mRNA cap guanine-N7 methyltransferase

An mRNA cap guanine-N7 methyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43148]

EC 2.1.1.56;
RG7MT1;
mRNA (guanine-N(7)-)-methyltransferase;
mRNA cap methyltransferase;
hCMT1;
hMet;
hcm1p

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sinefungin	Homo sapiens (human)	IC50	0.0335	3	3

This protein enables 3 target(s):

Target	Category	Definition
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
mRNA 5'-cap (guanine-N7-)-methyltransferase activity	molecular function	Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine. [EC:2.1.1.56]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]

This protein is located in 3 target(s):

Target	Category	Definition
fibrillar center	cellular component	A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. [PMID:10754561]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

This protein is part of 3 target(s):

Target	Category	Definition
mRNA capping enzyme complex	cellular component	A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping. [GOC:vw, PMID:10347220, PMID:12455993, PMID:9345280]
receptor complex	cellular component	Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators]
mRNA cap methyltransferase RNMT:RAMAC complex	cellular component	A protein complex that consists of RNA guanine-7 methyltransferase (RNMT) and RNA guanine-7 methyltransferase activating subunit (RAMAC) and is involved in mRNA cap methylation. [PMID:22099306]

This protein is involved in 3 target(s):

Target	Category	Definition
7-methylguanosine mRNA capping	biological process	The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively. [GOC:mah, PMID:9266685]
RNA 5'-cap (guanine-N7)-methylation	biological process	The process whereby a guanine in 5-cap is methylated at the N7 position of guanine. [GOC:hjd]
cellular response to leukemia inhibitory factor	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. [PMID:12801913]