ergoline and Pheochromocytoma

Regulation of dopamine (DA) release from PC12 cells was investigated. Apomorphine and quinpirole, a selective D2 agonist, significantly reduced K(+)-evoked DA release, and this reduction was reversed by haloperidol. Furthermore, spiroperidol, a selective D2 antagonist, and haloperidol, a nonselective DA antagonist, enhanced the K(+)-evoked DA release. Pertussis toxin treatment of the cells abolished the quinpirole-induced reduction of K(+)-evoked DA release. Also, the haloperidol-induced enhancement of K(+)-evoked DA release was not seen in pertussis toxin treated cells. These results, therefore, suggest the presence of D2 receptors on PC12 cells which result in the modulation of K(+)-evoked DA release via a pertussis toxin-sensitive G protein.

Topics: Adrenal Gland Neoplasms; Animals; Apomorphine; Cell Line; Dopamine; Dopamine Antagonists; Ergolines; GTP-Binding Proteins; Haloperidol; Nicotine; Pertussis Toxin; Pheochromocytoma; Potassium; Quinpirole; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Virulence Factors, Bordetella

Topics: Adrenal Gland Neoplasms; Ergolines; Female; Humans; Hypertension; Injections, Intravenous; Middle Aged; Nicergoline; Pheochromocytoma; Postoperative Complications

Topics: Adrenal Gland Neoplasms; Ergolines; Female; Humans; Hypertension; Intraoperative Care; Middle Aged; Nicergoline; Pheochromocytoma

Topics: Adrenal Gland Neoplasms; Adult; Anesthesia, General; Ergolines; Hemodynamics; Humans; Injections, Intravenous; Intraoperative Period; Male; Nicergoline; Pheochromocytoma; Preoperative Care