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clomipramine and Pheochromocytoma

clomipramine has been researched along with Pheochromocytoma in 3 studies

Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.

Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)

Research Excerpts

ExcerptRelevanceReference
" In the VMAT-expressing NE tumour cell lines GOT1 and BON and in VMAT-expressing primary NE tumour cell cultures (carcinoids, n=4 and pheochromocytomas, n=4), reserpine significantly reduced the uptake of (123)I-MIBG."3.72Uptake of meta-iodobenzylguanidine in neuroendocrine tumours is mediated by vesicular monoamine transporters. ( Ahlman, H; Bernhardt, P; Forssell-Aronsson, E; Johanson, V; Kölby, L; Levin-Jakobsen, AM; Nilsson, O; Wängberg, B, 2003)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's2 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kölby, L2
Bernhardt, P2
Levin-Jakobsen, AM1
Johanson, V1
Wängberg, B1
Ahlman, H2
Forssell-Aronsson, E2
Nilsson, O2
Jakobsen, AM1
Korzets, A1
Floro, S1
Ori, Y1
Weizer, N1
Gruzman, C1

Other Studies

3 other studies available for clomipramine and Pheochromocytoma

ArticleYear
Uptake of meta-iodobenzylguanidine in neuroendocrine tumours is mediated by vesicular monoamine transporters.
    British journal of cancer, 2003, Oct-06, Volume: 89, Issue:7

    Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Adrenergic Uptake Inhibitors; Animals; Antineoplasti

2003
Importance of vesicle proteins in the diagnosis and treatment of neuroendocrine tumors.
    Annals of the New York Academy of Sciences, 2004, Volume: 1014

    Topics: 3-Iodobenzylguanidine; Adenocarcinoma; Adrenal Gland Neoplasms; Adrenergic Uptake Inhibitors; Biopsy

2004
Clomipramine-induced pheochromocytoma crisis: a near fatal complication of a tricyclic antidepressant.
    Journal of clinical psychopharmacology, 1997, Volume: 17, Issue:5

    Topics: Adrenal Gland Neoplasms; Antidepressive Agents, Tricyclic; Bipolar Disorder; Clomipramine; Drug Ther

1997