyryl cAMP and forskolin, known differentiating agents for pheochromocytoma PC12 cells, induced sustained activation of sphingosine kinase, the enzyme responsible for the formation of the sphingolipid second messenger, sphingosine-1-phosphate, which mediates the mitogenic effects of certain growth factors." | 3.69 | Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors. ( Edsall, LC; Rius, RA; Spiegel, S, 1997) |
| " A tyrosine kinase inhibitor, herbimycin, inhibited neurite outgrowth of rat pheochromocytoma PC12 cells induced by NGF but not that by dibutyryl-cAMP." | 3.68 | Specific inhibition of NGF receptor tyrosine kinase activity by K-252a. ( Hashimoto, Y; Hattori, S; Muroya, K; Nakamura, S, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (27.27) | 18.7374 |
| 1990's | 13 (59.09) | 18.2507 |
| 2000's | 3 (13.64) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahn, JY | 1 |
| Kang, L | 1 |
| Kim, HJ | 1 |
| Kang, H | 1 |
| Kim, SH | 1 |
| Kim, JY | 1 |
| Kim, SK | 1 |
| Wang, KC | 1 |
| Cho, BK | 1 |
| Lee, KW | 1 |
| Roh, JK | 1 |
| Kim, M | 1 |
| Sobue, S | 1 |
| Hagiwara, K | 1 |
| Banno, Y | 1 |
| Tamiya-Koizumi, K | 1 |
| Suzuki, M | 1 |
| Takagi, A | 1 |
| Kojima, T | 1 |
| Asano, H | 1 |
| Nozawa, Y | 1 |
| Murate, T | 1 |
| Nakanishi, N | 1 |
| Onozawa, S | 1 |
| Matsumoto, R | 1 |
| Kurihara, K | 1 |
| Ueha, T | 1 |
| Hasegawa, H | 1 |
| Minami, N | 1 |
| Rius, RA | 1 |
| Edsall, LC | 1 |
| Spiegel, S | 1 |
| Macdonald, NJ | 1 |
| Taglialatela, G | 1 |
| Tapley, P | 1 |
| Lamballe, F | 1 |
| Barbacid, M | 1 |
| Muroya, K | 1 |
| Hashimoto, Y | 1 |
| Hattori, S | 1 |
| Nakamura, S | 1 |
| Knüsel, B | 1 |
| Kaplan, DR | 1 |
| Winslow, JW | 1 |
| Rosenthal, A | 1 |
| Burton, LE | 1 |
| Beck, KD | 1 |
| Rabin, S | 1 |
| Nikolics, K | 1 |
| Hefti, F | 1 |
| Loeb, DM | 1 |
| Maragos, J | 1 |
| Martin-Zanca, D | 1 |
| Chao, MV | 1 |
| Parada, LF | 1 |
| Greene, LA | 3 |
| Rukenstein, A | 1 |
| Rydel, RE | 1 |
| Nagashima, K | 1 |
| Nakanishi, S | 1 |
| Matsuda, Y | 3 |
| Tischler, AS | 1 |
| Ruzicka, LA | 1 |
| Perlman, RL | 1 |
| Nikodijevic, B | 1 |
| Creveling, CR | 1 |
| Koizumi, S | 4 |
| Guroff, G | 4 |
| Rowland-Gagné, E | 1 |
| Sano, M | 1 |
| Nishiyama, K | 1 |
| Kitajima, S | 1 |
| Hashimoto, S | 2 |
| Hagino, A | 1 |
| Lazarovici, P | 2 |
| Levi, BZ | 1 |
| Lelkes, PI | 1 |
| Fujita, K | 2 |
| Ozato, K | 1 |
| Smith, DS | 1 |
| King, CS | 1 |
| Pearson, E | 1 |
| Gittinger, CK | 1 |
| Landreth, GE | 1 |
| Rausch, DM | 1 |
| Dickens, G | 1 |
| Doll, S | 1 |
| Rudkin, BB | 1 |
| Tocco, M | 1 |
| Eiden, LE | 1 |
| Doherty, P | 1 |
| Seaton, P | 1 |
| Flanigan, TP | 1 |
| Walsh, FS | 1 |
| Contreras, ML | 1 |
| Hama, T | 1 |
22 other studies available for staurosporine aglycone and Pheochromocytoma
| Article | Year |
|---|---|
Induction method of tyrosine kinase A-mediated cell death in rat pheochromocytoma.
Topics: Animals; Apoptosis; Blotting, Western; Carbazoles; Cell Survival; Culture Media, Serum-Free; Enzyme | 2005 |
Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor-induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12.
Topics: Animals; Blotting, Western; Brain; Carbazoles; Chromatin Immunoprecipitation; Electrophoretic Mobili | 2005 |
Effects of protein kinase inhibitors and protein phosphatase inhibitors on cyclic AMP-dependent down-regulation of vesicular monoamine transport in pheochromocytoma PC12 cells.
Topics: Animals; Biogenic Monoamines; Biological Transport; Bucladesine; Carbazoles; Cyclic AMP; Down-Regula | 1995 |
Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors.
Topics: Animals; Carbazoles; Carrier Proteins; Cytosol; Enzyme Activation; Epidermal Growth Factor; Growth S | 1997 |
Tumor necrosis factor-alpha and nerve growth factor synergistically induce iNOS in pheochromocytoma cells.
Topics: Adrenal Gland Neoplasms; Animals; Carbazoles; Dose-Response Relationship, Drug; Drug Synergism; Enzy | 2000 |
K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors.
Topics: 3T3 Cells; Animals; Carbazoles; Cell Differentiation; Cell Transformation, Neoplastic; Enzyme Activa | 1992 |
Specific inhibition of NGF receptor tyrosine kinase activity by K-252a.
Topics: Adrenal Gland Neoplasms; Amino Acid Sequence; Animals; Benzoquinones; Bucladesine; Carbazoles; Glyco | 1992 |
K-252b selectively potentiates cellular actions and trk tyrosine phosphorylation mediated by neurotrophin-3.
Topics: Adrenal Gland Neoplasms; Alkaloids; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Cells, C | 1992 |
The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines.
Topics: Adrenal Gland Neoplasms; Animals; Blotting, Northern; Carbazoles; Cell Differentiation; Cell Divisio | 1991 |
Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms.
Topics: Adrenal Gland Neoplasms; Animals; Blood; Carbazoles; Cell Survival; Culture Media; Indole Alkaloids; | 1991 |
Inhibition of nerve growth factor-induced neurite outgrowth of PC12 cells by a protein kinase inhibitor which does not permeate the cell membrane.
Topics: Adrenal Gland Neoplasms; Animals; Carbazoles; Cell Division; Cell Line; Cell Membrane Permeability; | 1991 |
Mimicry and inhibition of nerve growth factor effects: interactions of staurosporine, forskolin, and K252a in PC12 cells and normal rat chromaffin cells in vitro.
Topics: Adrenal Gland Neoplasms; Adrenal Medulla; Alkaloids; Animals; Animals, Newborn; Axons; Carbazoles; C | 1990 |
Nerve growth factor and K-252a increase catecholamine release from PC12 cells.
Topics: Adrenal Gland Neoplasms; Animals; Carbazoles; Catecholamines; Chromatography, High Pressure Liquid; | 1990 |
Multiple pathways of N-kinase activation in PC12 cells.
Topics: Animals; Carbazoles; Chromatography; Cyclic AMP; Down-Regulation; Enzyme Activation; Indole Alkaloid | 1990 |
A nerve growth factor-dependent protein kinase that phosphorylates microtubule-associated proteins in vitro: possible involvement of its activity in the outgrowth of neurites from PC12 cells.
Topics: Adrenal Gland Neoplasms; Animals; Axons; Bucladesine; Carbazoles; Indole Alkaloids; Kinetics; Magnes | 1990 |
Nerve growth factor-induced transient increase in the phosphorylation of ribosomal protein S6 mediated through a mechanism independent of cyclic AMP-dependent protein kinase and protein kinase C.
Topics: Adenosine Triphosphate; Adrenal Gland Neoplasms; Animals; Bucladesine; Carbazoles; Cell-Free System; | 1990 |
K-252a inhibits the increase in c-fos transcription and the increase in intracellular calcium produced by nerve growth factor in PC12 cells.
Topics: Adrenal Gland Neoplasms; Animals; Calcium; Carbazoles; Cell Line; DNA-Binding Proteins; Indole Alkal | 1989 |
Selective inhibition of nerve growth factor-stimulated protein kinases by K-252a and 5'-S-methyladenosine in PC12 cells.
Topics: Adenosine; Adrenal Gland Neoplasms; Animals; Carbazoles; Cyclic AMP; Enzyme Activation; Epidermal Gr | 1989 |
Differentiation of PC12 cells with v-src: comparison with nerve growth factor.
Topics: Adrenal Gland Neoplasms; Amphibian Proteins; Animals; Binding, Competitive; Carbazoles; Carrier Prot | 1989 |
K-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in PC12h cells.
Topics: Animals; Bucladesine; Carbazoles; Cell Differentiation; Indole Alkaloids; Molecular Weight; Nerve Gr | 1988 |
Factors controlling the expression of the NGF receptor in PC12 cells.
Topics: Animals; Carbazoles; Cholera Toxin; Deoxyadenosines; Fibroblast Growth Factors; Indole Alkaloids; Ne | 1988 |
K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells.
Topics: Adrenal Gland Neoplasms; Carbazoles; Indole Alkaloids; Nerve Growth Factors; Pheochromocytoma | 1988 |