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pirenzepine and Pheochromocytoma

pirenzepine has been researched along with Pheochromocytoma in 5 studies

Pirenzepine: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.

Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)

Research Excerpts

ExcerptRelevanceReference
"The high affinity binding of the muscarinic ligand 3H-N-methylscopolamine (3H-NMS) to intact cells of the rat pheochromocytoma cell line PC12 was studied."3.67Muscarinic cholinergic receptors in a rat phaeochromocytoma cell line. ( Cross, AJ; Frith, C; Johnson, JA; Taylor, GR, 1984)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19905 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cross, AJ1
Johnson, JA1
Frith, C1
Taylor, GR1
Horwitz, J1
Takashima, A1
Kenimer, JG1
Michel, AD1
Stefanich, E1
Whiting, RL1
Gatti, G1
Madeddu, L1
Pandiella, A1
Pozzan, T1
Meldolesi, J1

Other Studies

5 other studies available for pirenzepine and Pheochromocytoma

ArticleYear
Muscarinic cholinergic receptors in a rat phaeochromocytoma cell line.
    Biochemical and biophysical research communications, 1984, Feb-29, Volume: 119, Issue:1

    Topics: Animals; Benzodiazepinones; Cell Line; N-Methylscopolamine; Pheochromocytoma; Pirenzepine; Rats; Rec

1984
Muscarinic receptor stimulation increases inositol-phospholipid metabolism and inhibits cyclic AMP accumulation in PC12 cells.
    Journal of neurochemistry, 1989, Volume: 53, Issue:1

    Topics: Animals; Cyclic AMP; Muscarine; N-Methylscopolamine; Pheochromocytoma; Phorbol Esters; Phosphatidyli

1989
Muscarinic-stimulated norepinephrine release and phosphoinositide hydrolysis in PC12 cells are independent events.
    The Journal of biological chemistry, 1989, Jun-25, Volume: 264, Issue:18

    Topics: Adrenal Gland Neoplasms; Animals; Atropine; Cell Line; Diamines; Hydrolysis; Kinetics; Methacholine

1989
PC12 phaeochromocytoma cells contain an atypical muscarinic receptor binding site.
    British journal of pharmacology, 1989, Volume: 97, Issue:3

    Topics: Adrenal Gland Neoplasms; Animals; Binding, Competitive; Cell Membrane; Kinetics; Myocardium; N-Methy

1989
Second-messenger generation in PC12 cells. Interactions between cyclic AMP and Ca2+ signals.
    The Biochemical journal, 1988, Nov-01, Volume: 255, Issue:3

    Topics: Animals; Calcium; Carbachol; Cell Differentiation; Cell Line; Clonidine; Cyclic AMP; Imidazoles; Ner

1988