1-(5-isoquinolinesulfonyl)-2-methylpiperazine has been researched along with Pheochromocytoma in 4 studies
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
1-(5-isoquinolinesulfonyl)-2-methylpiperazine : A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group.
Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ishii, A | 1 |
| Kiuchi, K | 1 |
| Kobayashi, R | 1 |
| Sumi, M | 1 |
| Hidaka, H | 3 |
| Nagatsu, T | 1 |
| Tokumitsu, H | 2 |
| Chijiwa, T | 1 |
| Hagiwara, M | 1 |
| Mizutani, A | 1 |
| Terasawa, M | 1 |
| Posypanova, GA | 1 |
| Severin, SE | 1 |
| Kondratyev, AD | 1 |
| Watanabe, M | 1 |
4 other studies available for 1-(5-isoquinolinesulfonyl)-2-methylpiperazine and Pheochromocytoma
| Article | Year |
|---|---|
A selective Ca2+/calmodulin-dependent protein kinase II inhibitor, KN-62, inhibits the enhanced phosphorylation and the activation of tyrosine hydroxylase by 56 mM K+ in rat pheochromocytoma PC12h cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Gland Neoplasms; Animals; Calcium-Calmodulin- | 1991 |
KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Binding Sites; Binding, Competitive; Calcimy | 1990 |
Effect of protein kinase modulators on the induction of morphological differentiation of pheochromocytoma PC12 cells by nerve and fibroblast growth factors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Axons; Cell Differentiation; Cyclic AMP; Cyc | 1990 |
Search for the functional substrate proteins of protein kinases and their selective inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenal Gland Neoplasms; Animals; Calcium; Calcium-Ca | 1990 |